CN111632105A - 一种止咳橘红颗粒及其制备方法 - Google Patents
一种止咳橘红颗粒及其制备方法 Download PDFInfo
- Publication number
- CN111632105A CN111632105A CN201910139390.3A CN201910139390A CN111632105A CN 111632105 A CN111632105 A CN 111632105A CN 201910139390 A CN201910139390 A CN 201910139390A CN 111632105 A CN111632105 A CN 111632105A
- Authority
- CN
- China
- Prior art keywords
- parts
- extract
- granules
- water
- gypsum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008187 granular material Substances 0.000 title claims abstract description 54
- 206010011224 Cough Diseases 0.000 title claims abstract description 45
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 title claims description 13
- 238000002360 preparation method Methods 0.000 title description 27
- 239000000463 material Substances 0.000 claims abstract description 32
- 229910052602 gypsum Inorganic materials 0.000 claims abstract description 23
- 239000010440 gypsum Substances 0.000 claims abstract description 23
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims abstract description 20
- 239000004376 Sucralose Substances 0.000 claims abstract description 20
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000001630 malic acid Substances 0.000 claims abstract description 20
- 235000011090 malic acid Nutrition 0.000 claims abstract description 20
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims abstract description 20
- 235000019408 sucralose Nutrition 0.000 claims abstract description 20
- 239000007787 solid Substances 0.000 claims abstract description 16
- 239000004375 Dextrin Substances 0.000 claims abstract description 15
- 229920001353 Dextrin Polymers 0.000 claims abstract description 15
- 235000019425 dextrin Nutrition 0.000 claims abstract description 15
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 11
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 11
- 235000006753 Platycodon grandiflorum Nutrition 0.000 claims abstract description 11
- 244000197580 Poria cocos Species 0.000 claims abstract description 11
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 11
- 244000276331 Citrus maxima Species 0.000 claims abstract description 10
