CN114099628A - Traditional Chinese medicine composition for reducing hypertension and preparation method thereof - Google Patents

Traditional Chinese medicine composition for reducing hypertension and preparation method thereof Download PDF

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CN114099628A
CN114099628A CN202111495828.5A CN202111495828A CN114099628A CN 114099628 A CN114099628 A CN 114099628A CN 202111495828 A CN202111495828 A CN 202111495828A CN 114099628 A CN114099628 A CN 114099628A
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traditional chinese
chinese medicine
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ruddle
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吕向东
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Zhejiang Yanghe Health Management Technology Co ltd
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Abstract

The invention provides a traditional Chinese medicine composition for reducing hypertension and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. A traditional Chinese medicine composition for reducing hypertension comprises the following raw materials in parts by weight: 20-30 parts of humifuse euphorbia, 10-20 parts of salvia miltiorrhiza, 5-14 parts of ligusticum chuanxiong hort, 6-18 parts of radix curcumae, 6-15 parts of dogwood, 9-18 parts of siegesbeckia orientalis, 10-20 parts of ruddle, 5-12 parts of malt, 5-12 parts of oriental wormwood, 3-8 parts of arisaema cum bile, 5-10 parts of radish seed, 5-10 parts of dendrobium, 3-9 parts of polygala tenuifolia, 3-9 parts of lily and 3-7 parts of liquorice. The medicine prepared by the invention has the effects of removing blood stasis, dredging collaterals, tonifying kidney, astringing kidney, soothing liver, regulating qi, clearing heart fire and soothing nerves, so that the traditional Chinese medicine formula treats both symptoms and root causes, can quickly treat symptoms, relieve symptoms, and treat root causes slowly, so that the yin and yang of the liver and kidney are balanced to reduce side effects, and the blood pressure reducing effect is obvious.

Description

Traditional Chinese medicine composition for reducing hypertension and preparation method thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for reducing hypertension and a preparation method thereof.
Background
Hypertension is a common disease and frequently encountered disease in the middle and western medicine world for a long time, early symptoms of the hypertension are dizziness, headache, palpitation, insomnia, tension, vexation, fatigue and the like, then organs such as heart, brain, kidney and the like can be gradually affected, and diseases such as hypertensive heart disease, renal failure, cerebrovascular accident and the like can be complicated in severe cases. The traditional Chinese medicine considers that the disease belongs to the categories of dizziness, liver yang, liver wind and stroke, and the diseases are usually caused by external factors or internal factors affecting liver and kidney, and gradually develop into yin deficiency and yang excess and yin and yang deficiency from yang excess or yin deficiency, and the up-flaming of heart fire or disharmony of Chong and ren meridians can also promote the yin-yang imbalance of liver and kidney, so as to cause hypertension.
At present, hypertension is mainly controlled by medicines, western medicines have quick response but large side effects, and long-term treatment by the western medicines can cause large dose of medicine to be taken at later stage, so that dose-dependent adverse reactions are increased.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for reducing hypertension, which can effectively reduce hypertension and has a remarkable effect.
The invention also aims to provide a preparation method of the traditional Chinese medicine composition for reducing hypertension, and the medicine prepared by the preparation method can fully exert the drug effects of the raw medicinal materials.
The technical problem to be solved by the invention is realized by adopting the following technical scheme.
On one hand, the embodiment of the application provides a traditional Chinese medicine composition for reducing hypertension, and the dosage of the raw materials is as follows by weight: 20-30 parts of humifuse euphorbia, 10-20 parts of salvia miltiorrhiza, 5-14 parts of ligusticum chuanxiong hort, 6-18 parts of radix curcumae, 6-15 parts of dogwood, 9-18 parts of siegesbeckia orientalis, 10-20 parts of ruddle, 5-12 parts of malt, 5-12 parts of oriental wormwood, 3-8 parts of arisaema cum bile, 5-10 parts of radish seed, 5-10 parts of dendrobium, 3-9 parts of polygala tenuifolia, 3-9 parts of lily and 3-7 parts of liquorice.
On the other hand, the embodiment of the application provides a preparation method of a traditional Chinese medicine composition for reducing hypertension, which comprises the following steps:
steaming Saviae Miltiorrhizae radix, Corni fructus and Siegesbeckiae herba with wine, processing cortex et radix Polygalae and Bulbus Lilii with honey, mixing Saviae Miltiorrhizae radix, Corni fructus and Siegesbeckiae herba steamed with wine with honey, extracting with water for 2-4 times, and filtering to obtain first filtrate;
calcining and quenching ruddle with vinegar, drying in the sun and crushing to obtain ruddle powder;
pulverizing herba Euphorbiae Humifusae, rhizoma Ligustici Chuanxiong, radix Curcumae, fructus Hordei Germinatus, herba Artemisiae Scopariae, Arisaema cum bile, Raphani semen, herba Dendrobii and Glycyrrhrizae radix, mixing with Haematitum powder, extracting with ethanol for 2-4 times, and filtering to obtain second filtrate;
mixing the first filtrate and the second filtrate, concentrating to obtain Chinese medicinal concentrated solution, and making into common dosage forms.
