CN115054675A - Traditional Chinese medicine composition for reducing blood pressure and blood fat and preparation method thereof - Google Patents
Traditional Chinese medicine composition for reducing blood pressure and blood fat and preparation method thereof Download PDFInfo
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- CN115054675A CN115054675A CN202210862139.1A CN202210862139A CN115054675A CN 115054675 A CN115054675 A CN 115054675A CN 202210862139 A CN202210862139 A CN 202210862139A CN 115054675 A CN115054675 A CN 115054675A
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Abstract
The application provides a traditional Chinese medicine composition for reducing blood pressure and blood fat and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. A traditional Chinese medicine composition for reducing blood pressure and blood fat comprises the following raw materials in parts by weight: 30-50 parts of salvia miltiorrhiza, 25-45 parts of American ginseng, 20-30 parts of pseudo-ginseng, 20-30 parts of hawthorn, 20-30 parts of dendrobium, 15-25 parts of dogwood, 15-25 parts of malt, 18-28 parts of oriental wormwood, 8-18 parts of ruddle, 15-25 parts of ginkgo leaf, 5-10 parts of alfalfa, 5-10 parts of kudzu root, 2-6 parts of pinellia tuber and 4-8 parts of ginger. The traditional Chinese medicine composition has the comprehensive effects of removing blood stasis, dredging collaterals, tonifying kidney, astringing kidney, soothing liver, regulating qi, nourishing yin and tonifying qi, treats both principal and secondary aspects of diseases, has no side effect, can balance yin and yang of liver and kidney, nourish yin, suppress yang and tonify spleen and stomach, has a remarkable effect on blood pressure and blood fat, and obviously shortens the treatment period of the disease course.
Description
Technical Field
The application relates to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for reducing blood pressure and blood fat and a preparation method thereof.
Background
Hypertension and hyperlipidemia are directly related to genetic genes, life style, obesity and the like. Hypertension and hyperlipidemia may be associated therewith. Hypertension and hyperlipidemia are important risk factors for the development of atherosclerosis, and if both diseases exist at the same time, the development and progression of atherosclerosis are accelerated, so that hypertension and hyperlipidemia are both diseases requiring active simultaneous treatment. A large number of people at home and abroad have physiological phenomena of high blood fat and blood pressure, and the hypertension is often accompanied with the hyperlipidemia to have symptoms of dizziness, headache, palpitation, insomnia, tension, vexation, fatigue and the like. The traditional Chinese medicine considers that hypertension and hyperlipidemia gradually develop into yin deficiency and yang excess and yin and yang deficiency from yang excess or yin deficiency due to external factors or internal factors affecting liver and kidney, and the inflammation of heart fire or disharmony of thoroughfare and conception vessels can also promote the imbalance of yin and yang of liver and kidney, so that the hypertension and hyperlipidemia are higher.
At present, the control of blood pressure and blood fat mainly depends on medicines, western medicines have quick effect but great side effects, and long-term treatment depending on the western medicines may be taken at a later stage with a larger dosage, so that the dose-dependent adverse reaction is increased.
Disclosure of Invention
The application aims to provide the traditional Chinese medicine composition for reducing blood pressure and blood fat, and the traditional Chinese medicine composition has a good effect of reducing blood pressure and blood fat.
Another objective of the present application is to provide a method for preparing a Chinese medicinal composition for lowering blood pressure and blood lipid, which can extract more active ingredients of the Chinese medicinal materials and fully exert the medicinal effects of the raw material herbs.
The technical problem to be solved by the application is achieved by adopting the following technical scheme.
On the one hand, the embodiment of the application provides a traditional Chinese medicine composition for reducing blood pressure and blood fat, which comprises the following raw materials in parts by weight: 30-50 parts of salvia miltiorrhiza, 25-45 parts of American ginseng, 20-30 parts of pseudo-ginseng, 20-30 parts of hawthorn, 20-30 parts of dendrobium, 15-25 parts of dogwood, 15-25 parts of malt, 18-28 parts of oriental wormwood, 8-18 parts of ruddle, 15-25 parts of ginkgo leaf, 5-10 parts of alfalfa, 5-10 parts of kudzu root, 2-6 parts of pinellia tuber and 4-8 parts of ginger.