- 235000001759 Citrus maxima Nutrition 0.000 claims abstract description 10
- 244000144725 Amygdalus communis Species 0.000 claims abstract description 7
- 235000004347 Perilla Nutrition 0.000 claims abstract description 7
- 244000124853 Perilla frutescens Species 0.000 claims abstract description 7
- 235000003893 Prunus dulcis var amara Nutrition 0.000 claims abstract description 7
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 7
- 235000011477 liquorice Nutrition 0.000 claims abstract description 7
- 241000490229 Eucephalus Species 0.000 claims abstract description 6
- 241000628997 Flos Species 0.000 claims abstract description 4
- 241000405911 Rehmannia glutinosa Species 0.000 claims abstract description 4
- 244000274050 Platycodon grandiflorum Species 0.000 claims abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 83
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 53
- 239000000243 solution Substances 0.000 claims description 50
- 238000002156 mixing Methods 0.000 claims description 30
- 239000000706 filtrate Substances 0.000 claims description 24
- 238000001914 filtration Methods 0.000 claims description 24
- 238000000605 extraction Methods 0.000 claims description 21
- 238000005303 weighing Methods 0.000 claims description 11
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 10
- 235000004869 Tussilago farfara Nutrition 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- 241000405414 Rehmannia Species 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 7
- 239000006228 supernatant Substances 0.000 claims description 7
- 235000008326 Trichosanthes anguina Nutrition 0.000 claims description 6
- 244000078912 Trichosanthes cucumerina Species 0.000 claims description 6
- 238000011084 recovery Methods 0.000 claims description 6
- 239000012530 fluid Substances 0.000 claims description 5
- 238000001556 precipitation Methods 0.000 claims description 5
- 239000007864 aqueous solution Substances 0.000 claims description 4
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 238000010992 reflux Methods 0.000 claims description 4
- 235000013399 edible fruits Nutrition 0.000 claims description 2
