CN108201138A - 一种解酒护肝组合物、组合物的制剂及其制备方法 - Google Patents
一种解酒护肝组合物、组合物的制剂及其制备方法 Download PDFInfo
- Publication number
- CN108201138A CN108201138A CN201711374804.8A CN201711374804A CN108201138A CN 108201138 A CN108201138 A CN 108201138A CN 201711374804 A CN201711374804 A CN 201711374804A CN 108201138 A CN108201138 A CN 108201138A
- Authority
- CN
- China
- Prior art keywords
- composition
- parts
- relieving alcoholism
- protecting liver
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004185 liver Anatomy 0.000 title claims abstract description 52
- 239000000203 mixture Substances 0.000 title claims abstract description 38
- 208000007848 Alcoholism Diseases 0.000 title claims abstract description 31
- 201000007930 alcohol dependence Diseases 0.000 title claims abstract description 30
- 238000002360 preparation method Methods 0.000 title claims abstract description 29
- 239000000843 powder Substances 0.000 claims abstract description 57
- 229960003237 betaine Drugs 0.000 claims abstract description 18
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 244000046146 Pueraria lobata Species 0.000 claims abstract description 17
- 235000010575 Pueraria lobata Nutrition 0.000 claims abstract description 17
- 240000008042 Zea mays Species 0.000 claims abstract description 17
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims abstract description 17
- 108010038807 Oligopeptides Proteins 0.000 claims abstract description 15
- 102000015636 Oligopeptides Human genes 0.000 claims abstract description 15
- 241000219099 Parthenocissus quinquefolia Species 0.000 claims abstract description 15
- 235000009388 Parthenocissus quinquefolia Nutrition 0.000 claims abstract description 15
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims abstract description 14
- 235000005822 corn Nutrition 0.000 claims abstract description 14
- 239000004615 ingredient Substances 0.000 claims abstract description 6
- 239000008187 granular material Substances 0.000 claims abstract description 3
- 239000002775 capsule Substances 0.000 claims abstract 2
- 239000003826 tablet Substances 0.000 claims abstract 2
- 238000000605 extraction Methods 0.000 claims description 15
- 235000013305 food Nutrition 0.000 claims description 8
- 230000036541 health Effects 0.000 claims description 7
- 239000003085 diluting agent Substances 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 239000000796 flavoring agent Substances 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 102000004190 Enzymes Human genes 0.000 claims description 4
- 108090000790 Enzymes Proteins 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- 235000013355 food flavoring agent Nutrition 0.000 claims description 4