On the other hand, the embodiment of the application provides a preparation method of a traditional Chinese medicine composition for reducing blood pressure and blood fat, which comprises the following steps:
calcining and quenching ruddle with vinegar, sun-drying and pulverizing to obtain ruddle powder, drying Saviae Miltiorrhizae radix, radix Panacis Quinquefolii, Notoginseng radix, fructus crataegi, herba Dendrobii, Corni fructus, fructus Hordei Germinatus, herba Artemisiae Scopariae, folium Ginkgo, herba Medicaginis, radix Puerariae, rhizoma Pinelliae and rhizoma Zingiberis recens, pulverizing, sieving, and mixing with ruddle powder to obtain medicinal powder;
adding water into the above medicinal powder, adding cosolvent, decocting with water for 2 times, filtering, and mixing filtrates to obtain Chinese medicinal extractive solution;
concentrating the above Chinese medicinal extractive solution, and making into common medical dosage forms.
The effects of the raw materials are as follows:
red sage root: bitter taste and slightly cold nature, which enter heart and liver meridians, has the efficacies of activating blood circulation and removing stasis, stimulating the menstrual flow and relieving pain, clearing heart fire and relieving restlessness, cooling blood and eliminating carbuncle, and is used for treating chest stuffiness and pains, epigastric and abdominal pain, abdominal mass and mass, heat arthralgia pain, vexation and insomnia, irregular menstruation, dysmenorrheal and amenorrhea, sore and ulcer and sore pain.
American ginseng: sweet and slightly bitter taste, cool nature, heart, lung and kidney meridians entered, has the efficacies of invigorating qi and nourishing yin, clearing heat and promoting fluid production, and is used for qi deficiency and yin deficiency, internal heat, cough, asthma, phlegm blood, deficiency heat, vexation and fatigue, diabetes, dry mouth and throat.
Pseudo-ginseng: sweet and slightly bitter taste, warm nature, liver and stomach channels, has effects of removing blood stasis, stopping bleeding, detumescence and relieving pain, and can be used for hemoptysis, hematemesis, epistaxis, hematochezia, metrorrhagia, traumatic hemorrhage, thoracico-abdominal pain, and traumatic swelling and pain.
Hawthorn fruit: sour, sweet and slightly warm in taste, and has the effects of promoting digestion, invigorating stomach, promoting qi circulation and removing blood stasis, and can be used for treating meat food stagnation, gastric cavity fullness, dysentery abdominal pain, blood stasis amenorrhea, puerperal blood stasis, heart and abdomen stabbing pain, hernia pain; hyperlipidemia.
Dendrobe: sweet taste and slightly cold nature, has the efficacies of benefiting stomach, promoting fluid production, nourishing yin and clearing heat, and is used for treating yin deficiency and fluid deficiency, dry mouth, polydipsia, poor appetite, retching, asthenic fever after disease and dim and unclear eyes.
Dogwood: sour and astringent taste, mild nature, and liver and kidney meridian tropism, has effects of invigorating liver and kidney, and arresting seminal emission, and can be used for treating giddiness tinnitus, soreness of waist and knees, sexual impotence, nocturnal emission, enuresis, pollakisuria, metrorrhagia leukorrhagia, and hyperhidrosis. Internal heat to quench thirst.
Malt: has sweet taste and neutral nature, and has effects of activating qi-flowing, resolving food stagnation, invigorating spleen, promoting appetite, removing milk, and relieving flatulence, and can be used for treating dyspepsia, abdominal pain, spleen deficiency, anorexia, breast pain, and breast milk stagnation.
Herba artemisiae scopariae: bitter and pungent in taste, slightly cold in nature, and has effects of clearing away damp-heat and eliminating jaundice due to spleen, stomach, liver and gallbladder meridians, and can be used for treating jaundice, oliguria, eczema and pruritus; infectious icteric hepatitis
Haematitum: bitter and sweet taste, slightly cold nature, entering liver, stomach and heart channels, has effects of suppressing hyperactive liver and subsiding yang, lowering adverse qi, cooling blood and stopping bleeding, and can be used for treating headache, giddiness, cardiopalmus, mania, convulsive epilepsy, emesis, hiccup, dysphagia, cough, asthma, hematemesis, epistaxis, metrorrhagia, hematochezia and hematuria.
Ginkgo leaf: sweet, bitter and astringent taste, mild nature, heart and lung meridian tropism, has effects of astringing lung, relieving asthma, promoting blood circulation for removing blood stasis, and relieving pain, and can be used for treating cough and asthma due to lung deficiency; coronary heart disease, angina pectoris, and hyperlipidemia.