- 238000005469 granulation Methods 0.000 claims description 2
- 230000003179 granulation Effects 0.000 claims description 2
- 240000000377 Tussilago farfara Species 0.000 claims 1
- 241000675108 Citrus tangerina Species 0.000 abstract description 10
- 206010062717 Increased upper airway secretion Diseases 0.000 abstract description 8
- 208000026435 phlegm Diseases 0.000 abstract description 8
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 230000001603 reducing effect Effects 0.000 abstract description 3
- 238000012360 testing method Methods 0.000 abstract description 3
- 239000007779 soft material Substances 0.000 description 10
- 240000003582 Platycodon grandiflorus Species 0.000 description 7
- 241000249864 Tussilago Species 0.000 description 7
- 239000012153 distilled water Substances 0.000 description 6
- 244000018633 Prunus armeniaca Species 0.000 description 5
- 235000009827 Prunus armeniaca Nutrition 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 239000008213 purified water Substances 0.000 description 5
- 241000132092 Aster Species 0.000 description 4
- 241000282461 Canis lupus Species 0.000 description 4
- 235000017443 Hedysarum boreale Nutrition 0.000 description 4
- 235000007858 Hedysarum occidentale Nutrition 0.000 description 4
- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 description 4
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 description 4
- 239000011507 gypsum plaster Substances 0.000 description 4
- 229960003531 phenolsulfonphthalein Drugs 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000003304 gavage Methods 0.000 description 3
- MCTQNEBFZMBRSQ-GEEYTBSJSA-N Chrysoidine Chemical compound Cl.NC1=CC(N)=CC=C1\N=N\C1=CC=CC=C1 MCTQNEBFZMBRSQ-GEEYTBSJSA-N 0.000 description 2
- 238000012449 Kunming mouse Methods 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 239000003651 drinking water Substances 0.000 description 2
- 235000020188 drinking water Nutrition 0.000 description 2
- 238000005265 energy consumption Methods 0.000 description 2
- 238000012869 ethanol precipitation Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 210000003437 trachea Anatomy 0.000 description 2
