KR20220125231A - 다형체 카바졸 유도체 및 이의 용도 - Google Patents

다형체 카바졸 유도체 및 이의 용도 Download PDF

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Publication number
KR20220125231A
KR20220125231A KR1020227021719A KR20227021719A KR20220125231A KR 20220125231 A KR20220125231 A KR 20220125231A KR 1020227021719 A KR1020227021719 A KR 1020227021719A KR 20227021719 A KR20227021719 A KR 20227021719A KR 20220125231 A KR20220125231 A KR 20220125231A
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South Korea
Prior art keywords
compound
cancer
present
salt
ahr
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KR1020227021719A
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English (en)
Korean (ko)
Inventor
알프레도 씨. 카스트로
3세 제임스 마틴 놀란
사라 진 베튠
코린 마리 폴버트
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이케나 온콜로지, 인코포레이티드
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Publication of KR20220125231A publication Critical patent/KR20220125231A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020227021719A 2019-11-26 2020-11-25 다형체 카바졸 유도체 및 이의 용도 Pending KR20220125231A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962940481P 2019-11-26 2019-11-26
US62/940,481 2019-11-26
PCT/US2020/062197 WO2021108528A1 (en) 2019-11-26 2020-11-25 Polymorphic carbazole derivatives and uses thereof

Publications (1)

Publication Number Publication Date
KR20220125231A true KR20220125231A (ko) 2022-09-14

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ID=73856339

Family Applications (1)

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KR1020227021719A Pending KR20220125231A (ko) 2019-11-26 2020-11-25 다형체 카바졸 유도체 및 이의 용도

Country Status (14)

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US (3) US11591339B2 (https=)
EP (2) EP4065582B1 (https=)
JP (2) JP2023502531A (https=)
KR (1) KR20220125231A (https=)
CN (1) CN115279764B (https=)
AU (1) AU2020394424A1 (https=)
CA (1) CA3159317A1 (https=)
ES (1) ES3028099T3 (https=)
FI (1) FI4065582T3 (https=)
IL (1) IL293326A (https=)
MX (1) MX2022006308A (https=)
PL (1) PL4065582T3 (https=)
PT (1) PT4065582T (https=)
WO (1) WO2021108528A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
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AU2020394424A1 (en) 2019-11-26 2022-06-16 Ikena Oncology, Inc. Polymorphic carbazole derivatives and uses thereof
US12570638B2 (en) 2020-05-20 2026-03-10 Sail Biomedicines, Inc. Fused imidazole derivatives as AHR antagonists

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Publication number Publication date
WO2021108528A1 (en) 2021-06-03
PL4065582T3 (pl) 2025-08-18
JP2025113368A (ja) 2025-08-01
US20230286990A1 (en) 2023-09-14
US20250276975A1 (en) 2025-09-04
CN115279764B (zh) 2026-04-07
EP4529955A3 (en) 2025-07-16
US12162884B2 (en) 2024-12-10
EP4065582B1 (en) 2025-02-19
EP4065582A1 (en) 2022-10-05
MX2022006308A (es) 2022-06-22
FI4065582T3 (fi) 2025-05-25
US11591339B2 (en) 2023-02-28
AU2020394424A1 (en) 2022-06-16
EP4529955A2 (en) 2025-04-02
CN115279764A (zh) 2022-11-01
PT4065582T (pt) 2025-05-22
JP2023502531A (ja) 2023-01-24
IL293326A (en) 2022-07-01
CA3159317A1 (en) 2021-06-03
ES3028099T3 (en) 2025-06-18
US20210253579A1 (en) 2021-08-19

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