Alfalfa: bitter taste and neutral nature, and has the effects of clearing spleen and stomach, benefiting large and small intestines and removing urinary bladder calculus.
Kudzu root: has sweet and pungent taste, is cool in nature, and can enter spleen and stomach channels, has effects of relieving muscles and fever, promoting fluid production, promoting eruption, invigorating yang and relieving diarrhea, and can be used for treating fever and headache due to exogenous pathogens, neck and back pain, thirst, diabetes, measles without adequate eruption, dysentery due to heat, and diarrhea; hypertension neck and neck pain.
Pinellia ternata: pungent, warm and toxic in flavor, entering spleen, stomach and lung channels, has the effects of eliminating dampness and phlegm, lowering adverse qi and preventing vomiting, and relieving distension and fullness and dissipating stagnation, and is used for treating excessive phlegm and cough, phlegm and fluid retention and dizziness and palpitation, wind phlegm and vertigo, phlegm syncope and headache, vomiting and regurgitation, fullness and stuffiness in chest and epigastrium, and globus hystericus.
Ginger: has pungent taste and slightly warm nature, enters lung, spleen and stomach channels, has effects of relieving exterior syndrome, dispelling cold, warming middle warmer, relieving vomit, eliminating phlegm and relieving cough, and can be used for treating wind-cold type common cold, stomach cold type emesis, and cold phlegm cough.
Compared with the prior art, the embodiment of the application has at least the following advantages or beneficial effects:
the application adopts salvia miltiorrhiza, American ginseng, pseudo-ginseng, hawthorn, dendrobium, dogwood, malt, oriental wormwood, ruddle, ginkgo leaf, alfalfa, radix puerariae and pinellia ternate as raw materials, and for hyperlipidemia accompanied by hypertension, the raw materials are fundamentally in yin-yang imbalance of viscera, vertigo can be directly caused by kidney deficiency, yin-yang balance of liver can be influenced, and spleen governs transportation and transformation of food essence is biochemical for qi and blood. When the liver and kidney are abnormal and the water metabolism is disturbed, water dampness is produced; phlegm is produced due to long retention of damp pathogen; long-term disease entering collaterals will cause blood stasis. According to the application, firstly, the salvia miltiorrhiza, the pseudo-ginseng and the ginkgo leaf are used for activating blood circulation to dissipate blood stasis, the pinellia tuber is used for dispersing glomus and dissipating stagnation, the effects of removing blood stasis, dredging collaterals, relieving swelling and dissipating stagnation are achieved together, then the malt is used for strengthening the spleen and stomach, soothing the liver and promoting qi circulation, the artemisia capillaris is used for purging liver heat and soothing liver depression, the effects of soothing the liver depression and regulating the liver qi are achieved by combining the malt with the artemisia capillaris, the effects of calming the liver and suppressing yang, the radix puerariae is used for raising the yang and relieving diarrhea, the dogwood is used for tonifying the liver and kidney, the bones and muscles are strengthened, the liver and depression are relieved, the American ginseng and the dendrobium are used for tonifying qi and yin, the hawthorn and the alfalfa are used for tonifying the stomach, and the effects of tonifying the spleen and qi, and nourishing the yin and the kidney are achieved by combining together. The traditional Chinese medicine composition has the comprehensive effects of removing blood stasis, dredging collaterals, tonifying kidney, astringing kidney, soothing liver, regulating qi and nourishing yin and tonifying qi, can treat both symptoms and root causes, has no side effect, can balance liver and kidney yin and yang, nourish yin, suppress yang and tonify spleen and stomach, has a remarkable effect on blood pressure and blood fat, and obviously shortens the treatment period of the disease course.
In addition, the preparation method is simple and convenient in flow, and as the traditional Chinese medicine raw materials contain a large amount of ketone, phenol, alkaloid and other active ingredients which are difficult to dissolve in water, the cosolvent nicotinamide is added, the nicotinamide can be combined with ketone substances to form soluble intermolecular complexes in the water, so that the active ingredients in the traditional Chinese medicine are more soluble in the water, the drug effects of the medicinal materials can be fully exerted after twice repeated decoction, more beneficial substances in the raw medicinal materials can be extracted after concentration, and the proportion of the beneficial substances in the finished product is improved.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions of the embodiments of the present application will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present application will be described in detail below with reference to specific examples.