The effects of the raw materials are as follows:
ligusticum wallichii: it is pungent in flavor and warm in nature, enters liver and gallbladder channels, has effects of activating qi-flowing, resolving stagnation, dispelling pathogenic wind, removing dampness, promoting blood circulation and relieving pain, and can be used for treating wind cold headache, dizziness, hypochondriac pain, abdominal pain, cold arthralgia, spasm of tendons, amenorrhea, dystocia, puerperal blood stasis, pain, carbuncle, ulcer, etc.
Red sage root: bitter taste and slightly cold nature, which enter heart and liver meridians, has the efficacies of activating blood circulation and removing stasis, stimulating the menstrual flow and relieving pain, clearing heart fire and relieving restlessness, cooling blood and eliminating carbuncle, and is used for treating chest stuffiness and pains, epigastric and abdominal pain, abdominal mass and mass, heat arthralgia pain, vexation and insomnia, irregular menstruation, dysmenorrheal and amenorrhea, sore and ulcer and sore pain.
B, humifuse: sweet taste and warm nature, has the efficacies of activating blood circulation, dispelling wind and relieving pain, and is mainly used for treating postpartum blood stasis, abdominal mass, leucorrhea with reddish discharge, rheumatic arthralgia and myalgia and migraine.
Turmeric root-tuber: is pungent, bitter and cold in nature, has effects of promoting blood circulation, relieving pain, activating qi-flowing, resolving stagnation, clearing heart fire, cooling blood, promoting bile flow, and eliminating jaundice, and can be used for treating chest and hypochondrium stabbing pain, thoracic obstruction, cardialgia, amenorrhea, dysmenorrhea, breast pain, fever unconsciousness, epilepsy, hematemesis, epistaxis, jaundice, and dark urine.
Dogwood fruit: sour and astringent taste, mild nature, and entering liver and kidney meridians, has effects of invigorating liver and kidney, and arresting seminal emission, and can be used for treating giddiness tinnitus, soreness of waist and knees, sexual impotence, nocturnal emission, enuresis, pollakisuria, metrorrhagia leukorrhagia, profuse sweat, asthenia, and internal heat diabetes.
Siegesbeckia herb: bitter taste and cold nature, enters liver, spleen and kidney meridians, has the functions of dispelling wind-damp, benefiting bones and muscles and reducing blood pressure, and is used for treating quadriplegia, arthralgia and myalgia, weakness of waist and knees, malaria, acute hepatitis, hypertension, furuncle and pyogenic infections and traumatic hemorrhage.
Haematitum: bitter and sweet taste, slightly cold nature, entering liver, stomach and heart channels, has effects of suppressing hyperactive liver and subsiding yang, lowering adverse qi, cooling blood and stopping bleeding, and can be used for treating headache, giddiness, cardiopalmus, mania, convulsive epilepsy, emesis, hiccup, dysphagia, cough, asthma, hematemesis, epistaxis, metrorrhagia, hematochezia and hematuria.
Malt: has sweet taste and neutral nature, and has effects of activating qi-flowing, resolving food stagnation, invigorating spleen, promoting appetite, removing milk, and relieving flatulence, and can be used for treating dyspepsia, abdominal pain, spleen deficiency, anorexia, breast pain, and breast milk stagnation.
Herba artemisiae scopariae: bitter and pungent in taste, slightly cold in nature, entering spleen channel, stomach channel and bladder channel, has effects of clearing damp-heat, promoting bile flow and eliminating jaundice, and can be used for treating jaundice, oliguria, damp-warm and summer-damp, and eczema and pruritus.
Bile star: bitter and slightly pungent taste, cool in nature, entering liver, gallbladder and lung channels, has the effects of clearing fire, resolving phlegm, calming wind and arresting convulsion, and can be used for treating apoplexy, infantile convulsion, epilepsy, headache, giddiness, dyspnea and cough, etc.
Radish seed: has pungent and sweet taste and neutral nature, has the effects of promoting digestion, relieving flatulence, descending qi and eliminating phlegm, and can be used for treating diet stagnation, abdominal distention and pain, constipation, stagnation and dysentery, phlegm accumulation and cough and asthma.
