CN1152720C - 一种具有用于在压力下分配液体的可膨胀液囊的移动式泵 - Google Patents

一种具有用于在压力下分配液体的可膨胀液囊的移动式泵 Download PDF

Info

Publication number
CN1152720C
CN1152720C CNB988011239A CN98801123A CN1152720C CN 1152720 C CN1152720 C CN 1152720C CN B988011239 A CNB988011239 A CN B988011239A CN 98801123 A CN98801123 A CN 98801123A CN 1152720 C CN1152720 C CN 1152720C
Authority
CN
China
Prior art keywords
liquid
liquid capsule
movable pump
shell
end cap
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB988011239A
Other languages
English (en)
Other versions
CN1236325A (zh
Inventor
R��W���ܿ�ѷ
R·W·杰克逊
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
Original Assignee
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter International Inc filed Critical Baxter International Inc
Publication of CN1236325A publication Critical patent/CN1236325A/zh
Application granted granted Critical
Publication of CN1152720C publication Critical patent/CN1152720C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/148—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags
    • A61M5/152—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags pressurised by contraction of elastic reservoirs

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Steroid Compounds (AREA)
  • Rotary Pumps (AREA)
  • Eye Examination Apparatus (AREA)
  • Fluid-Driven Valves (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

在预定流量压力下分配液体的移动式泵(10)包括具有第一个和第二个端盖(14、16)的外壳(12)，两个端盖装在外壳(12)上并密封外壳(12)。每个端盖(14、16)上有孔(18、20)。外壳(12)装载可加压液囊(22)以便容纳和输送液体。处于未膨胀状态和膨胀状态之间的液囊(22)可膨胀。液囊(22)有自由端(30)和固定端，前者限定与第二个端盖孔(20)相连通的液囊开口，后者限定与第一个端盖孔(18)相连通的开口。外壳(12)装载挠性管(40)，挠性管(40)在液囊自由端(30)和第二个端盖孔(20)之间延伸并与它们相连通。移动式泵(10)有位于挠性管(40)和液囊(22)之间的连接件(32)以显示移动式泵(10)中的液体容积。当液囊(22)在膨胀状态和未膨胀状态之间变化时连接件(32)在外壳(12)内纵向移动显示移动式泵(10)中的液体容积。移动式泵(10)包括在第二个端盖(16)上的注液口(20)和从第一个端盖孔(18)延伸以便给患者输送液体的管路(50)。