The embodiment of the application provides a traditional Chinese medicine composition for reducing blood pressure and blood fat, which comprises the following raw materials in parts by weight: 30-50 parts of salvia miltiorrhiza, 25-45 parts of American ginseng, 20-30 parts of pseudo-ginseng, 20-30 parts of hawthorn, 20-30 parts of dendrobium, 15-25 parts of dogwood, 15-25 parts of malt, 18-28 parts of oriental wormwood, 8-18 parts of ruddle, 15-25 parts of ginkgo leaf, 5-10 parts of alfalfa, 5-10 parts of kudzu root, 2-6 parts of pinellia tuber and 4-8 parts of ginger.
In the above embodiments, the raw materials of salvia miltiorrhiza, American ginseng, pseudo-ginseng, hawthorn, dendrobium, dogwood, malt, oriental wormwood, ruddle, ginkgo leaf, alfalfa, kudzu vine root and pinellia ternate are adopted, and for hyperlipidemia accompanied by hypertension, the essential is viscera yin-yang imbalance, kidney deficiency can directly cause dizziness, and can also influence liver yin-yang balance, and spleen governs transportation and transformation of food essence, which is the biochemical of qi and blood. When the liver and kidney are abnormal and the water metabolism is disturbed, water dampness is produced; phlegm is produced due to long retention of damp pathogen; long-term disease entering collaterals will cause blood stasis. According to the application, firstly, the salvia miltiorrhiza, the pseudo-ginseng and the ginkgo leaf are used for activating blood circulation to dissipate blood stasis, the pinellia tuber is used for dispersing glomus and dissipating stagnation, the effects of removing blood stasis, dredging collaterals, relieving swelling and dissipating stagnation are achieved together, then the malt is used for strengthening the spleen and stomach, soothing the liver and promoting qi circulation, the artemisia capillaris is used for purging liver heat and soothing liver depression, the effects of soothing the liver depression and regulating the liver qi are achieved by combining the malt with the artemisia capillaris, the effects of calming the liver and suppressing yang, the radix puerariae is used for raising the yang and relieving diarrhea, the dogwood is used for tonifying the liver and kidney, the bones and muscles are strengthened, the liver and depression are relieved, the American ginseng and the dendrobium are used for tonifying qi and yin, the hawthorn and the alfalfa are used for tonifying the stomach, and the effects of tonifying the spleen and qi, and nourishing the yin and the kidney are achieved by combining together. The traditional Chinese medicine composition has the comprehensive effects of removing blood stasis, dredging collaterals, tonifying kidney, astringing kidney, soothing liver, regulating qi and nourishing yin and tonifying qi, can treat both symptoms and root causes, has no side effect, can balance liver and kidney yin and yang, nourish yin, suppress yang and tonify spleen and stomach, has a remarkable effect on blood pressure and blood fat, and obviously shortens the treatment period of the disease course.
In some embodiments of the present application, the raw materials are used in the following amounts by weight: 42 parts of salvia miltiorrhiza, 34 parts of American ginseng, 27 parts of pseudo-ginseng, 25 parts of hawthorn, 24 parts of dendrobium, 20 parts of dogwood, 24 parts of malt, 25 parts of oriental wormwood, 13 parts of ruddle, 20 parts of ginkgo leaf, 6 parts of alfalfa, 6 parts of kudzu root, 4 parts of pinellia ternate and 6 parts of ginger.
In some embodiments of the present application, 5-15 parts by weight of brown sugar is also included.
In some embodiments of the present application, the composition further comprises 2 to 5 parts by weight of a cosolvent, wherein the cosolvent is nicotinamide.
The embodiment of the application also provides a preparation method of the traditional Chinese medicine composition for reducing blood pressure and blood fat, which comprises the following steps:
calcining and quenching ruddle with vinegar, sun-drying and pulverizing to obtain ruddle powder, drying Saviae Miltiorrhizae radix, radix Panacis Quinquefolii, Notoginseng radix, fructus crataegi, herba Dendrobii, Corni fructus, fructus Hordei Germinatus, herba Artemisiae Scopariae, folium Ginkgo, herba Medicaginis, radix Puerariae, rhizoma Pinelliae and rhizoma Zingiberis recens, pulverizing, mixing with ruddle powder, and sieving to obtain medicinal powder;
adding water into the above medicinal powder, adding cosolvent, decocting with water for 2 times, filtering, and mixing filtrates to obtain Chinese medicinal extractive solution;
concentrating the above Chinese medicinal extractive solution, and making into common medical dosage forms.