- 238000012545 processing Methods 0.000 claims description 4
- 239000003381 stabilizer Substances 0.000 claims description 4
- 239000006041 probiotic Substances 0.000 claims description 3
- 235000018291 probiotics Nutrition 0.000 claims description 3
- -1 pulvis Substances 0.000 claims description 3
- MVORZMQFXBLMHM-QWRGUYRKSA-N Gly-His-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)CN)CC1=CN=CN1 MVORZMQFXBLMHM-QWRGUYRKSA-N 0.000 claims description 2
- 241000234280 Liliaceae Species 0.000 claims description 2
- 108010038983 glycyl-histidyl-lysine Proteins 0.000 claims description 2
- 238000003809 water extraction Methods 0.000 claims 3
- 235000016068 Berberis vulgaris Nutrition 0.000 claims 1
- 241000335053 Beta vulgaris Species 0.000 claims 1
- 208000003643 Callosities Diseases 0.000 claims 1
- 206010020649 Hyperkeratosis Diseases 0.000 claims 1
- 240000006859 Jasminum officinale Species 0.000 claims 1
- 235000010254 Jasminum officinale Nutrition 0.000 claims 1
- 241000219780 Pueraria Species 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 235000013399 edible fruits Nutrition 0.000 claims 1
- 238000000855 fermentation Methods 0.000 claims 1
- 230000004151 fermentation Effects 0.000 claims 1
- 239000011344 liquid material Substances 0.000 claims 1
- 235000013379 molasses Nutrition 0.000 claims 1
- 230000009261 transgenic effect Effects 0.000 claims 1
- 235000013311 vegetables Nutrition 0.000 claims 1
- 239000002994 raw material Substances 0.000 abstract description 10
- 235000013361 beverage Nutrition 0.000 abstract description 8
- 239000007788 liquid Substances 0.000 abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 23
- 230000000694 effects Effects 0.000 description 19
- 235000019441 ethanol Nutrition 0.000 description 19
- 229920003266 Leaf® Polymers 0.000 description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 12
- KJXSIXMJHKAJOD-LSDHHAIUSA-N (+)-dihydromyricetin Chemical compound C1([C@@H]2[C@H](C(C3=C(O)C=C(O)C=C3O2)=O)O)=CC(O)=C(O)C(O)=C1 KJXSIXMJHKAJOD-LSDHHAIUSA-N 0.000 description 6
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 6
- 230000004060 metabolic process Effects 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- 102000007698 Alcohol dehydrogenase Human genes 0.000 description 5
- 108010021809 Alcohol dehydrogenase Proteins 0.000 description 5
- 108010081577 aldehyde dehydrogenase (NAD(P)+) Proteins 0.000 description 5
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 4
- 102000019197 Superoxide Dismutase Human genes 0.000 description 4
- 108010012715 Superoxide dismutase Proteins 0.000 description 4
- 244000269722 Thea sinensis Species 0.000 description 4
- 235000015165 citric acid Nutrition 0.000 description 4
- 235000015203 fruit juice Nutrition 0.000 description 4