- -1 18 to 25 percent Substances 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 206010013789 Dry throat Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 241000218989 Trichosanthes Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 235000011114 ammonium hydroxide Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000001256 steam distillation Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 210000000534 thyroid cartilage Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Otolaryngology (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种止咳橘红颗粒，其按重量百分比计由以下组分组成：浸膏以固体计18％～25％，糊精75％～80％，苹果酸0.1％～0.5％，三氯蔗糖0.02％～0.1％，所述浸膏由化橘红、陈皮、法半夏、茯苓、款冬花、甘草、瓜蒌皮、紫菀、麦冬、知母、桔梗、地黄、石膏、去皮炒苦杏仁、炒紫苏子制备而成。采用一定配比的糊精、苹果酸及三氯蔗糖与中药材浸膏组合，遮蔽掩盖了浸膏本身令人不喜的味道，经试验验证，口感好，止咳，化痰效果良好，更适合工业化大生产。
Description
技术领域
本发明涉及一种止咳橘红颗粒及其制备方法。
背景技术
止咳橘红颗粒，可清肺，止咳，化痰。临床上用于痰热阻肺引起的咳嗽痰多，胸满气短，咽干喉痒。止咳橘红颗粒为纯天然植物药，选用正宗化州橘红，止咳化痰能力强，所应用的药材均性质温和，不良反应少，尤其适用于儿童患者。
目前市场上的止咳橘红颗粒有无糖和含糖的两种，尽管含糖的止咳橘红颗粒一定程度上改善了口感，但味道依然不尽如人意，病人尤其是儿童患者依从性一般，无糖的止咳橘红颗粒口感更糟。并且原止咳橘红颗粒的药材浸膏制备工艺复杂，大规模生产能耗高，效率低。
发明内容
本发明要解决的技术问题是提供一种口感好且不含糖，制备方法简单的止咳橘红颗粒。
为解决上述技术问题，本发明公开了一种止咳橘红颗粒，其按重量百分比计由以下组分组成：浸膏以固体计18％～25％，糊精75％～80％，苹果酸0.1％～0.5％，三氯蔗糖0.02％～0.1％，所述浸膏由化橘红、陈皮、法半夏、茯苓、款冬花、甘草、瓜蒌皮、紫菀、麦冬、知母、桔梗、地黄、石膏、去皮炒苦杏仁、炒紫苏子制备而成。
浸膏优选由如下重量比的化橘红2～4份、陈皮1～3份、法半夏1～2份、茯苓1～3份、款冬花0.5～1.5份、甘草0.5～1.5份、瓜蒌皮1～3份、紫菀1～2份、麦冬1～3份、知母0.5～1.5份、桔梗1～2份、地黄1～3份、石膏1～3份、去皮炒苦杏仁1～3份、炒紫苏子1～2份制备而成。
更优选由如下重量比的化橘红3份、陈皮2份、法半夏1.5份、茯苓2份、款冬花1份、甘草1份、瓜蒌皮2份、紫菀1.5份、麦冬2份、知母1份、桔梗1.5份、地黄2份、石膏2份、去皮炒苦杏仁2份、炒紫苏子1.5份制备而成。
采用一定配比的糊精、苹果酸及三氯蔗糖与中药材浸膏组合，可遮蔽掩盖浸膏本身令人不喜的味道，带来良好的口感，且不含糖，适合不适用糖的患者。
其优选配比为：浸膏以固体计21％，糊精78.73％，苹果酸0.2％，三氯蔗糖0.07％。
其中所述浸膏可通过如下步骤制备：1)组分药材分别称量粗碎；2)石膏，水煎煮，滤过，滤液浓缩得浓缩液备用；3)其余十四味药材，水煎煮，滤过，滤液浓缩，加乙醇使含醇量达到55～65％，取醇沉后的上清液，滤过，滤液浓缩回收乙醇至无醇味；4)石膏浓缩液和收醇浓缩液合并，浓缩至相对密度1.1～1.3即得。
优选所述步骤2)中水煎煮为3次，第一次加10倍量水煎煮1.5小时，第二次、第三次分别加8倍量水煎煮1小时；所述步骤3)中水煎煮两次，第一次加8倍量水煎煮1小时，第二次加8倍量水煎煮1小时，滤过，滤液浓缩至相对密度1.03～1.07，加乙醇使含醇量达到60％，取醇沉24小时后的上清液，滤过，滤液浓缩回收乙醇至无醇味；4)石膏浓缩液和收醇浓缩液合并，浓缩至相对密度1.18～1.22即得。
与现有的浸膏制备方法相比，上述浸膏的制备方法工艺较为简单，流程可控性好，生产能耗低，效率高。
所述浸膏也可通过如下步骤制备：1)组分药材分别称量粗碎；2)石膏置热回流提取浓缩系统中，水煎煮，滤过，滤液浓缩得浓缩液备用；3)其余十四味药材，通过乙醇水溶液作为夹带剂的超临界CO2流体萃取，萃取液回收乙醇至无醇味；4)石膏浓缩液和收醇浓缩液合并，浓缩至相对密度1.18～1.22即得。
优选所述步骤3)中所述乙醇水溶液中乙醇含量为60％，添加量占CO2摩尔流量百分比为6％，萃取温度为55℃，萃取压力为16MPa，萃取时间为2小时。