In the embodiment, the preparation method has simple and convenient flow, and as the traditional Chinese medicine raw materials contain a large amount of ketone, phenol, alkaloid and other active ingredients which are difficult to dissolve in water, the cosolvent nicotinamide is added, the nicotinamide can be combined with ketone substances to form soluble intermolecular complexes in the water, so that the active ingredients in the traditional Chinese medicine are more dissolved in the water, the drug effects of the medicinal materials can be fully exerted after twice repeated decoction, more beneficial substances in the raw medicinal materials can be extracted after concentration, and the proportion of the beneficial substances in the finished product is improved.
In some embodiments of the present application, the vinegar calcining and quenching specifically comprises: cleaning Haematitum, calcining on smokeless furnace to red, immediately soaking and quenching in cold vinegar, mashing, and repeatedly calcining and quenching vinegar for 1-2 times. The vinegar calcining and quenching is suitable for mineral medicines capable of enhancing curative effect, and the ruddle is convenient to crush after being repeatedly calcined and quenched by vinegar, is beneficial to fully dissolving and decocting active ingredients, and can enhance the effects of enriching blood, stopping bleeding, opening stasis and relieving pain.
In some embodiments of the present application, when dried, the drying is carried out at 22-27 ℃ for 5-7 h.
In some embodiments of the present application, the mesh size of the powder is 50-80 mesh.
In some embodiments of the present application, the concentration step is performed by low-temperature reduced-pressure concentration at a concentration pressure of 7.55 to 9.33kPa and a concentration temperature of 40 to 45 ℃. After the low-temperature reduced pressure concentration, on one hand, the medicine concentration can be further improved, the medicine effect can be enhanced, and meanwhile, the loss of active ingredients in the traditional Chinese medicine can be avoided.
In some embodiments of the present application, after the above Chinese medicinal extract is concentrated, a filler and a binder are added to make a tablet, a pill or a granule.
The features and properties of the present application are described in further detail below with reference to examples.
Example 1
A traditional Chinese medicine composition for reducing blood pressure and blood fat is prepared by the following steps:
cleaning 13g of ruddle, calcining the ruddle on smokeless fire until the ruddle is red, immediately putting the ruddle into cold vinegar for immersion quenching, mashing the raw materials, repeatedly carrying out vinegar calcination quenching for 2 times, drying in the sun and crushing to obtain ruddle powder, drying 42g of salvia miltiorrhiza, 34g of American ginseng, 27g of pseudo-ginseng, 25g of hawthorn, 24g of dendrobium, 20g of dogwood, 24g of malt, 25g of oriental wormwood, 20g of ginkgo leaf, 6g of alfalfa, 6g of kudzuvine root, 4g of pinellia ternate and 6g of ginger for 6 hours at 25 ℃, crushing the raw materials, mixing the pulverized ruddle powder with the raw materials, and screening the mixture by a 65-mesh screen to obtain medicinal powder;
adding water into the medicinal powder, adding nicotinamide 3g, repeatedly decocting with water for 2 times, filtering, and mixing filtrates to obtain Chinese medicinal extractive solution;
adding brown sugar 10g into the above Chinese medicinal extractive solution, concentrating at low temperature under reduced pressure of 8.55kPa at 42 deg.C, adding filler and binder, wherein the filler is starch and the binder is dextrin, and making into pill.
Example 2
A traditional Chinese medicine composition for reducing blood pressure and blood fat is prepared by the following steps:
cleaning 15g of ruddle, calcining the ruddle on smokeless fire until the ruddle is red, immediately putting the ruddle into cold vinegar for immersion quenching, mashing, repeatedly carrying out 1-time vinegar calcining quenching, drying in the sun and crushing to obtain ruddle powder, drying 38g of salvia miltiorrhiza, 38g of American ginseng, 25g of pseudo-ginseng, 27g of hawthorn, 25g of dendrobium, 22g of dogwood, 22g of malt, 26g of oriental wormwood, 24g of ginkgo leaf, 7g of alfalfa, 7g of kudzuvine root, 4g of pinellia ternate and 4g of ginger at 25 ℃ for 6 hours, crushing again, mixing with the ruddle powder, and screening by a 65-mesh screen to obtain medicinal powder;
adding water into the medicinal powder, adding 4g nicotinamide, repeatedly decocting with water for 2 times, filtering, and mixing filtrates to obtain Chinese medicinal extractive solution;
adding brown sugar 5g into the above Chinese medicinal extractive solution, concentrating at 42 deg.C under 8.55kPa under reduced pressure, adding filler and binder, wherein the filler is starch and the binder is dextrin, and making into tablet.