Description

一种具有用于在压力下分配液体 的可膨胀液囊的移动式泵
技术领域
本发明涉及封闭的移动式泵。特别是本发明涉及具有可膨胀或可耐压液囊的封闭的移动式泵以贮存和输送给患者的液体。
背景技术
移动式泵或输注筒的技术众所周知。这样的装置用于在预定时间段内以大体恒定的液体流量给患者输注预定量的液体药物。一种已知泵包括一个筒形的、弹性的、可加压的液囊，其内有要输注的液体。该液囊受到其内贮存液体的压力。该泵包括外壳、固定在外壳一端的塞及塞上的通孔。该液囊的一端封装在塞上，液囊的腔与塞的孔相连通。该泵包括管路，例如与塞孔连接的管路，它限定输液管路以便从液囊将液体输送到患者的输注部位。
位于输液管路中的流量调节器允许液体以预定流量从液囊通过输液管路输送给(例如)患者。该流量调节器或节流器有毛细管。
该泵包括一个固定在液囊自由端的“浮动”的或活动的盖或指示件。根据液囊中的液体容积指示件在外壳内纵向“浮动”或活动。指示件包括管路、位于管路中的单向阀及注入口或注液口，通过该注液口向液囊注液。该注液口和管路及液囊相连通。
为了注满液囊，需要压紧外壳的两端或使外壳的两端向外壳中间弯曲以控制指示件并将输注装置(例如灌注器)插入外壳。然后使该灌注器与注液口连接，液体就从灌注器注入液囊。该灌注器与注液口的连接通常采用螺纹连接，其形成灌注器与注液口之间的密封。当注满液囊时，允许指示件移动以容纳膨胀的液囊。
而现有的泵工作时要达到期望的良好效果，还有很多不利因素。首先，由于指示件的浮动特性液囊的外面基本上是向大气层敞开的。这样，万一液囊破裂，液囊中的液体就会流入外壳内。万一液囊破裂，装在外壳上的端盖会使液体留在外壳内。可是，端盖通常与外壳分开包装，如果外壳上的端盖安装得不合适，万一液囊破裂就会导致液体从外壳中漏出。
此外，因为必须通过筒壁控制指示件，指示件的“浮动”性质可能使注满输注装置常常很困难。因为指示件“浮动”当灌注器拧在注入口上时液囊会被扭曲。很明显，扭曲弹性液囊会削弱弹性材料，这样就加大了液囊破裂的可能性。此外，相信已遇到的问题是灌注移动式泵期间液体素流的结果。特别是当液体“突破”单向阀时，流动阻力引起液体紊流，液体紊流又导致液体中夹杂着空气。液体中所夹杂的空气在液体中形成微小气泡。已注意到这些微小气泡会在节流器毛细管中积聚。熟悉本领域的技术人员认识到微小气泡积聚可能导致通过毛细管液流的阻塞。
发明内容
因此，仍需要充分密封输注液囊的移动式泵，其便于注满贮存液囊并将液囊破裂的可能性降至最低。本发明的目的在于提供一种移动式泵装置，这样的装置容易用在标准的医疗器械上，并减少或解决现有移动式泵遇到的灌注问题和流量受限制问题。
本发明提供一种具有一外壳和包含在所述外壳内的用于在压力下分配液体的可膨胀液囊的移动式泵，其中所述液囊的内部可通过所述液囊的一移动自由端的注射而被注液，所述移动式泵包括：所述外壳；其具有位于所述外壳之上并密封该外壳的第一和第二个固定端盖，第一个端盖上具有形成在其中用于分配所述液体的孔；所述第二端盖具有一进口，所述可膨胀液囊限定了一内贮存的容积，所述液囊由所述外壳所装载并且在未膨胀状态和已膨胀状态之间是可膨胀的，所述液囊具有一限定与所述第一端盖流动连通的孔，并且其特征在于：所述液囊还包括限定一注液开口的所述自由端，和在所述注液开口和所述进口之间延伸的一绕性管，从而通过所述液囊自由端开口与所述液囊的内部建立了流体连通。
在预定流量压力下分配液体的移动式泵包括一个外壳，它具有位于该外壳上并密封该外壳的第一个和第二个固定端盖。每个端盖上有孔。该外壳装载限定内贮存容积的可加压液囊，以便容纳和分配液体。
处于未膨胀状态和膨胀状态之间的液囊可膨胀。该液囊具有自由端和固定端，该自由端限定与第二个端盖孔相流体连通的液囊开口，该固定端限定与第一个端盖孔相流体连通的液囊开口。
该外壳装载的一段挠性管，该挠性管在液囊的自由端开口和向液囊注液的开口之间延伸并与液囊的自由端开口和第二个端盖孔流体连通。
在优选实施例中，移动式泵包括位于挠性管和液囊之间的连接件。当液囊在膨胀状态和未膨胀状态之间变化时该连接件可在外壳内纵向移动。在最佳的实施例中，外壳用透明的或半透明的材料制成，外壳上有标记。连接件最好又是指示件且其上有标记，连接件和外壳上的标记共同配合显示移动式泵中液体的容积。
移动式泵具有在第二个端盖孔形成的注入口或注液口，该口与挠性管和液囊相连通。在优选实施例中，注液口为凹型Luer接口，移动式泵具有形成凸型Luer接口的保护盖，以便与注液口相配合。
移动式泵具有与液囊相连通并从第一个端盖孔伸出的管路。该管路最好有流量调节器。
移动式泵包括至少一个位于其内的阀，以允许液体流入液囊并阻止液体从液囊回流。该阀最好位于伸进可膨胀液囊的指示件上。在本实施例中，该阀为鸭嘴形阀。
为了容纳液囊膨胀的容积，移动式泵至少在端盖其中之一上有一个排气孔。该排气孔的形状允许空气出入以使外壳内压力保持在一个大气压左右。在最佳的实施例中，排气孔用疏水性材料盖住，疏水性材料允许空气或气体通过却阻止液体通过。
本发明的其它特点和优点将在下面的详细描述、附图以及所附权利要求中见到。
附图说明
图1是体现本发明原理的封闭的移动式泵的侧视图，所示移动式泵中的液囊处于未膨胀状态；
图2所示为图1的移动式泵，其中的液囊处于膨胀状态；
图3是图2移动式泵的横截面图，所示移动式泵带有与其连接的管路和流量调节器。
具体实施方式
本发明可以有各种形式的实施，附图所示及下文所描述的此优选实施例是作为本发明的一个例子，而不是将本发明局限于附图所示特定实施例。
现在参见附图，特别是图1所示为体现本发明原理的移动式泵10。移动式泵10包括主体部分或外壳12和分别密封外壳12两端的第一个端盖14和第二个端盖16。外壳12、第一个端盖14和第二个端盖16形成壳体13，壳体13确定了内腔15。外壳12最好用透明的或半透明的塑料材料制成。第一个端盖14和第二个端盖16分别有孔18、20。一个可膨胀的液囊(或称贮液囊)22位于内腔15中，并与端盖孔其中之一18的固定端24固定连接。可膨胀的液囊22有内贮存容积26，在未膨胀状态(如图1所示)基本上确定标号为28的腔。腔28或内贮存容积26与端盖14的孔18内部连通，液囊22与端盖14固定连接。对本说明书来说，该端盖称为第一个端盖14。相反地，对面端盖称为第二个端盖16。
液囊22的自由端30装在“浮动”件或称活动件32上，如同图示连接件或称指示件32。“浮动”件32有开口34，可膨胀的液囊22与开口34连接，腔28或内贮存容积26与开口34内部连通。如图所示，指示件32上有标记36，其与外壳12上的标记38结合，可确定泵10中液体的容积L。
至少一段或一部分挠性管40在指示件32和开口0之间伸长，管40的开口0用来注满液囊22。开口0最好与第二个端盖孔20的注入口39相连通。挠性管40最好既与穿过指示件32的开口34相连通又与第二个端盖16上的孔20相连通。此结构基本上形成了隔离的液体贮存和液体输送回路，液体从第二个端盖16的孔20流入挠性管40，通过指示件32和液囊22，从第一个端盖14的孔18流出。管40有相当小的内径以便输液后移动式泵中可能残留的液体量降至最少。小直径管也减少灌注移动式泵10所需的时间(或使灌注移动式泵10所需的时间降至最小)。可是，正如本说明书中更详细讨论的，管40中最少量的空气(大约0.50ml)增强了移动式泵10的工作。
正如从图1和图2中明显地看到的那样，挠性管40使液囊22能膨胀、收缩。在优选实施例中，当液囊22膨胀时挠性管40自身绕成盘状(如图2所示)。其结果是当液囊22充分膨胀时挠性管40所占空间最小。此外，当液囊22膨胀时挠性管40的盘绕减少或消除了其在外壳12内移动时“压紧”该管的可能性。
在优选实施例中，移动式泵10至少有一个排气孔42，其功能将在本说明书中描述。排气孔42最好位于端盖14、端盖16的其中之一上。在此实施例中，第二个端盖16上有孔42，其用疏水性材料44盖住。空气可通过疏水性材料44，液体不能通过疏水性材料44。
在本实施例中，管路50与移动式泵10连接，管路50的形状是为了直接或间接地将液体从液囊输送给患者。图3所示典型结构(包括位于管路50内的流量调节器52)见Winchell美国专利第4904239号等等，该专利通常一起转让，该专利结合在本说明书中以供参考。患者输液管路50可与移动式泵10的端盖14连接。管路50最好与移动式泵10连接(例如，作为移动式泵10的一部分)。
对于此实施例来说，第二个端盖孔20可称为注液口20，第一个端盖孔18可称为输出口。移动式泵10至少有一个阀54，其结构允许液体L从注液口20流入液囊22并注满液囊22。在此实施例结构中，构成指示件32一部分(或安装在指示件32上)的“鸭嘴形”阀54伸进液囊22中。鸭嘴形阀54允许液体L从注液口20流入液囊22并防止液囊22中的液体通过注液口20回流。
移动式泵10还有输出口56，其从第一个端盖14的孔18向内伸进液囊22中。在此实施例结构中，液囊22可封装在开口34和口56上以隔离液体流动通道，防止接在外壳12内的液囊22周围产生泄漏。输出口56的结构可以过滤从液囊22流出的液体。或者，输出口56的结构最好使液体能流动畅通，液体可用输出口外的调节器52调节，例如在上面提到的Winchell等专利中所说明的那样。
注液口20可以包括安装部分和连接部分，例如Luer锁定接口，使得可用标准的、现有的医疗器械灌注移动式泵10。注液口20最好可与用来保护注液口20接口的保护盖58相配合，以保证泵10结构的完整性，减少泵10和液体L被污染的可能性。在典型实施例中，注液口20有凹型Luer锁定接口，保护盖58有与注液口20相配合的凸型Luer锁定接口。
本移动式泵10的优点是不需要为了注入液囊时控制指示件的位置而向内弯曲或压紧外壳。相反地，因为注液口20位于刚性端盖16上，端盖16通过挠性管40与弹性材料的液囊22连接，可控制端盖16或端盖16周围的外壳12，可使液体供应源(例如灌注器)与注液口20连接以便注满液囊22。这样，当将灌注器或其他液体供应源连接到移动式泵10上时，任何扭转运动(例如使用Luer接口所必须的扭转运动)只传送给刚性注液口20，而不传送给液囊22。
现在参见图2，当注满液囊22时，其膨胀。作用在指示件32上的来自膨胀液囊22的力使指示件32朝注液口20移动。当指示件32朝注液口20移动时，挠性管40盘绕以容纳膨胀的液囊22。当注入液囊22的液体达到期望量时，可断开供应源，再将保护盖58盖在注液口20上。此时，再盖上保护盖58减少了损害注液口20或污染移动式泵10中液体L的可能性。
熟悉本领域的技术人员认识到液囊22膨胀时必须从移动式泵10中排出外壳12中的空气以使外壳12内腔15的气压保持在一个大气压左右。虽然端盖16上的排气孔42的尺寸足够空气出入使得外壳12内的气压保持在一个大气压左右，但排气孔42的尺寸还是足够小到液囊22破裂后液体L的必然损失均在外壳12内。如上所述，在优选实施例中，排气孔42用疏水性材料44盖住。熟悉本领域的技术人员认识到这样的疏水性材料允许空气或其它气体实质上通过疏水性材料44使外壳12内的空间60基本上保持一个大气压，而疏水性材料阻止液体(例如万一液囊22破裂流出的水)的通过。
可以预料，本移动式泵10的各个元件可用现有的、通常所用的、可医用的材料制成。熟悉本领域的技术人员认识到这些材料可用各种现有的、可医用的技术互相粘结。例如，端盖14、端盖16用溶性粘结剂粘结在外壳12上。液囊22可装在指示件32的开口34上并且可通过机械附件装在输出口56上，例如图示圈64或类似物。
本移动式泵10的优点是可解决现有移动式泵遇到的问题。如上所述，在灌注移动式泵10之前注液口20和液囊22之间的挠性管40中有少量空气。本移动式泵在通过阀54注入液体之前，迫使这“缕”空气通过鸭嘴形阀54，而不是象现有移动式泵那样立即注入液体，实质上使注入液囊22的液体中夹杂着少量空气。对于熟悉本领域的技术人员，所夹杂空气的减少是明显的，结果是液体中形成的微小气泡大大减少或消失。当对此理论不加限制条件时，相信微小气泡的减少或消失会减少调节器毛细管62中微小气泡积聚的可能性。这样又会减少灌注移动式泵10时发生问题或流量调节器52发生阻塞的可能性。
由上述说明可以理解，在不脱离本发明新颖构思的精神和范围的情况下可进行许多改进和变型。应理解本发明并不局限于图示特定的实施例。所公开的内容将由所附权利要求覆盖落入权利要求范围的各种改进。

