CN115444773B - Anti-inflammatory repair composition containing glycol salicylate, and preparation method and application thereof - Google Patents
Anti-inflammatory repair composition containing glycol salicylate, and preparation method and application thereof Download PDFInfo
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- CN115444773B CN115444773B CN202211022382.9A CN202211022382A CN115444773B CN 115444773 B CN115444773 B CN 115444773B CN 202211022382 A CN202211022382 A CN 202211022382A CN 115444773 B CN115444773 B CN 115444773B
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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Abstract
The invention discloses an anti-inflammatory repair composition containing glycol salicylate, a preparation method and application thereof, wherein the anti-inflammatory repair composition containing glycol salicylate comprises the following components: a base oil phase comprising olive fruit oil and jojoba seed oil; the active phase comprises Rosa canina oil, ethylhexyl ferulate, grape seed oil, ethylene glycol salicylate, and flos Chrysanthemi oil. The anti-inflammatory repair composition containing glycol salicylate can be proved to solve the symptoms of various skin inflammations through a plurality of verifications such as chick embryo chorioallantoic membrane tests, and the anti-inflammatory repair composition can be obtained by mixing the active substances such as dog rose fruit oil, ferulic acid ethylhexyl ester, grape seed oil, glycol salicylate, white flower chamomile oil and the like, and the base oil phase formed by mixing olive fruit oil and jojoba seed oil with the active substances.
Description
Technical Field
The invention relates to the field of daily chemicals, in particular to an anti-inflammatory repair composition containing glycol salicylate, a preparation method and application thereof.
Background
Allergic reactions are supranormal or pathological reactions of the human body to antigens. During the allergic reaction, the allergen (antigen) plays a direct role and is the external factor of the allergic reaction; the organism has low immunity, and the oxidative damage of a large number of free radicals to cells is an internal cause of anaphylactic reaction. Skin allergy is a relatively common skin problem, and with the increasing use of cosmetics and other chemicals, environmental problems, the increasing pace of modern society life, increased pressure and other problems, more people with sensitive skin are increasingly involved.
The glycol salicylate is a derivative of salicylic acid, can be used for improving the aesthetic appearance of skin, the components of the white flower spring yellow chrysanthemum oil contain chamomile azulene, alpha-bisabolol and sesquiterpene lactone, can bring an anti-inflammatory effect, jojoba seed oil can be mixed with sebum, regulate skin humidity, reduce skin moisture loss, ensure that olive fruit oil has balanced fatty acid composition and contains a small amount of palmitate, provide good oxidation resistance stability, and have the linoleic acid and linolenic acid content of about 80 percent in the dog rose fruit oil, and mainly act on effectively coping with various specific skin inflammations.
There is a need for an anti-inflammatory repair composition having a soothing repair effect and which is mild and non-irritating and a product for its use.
Disclosure of Invention
The invention mainly aims to provide an anti-inflammatory repairing composition containing glycol salicylate, and preparation and application thereof, and aims to solve allergic symptoms and repair skin.
To achieve the above object, the present invention provides an anti-inflammatory repair composition containing glycol salicylate, which comprises:
a base oil phase comprising olive fruit oil and jojoba seed oil;
an active phase comprising Rosa canina oil, ethylhexyl ferulate, grapeseed oil, ethylene glycol salicylate, and chamomile oil.
Further, the anti-inflammatory repair composition containing glycol salicylate comprises the following components in percentage by weight: olive fruit oil (50-95 parts), jojoba seed oil (10-50 parts), dog rose fruit oil (1-5 parts), ethylhexyl ferulate (0.1-2.5 parts), grape seed oil (20-70 parts), glycol salicylate (1-5 parts), white flower chamomile oil (0.1-9 parts).
Further, the active phase comprises Rosa canina oil, dimethylmethoxychromanol, grapeseed oil, ethylene glycol salicylate, and chamomile oil.
Further, the active phase comprises dog rose hip oil, BHT, grape seed oil, glycol salicylate, white flower chamomile oil.
