CN115372487A - 盐酸格拉司琼中杂质e的hplc测定方法 - Google Patents
盐酸格拉司琼中杂质e的hplc测定方法 Download PDFInfo
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- CN115372487A CN115372487A CN202110541739.3A CN202110541739A CN115372487A CN 115372487 A CN115372487 A CN 115372487A CN 202110541739 A CN202110541739 A CN 202110541739A CN 115372487 A CN115372487 A CN 115372487A
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- impurity
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- granisetron hydrochloride
- ammonium acetate
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/06—Preparation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/86—Signal analysis
- G01N30/8675—Evaluation, i.e. decoding of the signal into analytical information
- G01N30/8679—Target compound analysis, i.e. whereby a limited number of peaks is analysed
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N2030/042—Standards
- G01N2030/047—Standards external
Abstract
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CN202110541739.3A CN115372487B (zh) | 2021-05-18 | 2021-05-18 | 盐酸格拉司琼中杂质e的hplc测定方法 |
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Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2124163A1 (es) * | 1995-03-01 | 1999-01-16 | Smithkline Beecham Plc | Un nuevo procedimiento para preparar compuestos farmaceuticamente activos. |
WO2003080606A1 (en) * | 2002-03-26 | 2003-10-02 | Laboratorios Vita, S.A. | Process for preparing a pharmaceutically active compound (granisetron) |
CN1451660A (zh) * | 2002-04-19 | 2003-10-29 | 浙江海正药业股份有限公司 | 一种制备格拉司琼及其盐的方法 |
US20040248960A1 (en) * | 2003-06-03 | 2004-12-09 | Chemagis Ltd. | Process for preparing 1-methylindazole-3-carboxylic acid |
WO2007054784A1 (en) * | 2005-11-10 | 2007-05-18 | Orchid Chemicals & Pharmaceuticals Limited | An improved process for the preparation of granisetron hydrochloride |
WO2007088557A1 (en) * | 2006-02-01 | 2007-08-09 | Natco Pharma Limited | Process for highly pure crystalline granisetron base |
ATE406770T1 (de) * | 2003-09-30 | 2008-09-15 | Intel Corp | Roaming-timer-verfahren und -vorrichtung für ein drahtloses netzwerk |
CN102131506A (zh) * | 2008-08-19 | 2011-07-20 | 台湾神隆股份有限公司 | 盐酸格拉司琼的多晶型和其制备方法 |
CN103415286A (zh) * | 2010-11-11 | 2013-11-27 | 阿克伦分子有限公司 | 用于治疗疼痛的化合物和方法 |
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2021
- 2021-05-18 CN CN202110541739.3A patent/CN115372487B/zh active Active
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2124163A1 (es) * | 1995-03-01 | 1999-01-16 | Smithkline Beecham Plc | Un nuevo procedimiento para preparar compuestos farmaceuticamente activos. |
WO2003080606A1 (en) * | 2002-03-26 | 2003-10-02 | Laboratorios Vita, S.A. | Process for preparing a pharmaceutically active compound (granisetron) |
CN1451660A (zh) * | 2002-04-19 | 2003-10-29 | 浙江海正药业股份有限公司 | 一种制备格拉司琼及其盐的方法 |
US20040248960A1 (en) * | 2003-06-03 | 2004-12-09 | Chemagis Ltd. | Process for preparing 1-methylindazole-3-carboxylic acid |
ATE406770T1 (de) * | 2003-09-30 | 2008-09-15 | Intel Corp | Roaming-timer-verfahren und -vorrichtung für ein drahtloses netzwerk |
WO2007054784A1 (en) * | 2005-11-10 | 2007-05-18 | Orchid Chemicals & Pharmaceuticals Limited | An improved process for the preparation of granisetron hydrochloride |
WO2007088557A1 (en) * | 2006-02-01 | 2007-08-09 | Natco Pharma Limited | Process for highly pure crystalline granisetron base |
CN102131506A (zh) * | 2008-08-19 | 2011-07-20 | 台湾神隆股份有限公司 | 盐酸格拉司琼的多晶型和其制备方法 |
CN103415286A (zh) * | 2010-11-11 | 2013-11-27 | 阿克伦分子有限公司 | 用于治疗疼痛的化合物和方法 |
Non-Patent Citations (4)
Title |
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ASHISH CHOKSHI 等: "Development of sublingual spray formulation containing ondansetron hydrochloride dihydrate", JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, vol. 53, pages 1 - 6 * |
EDA V.R. VISHNU 等: "Efficient Syntheses of exo-Granisetron Hydrochloride and other Potential Impurities Present in Granisetron Hydrochloride, an Anti-Emetic Drug", LETTERS IN ORGANIC CHEMISTRY, vol. 8, no. 10, pages 1056 - 1057 * |
JELENA MAKSI´C 等: "Hydrophilic interaction liquid chromatography in analysis ofgranisetron HCl and its related substances. Retention mechanismsand method development", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 123, pages 93 - 103 * |
李江 等: "HPLC测定盐酸格拉司琼葡萄糖注射液中盐酸格拉司琼含量及有关物质", 应用化工, vol. 40, no. 04, pages 711 - 713 * |
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