Claims (7)

1.一种具有一外壳和包含在所述外壳内的用于在压力下分配液体的可膨胀液囊的移动式泵，其中所述液囊的内部可通过所述液囊的一移动自由端的注射而被注液，所述移动式泵包括：
所述外壳；其具有位于所述外壳之上并密封该外壳的第一和第二个固定端盖，第一个端盖上具有形成在其中用于分配所述液体的孔；所述第二端盖具有一进口，所述可膨胀液囊限定了一内贮存的容积，所述液囊由所述外壳所装载并且在未膨胀状态和已膨胀状态之间是可膨胀的，所述液囊具有一限定与所述第一端盖流动连通的孔，并且其特征在于：
所述液囊还包括限定一注液开口的所述自由端，和在所述注液开口和所述进口之间延伸的一绕性管，从而通过所述液囊自由端开口与所述液囊的内部建立了流体连通。
2.按权利要求1的移动式泵，具有位于挠性管和液囊之间的连接件，当液囊在膨胀状态和未膨胀状态之间变化时该连接件可在外壳内纵向移动。
3.按权利要求2的移动式泵，其中该外亮用透明材料制成。
4.按权利要求3的移动式泵，其中该连接件是一个指示件并且其上有标记，该外壳上也有标记，外壳上的标记和指示件上的标记共同显示移动式泵中液体的可测定容积。
5.按权利要求1的移动式泵，其中上述端盖的其中之一有排气孔。
6.按权利要求5的移动式泵，其中该排气孔包括疏水性材料制成的覆盖物。
7.按权利要求1的移动式泵，包括在第一个端盖孔与移动式泵连接的管路，该管路包括流量调节器。
CNB988011239A 1997-12-24 1998-11-13 一种具有用于在压力下分配液体的可膨胀液囊的移动式泵 Expired - Fee Related CN1152720C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/997,787 1997-12-24
US08/997,787 US5897530A (en) 1997-12-24 1997-12-24 Enclosed ambulatory pump