Dendrobium: sweet and pungent in flavor, cool in nature, entering lung and stomach meridians, has effects of clearing heat and nourishing yin, and moistening lung for arresting cough, and can be used for treating cough due to lung heat, tuberculosis, hemoptysis, throat pain, fever polydipsia, rheumatalgia, menoxenia, and traumatic injury.
Polygala root: bitter and pungent taste, warm nature, heart, kidney and lung meridian tropism, has effects of tranquilizing mind, improving intelligence, eliminating phlegm, and relieving swelling, and can be used for treating insomnia and dreaminess, amnesia, palpitation, absent mindedness, expectoration, skin sore and ulcer, swelling and pain in breast caused by incoordination between heart and kidney.
Lily: has sweet taste and cold nature, and has effects of nourishing yin, moistening lung, clearing heart fire and tranquilizing mind, and can be used for treating chronic cough due to yin deficiency, blood-stained sputum, vexation, pavor, insomnia, dreaminess, and absentmindedness.
Licorice root: has sweet taste and mild nature, enters heart, lung, spleen and stomach channels, has the functions of invigorating spleen and replenishing qi, clearing away heat and toxic material, eliminating phlegm and stopping cough, relieving spasm and pain and harmonizing other medicines, and is used for treating weakness of spleen and stomach, lassitude and hypodynamia, palpitation and shortness of breath, cough and profuse sputum, abdominal and limb spasm and pain, carbuncle swelling and sore toxicity and relieving drug toxicity and pungency.
For hypertension, the essential point is yin-yang disharmony of viscera, while in the yin-yang disharmony of viscera, the spleen and kidney are used as the basis of the disease, 32174747, the deficiency of the kidney can directly cause dizziness, can influence the yin-yang balance of the liver, and the spleen mainly transports and transforms food essence, which is the source of the generation and transformation of qi and blood, the spleen and stomach are damaged, the qi deficiency does not promote blood circulation, the chronic disease causes qi stagnation and blood stasis, phlegm stasis and blood stasis mutually block the veins, blood stasis is formed once, the blood circulation is not smooth, the brain is not nourished, the brain is transformed, the eye is guided to be urgent, the eye is urgent, and the dizziness is produced, so the symptoms are treated firstly, the blood stasis is mainly removed, the collaterals are removed, then the viscera are nourished, and the root cause is slowly treated. Therefore, the humifuse euphorbia herb and the salvia miltiorrhiza are adopted to activate blood and remove stasis, both enter liver channels, have good effects of dispelling wind and relieving pain, and activating blood and dredging collaterals, and the ligusticum wallichii and the radix curcumae are used as monarch drugs together and have the effects of promoting qi circulation and relieving depression; the dogwood and the siegesbeckia orientalis have the effects of tonifying liver and kidney, clearing and activating the channels and collaterals, ochre calming the liver and suppressing yang, malt strengthening the spleen and stomach, soothing the liver and promoting qi circulation, and the artemisia capillaris purging liver heat and soothing liver depression, and the malt and the artemisia capillaris are used together to achieve the effects of soothing liver depression and regulating liver qi and are used as ministerial medicines together; the arisaema cum bile and the radish seed clear away fire and reduce phlegm, the bulbus dendrobii clear away heat and nourish yin, moisten lung and relieve cough, the three are all in lung channel, can remove phlegm stasis and clear away lung heat, and the polygala tenuifolia and the lily calm heart and calm nerves, are used as adjuvant drugs together; licorice root, radix Glycyrrhizae coordinates the effects of the other drugs in the recipe. The traditional Chinese medicine composition has the comprehensive effects of removing blood stasis, dredging collaterals, tonifying kidney, astringing kidney, soothing liver, regulating qi, clearing heart and soothing nerves, can treat both symptoms and root causes, can quickly treat symptoms, relieve symptoms, and treat root causes slowly to reduce side effects, enables the balance of yin and yang of the liver and kidney, has a remarkable blood pressure reduction effect, and obviously shortens the treatment period of the disease course.
Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:
the traditional Chinese medicine composition prepared by adopting humifuse euphorbia, salvia miltiorrhiza, ligusticum chuanxiong hort, radix curcumae, dogwood, siegesbeckia orientalis, ruddle, malt, oriental wormwood, arisaema cum bile, semen raphani, dendrobium officinale, polygala tenuifolia, lily and liquorice as raw materials aims at hypertension, mainly promotes blood circulation and removes blood stasis, warms and tonifies liver and kidney, removes heat and eliminates phlegm, calms heart and soothes nerves, has comprehensive effects of removing blood stasis and dredging collaterals, tonifying kidney and astringing kidney, soothing liver and regulating qi, and clearing heart and soothing nerves, can treat both symptoms and root causes in the traditional Chinese medicine composition, can quickly treat symptoms, relieve symptoms, and treat the root causes slowly, balances yin and yang of liver and kidney, reduces side effects, has an obvious blood pressure reduction effect, and obviously shortens the treatment period of a disease course.