- 229920001285 xanthan gum Polymers 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 240000006053 Garcinia mangostana Species 0.000 description 3
- 235000017048 Garcinia mangostana Nutrition 0.000 description 3
- 229920002148 Gellan gum Polymers 0.000 description 3
- RXUWDKBZZLIASQ-UHFFFAOYSA-N Puerarin Natural products OCC1OC(Oc2c(O)cc(O)c3C(=O)C(=COc23)c4ccc(O)cc4)C(O)C(O)C1O RXUWDKBZZLIASQ-UHFFFAOYSA-N 0.000 description 3
- 240000007651 Rubus glaucus Species 0.000 description 3
- 235000011034 Rubus glaucus Nutrition 0.000 description 3
- 235000009122 Rubus idaeus Nutrition 0.000 description 3
- 239000004383 Steviol glycoside Substances 0.000 description 3
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 230000002075 anti-alcohol Effects 0.000 description 3
- 235000015197 apple juice Nutrition 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 235000008504 concentrate Nutrition 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- KQILIWXGGKGKNX-UHFFFAOYSA-N dihydromyricetin Natural products OC1C(=C(Oc2cc(O)cc(O)c12)c3cc(O)c(O)c(O)c3)O KQILIWXGGKGKNX-UHFFFAOYSA-N 0.000 description 3
- 235000021433 fructose syrup Nutrition 0.000 description 3
- 239000000216 gellan gum Substances 0.000 description 3
- 235000010492 gellan gum Nutrition 0.000 description 3
- 235000009973 maize Nutrition 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- HKEAFJYKMMKDOR-VPRICQMDSA-N puerarin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=C(O)C=CC(C2=O)=C1OC=C2C1=CC=C(O)C=C1 HKEAFJYKMMKDOR-VPRICQMDSA-N 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- 235000019411 steviol glycoside Nutrition 0.000 description 3
- 229930182488 steviol glycoside Natural products 0.000 description 3
- 150000008144 steviol glycosides Chemical class 0.000 description 3
- 235000019202 steviosides Nutrition 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 102100036475 Alanine aminotransferase 1 Human genes 0.000 description 2
- 108010082126 Alanine transaminase Proteins 0.000 description 2
- 206010001605 Alcohol poisoning Diseases 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 241000563984 Ampelopsis Species 0.000 description 2
- 208000004930 Fatty Liver Diseases 0.000 description 2
- 206010061998 Hepatic lesion Diseases 0.000 description 2
- 206010019708 Hepatic steatosis Diseases 0.000 description 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 2
- BAWFJGJZGIEFAR-NNYOXOHSSA-O NAD(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-O 0.000 description 2
- 241000037826 Polygonatum kingianum Species 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 239000004376 Sucralose Substances 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 230000001476 alcoholic effect Effects 0.000 description 2