Further, the active phase comprises Rosa canina oil, tocopherol (vitamin E), grape seed oil, glycol salicylate, and chamomile oil.
Further, the anti-inflammatory repair composition containing glycol salicylate can be compounded with any one or more components of retinol, retinaldehyde, phytosterols, ceramide and HPR.
Further, the anti-inflammatory repair composition containing glycol salicylate can be compounded with any one or more components of ferulic acid, ethyl ferulate, 4-butyl resorcinol, phenethyl resorcinol and glycyrrhetinic acid esters.
The invention also provides a preparation method of the anti-inflammatory repair composition containing glycol salicylate, which comprises the following steps:
s1: pre-dispersing ethylhexyl ferulate with Rosa canina oil to obtain a first phase;
s2: mixing the white flower chamomile oil with glycol salicylate to obtain a second phase;
s3, mixing olive fruit oil and jojoba seed oil to obtain a third object phase;
s4: mixing grape seed oil into a first phase;
and S5, mixing the first phase with the second phase and the third phase to obtain the anti-inflammatory repair composition containing the glycol salicylate.
The invention also provides an anti-inflammatory repair cream containing glycol salicylate, which comprises the following components:
emulsifying agents including cetostearyl alcohol, cetostearyl glucoside, water, PEG-100 stearate, glycerol;
a co-emulsifier comprising cetostearyl alcohol;
an emollient comprising polydimethylsiloxane, isohexadecane;
a cooling agent comprising menthol and menthol lactate;
a solvent comprising water;
a thickener comprising carbomers, xanthan gum, acacia gum;
a preservative comprising propyl paraben;
a chelating agent comprising disodium EDTA;
a humectant comprising glycerin, 1, 2-hexanediol;
an anti-inflammatory repair composition, such as any one of the above.
Further, the anti-inflammatory repair cream can be compounded with a humectant and a skin cream, wherein the humectant comprises sodium hyaluronate and panthenol; the skin caring cream comprises isononyl isononanoate, butter fruit tree fruit cream and squalane.
Of course, the person skilled in the art can apply the present invention to other cosmetic products according to the actual needs.
The invention adopts a first component capable of preventing grease from rancidity after the ethylhexyl ferulate is premixed with the Rosa canina fruit oil, then grape seed oil, the pre-dispersed white flower chamomile oil, glycol salicylate and the first component are mixed to obtain an active phase, and then the basic oil phase obtained by mixing the olive fruit oil and the jojoba seed oil is mixed with the active phase to obtain the anti-inflammatory repair composition, which can effectively cope with various specific skin inflammation problems.
Detailed Description
The technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention, and it is apparent that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
It should be noted that all directional indications (such as up, down, left, right, front, and rear … …) in the embodiments of the present invention are merely used to explain the relative positional relationship between the components, the movement condition, etc. in a specific posture, and if the specific posture is changed, the directional indication is changed accordingly.
Furthermore, the description of "first," "second," etc. in this disclosure is for descriptive purposes only and is not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include at least one such feature. In addition, the technical solutions of the embodiments may be combined with each other, but it is necessary to base that the technical solutions can be realized by those skilled in the art, and when the technical solutions are contradictory or cannot be realized, the combination of the technical solutions should be considered to be absent and not within the scope of protection claimed in the present invention.
The chemical formula:
glycol salicylate:
ethylhexyl ferulate:
example 1
An anti-inflammatory repair composition containing glycol salicylate, comprising, in weight percent:
58 parts of olive fruit oil, 35.5 parts of jojoba seed oil, 2 parts of ethylhexyl ferulate, 3 parts of dog rose fruit oil, 0.5 part of white flower chamomile flower oil and 1 part of glycol salicylate.