In addition, the preparation method has simple and convenient flow, the wine-steamed salvia miltiorrhiza, dogwood and siegesbeckia orientalis can moderate the drug properties and enhance the effects of promoting blood circulation and removing meridian obstruction, the polygala tenuifolia and lily are fried with honey to make the drug properties milder, the ruddle vinegar is convenient to crush after being calcined and quenched, the effective ingredients are favorably and fully dissolved and decocted, the drug effect is enhanced, more beneficial substances in the raw medicinal materials can be extracted after water extraction and alcohol extraction are respectively carried out, the proportion of the beneficial substances in the finished product is improved, and the concentrated solution is convenient to be subsequently prepared into pills, granules, tablets and the like after being concentrated into the traditional Chinese medicine concentrated solution, so that the preparation method is convenient to carry and take, and the prepared medicine has good treatment effect.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.
The embodiment of the invention provides a traditional Chinese medicine composition for reducing hypertension, which comprises the following raw materials in parts by weight: 20-30 parts of humifuse euphorbia, 10-20 parts of salvia miltiorrhiza, 5-14 parts of ligusticum chuanxiong hort, 6-18 parts of radix curcumae, 6-15 parts of dogwood, 9-18 parts of siegesbeckia orientalis, 10-20 parts of ruddle, 5-12 parts of malt, 5-12 parts of oriental wormwood, 3-8 parts of arisaema cum bile, 5-10 parts of radish seed, 5-10 parts of dendrobium, 3-9 parts of polygala tenuifolia, 3-9 parts of lily and 3-7 parts of liquorice.
In the embodiment, the humifuse euphorbia herb, the root of red-rooted salvia, the ligusticum wallichii, the radix curcumae, the dogwood, the siegesbeckia orientalis, the ruddle, the malt, the oriental wormwood, the arisaema cum bile, the radish seed, the dendrobium officinale, the polygala tenuifolia, the lily and the liquorice are used as raw materials, the prepared traditional Chinese medicine composition mainly has the effects of promoting blood circulation and removing blood stasis for hypertension, warming and nourishing the liver and kidney, clearing heat and eliminating phlegm, calming the heart and tranquilizing the mind, is combined in a whole formula, has the comprehensive effects of removing blood stasis and dredging collaterals, tonifying kidney and astringing the kidney, soothing the liver and regulating qi, and clearing the heart and tranquilizing the mind, can treat both symptoms and root causes in a prescription quickly, can relieve symptoms, can treat the root causes slowly, can reduce side effects, balance yin and yang of the liver and kidney, has an obvious blood pressure reduction effect, and can obviously shorten the treatment period of a disease course.
In some embodiments of the present invention, the raw materials are used in the following amounts by weight: 23 parts of humifuse euphorbia, 13 parts of salvia miltiorrhiza, 10 parts of ligusticum chuanxiong hort, 10 parts of radix curcumae, 10 parts of dogwood, 14 parts of siegesbeckia orientalis, 13 parts of ruddle, 9 parts of malt, 9 parts of oriental wormwood, 5 parts of arisaema cum bile, 7 parts of radish seed, 7 parts of dendrobium, 7 parts of polygala tenuifolia, 7 parts of lily and 5 parts of liquorice. The raw material can be used for early hypertension patients, and the dosage is light, so that better treatment effect can be achieved.
In some embodiments of the present invention, the raw materials are used in the following amounts by weight: 27 parts of humifuse euphorbia, 15 parts of salvia miltiorrhiza, 13 parts of ligusticum chuanxiong hort, 13 parts of radix curcumae, 13 parts of dogwood, 16 parts of siegesbeckia orientalis, 18 parts of ruddle, 9 parts of malt, 9 parts of oriental wormwood, 5 parts of arisaema cum bile, 9 parts of radish seed, 8 parts of bulbus dendrobii, 6 parts of polygala tenuifolia, 6 parts of lily and 5 parts of liquorice. The traditional Chinese medicine composition is suitable for the raw material dosage for middle-term hypertension patients, the dosage is increased in the aspects of promoting blood circulation to remove blood stasis, warming and nourishing liver and kidney, clearing heat and eliminating phlegm, and a better treatment effect can be achieved.