Publications (2)

Publication Number Publication Date
CN1236325A CN1236325A (zh) 1999-11-24
CN1152720C true CN1152720C (zh) 2004-06-09

Family

ID=25544397

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB988011239A Expired - Fee Related CN1152720C (zh) 1997-12-24 1998-11-13 一种具有用于在压力下分配液体的可膨胀液囊的移动式泵

Country Status (12)

Country Link
US (1) US5897530A (zh)
EP (1) EP0944405B1 (zh)
JP (1) JP3260388B2 (zh)
KR (1) KR100540965B1 (zh)
CN (1) CN1152720C (zh)
AT (1) ATE213171T1 (zh)
DE (1) DE69803831T2 (zh)
DK (1) DK0944405T3 (zh)
ES (1) ES2173645T3 (zh)
PT (1) PT944405E (zh)
TW (1) TW374733B (zh)
WO (1) WO1999033503A1 (zh)

Families Citing this family (164)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3207799B2 (ja) * 1997-12-03 2001-09-10 株式会社パイオラックス 薬液持続注入器
US6183461B1 (en) 1998-03-11 2001-02-06 Situs Corporation Method for delivering a medication
US6348043B1 (en) * 1998-12-29 2002-02-19 Mckinley Medical, Lllp Multi-dose infusion pump providing minimal flow between doses
US6554792B2 (en) * 1999-05-21 2003-04-29 Mallinckrodt Inc. Suspension device and method
ES2243270T3 (es) * 1999-05-21 2005-12-01 Mallinckrodt Inc. Dispositivo de resuspension de un agente de contraste.
DE10195354T1 (de) * 2000-02-03 2003-05-08 Medtronic Inc Katheter für variable Infusionsdurchflussmengen
US6485461B1 (en) * 2000-04-04 2002-11-26 Insulet, Inc. Disposable infusion device
US6544229B1 (en) 2000-05-01 2003-04-08 Baxter International Inc Linearly motile infusion pump
US6669669B2 (en) * 2001-10-12 2003-12-30 Insulet Corporation Laminated patient infusion device
US6740059B2 (en) * 2000-09-08 2004-05-25 Insulet Corporation Devices, systems and methods for patient infusion
DE60132507T2 (de) 2000-11-09 2008-12-24 Insulet Corp., Beverly Gerät zur transkutanen Abgabe von Medikamenten
EP1611834B1 (en) 2000-12-21 2011-03-16 Insulet Corporation Medical apparatus remote control and method
US6749581B2 (en) 2001-02-02 2004-06-15 Medtronic, Inc. Variable infusion rate catheter
US6562000B2 (en) 2001-02-02 2003-05-13 Medtronic, Inc. Single-use therapeutic substance delivery device with infusion rate control
EP1381408A4 (en) 2001-02-22 2007-06-13 Insulet Corp MODULAR INFUSION DEVICE AND METHOD
US20040078028A1 (en) * 2001-11-09 2004-04-22 Flaherty J. Christopher Plunger assembly for patient infusion device
US8775196B2 (en) 2002-01-29 2014-07-08 Baxter International Inc. System and method for notification and escalation of medical data
US10173008B2 (en) 2002-01-29 2019-01-08 Baxter International Inc. System and method for communicating with a dialysis machine through a network
US6692457B2 (en) 2002-03-01 2004-02-17 Insulet Corporation Flow condition sensor assembly for patient infusion device
US6830558B2 (en) 2002-03-01 2004-12-14 Insulet Corporation Flow condition sensor assembly for patient infusion device
US6656158B2 (en) 2002-04-23 2003-12-02 Insulet Corporation Dispenser for patient infusion device
US20040153032A1 (en) * 2002-04-23 2004-08-05 Garribotto John T. Dispenser for patient infusion device
US6656159B2 (en) 2002-04-23 2003-12-02 Insulet Corporation Dispenser for patient infusion device
US20050238507A1 (en) * 2002-04-23 2005-10-27 Insulet Corporation Fluid delivery device
JP3854190B2 (ja) * 2002-04-26 2006-12-06 株式会社ジェイテクト モータ制御装置
US8234128B2 (en) 2002-04-30 2012-07-31 Baxter International, Inc. System and method for verifying medical device operational parameters
US6723072B2 (en) 2002-06-06 2004-04-20 Insulet Corporation Plunger assembly for patient infusion device
US7018361B2 (en) 2002-06-14 2006-03-28 Baxter International Inc. Infusion pump
US7018360B2 (en) * 2002-07-16 2006-03-28 Insulet Corporation Flow restriction system and method for patient infusion device
AU2002950421A0 (en) * 2002-07-29 2002-09-12 Combined Resource Engineering Pty Ltd Fluid operating pump
US7144384B2 (en) * 2002-09-30 2006-12-05 Insulet Corporation Dispenser components and methods for patient infusion device
US7128727B2 (en) * 2002-09-30 2006-10-31 Flaherty J Christopher Components and methods for patient infusion device
US7815629B2 (en) 2002-11-04 2010-10-19 Deka Products Limited Partnership Apparatus for treating obesity by extracting food
US9055995B2 (en) * 2002-11-04 2015-06-16 Aspire Bariatrics, Inc. Method for treating obesity by extracting food
US7740624B2 (en) * 2002-11-04 2010-06-22 Aspiration Medical Technology, Llc Method for treating obesity by extracting food
CN100376294C (zh) * 2002-11-08 2008-03-26 山东威高集团医用高分子制品股份有限公司 精密镇痛输液器
US20040116866A1 (en) * 2002-12-17 2004-06-17 William Gorman Skin attachment apparatus and method for patient infusion device
US7341572B2 (en) * 2003-02-28 2008-03-11 Baxter International Inc. Infusor with flexible sheath
US6892755B2 (en) * 2003-02-28 2005-05-17 Baxter International Inc. Pressure regulator for infusor
US20040206771A1 (en) * 2003-04-18 2004-10-21 Eric Junkel Water toy with two port elastic fluid bladder
US20050182366A1 (en) * 2003-04-18 2005-08-18 Insulet Corporation Method For Visual Output Verification
US7220244B2 (en) * 2003-08-04 2007-05-22 Bioquiddity, Inc. Infusion apparatus with constant force spring energy source
US7169128B2 (en) * 2003-08-04 2007-01-30 Bioquiddity, Inc. Multichannel fluid delivery device
US20050033232A1 (en) * 2003-08-05 2005-02-10 Kriesel Marshall S. Infusion apparatus with modulated flow control
US20050065760A1 (en) * 2003-09-23 2005-03-24 Robert Murtfeldt Method for advising patients concerning doses of insulin
US20050070847A1 (en) * 2003-09-29 2005-03-31 Van Erp Wilhelmus Petrus Martinus Maria Rapid-exchange balloon catheter with hypotube shaft
TW200529900A (en) * 2004-02-12 2005-09-16 Nipro Corp Medicine liquid injector with weight measurer
US20050277884A1 (en) * 2004-05-26 2005-12-15 Kriesel Marshall S Fluid delivery apparatus with bellows reservoir
US20050277883A1 (en) * 2004-05-26 2005-12-15 Kriesel Marshall S Fluid delivery device
US7220245B2 (en) * 2004-05-26 2007-05-22 Kriesel Marshall S Infusion apparatus
US7470253B2 (en) * 2004-05-26 2008-12-30 Bioquiddity, Inc. Fluid delivery apparatus with adjustable flow rate control
US20070156090A1 (en) * 2004-05-26 2007-07-05 Kriesel Marshall S Fluid delivery apparatus