The preparation method comprises the following steps:
s1: weighing 2 parts of ethylhexyl ferulate and 3 parts of Rosa canina fruit oil, and pre-dispersing 2 parts of ethylhexyl ferulate with the Rosa canina fruit oil to obtain a first phase;
s2: weighing 0.5 part of white flower chamomile oil and 1 part of glycol salicylate, and mixing to obtain a second phase;
s3, weighing 58 parts of olive fruit oil and 35.5 parts of jojoba seed oil, and mixing to obtain a third object phase;
s4, mixing the first phase, the second phase and the third phase to obtain the embodiment 1.
Example 2
An anti-inflammatory repair composition containing glycol salicylate, comprising, in weight percent:
58 parts of olive fruit oil, 31.5 parts of jojoba seed oil, 2 parts of ethylhexyl ferulate, 4 parts of dog rose fruit oil, 3 parts of grape seed oil, 0.5 part of white flower chamomile flower oil and 1 part of glycol salicylate.
The preparation method comprises the following steps:
s1: weighing 2 parts of ethylhexyl ferulate and 4 parts of Rosa canina fruit oil, and pre-dispersing 2 parts of ethylhexyl ferulate with the Rosa canina fruit oil to obtain a first phase;
s2: weighing 0.5 part of white flower chamomile oil and 1 part of glycol salicylate, and mixing to obtain a second phase;
s3, weighing 58 parts of olive fruit oil and 31.5 parts of jojoba seed oil, and mixing to obtain a third object phase;
s4, weighing 3 parts of grape seed oil, and mixing 3 parts of grape seed oil into a first object phase;
s5, mixing the first phase with the second phase and the third phase to obtain the embodiment 2.
Example 3
An anti-inflammatory repair composition containing glycol salicylate, comprising, in weight percent:
57 parts of olive fruit oil, 35.5 parts of jojoba seed oil, 2 parts of ethylhexyl ferulate, 3 parts of dog rose fruit oil, 0.5 part of white flower chamomile flower oil and 2 parts of glycol salicylate.
The preparation method comprises the following steps:
s1: weighing 2 parts of ethylhexyl ferulate and 3 parts of Rosa canina fruit oil, and pre-dispersing 2 parts of ethylhexyl ferulate with the Rosa canina fruit oil to obtain a first phase;
s2: weighing 0.5 part of white flower chamomile oil and 2 parts of glycol salicylate, and mixing to obtain a second phase;
s3, weighing 57 parts of olive fruit oil and 35.5 parts of jojoba seed oil, and mixing to obtain a third object phase;
s4, mixing the first phase, the second phase and the third phase to obtain the embodiment 3.
Example 4
An anti-inflammatory repair composition containing glycol salicylate, comprising, in weight percent:
57 parts of olive fruit oil, 31.5 parts of jojoba seed oil, 2 parts of ethylhexyl ferulate, 4 parts of dog rose fruit oil, 3 parts of grape seed oil, 0.5 part of white flower chamomile flower oil and 2 parts of glycol salicylate.
The preparation method comprises the following steps:
s1: weighing 2 parts of ethylhexyl ferulate and 4 parts of Rosa canina fruit oil, and pre-dispersing 2 parts of ethylhexyl ferulate with the Rosa canina fruit oil to obtain a first phase;
s2: weighing 0.5 part of white flower chamomile oil and 2 parts of glycol salicylate, and mixing to obtain a second phase;
s3, weighing 57 parts of olive fruit oil and 31.5 parts of jojoba seed oil, and mixing to obtain a third object phase;
s4, weighing 3 parts of grape seed oil, and mixing 3 parts of grape seed oil into a first object phase;
s5, mixing the first phase with the second phase and the third phase to obtain the embodiment 4.
Example 5
An anti-inflammatory repair composition containing glycol salicylate, comprising, in weight percent:
57 parts of olive fruit oil, 31.5 parts of jojoba seed oil, 2 parts of ethylhexyl ferulate, 3 parts of dog rose fruit oil, 4 parts of grape seed oil, 0.5 part of white flower chamomile flower oil and 2 parts of glycol salicylate.