- 230000002929 anti-fatigue Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 238000001784 detoxification Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 208000010706 fatty liver disease Diseases 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 229930003944 flavone Natural products 0.000 description 2
- 235000011949 flavones Nutrition 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- 235000012055 fruits and vegetables Nutrition 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000005228 liver tissue Anatomy 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 235000019408 sucralose Nutrition 0.000 description 2
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 2
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 1
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 235000021537 Beetroot Nutrition 0.000 description 1
- 241000219310 Beta vulgaris subsp. vulgaris Species 0.000 description 1
- 241000206575 Chondrus crispus Species 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- 101710088194 Dehydrogenase Proteins 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010019799 Hepatitis viral Diseases 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 229920002774 Maltodextrin Polymers 0.000 description 1
- 239000005913 Maltodextrin Substances 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- DCTLJGWMHPGCOS-UHFFFAOYSA-N Osajin Chemical compound C1=2C=CC(C)(C)OC=2C(CC=C(C)C)=C(O)C(C2=O)=C1OC=C2C1=CC=C(O)C=C1 DCTLJGWMHPGCOS-UHFFFAOYSA-N 0.000 description 1
- 241000756042 Polygonatum Species 0.000 description 1
- 241001468611 Polygonatum cyrtonema Species 0.000 description 1
- 241000037831 Polygonatum sibiricum Species 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- OUZCFMSJGDEXRT-UHFFFAOYSA-N Scandinone Natural products O=C1C=2C(OC)=C(CC=C(C)C)C=3OC(C)(C)C=CC=3C=2OC=C1C1=CC=C(O)C=C1 OUZCFMSJGDEXRT-UHFFFAOYSA-N 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 240000000851 Vaccinium corymbosum Species 0.000 description 1
- 235000003095 Vaccinium corymbosum Nutrition 0.000 description 1
- 235000017537 Vaccinium myrtillus Nutrition 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 235000010358 acesulfame potassium Nutrition 0.000 description 1
- 229960004998 acesulfame potassium Drugs 0.000 description 1
- 239000000619 acesulfame-K Substances 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000005784 autoimmunity Effects 0.000 description 1