US20050267413A1 (en) * 2004-05-26 2005-12-01 Wang Jong H Flow monitoring devices and methods of use
US20060178633A1 (en) * 2005-02-03 2006-08-10 Insulet Corporation Chassis for fluid delivery device
US8029468B2 (en) * 2005-02-15 2011-10-04 Bioquiddity, Inc. Fluid delivery and mixing apparatus with flow rate control
US7694938B2 (en) * 2005-02-17 2010-04-13 Bioquiddity, Inc. Distal rate control device
US20080009835A1 (en) * 2005-02-17 2008-01-10 Kriesel Marshall S Fluid dispensing apparatus with flow rate control
US7837653B2 (en) * 2005-02-18 2010-11-23 Bioquiddity, Inc. Fluid delivery apparatus with vial fill
EP1874446A1 (en) 2005-04-25 2008-01-09 Entegris, Inc. Method and apparatus for treating fluids to reduce microbubbles
US7552240B2 (en) * 2005-05-23 2009-06-23 International Business Machines Corporation Method for user space operations for direct I/O between an application instance and an I/O adapter
EP1944672A3 (de) 2005-07-22 2008-07-30 RoweMed AG - Medical 4 Life Mechanisch betriebene Flüssigkeitspumpe
US7828772B2 (en) * 2006-03-15 2010-11-09 Bioquiddity, Inc. Fluid dispensing device
US7993304B2 (en) * 2006-03-15 2011-08-09 Bioquiddity, Inc. Fluid dispensing apparatus
WO2008005496A2 (en) * 2006-07-05 2008-01-10 Aspiration Medical Technology, Llc Shunt apparatus for treating obesity by extracting food
US20110082442A1 (en) * 2006-07-05 2011-04-07 Solovay Kenneth S Externally reinforced percutaneous gastrostomy tube with customizable smooth tube length
US8057435B2 (en) 2006-07-31 2011-11-15 Kriesel Joshua W Fluid dispenser
US8292848B2 (en) * 2006-07-31 2012-10-23 Bio Quiddity, Inc. Fluid dispensing device with additive
US8632513B2 (en) * 2006-08-03 2014-01-21 Aspire Bariatrics, Inc. Systems and methods for removing ingested material from a stomach
US8414561B2 (en) 2006-08-03 2013-04-09 Aspire Bariatrics, Llc Systems and methods for removing ingested material from a stomach
US9056164B2 (en) 2007-01-01 2015-06-16 Bayer Medical Care Inc. Radiopharmaceutical administration methods, fluid delivery systems and components thereof
US20080243077A1 (en) * 2007-04-02 2008-10-02 Bivin Donald B Fluid dispenser with uniformly collapsible reservoir
US7892213B2 (en) * 2007-04-20 2011-02-22 Carefusion 303, Inc. Fluid flow control system having capillary fluid flow restrictor
US20080319385A1 (en) * 2007-06-25 2008-12-25 Kriesel Marshall S Fluid dispenser with additive sub-system
US8211059B2 (en) * 2007-06-25 2012-07-03 Kriesel Marshall S Fluid dispenser with additive sub-system
US20090093774A1 (en) * 2007-10-04 2009-04-09 Baxter International Inc. Ambulatory pump with intelligent flow control
US8215157B2 (en) * 2007-10-04 2012-07-10 Baxter International Inc. System and method for measuring liquid viscosity in a fluid delivery system
DE102007049446A1 (de) * 2007-10-16 2009-04-23 Cequr Aps Katheter-Einführeinrichtung
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
US8057679B2 (en) 2008-07-09 2011-11-15 Baxter International Inc. Dialysis system having trending and alert generation
US10089443B2 (en) 2012-05-15 2018-10-02 Baxter International Inc. Home medical device systems and methods for therapy prescription and tracking, servicing and inventory
US7959598B2 (en) 2008-08-20 2011-06-14 Asante Solutions, Inc. Infusion pump systems and methods
MX2011002655A (es) * 2008-09-09 2011-06-16 Baxter Int Dispositivo para indicar la imprimacion de una linea de infusion.
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
AU2009293019A1 (en) 2008-09-19 2010-03-25 Tandem Diabetes Care Inc. Solute concentration measurement device and related methods
US8554579B2 (en) 2008-10-13 2013-10-08 Fht, Inc. Management, reporting and benchmarking of medication preparation
US8105269B2 (en) 2008-10-24 2012-01-31 Baxter International Inc. In situ tubing measurements for infusion pumps
US8316897B2 (en) * 2009-01-25 2012-11-27 Mattel, Inc. Water gun assembly
US20100211002A1 (en) * 2009-02-18 2010-08-19 Davis David L Electromagnetic infusion pump with integral flow monitor
US8197235B2 (en) * 2009-02-18 2012-06-12 Davis David L Infusion pump with integrated permanent magnet
US8353864B2 (en) * 2009-02-18 2013-01-15 Davis David L Low cost disposable infusion pump
US8137083B2 (en) 2009-03-11 2012-03-20 Baxter International Inc. Infusion pump actuators, system and method for controlling medical fluid flowrate
US20110152770A1 (en) 2009-07-30 2011-06-23 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US8672873B2 (en) 2009-08-18 2014-03-18 Cequr Sa Medicine delivery device having detachable pressure sensing unit
US8547239B2 (en) * 2009-08-18 2013-10-01 Cequr Sa Methods for detecting failure states in a medicine delivery device
US8382447B2 (en) 2009-12-31 2013-02-26 Baxter International, Inc. Shuttle pump with controlled geometry
NL1037733C2 (nl) * 2010-02-22 2011-08-23 Yusuf Galipoglu Draagbare mechanische blik voor vloeibare stof en infuus systeem.
US9108047B2 (en) 2010-06-04 2015-08-18 Bayer Medical Care Inc. System and method for planning and monitoring multi-dose radiopharmaceutical usage on radiopharmaceutical injectors
US8567235B2 (en) 2010-06-29 2013-10-29 Baxter International Inc. Tube measurement technique using linear actuator and pressure sensor
US9211378B2 (en) 2010-10-22 2015-12-15 Cequr Sa Methods and systems for dosing a medicament
EP4406568A3 (en) 2012-03-30 2024-10-16 Insulet Corporation Fluid delivery device with transcutaneous access tool, insertion mechanism and blood glucose monitoring for use therewith
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US9555186B2 (en) 2012-06-05 2017-01-31 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
CN103536982A (zh) * 2012-07-13 2014-01-29 江苏先声药业有限公司 一种重组人血管内皮抑制素持续给药系统
WO2014035478A1 (en) 2012-08-31 2014-03-06 Baxter Corporation Englewood Medication requisition fulfillment system and method
JP2015536181A (ja) 2012-10-26 2015-12-21 バクスター・コーポレーション・イングルウッドＢａｘｔｅｒ Ｃｏｒｐｏｒａｔｉｏｎ Ｅｎｇｌｅｗｏｏｄ 医学的用量調製システムのためのワーク・ステーションの改善
KR102078768B1 (ko) 2012-10-26 2020-02-19 백스터 코포레이션 잉글우드 의료 투여분 조제 시스템을 위한 개선된 이미지 취득
US20140155829A1 (en) * 2012-11-30 2014-06-05 Seik Oh Disposable ambulatory infusion pump having telescopic housing
