CA3159317A1 - Polymorphic carbazole derivatives and uses thereof - Google Patents

Polymorphic carbazole derivatives and uses thereof Download PDF

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Publication number
CA3159317A1
CA3159317A1 CA3159317A CA3159317A CA3159317A1 CA 3159317 A1 CA3159317 A1 CA 3159317A1 CA 3159317 A CA3159317 A CA 3159317A CA 3159317 A CA3159317 A CA 3159317A CA 3159317 A1 CA3159317 A1 CA 3159317A1
Authority
CA
Canada
Prior art keywords
compound
cancer
present
salt
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3159317A
Other languages
English (en)
French (fr)
Inventor
Alfredo C. Castro
Iii James Martin Nolan
Sarah Jean BETHUNE
Corinne Marie FOLBERTH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ImageneBio Inc
Original Assignee
Ikena Oncology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ikena Oncology Inc filed Critical Ikena Oncology Inc
Publication of CA3159317A1 publication Critical patent/CA3159317A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3159317A 2019-11-26 2020-11-25 Polymorphic carbazole derivatives and uses thereof Pending CA3159317A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962940481P 2019-11-26 2019-11-26
US62/940,481 2019-11-26
PCT/US2020/062197 WO2021108528A1 (en) 2019-11-26 2020-11-25 Polymorphic carbazole derivatives and uses thereof

Publications (1)

Publication Number Publication Date
CA3159317A1 true CA3159317A1 (en) 2021-06-03

Family

ID=73856339

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3159317A Pending CA3159317A1 (en) 2019-11-26 2020-11-25 Polymorphic carbazole derivatives and uses thereof

Country Status (14)

Country Link
US (3) US11591339B2 (https=)
EP (2) EP4065582B1 (https=)
JP (2) JP2023502531A (https=)
KR (1) KR20220125231A (https=)
CN (1) CN115279764B (https=)
AU (1) AU2020394424A1 (https=)
CA (1) CA3159317A1 (https=)
ES (1) ES3028099T3 (https=)
FI (1) FI4065582T3 (https=)
IL (1) IL293326A (https=)
MX (1) MX2022006308A (https=)
PL (1) PL4065582T3 (https=)
PT (1) PT4065582T (https=)
WO (1) WO2021108528A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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AU2020394424A1 (en) 2019-11-26 2022-06-16 Ikena Oncology, Inc. Polymorphic carbazole derivatives and uses thereof
US12570638B2 (en) 2020-05-20 2026-03-10 Sail Biomedicines, Inc. Fused imidazole derivatives as AHR antagonists

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Also Published As

Publication number Publication date
WO2021108528A1 (en) 2021-06-03
PL4065582T3 (pl) 2025-08-18
JP2025113368A (ja) 2025-08-01
US20230286990A1 (en) 2023-09-14
US20250276975A1 (en) 2025-09-04
CN115279764B (zh) 2026-04-07
EP4529955A3 (en) 2025-07-16
US12162884B2 (en) 2024-12-10
EP4065582B1 (en) 2025-02-19
KR20220125231A (ko) 2022-09-14
EP4065582A1 (en) 2022-10-05
MX2022006308A (es) 2022-06-22
FI4065582T3 (fi) 2025-05-25
US11591339B2 (en) 2023-02-28
AU2020394424A1 (en) 2022-06-16
EP4529955A2 (en) 2025-04-02
CN115279764A (zh) 2022-11-01
PT4065582T (pt) 2025-05-22
JP2023502531A (ja) 2023-01-24
IL293326A (en) 2022-07-01
ES3028099T3 (en) 2025-06-18
US20210253579A1 (en) 2021-08-19

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