- 230000003542 behavioural effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 235000021014 blueberries Nutrition 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- VDTNNGKXZGSZIP-UHFFFAOYSA-N carbutamide Chemical compound CCCCNC(=O)NS(=O)(=O)C1=CC=C(N)C=C1 VDTNNGKXZGSZIP-UHFFFAOYSA-N 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000003412 degenerative effect Effects 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000011194 food seasoning agent Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 231100000753 hepatic injury Toxicity 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000000971 hippocampal effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 210000002490 intestinal epithelial cell Anatomy 0.000 description 1
- BJHIKXHVCXFQLS-UYFOZJQFSA-N keto-D-fructose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C(=O)CO BJHIKXHVCXFQLS-UYFOZJQFSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- 229940035034 maltodextrin Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 206010027175 memory impairment Diseases 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 229930189775 mogroside Natural products 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000003739 neck Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 235000015096 spirit Nutrition 0.000 description 1
- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 210000000225 synapse Anatomy 0.000 description 1
- 208000037816 tissue injury Diseases 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
一种解酒护肝组合物、组合物的制剂及其制备方法，含有以下重量份的成分：玉米低聚肽粉10‑100份、葛根粉10‑100份、果蔬酵素4‑60份、显齿蛇葡萄叶粉4‑40份及黄精粉2‑20份、甜菜碱0‑20份，合理的设置了各原料之间的比例。所述解酒护肝组合物的制剂，所述制剂可以为液体饮料、粉剂、颗粒剂、胶囊或片剂，并具有辅助解酒护肝的作用。
Description
技术领域
本发明涉及食品和保健品领域，具体涉及一种解酒护肝组合物、组合物的制剂及其制备方法。
背景技术
酒是世界各国人民共同的宝贵财富，酒的历史源远流长；我国的酒已有数千年历史。历代中国文人对酒更是褒赞不绝，从而形成了独具特色、丰富多彩的酒文化。这种特殊的文化形式，在传统中国文化中有独特的地位。酒几乎渗透到社会生活中的各个领域。不管是商务人士的应酬还是年轻人的青春期躁动，都离不开酒，然而过度饮酒易造成疾病。酒精对肝脏、肾脏、胃肠道等都有损伤。我国近年来由于过量饮酒导致肝损害的发病率呈逐年上升趋势，酒精已成为继病毒性肝炎之后导致肝损害的第二大病因。随着生活水平不断提高，人们对健康，保健意识的增强，因此通过各种方法来解除和减轻饮酒带来的不适及对身体的损害。人们对解酒产品的需求也越来越大。市场上多数解酒药物都或多或少地存在着毒副作用，因此从食物及天然药物中寻找更安全有效的理想解酒护肝途径，是缓解饮酒后身体不适及保护肝脏的新方向。通过将药食同源的植物提取物为主要原料加工而成的健康植物产品，具有愉悦口感，兼有辅助解酒及护肝保健的功效。
发明内容
本发明所要解决的技术问题是：针对现有技术中存在的问题，提供一种安全可靠、口感饱满愉悦，并且能够辅助解酒护肝的功能制剂及其制备方法。
为了解决上述问题，本发明提供了一种具有解酒护肝功能的组合物。
本发明提供的解酒护肝功能的组合物，含有以下重量份的成分：玉米低聚肽粉10-100份、葛根速溶粉10-100份、果蔬酵素4-60份、显齿蛇葡萄叶速溶粉4-40份及黄精速溶粉2-20份、甜菜碱(天然提取)0-20份。
进一步，上述组合物中含有以下重量份的成分；玉米低聚肽粉30-80份、葛根速溶粉20-70份、果蔬酵素10-40份、显齿蛇葡萄叶速溶粉10-30份及黄精速溶粉2-10份、甜菜碱(天然提取)0-10份。
当采取上述比例时，解酒护肝效果会更好。
在上述配方中：
所述的份数可以为本领域常用的重量单位，如毫克(mg)、克(g)、千克 (kg)等，也可以为其他任意数值的重量单位。
所述的玉米低聚肽粉，低聚肽含量不低于75％(质量分数)，可以通过酶解方法制备也可以市售获得。
所述的葛根速溶粉，葛根素含量不低于4％(质量分数)，可以通过常规提取方法制备也可以市售获得。
所述的显齿蛇葡萄叶速溶粉，二氢杨梅素含量不低于25％(质量分数)，可以通过常规提取方法制备也可以市售获得。
上述原料中各种参数的限定，有利于进一步提高解酒护肝效果。
本发明还提供了含有上述解酒护肝的组合物的制剂，该制剂中包含上述的解酒护肝的组合物和辅料。对于辅料，本领域技术人员可以根据制备的剂型以及实际的需要进行适当的选择，并不限于本发明列举的辅料。
进一步，该制剂由组合物和食品上可接受的果汁、载体、稀释剂、稳定剂和/或调味剂组成，所述制剂为液体饮料、粉剂、颗粒剂或片剂等也可以为其他本领域常规使用的剂型。
食品上可接受的果汁、载体或稀释剂及调味剂均是本领域的常规品种，是所述领域的技术人员容易实现的，进一步，选自果汁、稀释剂、甜味剂、酸味剂、稳定剂、香味剂、填充剂、粘合剂或润滑剂中的一种或几种，其中：