CA2901896C (en) 2013-02-23 2021-03-30 Steven E. Wojcik Apparatus and method for draining material from a stomach
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
US9603995B2 (en) * 2013-03-15 2017-03-28 Tandem Diabetes Care. Inc. Device and method for setting therapeutic parameters for an infusion device
DK3010568T3 (da) * 2013-06-18 2019-05-06 Enable Injections Inc Indretning til overførsel med flakon og injektion
ITBO20130338A1 (it) * 2013-06-28 2014-12-29 Raffaele Longo Catetere
US9561324B2 (en) 2013-07-19 2017-02-07 Bigfoot Biomedical, Inc. Infusion pump system and method
CN105013043B (zh) * 2014-05-03 2017-12-26 上海市第一人民医院 微型自动恒压输液器
CA2953392A1 (en) 2014-06-30 2016-01-07 Baxter Corporation Englewood Managed medical information exchange
US11575673B2 (en) 2014-09-30 2023-02-07 Baxter Corporation Englewood Central user management in a distributed healthcare information management system
US11107574B2 (en) 2014-09-30 2021-08-31 Baxter Corporation Englewood Management of medication preparation with formulary management
JP6593671B2 (ja) * 2014-11-10 2019-10-23 株式会社塚田メディカル・リサーチ 液体供給装置
AU2015358483A1 (en) 2014-12-05 2017-06-15 Baxter Corporation Englewood Dose preparation data analytics
CA2978455A1 (en) 2015-03-03 2016-09-09 Baxter Corporation Englewood Pharmacy workflow management with integrated alerts
EP3314488B1 (en) 2015-06-25 2024-03-13 Gambro Lundia AB Medical device system and method having a distributed database
PL3313216T3 (pl) * 2015-06-29 2019-07-31 Philip Morris Products S.A. Wkład do układu wytwarzania aerozolu
WO2017007123A1 (ko) * 2015-07-08 2017-01-12 (주)더블유앤지 벌룬 인퓨저
EP3380061A4 (en) 2015-11-24 2019-07-24 Insulet Corporation AUTOMATED WEARABLE DRUG DELIVERY SYSTEM
US10413665B2 (en) 2015-11-25 2019-09-17 Insulet Corporation Wearable medication delivery device
WO2017123525A1 (en) 2016-01-13 2017-07-20 Bigfoot Biomedical, Inc. User interface for diabetes management system
CN112933333B (zh) 2016-01-14 2023-03-28 比格福特生物医药公司 调整胰岛素输送速率
US10610643B2 (en) 2016-01-14 2020-04-07 Bigfoot Biomedical, Inc. Occlusion resolution in medication delivery devices, systems, and methods
ITUA20163823A1 (it) * 2016-05-26 2017-11-26 Adria Med S R L Dispositivo per l’infusione di soluzioni medicali
EP3463510B1 (en) 2016-05-26 2019-11-13 Insulet Corporation Single dose drug delivery device
US10363372B2 (en) 2016-08-12 2019-07-30 Insulet Corporation Plunger for drug delivery device
WO2018035051A1 (en) 2016-08-14 2018-02-22 Insulet Corporation Drug delivery device with detection of position of the plunger
WO2018067645A1 (en) 2016-10-07 2018-04-12 Insulet Corporation Multi-stage delivery system
US11946466B2 (en) * 2016-10-27 2024-04-02 Baxter International Inc. Medical fluid therapy machine including pneumatic pump box and accumulators therefore
US10780217B2 (en) 2016-11-10 2020-09-22 Insulet Corporation Ratchet drive for on body delivery system
US11278665B2 (en) 2016-11-22 2022-03-22 Eitan Medical Ltd. Method for delivering a therapeutic substance
US11096624B2 (en) 2016-12-12 2021-08-24 Bigfoot Biomedical, Inc. Alarms and alerts for medication delivery devices and systems
KR102476516B1 (ko) 2016-12-21 2022-12-09 감브로 룬디아 아베 외부 도메인을 지원하는 안전한 클러스터 도메인을 구비한 정보 기술 인프라를 포함하는 의료 장치 시스템
US11027063B2 (en) 2017-01-13 2021-06-08 Bigfoot Biomedical, Inc. Insulin delivery methods, systems and devices
US10881792B2 (en) 2017-01-13 2021-01-05 Bigfoot Biomedical, Inc. System and method for adjusting insulin delivery
WO2018136699A1 (en) 2017-01-19 2018-07-26 Insulet Corporation Cartridge hold-up volume reduction
US11045603B2 (en) 2017-02-22 2021-06-29 Insulet Corporation Needle insertion mechanisms for drug containers
US10695485B2 (en) 2017-03-07 2020-06-30 Insulet Corporation Very high volume user filled drug delivery device
WO2019018197A1 (en) * 2017-07-17 2019-01-24 Baxter International Inc. STERILE PRODUCT BAG WITH FILTER ORIFICE
US10973978B2 (en) 2017-08-03 2021-04-13 Insulet Corporation Fluid flow regulation arrangements for drug delivery devices
EP3662161B1 (en) 2017-08-03 2024-05-01 Insulet Corporation Micro piston pump
KR101834787B1 (ko) * 2017-08-31 2018-04-13 제이에스케이바이오메드(주) 왕복 디스크가 구비된 마이크로젯 약물 주사 장치
US11786668B2 (en) 2017-09-25 2023-10-17 Insulet Corporation Drug delivery devices, systems, and methods with force transfer elements
US10898656B2 (en) 2017-09-26 2021-01-26 Insulet Corporation Needle mechanism module for drug delivery device
US11147931B2 (en) 2017-11-17 2021-10-19 Insulet Corporation Drug delivery device with air and backflow elimination
USD928199S1 (en) 2018-04-02 2021-08-17 Bigfoot Biomedical, Inc. Medication delivery device with icons
US10874803B2 (en) 2018-05-31 2020-12-29 Insulet Corporation Drug cartridge with drive system
US11229736B2 (en) 2018-06-06 2022-01-25 Insulet Corporation Linear shuttle pump for drug delivery
AU2019321418A1 (en) * 2018-08-13 2021-02-18 410 Medical, Inc. Systems, apparatus, and methods for reducing fluid pressure in a fluid line
EP3744368A1 (en) 2018-10-05 2020-12-02 Sorrel Medical Ltd. Triggering sequence
EP3887680B1 (en) 2018-11-28 2022-10-26 Insulet Corporation Drug delivery shuttle pump system and valve assembly
USD920343S1 (en) 2019-01-09 2021-05-25 Bigfoot Biomedical, Inc. Display screen or portion thereof with graphical user interface associated with insulin delivery
US11369735B2 (en) 2019-11-05 2022-06-28 Insulet Corporation Component positioning of a linear shuttle pump
CN110965615B (zh) * 2019-12-21 2021-02-02 程小燕 一种卫生间小便池冲水装置
US11951284B2 (en) 2020-08-27 2024-04-09 Tandem Diabetes Care, Inc. Transitioning to other modes in automated insulin delivery
US11464902B1 (en) * 2021-02-18 2022-10-11 Fresenius Kabi Deutschland Gmbh Wearable medicament delivery device with compressible reservoir and method of use thereof
US11311666B1 (en) 2021-02-18 2022-04-26 Fresenius Kabi Deutschland Gmbh Modular wearable medicament delivery device and method of use thereof
WO2024147928A1 (en) 2023-01-06 2024-07-11 Insulet Corporation Automatically or manually initiated meal bolus delivery with subsequent automatic safety constraint relaxation
CN117849895B (zh) * 2023-12-25 2024-09-10 北京清大天达光电科技股份有限公司 一种腔体异物检测装置