Example 3
A traditional Chinese medicine composition for reducing blood pressure and blood fat is prepared by the following steps:
cleaning 8g of ruddle, calcining the ruddle on smokeless fire until the ruddle is red, immediately putting the ruddle into cold vinegar for immersion quenching, mashing, repeatedly carrying out 1-time vinegar calcining quenching, drying in the sun and crushing to obtain ruddle powder, drying 30g of salvia miltiorrhiza, 25g of American ginseng, 20g of pseudo-ginseng, 20g of hawthorn, 20g of dendrobium, 15g of dogwood, 15g of malt, 18g of oriental wormwood, 15g of ginkgo leaf, 5g of alfalfa, 5g of kudzuvine root, 2g of pinellia ternate and 8g of ginger at 22 ℃ for 5 hours, crushing again, mixing with the ruddle powder, and sieving with a 50-mesh sieve to obtain medicinal powder;
adding water into the medicinal powder, adding nicotinamide 2g, repeatedly decocting with water for 2 times, filtering, and mixing filtrates to obtain Chinese medicinal extractive solution;
adding 15g of brown sugar into the Chinese medicinal extractive solution, concentrating at low temperature under reduced pressure of 7.55kPa at 40 deg.C, adding filler and binder, wherein the filler is starch and the binder is dextrin, and making into granule.
Example 4
A traditional Chinese medicine composition for reducing blood pressure and blood fat is prepared by the following steps:
cleaning 18g of ruddle, calcining the ruddle on smokeless fire until the ruddle is red, immediately putting the ruddle into cold vinegar for immersion and quenching, mashing, repeatedly carrying out vinegar calcination and quenching for 2 times, drying in the sun and crushing to obtain ruddle powder, drying 50g of salvia miltiorrhiza, 45g of American ginseng, 30g of pseudo-ginseng, 30g of hawthorn, 30g of dendrobium, 25g of dogwood, 25g of malt, 28g of oriental wormwood, 25g of ginkgo leaf, 10g of alfalfa, 10g of kudzuvine root, 6g of pinellia tuber and 8g of ginger at 27 ℃ for 7 hours, crushing again, mixing with the ruddle powder, and sieving with a 80-mesh sieve to obtain medicinal powder;
adding water into the medicinal powder, adding 5g nicotinamide, repeatedly decocting with water for 2 times, filtering, and mixing filtrates to obtain Chinese medicinal extractive solution;
concentrating the above Chinese medicinal extractive solution at 45 deg.C under 9.33kPa under reduced pressure, adding filler and binder, wherein the filler is starch and the binder is dextrin, and making into pill.
Example 5
A traditional Chinese medicine composition for reducing blood pressure and blood fat is prepared by the following steps:
cleaning 16g of ruddle, calcining the ruddle on smokeless fire until the ruddle is red, immediately putting the ruddle into cold vinegar for immersion and quenching, mashing, repeatedly carrying out vinegar calcination and quenching for 2 times, drying in the sun and crushing to obtain ruddle powder, drying 42g of salvia miltiorrhiza, 28g of American ginseng, 23g of pseudo-ginseng, 23g of hawthorn, 26g of dendrobium, 18g of dogwood, 18g of malt, 25g of oriental wormwood, 13g of ginkgo leaf, 7g of alfalfa, 10g of radix puerariae, 5g of pinellia ternate and 5g of ginger at 24 ℃ for 5 hours, crushing again, mixing with the ruddle powder, and screening by a 55-mesh screen to obtain medicinal powder;
adding water into the medicinal powder, adding 5g nicotinamide, repeatedly decocting with water for 2 times, filtering, and mixing filtrates to obtain Chinese medicinal extractive solution;
adding brown sugar 12g into the above Chinese medicinal extractive solution, concentrating at low temperature under reduced pressure of 8.31kPa at 41 deg.C, adding filler and binder, wherein the filler is starch and the binder is dextrin, and making into pill.