通过乙醇水溶液作为夹带剂的超临界CO2流体萃取药材中有效成分的方法萃取浸膏，提取效率高，所需时间短，可控性好，药效好。
本发明所公开的止咳橘红颗粒，可通过如下步骤制备1)取浸膏加适量水后加入苹果酸和三氯蔗糖，搅拌均匀，备用；2)浸膏溶液倒入糊精中制粒；3)制得的颗粒干燥、整粒，混合即得。
本发明所公开的止咳橘红颗粒，经试验验证，口感好，止咳，化痰效果良好，更适合工业化大生产。
具体实施方式
以下通过具体实施例再对本发明的上述内容作进一步的详细说明。但不应将此理解为本发明上述主题的范围仅局限于以下的实施例。在不脱离本发明上述技术思想的情况下，根据本领域普通技术知识和惯用手段做出的各种替换或变更，均应包括在本发明的范围内。
实施例1
(制备2000g颗粒)
浸膏处方：
浸膏制备方法：
1)组分药材分别称量粗碎；
2)石膏加水进行煎煮，第一次加10倍量饮用水煎煮1小时，第二次加8倍量饮用水煎煮1小时，滤过，滤液备用。
3)化橘红、陈皮、款冬花、苦杏仁四味，加4倍量水，进行水蒸汽蒸馏，收集蒸馏液；蒸馏器内药液滤过，滤液加乙醇使含醇量达到60％，搅匀，静置，滤过，滤液备用；
4)其余法半夏等十味与上述药渣混匀，用60％乙醇作溶剂，浸渍24小时后进行渗漉，收集漉液。
5)取醇沉24小时后的上清液，滤过，滤液与渗漉液合并，回收乙醇至无醇味。
6)浓缩液与石膏水煎液、蒸馏液合并浓缩至相对密度1.35-1.38g/cm3(50℃)，收膏(以固体计)402g。
颗粒处方：
| 浸膏(含固量) | 402g | 糊精 | 1595.6g |
| 苹果酸 | 2g | 三氯蔗糖 | 0.4g |
颗粒制备方法：
1)取浸膏加入适当纯化水，搅拌均匀，备用；
2)浸膏溶液加入苹果酸和三氯蔗糖于混合制粒机内混合均匀制成软材；
3)软材通过摇摆制粒机制粒；
4)制得的颗粒干燥、整粒，混合即得。
实施例2
(制备2000g颗粒)
浸膏处方：
| 化橘红 | 232g | 陈皮 | 154g | 法半夏 | 116g |
| 茯苓 | 154g | 款冬花 | 77g | 甘草 | 77g |
| 瓜蒌皮 | 154g | 紫菀 | 116g | 麦冬 | 154g |
| 知母 | 77g | 桔梗 | 116g | 地黄 | 154g |
| 石膏 | 154g | 去皮炒苦杏仁 | 154g | 炒紫苏子 | 116g |
浸膏制备方法：
1)组分药材分别称量粗碎；
2)石膏，水煎煮3次，第一次加10倍量水煎煮1小时，第二次、第三次加8倍量水煎煮1小时，滤过，滤液浓缩得浓缩液备用；
3)其余十四味药材，水煎煎煮两次，第一次加8倍量水煎煮2小时，第二次加8倍量水煎煮2小时，滤过，滤液浓缩至相对密度约1.05，加乙醇使含醇量达到60％，取醇沉24小时后的上清液，滤过，滤液浓缩回收乙醇至无醇味；
4)石膏浓缩液和收醇浓缩液合并，浓缩至相对密度约1.35，称重，得浸膏(以固体计)360g。
颗粒处方：
| 浸膏(含固量) | 360g | 糊精 | 1628g |
| 苹果酸 | 10g | 三氯蔗糖 | 2g |
颗粒制备方法：
1)取浸膏加入适当纯化水，搅拌均匀，备用；
2)浸膏溶液加入苹果酸和三氯蔗糖于混合制粒机内混合均匀制成软材；
3)软材通过摇摆制粒机制粒；
4)制得的颗粒干燥、整粒，混合即得。以固体计18％～25％，糊精75％～80％，苹果酸0.1％～0.5％，三氯蔗糖0.02％～0.1％，
实施例3
(制备2000g颗粒)
浸膏处方：
| 化橘红 | 232g | 陈皮 | 154g | 法半夏 | 116g |
| 茯苓 | 154g | 款冬花 | 77g | 甘草 | 77g |
| 瓜蒌皮 | 154g | 紫菀 | 116g | 麦冬 | 154g |
| 知母 | 77g | 桔梗 | 116g | 地黄 | 154g |
| 石膏 | 154g | 去皮炒苦杏仁 | 154g | 炒紫苏子 | 116g |
浸膏制备方法：
1)组分药材分别称量粗碎；
2)石膏，水煎煮3次，第一次加10倍量水煎煮1.5小时，第二次、第三次分别加8倍量水煎煮1小时，滤过，滤液浓缩得浓缩液备用；
3)其余十四味药材，水煎煎煮两次，第一次加8倍量水煎煮1小时，第二次加8倍量水煎煮1小时，滤过，滤液浓缩至相对密度约1.05，加乙醇使含醇量达到60％，取醇沉24小时后的上清液，滤过，滤液浓缩回收乙醇至无醇味；
4)石膏浓缩液和收醇浓缩液合并，浓缩至相对密度约1.34，称重，得浸膏(以固体计)430g。
颗粒处方：
| 浸膏(含固量) | 430g | 糊精 | 1628g |
| 苹果酸 | 10g | 三氯蔗糖 | 2g |
颗粒制备方法：
1)取浸膏加入适当纯化水，搅拌均匀，备用；
2)浸膏溶液加入苹果酸和三氯蔗糖于混合制粒机内混合均匀制成软材；
3)软材通过摇摆制粒机制粒；
4)制得的颗粒干燥、整粒，混合即得。
实施例4
(制备2000g颗粒)
浸膏处方：
| 化橘红 | 232g | 陈皮 | 154g | 法半夏 | 116g |