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3760806A (en) * 1971-01-13 1973-09-25 Alza Corp Helical osmotic dispenser with non-planar membrane
US4201207A (en) * 1973-03-26 1980-05-06 Alza Corporation Bladder for liquid dispenser
US4318400A (en) * 1980-01-18 1982-03-09 Alza Corporation Medical infusor
US4386929A (en) * 1980-01-18 1983-06-07 Alza Corporation Elastomeric bladder assembly
US4419096A (en) * 1982-02-22 1983-12-06 Alza Corporation Elastomeric bladder assembly
DE3581808D1 (de) * 1985-01-07 1991-03-28 Baxter Int Infusionsgeraet mit durchflussregler an seinem distalen ende.
US4741733A (en) * 1985-01-07 1988-05-03 Baxter Travenol Laboratories, Inc. Infusor having a distal flow regulator
US4904239A (en) * 1985-01-07 1990-02-27 Baxter International Inc. Infusor having a distal flow regulator
WO1987000758A1 (en) * 1985-08-06 1987-02-12 Baxter Travenol Laboratories, Inc. Patient-controlled delivery of beneficial agents
US4769008A (en) * 1986-11-26 1988-09-06 Infusion Systems Corporation Pressurized fluid dispenser
US4909790A (en) * 1987-06-18 1990-03-20 Nissho Corporation Liquid infusion device
JPH0687896B2 (ja) * 1987-11-20 1994-11-09 株式会社ニッショー バルーンインフューザー
US5080652A (en) * 1989-10-31 1992-01-14 Block Medical, Inc. Infusion apparatus
CA2053854C (en) * 1990-02-28 1999-07-13 Osamu Tsukada Infuser with balloon for continuously infusing solution of medicine
US5137175A (en) * 1990-02-28 1992-08-11 Gmi Engineering & Management Institute Fluid storing and dispensing
US5178610A (en) * 1990-07-05 1993-01-12 Nissho Corporation Liquid infusion device
US5083678A (en) * 1990-08-27 1992-01-28 James River Corporation Collapsible dispenser bottle
WO1992006721A1 (es) * 1990-10-23 1992-04-30 Industrias Palex, S.A. Dispositivo infusor de soluciones medicamentosas a presion, portatil
FR2672803A1 (fr) * 1991-02-15 1992-08-21 Renaudeaux Jean Pierre Dispositif d'injection de medicaments en phase liquide.
US5135497A (en) * 1991-07-08 1992-08-04 Baxter International Inc. Large volume pressurized fluid dispenser
US5298025A (en) * 1991-07-08 1994-03-29 Baxter International Inc. Sequential flow rate infusion rate
US5224934A (en) * 1991-12-06 1993-07-06 Block Medical, Inc. Patient controlled bolus dosage infuser
US5354278A (en) * 1992-04-17 1994-10-11 Science Incorporated Fluid dispenser
US5263940A (en) * 1992-04-17 1993-11-23 Science Incorporated Fluid dispenser
US5484415A (en) * 1992-04-17 1996-01-16 Science Incorporated Fluid dispensing apparatus
JP3259267B2 (ja) * 1993-12-28 2002-02-25 ニプロ株式会社 薬液注入器具
JP3499317B2 (ja) * 1995-01-24 2004-02-23 オーベクス株式会社 液体供給装置
US5897527A (en) * 1995-06-06 1999-04-27 Tsukada Medical Research Co., Ltd. Portable analgesic system