例如：所述稀释剂选自水；所述果汁选自苹果浓缩汁、柠檬浓缩汁、罗汉果浓缩汁等；所述甜味剂选自蔗糖、葡萄糖、乳糖、木糖醇、赤藓糖醇、麦芽糖醇、三氯蔗糖、安赛蜜、阿斯巴甜、果葡糖浆、结晶果糖、罗汉果甜苷、甜菊糖苷等；所述酸味剂选自柠檬酸或苹果酸等；所述稳定剂选自果胶、结冷胶、卡拉胶或黄原胶等。所述香味剂选自食品用香精，如树莓香精、蓝莓香精等；所述填充剂选自糖粉、果粉、淀粉、麦芽糊精等；所述粘合剂选自淀粉、海藻酸及其盐类、甲基纤维素、羧甲基纤维素钠、乙基纤维素或聚乙烯吡咯烷酮等；所述润滑剂选自硬脂酸镁、硬脂酸锌、滑石粉、十二烷基磺酸钠、二氧化硅等。
本发明提供的解酒护肝的组合物具有以下优点：
本发明中包含葛根速溶粉，葛根，始载于《神农本草经》，具有解肌退热、生津、升阳止泻等功效，属于无毒中药。现代药理学表明葛根具有提高肝细胞的再生能力，恢复肝脏正常机能，预防肝脏脂肪堆积，促进新陈代谢，增强肝脏解毒功能，预防酒精对肝脏的损伤；强化肝胆细胞自身免疫力，抵抗病毒入侵等作用功效。在葛根的有效成分中，异黄酮类最受关注，其中又以葛根素研究更受关注。葛根素可防治慢性乙醇中毒引起的记忆减退，提高脑SOD活性，从而减少脑内脂褐素积累，逆转乙醇导致的海马突触界面细微结构的衰退性变化。
玉米低聚肽能够提高血液中丙氨酸和亮氨酸的浓度，有助于产生辅酶 NAD+，为ADH和ALDH参与代谢乙醇提供稳定的反应底物，从而促进乙醇代谢。玉米低聚肽中Ala、Glu和Leu含量丰富，且小分子低聚肽更容易被小肠上皮细胞吸收能为脱氢酶提供稳定的NAD+，抑制血清中乙醇和乙醛浓度的升高。研究表明，在醒酒功能评价实验中，玉米低聚肽可降低醉酒后小鼠全血中的乙醇和乙醛含量，明显改善小鼠醉酒后的行为学指标，同时可明显增强醉酒小鼠肝组织中的ADH和ALDH活性，有显著醒酒功能。
果蔬酵素，精选优质果蔬，经益生菌发酵或自然长时发酵，富含益生菌代谢产物及有机酸，可有效降低谷草转氨酶(GOT)和谷丙转氨酶(GPT)活性，减少酒精对肝组织损伤，具有解酒保肝作用。
显齿蛇葡萄叶速溶粉，显齿蛇葡萄叶是葡萄科蛇葡萄属显齿蛇葡萄的嫩茎叶，又称藤茶，主要分布于我国广西、湖南等地，具有清热解毒功效。藤茶富含黄酮类化合物，总黄酮含量达40％，其主要成分二氢杨梅素含量高达25％。二氢杨梅素除具有黄酮类化合物的一般特性外，实验证明其具有解除酒精中毒、预防酒精肝、脂肪肝、降低肝癌的发病率等作用。藤茶可以有效延长醉酒潜伏期和缩短醒酒时间，其主要通过提高肝脏解酒酶(ADH、ALDH)活性。对于急性酒精性肝脏损失，藤茶能有效降低ALS、AST，增加肝脏SOD、GSH水平，减少肝脏MDA含量，对急性酒精性肝损伤有较好的保护作用。
甜菜碱(天然提取)，是自然界中很多动植物产品的重要组成成分，于19 世纪在糖用甜菜汁中第一次被发现。甜菜碱是一种抗脂肪肝银子-能预防或减少肝脏中脂肪的蓄积。甜菜碱含有亲电子甲基基团，能改善还原应激和氧化应激诱导的病理状况。甜菜碱在蛋氨酸循环中作为甲基供体，胆碱必须转化为甜菜碱才能发货作用，甲基也是肝脏的解毒功能正常发挥所必须的物质。甜菜碱具有提高机体的抗氧化能力，促进肝脏健康，
黄精是百合科黄精属多年生草本植物。《中国药典》2015年版记载黄精为滇黄精P.kingianum Coll.et Hemsl.、黄精P.sibiricum Red.多花黄精P.cyrtonema Hua的干燥根茎；甘、平；归脾、肺、肾经；具有补气养阴、健脾、润肺、益肾的作用；用于脾胃气虚、体倦乏力等。抗疲劳，提升免疫力。
本发明中既包含可以提高肝脏解酒酶，乙醇脱氢酶(ADH)、乙醛脱氢酶 (ALDH)活性的显齿蛇葡萄叶速溶粉和玉米低聚肽粉，促进酒精代谢，解除酒精中毒；同时含有可以加速清除乙醇代谢自由基，并提高超氧化物歧化酶 (SOD)活性的葛根速溶粉和甜菜碱(天然提取)；以及补气养阴、健脾，抗疲劳的黄精速溶粉，并合理的设置了各原料之间的比例。从促进乙醇代谢和护肝两方面入手，产品具有解酒护肝作用。
本发明的组合物采用的原料均为天然植物来源，因此具有食用安全、无副作用等优点。
本发明的解酒护肝的组合物在制备解酒护肝的食品、保健品和/或药品中进行广泛应用。
具体实施方式
以下对本发明的原理和特征进行描述，所举实例只用于解释本发明，并非用于限定本发明的范围。
以下实例用于说明本发明，但不用来限制本发明的范围。
实施例1：液体饮料
1、以制成该解酒护肝功能植物饮料1000g计，原料组成：
2、制备方法：按所述配方称取各原料；
a、混合：在烧杯Ⅰ将黄原胶、葛根速溶粉、显齿蛇葡萄叶速溶粉、玉米低聚肽粉、黄精速溶粉、甜菜碱(天然提取)、柠檬酸、混合均匀，待用；
b、粉体溶解：在烧杯Ⅱ中加入定量70～90℃的水，将步骤a中的待用物边搅拌边加入烧杯Ⅱ中，搅拌10～15min，充分溶解后备用；
c、混合调配：将果蔬酵素、果葡糖浆、苹果浓缩汁、罗汉果浓缩汁、树莓香精加入烧杯Ⅱ中，搅拌均匀；
d、杀菌、灌装；
e、冷却；
实施例2：液体饮料
1、以制成该解酒护肝功能植物饮料1000g计，原料组成：
2、制备方法如下：
a、混合：在烧杯Ⅰ将黄原胶、结冷胶、葛根速溶粉、显齿蛇葡萄叶速溶粉、玉米低聚肽粉、黄精速溶粉、甜菜碱(天然提取)、柠檬酸、三氯蔗糖、甜菊糖苷混合均匀，待用；
b、粉体溶解：在烧杯Ⅱ中加入定量70～90℃的水，将步骤a中的待用物边搅拌边加入烧杯Ⅱ中，搅拌10～15min，充分溶解后备用；
c、混合调配：将果葡糖浆、综合发酵果蔬汁、苹果浓缩汁、罗汉果浓缩汁、树莓香精加入烧杯Ⅱ中，搅拌均匀；
d、杀菌、灌装；
e、冷却；
实施例3：粉剂
1、原料组成：
| 组分 | 重量(g) | 重量百分比(％) |
| 葛根速溶粉 | 22 | 22 |
| 玉米低聚肽粉 | 50 | 50 |
| 显齿蛇葡萄叶速溶粉 | 10 | 10 |
| 果蔬酵素粉 | 15 | 12 |
| 黄精速溶粉 | 3 | 3 |
| 甜菜碱(天然提取) | 3 | 3 |
| 合计 | 100 | 100 |
2、制备方法：分别按上述配方称取葛根速溶粉、玉米低聚肽粉、显齿蛇葡萄叶速溶粉、果蔬酵素粉、黄精速溶粉、甜菜碱(天然提取)于三维混合机中混合均匀，得粉剂。
实施例4：固体饮料
1、原料：
2、制备方法：分别按上述配比称取葛根速溶粉、玉米低聚肽粉、显齿蛇葡萄叶速溶粉、果蔬酵素粉、黄精速溶粉、甜菜碱(天然提取)、蔗糖、甜菊糖苷、柠檬酸、天然香精、黄原胶、结冷胶于三维混合机中混合均匀，得固体饮料。