Example 6
A traditional Chinese medicine composition for reducing blood pressure and blood fat is prepared by the following steps:
cleaning 10g of ruddle, calcining the ruddle on smokeless fire until the ruddle is red, immediately putting the ruddle into cold vinegar for immersion quenching, mashing, repeatedly carrying out 1-time vinegar calcining quenching, drying in the sun and crushing to obtain ruddle powder, drying 32g of salvia miltiorrhiza, 26g of American ginseng, 28g of pseudo-ginseng, 27g of hawthorn, 27g of dendrobium, 15g of dogwood, 20g of malt, 20g of oriental wormwood, 17g of ginkgo leaf, 8g of alfalfa, 8g of radix puerariae, 5g of pinellia ternate and 7g of ginger at 26 ℃ for 7 hours, crushing again, mixing with the ruddle powder, and sieving with a 70-mesh sieve to obtain medicinal powder;
adding water into the medicinal powder, adding nicotinamide 3g, repeatedly decocting with water for 2 times, filtering, and mixing filtrates to obtain Chinese medicinal extractive solution;
concentrating the above Chinese medicinal extractive solution at 44 deg.C under 9.31kPa under reduced pressure, adding filler and binder, wherein the filler is starch and the binder is dextrin, and making into tablet.
The following are some typical cases:
in a male, 62 years old, the male often feels high blood pressure, blood fat and blood sugar, the blood pressure is 148/96mmHg, all symptoms are relieved after taking the traditional Chinese medicine composition prepared in the application example 1 for three months, the blood pressure is 140/89mmHg, and the total serum cholesterol and the serum triglyceride are reduced.
Jingzhi, women, 50 years old, who suffered from hypertension accompanied by high blood lipid, blood pressure measured was 159/98mmHg, the blood pressure lowering drugs were intermittently taken within one year, and the drug was stopped and repeated, and after taking the Chinese medicinal composition prepared in example 2 of the present application for three months, all symptoms were relieved, blood pressure measured was 142/91mmHg, and serum total cholesterol and serum triglyceride were all reduced.
After the male is aged 68 years old, the male suffers from hypertension for two years, then the male often feels chest distress, dizziness and palpitation, lipoma appears in eyes, the blood pressure is measured to be 162/98mmHg, after the Chinese medicinal composition prepared by the application example 2 is taken for four months, all symptoms are relieved, the lipoma is dissipated, the blood pressure is measured to be 144/93mmHg, and serum total cholesterol and serum triglyceride are reduced.
In summary, the application provides a traditional Chinese medicine composition for reducing blood pressure and blood fat, which adopts salvia miltiorrhiza, American ginseng, pseudo-ginseng, hawthorn, dendrobium, dogwood, malt, oriental wormwood, ruddle, ginkgo leaf, alfalfa, radix puerariae and pinellia ternate as raw materials, and for the hyperlipidemia accompanied by hypertension, the traditional Chinese medicine composition is fundamentally in viscera yin-yang imbalance, vertigo can be directly caused by kidney deficiency, the yin-yang balance of liver can be influenced, and spleen governs transportation and transformation of food essence, and is the biochemical treatment of qi and blood. When the liver and kidney are abnormal and the water metabolism is disturbed, water dampness is produced; phlegm is produced when damp pathogen accumulates for a long time; stasis is produced when the blood enters the collaterals in case of chronic disease. According to the application, firstly, the salvia miltiorrhiza, the pseudo-ginseng and the ginkgo leaf are used for activating blood circulation to dissipate blood stasis, the pinellia tuber is used for dispersing glomus and dissipating stagnation, the effects of removing blood stasis, dredging collaterals, relieving swelling and dissipating stagnation are achieved together, then the malt is used for strengthening the spleen and stomach, soothing the liver and promoting qi circulation, the artemisia capillaris is used for purging liver heat and soothing liver depression, the effects of soothing the liver depression and regulating the liver qi are achieved by combining the malt with the artemisia capillaris, the effects of calming the liver and suppressing yang, the radix puerariae is used for raising the yang and relieving diarrhea, the dogwood is used for tonifying the liver and kidney, the bones and muscles are strengthened, the liver and depression are relieved, the American ginseng and the dendrobium are used for tonifying qi and yin, the hawthorn and the alfalfa are used for tonifying the stomach, and the effects of tonifying the spleen and qi, and nourishing the yin and the kidney are achieved by combining together. The traditional Chinese medicine composition has the comprehensive effects of removing blood stasis, dredging collaterals, tonifying kidney, astringing kidney, soothing liver, regulating qi and nourishing yin and tonifying qi, can treat both symptoms and root causes, has no side effect, can balance liver and kidney yin and yang, nourish yin, suppress yang and tonify spleen and stomach, has a remarkable effect on blood pressure and blood fat, and obviously shortens the treatment period of the disease course.