The preparation method comprises the following steps:
s1: weighing 2 parts of ethylhexyl ferulate and 3 parts of Rosa canina fruit oil, and pre-dispersing 2 parts of ethylhexyl ferulate with the Rosa canina fruit oil to obtain a first phase;
s2: weighing 0.5 part of white flower chamomile oil and 2 parts of glycol salicylate, and mixing to obtain a second phase;
s3, weighing 57 parts of olive fruit oil and 31.5 parts of jojoba seed oil, and mixing to obtain a third object phase;
s4, weighing 4 parts of grape seed oil, and mixing the 4 parts of grape seed oil into a first object phase;
s5, mixing the first phase with the second phase and the third phase to obtain the embodiment 5.
Comparative example 1
An anti-inflammatory repair composition containing glycol salicylate, comprising, in weight percent:
57 parts of olive fruit oil, 30.5 parts of jojoba seed oil, 2 parts of ethylhexyl ferulate, 3 parts of dog rose fruit oil, 0.5 part of white flower chamomile flower oil and 7 parts of glycol salicylate.
The preparation method comprises the following steps:
s1: weighing 2 parts of ethylhexyl ferulate and 3 parts of Rosa canina fruit oil, and pre-dispersing 2 parts of ethylhexyl ferulate with the Rosa canina fruit oil to obtain a first phase;
s2: weighing 0.5 part of white flower chamomile oil and 7 parts of glycol salicylate, and mixing to obtain a second phase;
s3, weighing 57 parts of olive fruit oil and 30.5 parts of jojoba seed oil, and mixing to obtain a third object phase;
s4, mixing the first phase, the second phase and the third phase to obtain the comparative example 1.
Comparative example 2
An anti-inflammatory repair composition containing glycol salicylate, comprising, in weight percent:
57 parts of olive fruit oil, 35.5 parts of jojoba seed oil, 3 parts of ethylhexyl ferulate, 3 parts of dog rose fruit oil, 0.5 part of white flower chamomile flower oil and 1 part of glycol salicylate.
The preparation method comprises the following steps:
s1: weighing 3 parts of ethylhexyl ferulate and 3 parts of Rosa canina fruit oil, and pre-dispersing 3 parts of ethylhexyl ferulate with the Rosa canina fruit oil to obtain a first phase;
s2: weighing 0.5 part of white flower chamomile oil and 1 part of glycol salicylate, and mixing to obtain a second phase;
s3, weighing 57 parts of olive fruit oil and 35.5 parts of jojoba seed oil, and mixing to obtain a third object phase;
s4, mixing the first phase, the second phase and the third phase to obtain the comparative example 2.
The following is a comparison of effectiveness experiments conducted using examples 1-5 and comparative examples 1-2, and the specific experiments are as follows:
chicken embryo chorioallantoic membrane irritation assay:
the chick embryo chorioallantoic membrane (CAM) test is to test whether products at different concentration ratios are irritating. The eggshells of the air chamber parts of the nine-day-old chick embryos are stripped, white egg membranes are exposed, the egg membranes are wetted by using 0.9% sodium chloride (NaCl) solution, and inner membranes are removed by using tweezers, so that the vascular membranes are not damaged, and pre-experiments and formal experiments are carried out after the damaged blood vessels are not damaged.
The experimental steps are as follows:
s1, grouping the tests, wherein each group comprises at least 6 chick embryos, and negative control, positive control and blank control are required to be set for each test;
s2, CAM preparation, namely carrying out egg candling inspection on 9-day-old chick embryos, stripping off eggshell parts of air chambers, dripping normal saline on the surfaces of eggshell membranes to fully wet the eggshell membranes, and removing the eggshell membranes;
s3, placing the test ring on the CAM, and sucking 200 mu L of the test object to be dripped into the test ring;
s4, immediately observing the change degree of each toxic effect after 3min of action, and giving a stimulus score (ES).