| 茯苓 | 154g | 款冬花 | 77g | 甘草 | 77g |
| 瓜蒌皮 | 154g | 紫菀 | 116g | 麦冬 | 154g |
| 知母 | 77g | 桔梗 | 116g | 地黄 | 154g |
| 石膏 | 154g | 去皮炒苦杏仁 | 154g | 炒紫苏子 | 116g |
浸膏制备方法：
1)组分药材分别称量粗碎；
2)石膏置热回流提取浓缩系统中，水煎煮3次，第一次加10倍量水煎煮1.5小时，第二次、第三次分别加8倍量水煎煮1小时，滤过，滤液浓缩得浓缩液备用；
3)其余十四味药材，通过摩尔流量百分比为5％的65％乙醇水溶液作为夹带剂的超临界CO2流体萃取，萃取温度为50℃，萃取压力为17MPa，萃取时间为1.5小时，萃取液回收乙醇至无醇味；
4)石膏浓缩液和收醇浓缩液合并，浓缩至相对密度1.33，得浸膏(以固体计)380g。
颗粒处方：
| 浸膏(含固量) | 380g | 糊精 | 1614.6g |
| 苹果酸 | 4g | 三氯蔗糖 | 1.4g |
颗粒制备方法：
1)取浸膏加入适当纯化水，搅拌均匀，备用；
2)浸膏溶液加入苹果酸和三氯蔗糖于混合制粒机内混合均匀制成软材；
3)软材通过摇摆制粒机制粒；
4)制得的颗粒干燥、整粒，混合即得。
实施例5
(制备2000g颗粒)
浸膏处方：
| 化橘红 | 232g | 陈皮 | 154g | 法半夏 | 116g |
| 茯苓 | 154g | 款冬花 | 77g | 甘草 | 77g |
| 瓜蒌皮 | 154g | 紫菀 | 116g | 麦冬 | 154g |
| 知母 | 77g | 桔梗 | 116g | 地黄 | 154g |
| 石膏 | 154g | 去皮炒苦杏仁 | 154g | 炒紫苏子 | 116g |
浸膏制备方法：
1)组分药材分别称量粗碎；
2)石膏置热回流提取浓缩系统中，水煎煮3次，第一次加10倍量水煎煮1.5小时，第二次、第三次分别加8倍量水煎煮1小时，滤过，滤液浓缩得浓缩液备用；
3)其余十四味药材，通过摩尔流量百分比为6％的60％乙醇水溶液作为夹带剂的超临界CO2流体萃取，萃取温度为55℃，萃取压力为16MPa，萃取时间为2小时，萃取液回收乙醇至无醇味；
4)石膏浓缩液和收醇浓缩液合并，浓缩至相对密度1.32，得浸膏(以固体计)401g。
颗粒处方：
| 浸膏(含固量) | 401g | 糊精 | 1593.6g |
| 苹果酸 | 4g | 三氯蔗糖 | 1.4g |
颗粒制备方法：
1)取浸膏加入适当纯化水，搅拌均匀，备用；
2)浸膏溶液加入苹果酸和三氯蔗糖于混合制粒机内混合均匀制成软材；
3)软材通过摇摆制粒机制粒；
4)制得的颗粒干燥、整粒，混合即得。
本发明以上实施例所制备的止咳橘红颗粒的试验测试结果如下：
1)以上实施例所得到的止咳橘红颗粒均为棕黄色颗粒。
2)实施例所制备的止咳橘红颗粒的口感评价：健康志愿者300名，随机分成6组，50人/组，分别给予参比制剂【市售止咳橘红颗粒(无糖)康芝药业股份有限公司】和实施例1～5所制备得样品(1袋，用50ml开水溶解，冷却至60℃，一次饮用完毕)，做口味评分(0～10分)，统计均值。结果显示实施例制得的样品口感优于参比制剂，具体结果见表1。
表1
3)实施例所制备的止咳橘红颗粒的止咳疗效验证：昆明小鼠140只，雌雄各半，随机分为对照组，参比制剂组【市售止咳橘红颗粒(无糖，康芝药业股份有限公司)加蒸馏水配置成0.12g/ml溶液】及实施例1～5组(加蒸馏水配置成0.12g/ml溶液)，以灌胃方式给药，各组按0.06g/10g体重灌胃给药(对照组给予等量蒸馏水)，每日1次，连续3日，于末次给药后1h，将小鼠置于2L的密闭罩内，恒定压力用雾化器喷雾浓氨水15S，记录小鼠咳嗽潜伏期(从喷雾开始到小鼠出现第一次咳嗽的时间为潜伏期)和5min内咳嗽次数，统计均值。结果显示实施例制得的止咳橘红颗粒止咳效果良好，等于或优于参比制剂。具体结果见下表2
表2
| 潜伏期(sec) | 5min内咳嗽数 | |
| 对照组 | 15.6 | 22 |
| 参比制剂组 | 49.7 | 9 |
| 实施例1 | 51.9 | 11 |
| 实施例2 | 52.3 | 8 |
| 实施例3 | 56.1 | 8 |
| 实施例4 | 57.9 | 7 |
| 实施例5 | 60.8 | 5 |
4)实施例所制备的止咳橘红颗粒的祛痰疗效验证：昆明小鼠140只，雌雄各半，随机分为对照组，参比制剂组【市售止咳橘红颗粒(无糖，康芝药业股份有限公司)加蒸馏水配置成0.12g/ml溶液】及实施例1～5组(加蒸馏水配置成0.12g/ml溶液)，以灌胃方式给药，各组按0.06g/10g体重灌胃给药(对照组给予等量蒸馏水)，每日1次，连续3日，于末次给药后各组动物腹腔注射酚红0.1mL(5mg)/10g体重，注射酚红0.5h处死动物，剥离气管周围组织，剪下自甲状软骨下至气管分支处的一段气管，放人盛有2mL生理盐水的试管中，再加0.1mL氢氧化钠，用分光光度计，波长546nm测OD值。并根据酚红的标准曲线计算酚红含量，记录结果并进行统计学处理。结果显示实施例制得的止咳橘红颗粒祛痰效果良好，等于或优于参比制剂。具体结果见下表3
