CN1152847C - 甾族化合物衍生的酮缩醇的制备方法 - Google Patents

甾族化合物衍生的酮缩醇的制备方法 Download PDF

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Publication number
CN1152847C
CN1152847C CNB961217901A CN96121790A CN1152847C CN 1152847 C CN1152847 C CN 1152847C CN B961217901 A CNB961217901 A CN B961217901A CN 96121790 A CN96121790 A CN 96121790A CN 1152847 C CN1152847 C CN 1152847C
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China
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formula
compound
implication
same
group
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CNB961217901A
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English (en)
Chinese (zh)
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CN1168876A (zh
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F��T��L��������
F·T·L·布兰德
P·威里霍夫
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Organon NV
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Akzo Nobel NV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • C07J75/005—Preparation of steroids by cyclization of non-steroid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
CNB961217901A 1995-11-30 1996-11-29 甾族化合物衍生的酮缩醇的制备方法 Expired - Lifetime CN1152847C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL1001787 1995-11-30
NL1001787 1995-11-30

Publications (2)

Publication Number Publication Date
CN1168876A CN1168876A (zh) 1997-12-31
CN1152847C true CN1152847C (zh) 2004-06-09

Family

ID=19761947

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB961217901A Expired - Lifetime CN1152847C (zh) 1995-11-30 1996-11-29 甾族化合物衍生的酮缩醇的制备方法

Country Status (25)

Country Link
US (2) US5955622A (enExample)
EP (1) EP0776904B1 (enExample)
JP (1) JP3984315B2 (enExample)
KR (1) KR100430312B1 (enExample)
CN (1) CN1152847C (enExample)
AR (1) AR004813A1 (enExample)
AT (1) ATE190314T1 (enExample)
AU (1) AU713688B2 (enExample)
CA (1) CA2191397C (enExample)
CZ (1) CZ293396B6 (enExample)
DE (1) DE69606957T2 (enExample)
DK (1) DK0776904T3 (enExample)
ES (1) ES2145971T3 (enExample)
GR (1) GR3033527T3 (enExample)
HU (1) HUP9603296A3 (enExample)
IL (1) IL119649A (enExample)
IN (1) IN182807B (enExample)
MX (1) MX9605981A (enExample)
NO (1) NO307887B1 (enExample)
NZ (1) NZ299836A (enExample)
PL (1) PL185112B1 (enExample)
PT (1) PT776904E (enExample)
RU (1) RU2165430C2 (enExample)
TR (1) TR199600944A1 (enExample)
ZA (1) ZA969778B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104497088A (zh) * 2014-12-30 2015-04-08 湖南新合新生物医药有限公司 19-去甲-4-雄甾烯-3,17-二酮的制备方法

Families Citing this family (15)