And (3) observing results:
bleeding: blood flows from the blood vessels or capillaries of the CAM. And judging 0, 1,2 and 3 points according to no bleeding, mild bleeding, moderate bleeding and severe bleeding.
Coagulation: the protein denaturation inside and outside the blood vessel is manifested by thrombus, closing swelling, appearance of coagulation points inside and outside the blood vessel, opacification turbidity outside the blood vessel and the like. The blood coagulation is judged to be 0, 1,2 and 3 respectively according to the non-coagulation, the light coagulation, the moderate coagulation and the moderate coagulation.
Vascular lysis: refers to vascular ablation on the CAM membrane. And judging 0, 1,2 and 3 points according to the avascular ablation, the mild vascular ablation, the moderate vascular ablation and the severe vascular ablation respectively.
Results calculation and evaluation: the mean ES score was calculated according to the following formula, and the stimulation classification es= (sum of degrees of bleeding, coagulation, and blood vessel lysis observed in 6 chick embryos)/3 was determined according to table 1
| Endpoint scoring | Irritation classification |
| ES≤12 | No/light irritation |
| 12<ES<16 | Moderate irritation |
| ES≥16 | Severe irritation |
Table 1 evaluation of ES results
TABLE 2 results of stimulation experiments on chick embryos
Conclusion of experiment: the product has no irritation under the condition of optimal concentration ratio.
(II) test of antioxidant ability of vegetable oil by DPPH free radical method:
DPPH free radical scavenging ability
The experimental steps are as follows:
s1, setting a positive control, and dissolving and diluting the positive control into a series of concentration gradients of 0.08mg/mL, 0.04mg/mL, 0.02mg/mL and 0.01mg/mL by using 95% ethanol to verify a test system;
s2, treating a test object, namely diluting the water-soluble test object into a multi-stage concentration sample by using water, and diluting the oil-soluble test object into the multi-stage concentration sample by using 95% ethanol;
s3, using 10ml test tube to set up sample tube (T), sample background (T 0 ) DPPH tube (C) and solvent background (C) 0 ) 3 parallel tubes are required to be arranged for each sample tube (T) with tested concentration of each sample, and three parallel tubes are required to be arranged for the DPPH tube (C);
s4, after the sample tube (T) and the sample background (T 0 ) 1ml of sample test solution with the same concentration is added into each sample test solution;
s5 in all test tubes (T, T) 0 、C、C 0 ) Supplementing 3ml of solvent, and uniformly mixing;
s6, adding 1ml of DPPH ethanol solution into the sample tube (T) and the DPPH tube (C), and obtaining a sample background (T) 0 ) And solvent background (C) 0 ) Replacing with 95% ethanol, slightly shaking, and standing at room temperature for 5 min;
s7, transferring each reaction solution into a cuvette of 1cm, and measuring the absorbance at 517 nm.
DPPH clearance rate calculation formula: clearance (%) = (1- (T-T) 0 )/(C-C 0 ))×100％
Wherein:
t is the absorbance value of the sample tube, namely the absorbance value of the solution after the reaction of the sample and DPPH;
T 0 -sample background absorbance;
c, the average value of the DPPH tube absorbance value for 3 times, namely the absorbance value of the DPPH solution when no sample is added;
C 0 -solvent background absorbance.
TABLE 3DPPH free radical scavenging ability
Conclusion of experiment: within the allowable addition range, the 0.2mg/ml sample can reduce the irritation caused by oxidative stress to the skin, so that the stronger the free radical scavenging capability is, the stronger the skin barrier repairing capability is.