表3
Claims (9)
1.一种止咳橘红颗粒，其特征在于，按重量百分比计由以下组分组成：浸膏以固体计18％～25％，糊精75％～80％，苹果酸0.1％～0.5％，三氯蔗糖0.02％～0.1％，所述浸膏由化橘红、陈皮、法半夏、茯苓、款冬花、甘草、瓜蒌皮、紫菀、麦冬、知母、桔梗、地黄、石膏、去皮炒苦杏仁、炒紫苏子制备而成。
2.如权利要求1所述的止咳橘红颗粒，其特征在于，按重量百分比计由以下组分组成：浸膏以固体计21％，糊精78.73％，苹果酸0.2％，三氯蔗糖0.07％。
3.如权利要求1所述的止咳橘红颗粒，其特征在于：所述浸膏由如下重量比的化橘红2～4份、陈皮1～3份、法半夏1～2份、茯苓1～3份、款冬花0.5～1.5份、甘草0.5～1.5份、瓜蒌皮1～3份、紫菀1～2份、麦冬1～3份、知母0.5～1.5份、桔梗1～2份、地黄1～3份、石膏1～3份、去皮炒苦杏仁1～3份、炒紫苏子1～2份制备而成。
4.如权利要求3所述的止咳橘红颗粒，其特征在于：所述浸膏由如下重量比的化橘红3份、陈皮2份、法半夏1.5份、茯苓2份、款冬花1份、甘草1份、瓜蒌皮2份、紫菀1.5份、麦冬2份、知母1份、桔梗1.5份、地黄2份、石膏2份、去皮炒苦杏仁2份、炒紫苏子1.5份制备而成。
5.如权利要求1所述的止咳橘红颗粒，其特征在于，所述浸膏通过如下步骤制备：1)组分药材分别称量粗碎；2)石膏，水煎煮，滤过，滤液浓缩得浓缩液备用；3)其余十四味药材，水煎煮，滤过，滤液浓缩，加乙醇使含醇量达到55～65％，取醇沉后的上清液，滤过，滤液浓缩回收乙醇至无醇味；4)石膏浓缩液和收醇浓缩液合并，浓缩至相对密度1.1～1.3即得。
6.如权利要求5所述的止咳橘红颗粒，其特征在于，所述步骤2)中水煎煮为3次，第一次加10倍量水煎煮1.5小时，第二次、第三次分别加8倍量水煎煮1小时；所述步骤3)中水煎煮两次，第一次加8倍量水煎煮1小时，第二次加8倍量水煎煮1小时，滤过，滤液浓缩至相对密度1.03～1.07，加乙醇使含醇量达到60％，取醇沉24小时后的上清液，滤过，滤液浓缩回收乙醇至无醇味；4)石膏浓缩液和收醇浓缩液合并，浓缩至相对密度1.18～1.22即得。
7.如权利要求1所述的止咳橘红颗粒，其特征在于，所述浸膏通过如下步骤制备：1)组分药材分别称量粗碎；2)石膏置热回流提取浓缩系统中，水煎煮，滤过，滤液浓缩得浓缩液备用；3)其余十四味药材，通过乙醇水溶液作为夹带剂的超临界CO2流体萃取，萃取液回收乙醇至无醇味；4)石膏浓缩液和收醇浓缩液合并，浓缩至相对密度1.18～1.22即得。
8.如权利要求7所述的止咳橘红颗粒，其特征在于，所述步骤3)中所述乙醇水溶液中乙醇含量为60％，添加量占CO2摩尔流量百分比为6％，萃取温度为55℃，萃取压力为16MPa，萃取时间为2小时。
9.如权利要求1-8任一项所述的止咳橘红颗粒的制备方法，其特征在于，包括如下步骤：1)取浸膏加适量水后加入苹果酸和三氯蔗糖，搅拌均匀，备用；2)浸膏溶液倒入糊精中制粒；3)制得的颗粒干燥、整粒，混合即得。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910139390.3A CN111632105A (zh) | 2019-02-22 | 2019-02-22 | 一种止咳橘红颗粒及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910139390.3A CN111632105A (zh) | 2019-02-22 | 2019-02-22 | 一种止咳橘红颗粒及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111632105A true CN111632105A (zh) | 2020-09-08 |
Family
ID=72322681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910139390.3A Pending CN111632105A (zh) | 2019-02-22 | 2019-02-22 | 一种止咳橘红颗粒及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111632105A (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114224849A (zh) * | 2022-01-26 | 2022-03-25 | 北京东方运嘉科技发展有限公司 | 一种儿童用苏黄止咳颗粒及其制备方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101496870A (zh) * | 2008-01-28 | 2009-08-05 | 北京亚东生物制药有限公司 | 一种止咳化痰的中药组合物及其制备方法和质量控制方法 |