Also Published As

Publication number Publication date
US5897530A (en) 1999-04-27
PT944405E (pt) 2002-07-31
TW374733B (en) 1999-11-21
EP0944405B1 (en) 2002-02-13
JP3260388B2 (ja) 2002-02-25
ES2173645T3 (es) 2002-10-16
DE69803831D1 (de) 2002-03-21
ATE213171T1 (de) 2002-02-15
KR20000068176A (ko) 2000-11-25
JP2000510383A (ja) 2000-08-15
EP0944405A1 (en) 1999-09-29
CN1236325A (zh) 1999-11-24
DK0944405T3 (da) 2002-04-02
DE69803831T2 (de) 2002-10-31
KR100540965B1 (ko) 2006-01-10
WO1999033503A1 (en) 1999-07-08

Similar Documents

Publication Publication Date Title
CN1152720C (zh) 一种具有用于在压力下分配液体的可膨胀液囊的移动式泵
US4953753A (en) Fluid dispensing apparatus with prestressed bladder
CA1286938C (en) Pressurized fluid dispenser
US6123685A (en) Syringe for infusion
US4583920A (en) Positive displacement diaphragm pumps employing displacer valves
US5178610A (en) Liquid infusion device
RU96105069A (ru) Устройство для введения лекарственного препарата
JP4812762B2 (ja) 液体投与装置
US20010027290A1 (en) Needleless injector cartridge
CN1128957A (zh) 可植入的药物释放装置
US6413239B1 (en) Infusion pump
RU98104423A (ru) Аппарат для инфузии под давлением
US5298025A (en) Sequential flow rate infusion rate
EP0882466A3 (de) Vorrichtung zur dosierten Verabreichung einer Medikamentflüssigkeit
US5352201A (en) Compact uniform pressure infusion apparatus
US5135497A (en) Large volume pressurized fluid dispenser
AU683219B2 (en) Fluid delivery apparatus
CN1919701A (zh) 稳压式储罐
JPH10113385A (ja) 薬液持続注入具
KR100489554B1 (ko) 맥동 감소장치
CN219517562U (zh) 单向阀及具有该单向阀的输注泵
EP0584714A1 (en) Medical solution delivery system
KR102160197B1 (ko) 수액의 주입을 제어하는 밸브 장치
CN110201265B (zh) 输液装置
ES2622198T3 (es) Válvula de descarga a prueba de fallas para tanques presurizados

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20040609

Termination date: 20171113