(III) capsaicin stimulates keratinocytes (relief test):
the experimental steps are as follows:
s1, cell inoculation according to 1.8E 5 Seeding Density of individual/well keratinocytes were seeded into six well plates and placed at 37℃in 5% CO 2 Is incubated overnight in an incubator;
s2, preparing a solution, wherein the concentration of a positive control solution is 15.6 mug/ml, and the concentration of a sample is 0.8mg/ml;
s3, drug administration is carried out, when the cell plating rate in the six-hole plate to be tested reaches 40% -50%, group drug administration is carried out, 3 compound holes are arranged in each group, and the drug administration amount of each hole is 2ml;
s4, after the drug administration is completed, placing the six-hole plate at 37 ℃ and 5% CO 2 Incubating for 24 hours in an incubator;
s5, detection of capsaicin receptor (TRPV 1), wherein the capsaicin receptor (TRPV 1) is detected and analyzed by immunofluorescence after fixation with 4% paraformaldehyde for 30 min.
TABLE 4 results of relaxation test
Conclusion of experiment:
compared with the BC group, the TRPV1 protein content of the NC group is obviously increased, which proves that the test stimulation condition is effective.
Compared with the NC group, the TRPV1 protein content of the PC group is obviously reduced, which proves that the positive control detection is effective.
Compared with NC group, the TRPV1 protein content of the sample is obviously reduced at the concentration of 0.80mg/mL, and the protein expression quantity is reduced by 28.3%.
Experimental results show that the anti-inflammatory repair composition containing glycol salicylate has anti-inflammatory repair effect, and the irritation is obviously reduced compared with the comparative example representing the prior art, and the anti-sensitivity effect of the product can be improved by adding the white flower chamomile oil.
The anti-inflammatory repair composition containing glycol salicylate, which is disclosed by the invention, has the advantages of obvious curative effect, no toxic or side effect, good stability and convenience for patients to use, and is proved by an oxidation resistance test and a relaxation test of vegetable oil measured by a chick embryo chorioallantoic membrane test and a DPPH free radical method. The invention improves the irritation when the concentration is higher than the optimal proportion, so the invention verifies that the product has no irritation and free radical scavenging capability in the optimal concentration through repeated experiments.
In combination with all the above examples, the anti-inflammatory repair composition containing glycol salicylate in the invention can prove to have symptoms and mechanisms of skin inflammation through a plurality of verifications such as chick embryo chorioallantoic membrane test, DPPH free radical method measurement, relaxation test and the like, and the anti-inflammatory repair composition can effectively cope with various specific skin inflammation problems by adopting an active phase containing dog rose-hip oil, ethylhexyl ferulate, grape seed oil, glycol salicylate and white flower chamomile oil and mixing a base oil phase formed by mixing olive fruit oil and jojoba seed oil with the active phase.
The foregoing description is only of the preferred embodiments of the present invention and is not intended to limit the scope of the invention, and all equivalent structural changes made by the present invention or direct/indirect application in other related technical fields are included in the scope of the present invention under the inventive concept of the present invention.
Claims (9)
1. An anti-inflammatory repair composition comprising glycol salicylate, comprising the following components:
the essential oil phase comprises, by weight, 50-95 parts of olive fruit oil and 10-50 parts of jojoba seed oil;
the active phase comprises the following components in parts by weight: 1-5 parts of Rosa canina fruit oil, 0.1-2.5 parts of ethylhexyl ferulate, 0, 3 or 4 parts of grape seed oil, 1-5 parts of ethylene glycol salicylate, and 0.1-9 parts of white flower chamomile oil.
2. An anti-inflammatory repair composition comprising glycol salicylate according to claim 1 wherein the active phase further comprises dimethylmethoxy chromanol.
3. An anti-inflammatory repair composition comprising glycol salicylate according to claim 1 wherein the active phase further comprises BHT.
4. An anti-inflammatory repair composition comprising glycol salicylate according to claim 1, wherein the active phase further comprises tocopherol.
5. An ethylene glycol salicylate-containing anti-inflammatory repair composition as claimed in claim 1 wherein the ethylene glycol salicylate-containing anti-inflammatory repair composition is capable of complexing any one or more of retinol, retinal, phytosterols, ceramides, HPR.