| CN102964408A (zh) * | 2012-12-19 | 2013-03-13 | 广东中大天翼生物科技发展有限公司 | 一种从橘红中提取柚皮苷的方法 |
-
2019
- 2019-02-22 CN CN201910139390.3A patent/CN111632105A/zh active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101496870A (zh) * | 2008-01-28 | 2009-08-05 | 北京亚东生物制药有限公司 | 一种止咳化痰的中药组合物及其制备方法和质量控制方法 |
| CN102964408A (zh) * | 2012-12-19 | 2013-03-13 | 广东中大天翼生物科技发展有限公司 | 一种从橘红中提取柚皮苷的方法 |
Non-Patent Citations (2)
| Title |
|---|
| 姜国志等: "舒筋通络颗粒矫味剂的筛选与评价", 《西北药学杂志》 * |
| 康芝药业: "2016年中国制药品牌榜", 《HTTPS://WWW.YAOZUI.COM/P/151416》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114224849A (zh) * | 2022-01-26 | 2022-03-25 | 北京东方运嘉科技发展有限公司 | 一种儿童用苏黄止咳颗粒及其制备方法 |
| CN116270821A (zh) * | 2022-01-26 | 2023-06-23 | 北京东方运嘉科技发展有限公司 | 一种苏黄止咳颗粒及其制备方法和质量标准 |
| CN116270821B (zh) * | 2022-01-26 | 2024-09-17 | 北京东方运嘉药业有限公司 | 一种苏黄止咳颗粒及其制备方法 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107495367B (zh) | 一种提高耐缺氧能力的食品、保健品或药物组合物及其制备方法和用途 | |
| CN115501266B (zh) | 一种含太子参的泡腾颗粒及其生产工艺 | |
| CN104147344B (zh) | 龙牡壮骨颗粒的制备方法 | |
| CN114028514B (zh) | 一种具有改善记忆作用枸杞子药食两用组合物及其制备方法与应用 | |
| CN110916189A (zh) | 一种具有润肺功能的人参方便食品的制备方法 | |
| CN1919272B (zh) | 一种中药浓缩丸 | |
| CN102846879B (zh) | 一种降血脂的组合物 | |
| CN110123972B (zh) | 遮蔽苦味的消积健儿颗粒及其制备方法与应用 | |
| CN111632105A (zh) | 一种止咳橘红颗粒及其制备方法 | |
| CN110859915A (zh) | 一种止咳橘红颗粒及其制备方法 | |
| CN114404517A (zh) | 一种用于痛风和降低尿酸的组合物及其用途与制备方法 | |
| CN1306953C (zh) | 一种治疗胃炎和消化性溃疡的中药组合物制备方法 | |
| CN102755519B (zh) | 葛根葛花抗口腔溃疡颗粒及其制备方法 | |
| CN103990091A (zh) | 一种用于治疗感冒发热的药物组合物及其制备方法 | |
| CN104000180A (zh) | 一种辅助降血糖的人参组合物、制备方法及其用途 | |
| CN107029110B (zh) | 用于治疗脾虚血虚所致贫血病的中药复方制剂及制备方法 | |
| CN112057593A (zh) | 香砂内金颗粒片 | |
| CN117503833B (zh) | 一种食药两用的壮阳补肾中药组合物及其制备方法 | |
| CN116392448B (zh) | 一种用于小儿咳喘的泡腾颗粒及其制备方法 | |
| CN110101798B (zh) | 一种解酒护肝剂及其制备方法 | |
| CN107029081B (zh) | 用于治疗肾虚血亏所致贫血病的中药复方制剂及制备方法 | |
| CN107007802B (zh) | 用于治疗阴阳两虚所致白血病的中药复方制剂及制备方法 | |
| CN116585427A (zh) | 一种抗急性酒精性肝损伤中药组合物及其制备方法和医药应用 | |
| CN106728866A (zh) | 一种治疗体虚咳嗽的保健茶及其制备方法 | |
| CN118750561A (zh) | 一种用于新冠病毒感染恢复期的中药组合物及其制备方法和应用 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20200908 |
|
| WD01 | Invention patent application deemed withdrawn after publication |