以上所述仅是本发明的优选实施方式，应当指出，对于本技术领域的普通技术人员，在不脱离本发明原理的前提下，还可以做出若干改进和润饰，这些改进和润饰也应视为本发明的保护范围。
Claims (12)
1.一种解酒护肝的组合物，其特征在于，该组合物中含有以下重量份的成分：玉米低聚肽粉10-100份、葛根速溶粉10-100份、果蔬酵素4-60份、显齿蛇葡萄叶速溶粉4-40份及黄精速溶粉2-20份、甜菜碱(天然提取)0-20份。
2.根据权利要求1所述解酒护肝的组合物，其特征在于，该组合物中含有以下重量份的成分；玉米低聚肽粉30-80份、葛根速溶粉20-70份、果蔬酵素10-40份、显齿蛇葡萄叶速溶粉10-30份及黄精速溶粉2-10份、甜菜碱(天然提取)0-10份。
3.根据权利要求1所述解酒护肝的组合物，其特征在于，所述玉米低聚肽粉选自优质非转基因玉米，通过现代生物复合酶酶切技术加工制得，符合新食品原料要求。
4.根据权利要求1所述解酒护肝的组合物，其特征在于，所述葛根速溶粉选自豆科葛属野葛的干燥根经水提取加工制得。
5.根据权利要求1所述解酒护肝的组合物，其特征在于，所述果蔬酵素选自多种水果、蔬菜复合经益生菌发酵制得或自然长时发酵制得。
6.根据权利要求1所述解酒护肝的组合物，其特征在于，所述显齿蛇葡萄叶速溶粉选自于葡萄科蛇葡萄属植物显齿蛇葡萄的幼嫩叶经水提取加工制得。
7.根据权利要求1所述解酒护肝的组合物，其特征在于，所述黄精速溶粉选自百合科黄精属黄精的干燥根茎经水提取加工制得。
8.根据权利要求1所述解酒护肝的组合物，其特征在于，所述甜菜碱(天然提取)选自天然甜菜糖蜜提取制得。
9.一种解酒护肝组合物的制剂，其特征在于，包括权利要求1-8任一项所述的解酒护肝的组合物和辅料。
10.根据权利要求9所述解酒护肝组合物的制剂，其特征在于，该制剂由权利要求1-8任一项所述的解酒护肝的组合物和食品上可接受的载体、稀释剂、稳定剂和/或调味剂组成。
11.根据权利要求9或10所述解酒护肝组合物的制剂，其特征在于，所述制剂为液体饮料、粉剂、颗粒剂、胶囊或片剂。
12.根据权利要求1-8任一项所述的解酒护肝的组合物在制备解酒护肝的食品、保健品和/或药品中进行应用。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711374804.8A CN108201138A (zh) | 2017-12-19 | 2017-12-19 | 一种解酒护肝组合物、组合物的制剂及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711374804.8A CN108201138A (zh) | 2017-12-19 | 2017-12-19 | 一种解酒护肝组合物、组合物的制剂及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108201138A true CN108201138A (zh) | 2018-06-26 |
Family
ID=62605796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711374804.8A Pending CN108201138A (zh) | 2017-12-19 | 2017-12-19 | 一种解酒护肝组合物、组合物的制剂及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108201138A (zh) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109007676A (zh) * | 2018-08-17 | 2018-12-18 | 江苏新申奥生物科技有限公司 | 一种含乙醛脱氢酶的乳酸菌冻干粉及其制备方法 |
| CN110101042A (zh) * | 2019-05-21 | 2019-08-09 | 广州正广生物科技有限公司 | 一种解酒护肝组合物及其制备方法 |
| CN110973625A (zh) * | 2019-12-30 | 2020-04-10 | 广西长寿奥秘科技有限公司 | 基于火麻仁的护肝醒酒组合物及其制备方法和应用 |
| CN111671026A (zh) * | 2020-07-31 | 2020-09-18 | 广东粤微食用菌技术有限公司 | 解酒醒酒保护胃肠道的姜黄复合解酒护肝饮及其制备方法 |
| CN112089048A (zh) * | 2019-11-21 | 2020-12-18 | 上海易天生物科技有限公司 | 一种解酒护肝保健食品的配方 |
| CN114522218A (zh) * | 2022-03-14 | 2022-05-24 | 唐建 | 一种快速解酒护肝保肝的组合物及其制备方法 |
| CN114916666A (zh) * | 2022-04-20 | 2022-08-19 | 杭州曼士元食品科技有限公司 | 一种解酒组合物 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101731630A (zh) * | 2010-01-22 | 2010-06-16 | 完美（中国）日用品有限公司 | 一种具有解酒、护肝功效的保健食品 |
| CN105639525A (zh) * | 2016-02-03 | 2016-06-08 | 大管家（上海）健康产业有限公司 | 护肝排毒果蔬酵素及其制备方法 |
| CN107007813A (zh) * | 2017-05-27 | 2017-08-04 | 云南德彩堂生物医药科技有限公司 | 一种高效解酒护肝组合物，其制备方法和应用 |
| CN107348059A (zh) * | 2017-09-01 | 2017-11-17 | 黄山华绿园生物科技有限公司 | 解酒茶及其制作工艺 |
-
2017
- 2017-12-19 CN CN201711374804.8A patent/CN108201138A/zh active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101731630A (zh) * | 2010-01-22 | 2010-06-16 | 完美（中国）日用品有限公司 | 一种具有解酒、护肝功效的保健食品 |