* Cited by examiner, † Cited by third party
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TW200611909A (en) * 2004-08-04 2006-04-16 Akzo Nobel Nv Process for the preparation 2-substituted-derivatives of estrone and estradiol
TW200613316A (en) 2004-08-26 2006-05-01 Akzo Nobel Nv Process for the preparation of estrone and/or estradiol-derivates
HUP0501132A2 (en) 2005-12-05 2007-06-28 Richter Gedeon Nyrt 17-alpha-cyanomethyl-17betha-hydroxyestra-4,9-diene-3-one of high purity and process for its production
ITMI20062504A1 (it) 2006-12-22 2008-06-23 Antibioticos Spa Procedimento per la preparazione di 17alfa-cianometil-17beta-idrossi steroidi
US8673968B2 (en) * 2009-04-06 2014-03-18 Evestra, Inc. Progesterone antagonists
EP2560984B1 (en) 2010-04-20 2015-04-01 Lupin Limited Process for the preparation of dienogest substantially free of impurities
CN101863947A (zh) * 2010-06-29 2010-10-20 沈阳药科大学 一种地诺孕素的合成方法
CN102718828A (zh) * 2011-03-30 2012-10-10 西藏海思科药业集团股份有限公司 一种地诺孕素的制备方法
US9096641B2 (en) 2013-06-05 2015-08-04 Evestra, Inc. Imidazolyl progesterone antagonists
CN108997463B (zh) * 2018-08-09 2021-05-14 四川理工学院 一种雌甾-4，9-二烯-3，17-二酮制备方法
CN112409434B (zh) * 2020-11-27 2021-10-26 厦门欧瑞捷生物科技有限公司 一种去氢孕酮的合成方法
CN113861158B (zh) * 2021-11-22 2023-02-10 湖南新合新生物医药有限公司 一种合成甲基双烯双酮关键中间体的方法
CN114409717B (zh) * 2021-12-17 2023-03-17 湖南科益新生物医药有限公司 替勃龙中间体醚化物和替勃龙的制备方法
CN114456223B (zh) * 2022-01-24 2023-07-21 湖南科益新生物医药有限公司 3-缩酮的合成方法
CN117304244B (zh) * 2023-08-14 2024-09-20 江西君业生物制药有限公司 一种19-去甲-4-雄烯二酮的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE632347A (enExample) *
DE296931C (enExample) 1915-11-05 1917-03-06
BE657260A (enExample) * 1962-03-06
NL127071C (enExample) * 1964-12-31
FR2201287A1 (en) * 1972-09-27 1974-04-26 Roussel Uclaf Epoxidation using hexafluoroacetone hydroperoxide - for treatment of unsatd. cyclic cpds esp steroids
DE3113053A1 (de) * 1981-04-01 1982-10-21 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung eines tricyclischen steroid-abbauprodukts
US4400524A (en) * 1981-07-28 1983-08-23 The Upjohn Company Grignard reagents prepared from 5-halopentan-2-one propylene ketals
DE3208432A1 (de) * 1982-03-09 1983-09-15 The Upjohn Co., 49001 Kalamazoo, Mich. Verfahren zur herstellung von 19-norandrostendion, zwischenprodukt des 19-norandrostendions und verfahren zu seiner herstellung
HU201091B (en) * 1985-12-26 1990-09-28 Mitsubishi Chem Ind Process for producing gonatriene derivatives and pharmaceutical compositions comprising same
DD296931A5 (de) * 1987-08-28 1991-12-19 Jenapharm Gmbh Jena,De Verfahren zur herstellung von 13 beta-alkyl-5(10),9(11)-gonadienderivaten
NZ232422A (en) * 1989-02-16 1992-11-25 Merck & Co Inc 13-ketal milbemycin derivatives and parasiticides
EP0538348B1 (de) * 1990-07-09 1996-10-02 JENAPHARM GmbH UNGESÄTTIGTE 15-DEHYDRO-17alpha-CYANOMETHYL-17beta- HYDROXYSTEROIDE
CA2100514C (en) * 1992-07-29 2005-03-29 Johannes A. M. Hamersma 17-spiromethylene steroids
WO1995004536A1 (en) * 1993-08-04 1995-02-16 Akzo Nobel N.V. Antiglucocorticoid steroids for the treatment of anxiety disorders

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104497088A (zh) * 2014-12-30 2015-04-08 湖南新合新生物医药有限公司 19-去甲-4-雄甾烯-3,17-二酮的制备方法

Also Published As

Publication number Publication date
AU7404196A (en) 1997-06-05
US5955622A (en) 1999-09-21
ES2145971T3 (es) 2000-07-16
AU713688B2 (en) 1999-12-09
KR100430312B1 (ko) 2004-07-30
JP3984315B2 (ja) 2007-10-03
NZ299836A (en) 1997-11-24
PL317248A1 (en) 1997-06-09
CZ350496A3 (cs) 1998-03-18
NO965113D0 (no) 1996-11-29
NO307887B1 (no) 2000-06-13
MX9605981A (es) 1998-04-30
IL119649A0 (en) 1997-02-18
HUP9603296A2 (en) 1997-08-28
PT776904E (pt) 2000-07-31
PL185112B1 (pl) 2003-02-28
IL119649A (en) 2002-03-10
EP0776904A2 (en) 1997-06-04
ZA969778B (en) 1997-06-17
KR970027102A (ko) 1997-06-24
HUP9603296A3 (en) 1998-07-28
IN182807B (enExample) 1999-04-24
DK0776904T3 (da) 2000-07-31
CA2191397C (en) 2006-08-01
CZ293396B6 (cs) 2004-04-14
DE69606957D1 (de) 2000-04-13
TR199600944A1 (tr) 1997-06-21
ATE190314T1 (de) 2000-03-15
HU9603296D0 (en) 1997-01-28
AR004813A1 (es) 1999-03-10
NO965113L (no) 1997-06-02
EP0776904B1 (en) 2000-03-08
EP0776904A3 (en) 1997-12-17
RU2165430C2 (ru) 2001-04-20
DE69606957T2 (de) 2000-10-05
CA2191397A1 (en) 1997-05-31
JPH09183792A (ja) 1997-07-15
GR3033527T3 (en) 2000-09-29
CN1168876A (zh) 1997-12-31
US6005124A (en) 1999-12-21

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Owner name: ORGANON NV

Free format text: FORMER OWNER: AKZO NOVEL N.V. CORP.

Effective date: 20070105

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Effective date of registration: 20070105

Address after: Holland

Patentee after: Organon NV

Address before: Holland Arnhem

Patentee before: Akzo Nobel N. V.