In addition, the application also provides a preparation method of the traditional Chinese medicine composition for reducing blood pressure and blood fat, the preparation method has simple and convenient flow, and as the traditional Chinese medicine raw materials contain a large amount of ketone, phenol, alkaloid and other active ingredients which are difficult to dissolve in water, the cosolvent nicotinamide is added, and can be combined with ketone substances to form soluble intermolecular complexes in water, so that the active ingredients in the traditional Chinese medicine are more soluble in water, the drug effect of each medicinal material can be fully exerted after twice repeated decoction, more beneficial substances in the raw medicinal materials can be extracted after concentration, and the proportion of the beneficial substances in a finished product is improved.
The embodiments described above are some, but not all embodiments of the present application. The detailed description of the embodiments of the present application is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
Claims (10)
1. The traditional Chinese medicine composition for reducing blood pressure and blood fat is characterized by comprising the following raw materials in parts by weight: 30-50 parts of salvia miltiorrhiza, 25-45 parts of American ginseng, 20-30 parts of pseudo-ginseng, 20-30 parts of hawthorn, 20-30 parts of dendrobium, 15-25 parts of dogwood, 15-25 parts of malt, 18-28 parts of oriental wormwood, 8-18 parts of ruddle, 15-25 parts of ginkgo leaf, 5-10 parts of alfalfa, 5-10 parts of kudzu root, 2-6 parts of pinellia tuber and 4-8 parts of ginger.
2. The traditional Chinese medicine composition for reducing blood pressure and blood fat according to claim 1, wherein the dosage of the raw materials is respectively as follows by weight: 42 parts of salvia miltiorrhiza, 34 parts of American ginseng, 27 parts of pseudo-ginseng, 25 parts of hawthorn, 24 parts of dendrobium, 20 parts of dogwood, 24 parts of malt, 25 parts of oriental wormwood, 13 parts of ruddle, 20 parts of ginkgo leaf, 6 parts of alfalfa, 6 parts of kudzu root, 4 parts of pinellia ternate and 6 parts of ginger.
3. The traditional Chinese medicine composition for reducing blood pressure and blood fat as claimed in claim 1, further comprising 5-15 parts by weight of brown sugar.
4. The traditional Chinese medicine composition for reducing blood pressure and blood fat according to claim 1, further comprising 2-5 parts by weight of a cosolvent, wherein the cosolvent is nicotinamide.
5. A method for preparing the Chinese medicinal composition for lowering blood pressure and blood fat according to any one of claims 1 to 4, which comprises the following steps:
calcining and quenching ruddle with vinegar, sun-drying and pulverizing to obtain ruddle powder, drying Saviae Miltiorrhizae radix, radix Panacis Quinquefolii, Notoginseng radix, fructus crataegi, herba Dendrobii, Corni fructus, fructus Hordei Germinatus, herba Artemisiae Scopariae, folium Ginkgo, herba Medicaginis, radix Puerariae, rhizoma Pinelliae and rhizoma Zingiberis recens, pulverizing, mixing with ruddle powder, and sieving to obtain medicinal powder;
adding water into the medicinal powder, adding cosolvent, decocting with water for 2 times, filtering, and mixing filtrates to obtain Chinese medicinal extractive solution;
concentrating the Chinese medicinal extractive solution, and making into common medical dosage forms.
6. The preparation method of the traditional Chinese medicine composition for reducing blood pressure and blood fat as claimed in claim 5, wherein the vinegar calcining and quenching steps are as follows: cleaning Haematitum, calcining on smokeless furnace to red, immediately soaking and quenching in cold vinegar, mashing, and repeatedly calcining and quenching vinegar for 1-2 times.
7. The preparation method of the Chinese medicinal composition for lowering blood pressure and blood fat as claimed in claim 5, wherein the drying is carried out at 22-27 ℃ for 5-7 h.
8. The method for preparing a Chinese medicinal composition for lowering blood pressure and blood fat as claimed in claim 5, wherein the mesh number of the medicinal powder is 50-80 meshes.
9. The method for preparing a Chinese medicinal composition for lowering blood pressure and blood fat as claimed in claim 5, wherein the concentration step adopts low temperature reduced pressure concentration, the concentration pressure is 7.55-9.33kPa, and the concentration temperature is 40-45 ℃.
10. The method for preparing a Chinese medicinal composition for lowering blood pressure and blood fat as claimed in claim 5, wherein the Chinese medicinal extract is concentrated, and then added with filler and binder to make into tablet, pill or granule.
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Application publication date: 20220916 |