| CN105639525A (zh) * | 2016-02-03 | 2016-06-08 | 大管家（上海）健康产业有限公司 | 护肝排毒果蔬酵素及其制备方法 |
| CN107007813A (zh) * | 2017-05-27 | 2017-08-04 | 云南德彩堂生物医药科技有限公司 | 一种高效解酒护肝组合物，其制备方法和应用 |
| CN107348059A (zh) * | 2017-09-01 | 2017-11-17 | 黄山华绿园生物科技有限公司 | 解酒茶及其制作工艺 |
Non-Patent Citations (2)
| Title |
|---|
| 五嘉茶韩方茶研究所: "《水喝对了自然瘦》", 30 June 2014, 湖南科学技术出版社 * |
| 柴瑞震: "《肝病营养配餐1288例》", 31 March 2016, 重庆出版社 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109007676A (zh) * | 2018-08-17 | 2018-12-18 | 江苏新申奥生物科技有限公司 | 一种含乙醛脱氢酶的乳酸菌冻干粉及其制备方法 |
| CN110101042A (zh) * | 2019-05-21 | 2019-08-09 | 广州正广生物科技有限公司 | 一种解酒护肝组合物及其制备方法 |
| CN112089048A (zh) * | 2019-11-21 | 2020-12-18 | 上海易天生物科技有限公司 | 一种解酒护肝保健食品的配方 |
| CN110973625A (zh) * | 2019-12-30 | 2020-04-10 | 广西长寿奥秘科技有限公司 | 基于火麻仁的护肝醒酒组合物及其制备方法和应用 |
| CN111671026A (zh) * | 2020-07-31 | 2020-09-18 | 广东粤微食用菌技术有限公司 | 解酒醒酒保护胃肠道的姜黄复合解酒护肝饮及其制备方法 |
| CN114522218A (zh) * | 2022-03-14 | 2022-05-24 | 唐建 | 一种快速解酒护肝保肝的组合物及其制备方法 |
| CN114522218B (zh) * | 2022-03-14 | 2022-11-18 | 唐建 | 一种快速解酒护肝保肝的组合物及其制备方法 |
| CN114916666A (zh) * | 2022-04-20 | 2022-08-19 | 杭州曼士元食品科技有限公司 | 一种解酒组合物 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108201138A (zh) | 一种解酒护肝组合物、组合物的制剂及其制备方法 | |
| CN102106580B (zh) | 一种醒酒护肝保健饮料 | |
| CN102960808B (zh) | 解酒抗疲劳饮料 | |
| TWI500391B (zh) | 解酒與預防宿醉的組合物及包含組合物的飲料 | |
| CN101518353A (zh) | 一种解酒败火护肝饮料及制备方法 | |
| CN102038260B (zh) | 中药解酒保健饮料及其制备方法 | |
| CN106135891A (zh) | 一种对酒精性肝损伤具有保护功能的保健食品 | |
| CN105166923A (zh) | 一种玉米肽保健食品及制作方法 | |
| CN106260409A (zh) | 一种护肝醒酒软糖及其制备工艺 | |
| CN110897147A (zh) | 铁皮石斛解酒保肝组合物和制法 | |
| CN102178885A (zh) | 一种用于醒酒的药物组合物 | |
| CN103191214B (zh) | 一种解酒护肝制剂 | |
| CN105533358A (zh) | 一种菊花解酒伴饮 | |
| CN101006862A (zh) | 竹汁麦冬绞股蓝保健制剂及其生产方法 | |
| CN101745087A (zh) | 一种具有解酒防醉作用的组合物及其制备方法 | |
| CN103006922A (zh) | 一种具有解酒护肝功能的组合物 | |
| CN105454944A (zh) | 一种人参饮料及其制备方法 | |
| CN106822622A (zh) | 一种解酒护肝口服组合物及其制备方法 | |
| KR101565964B1 (ko) | 아위버섯의 물 추출물을 유효성분으로 함유하는 고지혈증 예방 또는 치료용 조성물 | |
| CN105029553A (zh) | 一种果汁蛋钙中药保健饮料及其制备方法 | |
| CN104644734B (zh) | 一种治疗ⅱ型糖尿病及其并发症的药物 | |
| CN104783031B (zh) | 一种护肝护脑组合物 | |
| CN107223961A (zh) | 一种具有解酒保肝作用的组合物及其制备方法 | |
| CN104997018A (zh) | 一种红豆杉酵素保健品及其制备方法和应用 | |
| CN108652000A (zh) | 一种复方刺龙芽护肝解酒固体制品及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20200814 Address after: Room 103, building 3, 399 Jucheng Road, Juyuan community, Jiading District, Shanghai Applicant after: Yanding health food (Shanghai) Co., Ltd Address before: 200000, 3, 302, 2, 5796 Shanghai Yi highway, Jiading District, Shanghai. Applicant before: SHANGHAI ROYOUNG BIOTECH Co.,Ltd. |
|
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180626 |