CN115279764B - 多晶型咔唑衍生物及其用途 - Google Patents

多晶型咔唑衍生物及其用途

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Publication number
CN115279764B
CN115279764B CN202080092193.1A CN202080092193A CN115279764B CN 115279764 B CN115279764 B CN 115279764B CN 202080092193 A CN202080092193 A CN 202080092193A CN 115279764 B CN115279764 B CN 115279764B
Authority
CN
China
Prior art keywords
compound
cancer
peaks
provides
ahr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202080092193.1A
Other languages
English (en)
Chinese (zh)
Other versions
CN115279764A (zh
Inventor
A·C·卡斯特罗
J·M·诺兰三世
S·J·贝休恩
C·M·福尔伯思
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ekina Oncology
Original Assignee
Ekina Oncology
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Publication date
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Publication of CN115279764A publication Critical patent/CN115279764A/zh
Application granted granted Critical
Publication of CN115279764B publication Critical patent/CN115279764B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202080092193.1A 2019-11-26 2020-11-25 多晶型咔唑衍生物及其用途 Active CN115279764B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962940481P 2019-11-26 2019-11-26
US62/940,481 2019-11-26
PCT/US2020/062197 WO2021108528A1 (en) 2019-11-26 2020-11-25 Polymorphic carbazole derivatives and uses thereof

Publications (2)

Publication Number Publication Date
CN115279764A CN115279764A (zh) 2022-11-01
CN115279764B true CN115279764B (zh) 2026-04-07

Family

ID=73856339

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080092193.1A Active CN115279764B (zh) 2019-11-26 2020-11-25 多晶型咔唑衍生物及其用途

Country Status (14)

Country Link
US (3) US11591339B2 (https=)
EP (2) EP4065582B1 (https=)
JP (2) JP2023502531A (https=)
KR (1) KR20220125231A (https=)
CN (1) CN115279764B (https=)
AU (1) AU2020394424A1 (https=)
CA (1) CA3159317A1 (https=)
ES (1) ES3028099T3 (https=)
FI (1) FI4065582T3 (https=)
IL (1) IL293326A (https=)
MX (1) MX2022006308A (https=)
PL (1) PL4065582T3 (https=)
PT (1) PT4065582T (https=)
WO (1) WO2021108528A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
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MX2019012431A (es) 2017-04-21 2020-08-03 Ikena Oncology Inc Inhibidores del receptor de hidrocarburos de arilo (ahr) de indol y usos de los mismos.
AU2020394424A1 (en) 2019-11-26 2022-06-16 Ikena Oncology, Inc. Polymorphic carbazole derivatives and uses thereof
US12570638B2 (en) 2020-05-20 2026-03-10 Sail Biomedicines, Inc. Fused imidazole derivatives as AHR antagonists

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Publication number Priority date Publication date Assignee Title
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Also Published As

Publication number Publication date
WO2021108528A1 (en) 2021-06-03
PL4065582T3 (pl) 2025-08-18
JP2025113368A (ja) 2025-08-01
US20230286990A1 (en) 2023-09-14
US20250276975A1 (en) 2025-09-04
EP4529955A3 (en) 2025-07-16
US12162884B2 (en) 2024-12-10
EP4065582B1 (en) 2025-02-19
KR20220125231A (ko) 2022-09-14
EP4065582A1 (en) 2022-10-05
MX2022006308A (es) 2022-06-22
FI4065582T3 (fi) 2025-05-25
US11591339B2 (en) 2023-02-28
AU2020394424A1 (en) 2022-06-16
EP4529955A2 (en) 2025-04-02
CN115279764A (zh) 2022-11-01
PT4065582T (pt) 2025-05-22
JP2023502531A (ja) 2023-01-24
IL293326A (en) 2022-07-01
CA3159317A1 (en) 2021-06-03
ES3028099T3 (en) 2025-06-18
US20210253579A1 (en) 2021-08-19

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