6. An ethylene glycol salicylate-containing anti-inflammatory repair composition as claimed in claim 1 wherein the ethylene glycol salicylate-containing anti-inflammatory repair composition is capable of compounding any one or more of ferulic acid, ethyl ferulate, 4-butylresorcinol, phenethylresorcinol, glycyrrhetinic acid esters.
7. A process for the preparation of an anti-inflammatory repair composition comprising glycol salicylate according to any one of claims 1 to 6, comprising the steps of:
pre-dispersing ethylhexyl ferulate with Rosa canina oil to obtain a first phase;
mixing the white flower chamomile oil with glycol salicylate to obtain a second phase;
mixing olive fruit oil with jojoba seed oil to obtain a third phase;
mixing grape seed oil into a first phase;
mixing the first phase with the second phase and the third phase to obtain the anti-inflammatory repair composition containing glycol salicylate.
8. An anti-inflammatory repair cream comprising glycol salicylate, characterized in that the anti-inflammatory repair cream comprising glycol salicylate comprises:
emulsifying agents including cetostearyl alcohol, cetostearyl glucoside, water, PEG-100 stearate, glycerol;
a co-emulsifier comprising cetostearyl alcohol;
an emollient comprising polydimethylsiloxane, isohexadecane;
a cooling agent comprising menthol and menthol lactate;
a solvent comprising water;
a thickener comprising carbomers, xanthan gum, acacia gum;
a preservative comprising propyl paraben;
a chelating agent comprising disodium EDTA;
a humectant comprising glycerin, 1, 2-hexanediol;
an anti-inflammatory repair composition as claimed in any one of claims 1 to 6.
9. The anti-inflammatory repair cream of claim 8, wherein the anti-inflammatory repair cream is capable of formulating a moisturizing agent, a emollient lipid, the moisturizing agent comprising sodium hyaluronate, panthenol; the skin caring cream comprises isononyl isononanoate, butter fruit tree fruit cream and squalane.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211022382.9A CN115444773B (en) | 2022-08-23 | 2022-08-23 | Anti-inflammatory repair composition containing glycol salicylate, and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211022382.9A CN115444773B (en) | 2022-08-23 | 2022-08-23 | Anti-inflammatory repair composition containing glycol salicylate, and preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
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| CN115444773A CN115444773A (en) | 2022-12-09 |
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| WO2004096169A1 (en) * | 2003-04-29 | 2004-11-11 | Provincia Italiana Della Congregazione Dei Figli Dell'immacolata Concezione - Istituto Dermopatico Dell'immacolata | Dermatological formulation |
| CN108815039A (en) * | 2018-08-04 | 2018-11-16 | 彭红兵 | A kind of maintenance nourishing oil |
| CN109966183A (en) * | 2019-04-30 | 2019-07-05 | 广州栋方生物科技股份有限公司 | A kind of moisturizing remediation composition and its preparation method and application |
| CN110302103A (en) * | 2019-08-15 | 2019-10-08 | 武汉洛园生物科技有限公司 | A kind of the combination oil and preparation method of maintenance skin barrier |
| CN114533578A (en) * | 2022-03-10 | 2022-05-27 | 陕西畅想制药有限公司 | Cosmetic composition for removing pustular pox and preparation process thereof |
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| RU2668537C1 (en) * | 2017-04-19 | 2018-10-01 | Ирина Александровна Брынцева | Cosmetic product |
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| CN108815039A (en) * | 2018-08-04 | 2018-11-16 | 彭红兵 | A kind of maintenance nourishing oil |
| CN109966183A (en) * | 2019-04-30 | 2019-07-05 | 广州栋方生物科技股份有限公司 | A kind of moisturizing remediation composition and its preparation method and application |
| CN110302103A (en) * | 2019-08-15 | 2019-10-08 | 武汉洛园生物科技有限公司 | A kind of the combination oil and preparation method of maintenance skin barrier |
| CN114533578A (en) * | 2022-03-10 | 2022-05-27 | 陕西畅想制药有限公司 | Cosmetic composition for removing pustular pox and preparation process thereof |
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