In some embodiments of the invention, the malt is a raw malt. The raw malt has the effects of strengthening spleen and stomach, soothing liver and promoting qi circulation and is used for treating spleen deficiency and anorexia and milk stagnation. Unprocessed Mai ya can achieve the effects of soothing liver qi stagnation and regulating liver qi.
The embodiment of the invention also provides a preparation method of the traditional Chinese medicine composition for reducing hypertension, which comprises the following steps:
steaming Saviae Miltiorrhizae radix, Corni fructus and Siegesbeckiae herba with wine, processing cortex et radix Polygalae and Bulbus Lilii with honey, mixing Saviae Miltiorrhizae radix, Corni fructus and Siegesbeckiae herba steamed with wine with honey, extracting with water for 2-4 times, and filtering to obtain first filtrate; calcining and quenching ruddle with vinegar, drying in the sun and crushing to obtain ruddle powder; pulverizing herba Euphorbiae Humifusae, rhizoma Ligustici Chuanxiong, radix Curcumae, fructus Hordei Germinatus, herba Artemisiae Scopariae, Arisaema cum bile, Raphani semen, herba Dendrobii and Glycyrrhrizae radix, mixing with Haematitum powder, extracting with ethanol for 2-4 times, and filtering to obtain second filtrate; mixing the first filtrate and the second filtrate, concentrating to obtain Chinese medicinal concentrated solution, and making into common dosage forms.
In the embodiment, the preparation method is simple and convenient in flow, the wine-steamed salvia miltiorrhiza, dogwood and siegesbeckia orientalis can moderate the drug properties and enhance the effects of promoting blood circulation and dredging collaterals, the polygala tenuifolia and lily are fried with honey to make the drug properties milder, the ruddle vinegar is convenient to crush after being calcined and quenched, the effective ingredients are favorably and fully dissolved and decocted, the drug effects are enhanced, more beneficial substances in raw medicinal materials can be extracted after water extraction and alcohol extraction are respectively carried out, the proportion of the beneficial substances in finished products is improved, and the concentrated solution is convenient to subsequently prepare pills, granules, tablets and the like after being concentrated into a traditional Chinese medicine concentrated solution, so that the preparation method is convenient to carry and take, and the prepared medicine has a good treatment effect.
In some embodiments of the invention, the specific steps of wine steaming are: mixing Saviae Miltiorrhizae radix, Corni fructus and Siegesbeckiae herba with yellow wine, steaming in water container for 6-8 hr, taking out, and air drying. Steaming with wine can enhance drug effect and reduce side effects, and steaming Saviae Miltiorrhizae radix, Corni fructus and Siegesbeckiae herba can enhance blood circulation promoting and collaterals dredging effects.
In some embodiments of the present invention, when steaming with wine, the mass ratio of the salvia miltiorrhiza, the dogwood, the siegesbeckia orientalis and the yellow wine is 1: (4.5-5), and the degree of the yellow wine is 10-16 degrees. The yellow wine has thick taste and low degree, can enter blood system, conduct medicine vigor, promote blood circulation and conduct qi, and can play a role in coordinating the performance of traditional Chinese medicines by utilizing the properties of the yellow wine.
In some embodiments of the present invention, the vinegar calcining and quenching comprises the following specific steps: cleaning Haematitum, calcining on smokeless furnace to red, soaking and quenching in cold vinegar liquid, mashing, and repeatedly calcining and quenching vinegar for 1-2 times. The vinegar calcining and quenching is suitable for mineral medicines capable of enhancing curative effect, and the ruddle is convenient to crush after being repeatedly calcined and quenched by vinegar, is beneficial to fully dissolving and decocting active ingredients, and can enhance the effects of enriching blood, stopping bleeding, opening stasis and relieving pain.
In some embodiments of the present invention, the mass ratio of the raw material to ethanol in the ethanol extraction is 1: (7-8), and extracting with alcohol for 1.5-2.5h each time. Through controlling ethanol dosage and ethanol extraction time, beneficial ingredients in each raw material can be fully extracted better through ethanol extraction, the loss of the beneficial ingredients is avoided, and the drug effect of the product drug is further improved.
In some embodiments of the present invention, the Chinese medicinal concentrated solution has a relative density of 1.1-1.2 at 50-55 ℃. After concentration, on one hand, the concentration of the medicine can be further improved, the medicine effect is enhanced, and meanwhile, different dosage forms can be conveniently prepared, so that the use is more facilitated.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
A traditional Chinese medicine composition for reducing hypertension is prepared by the following steps:
adding 7.4g of yellow wine with the alcohol content of 13 degrees into 13g of salvia miltiorrhiza, 10g of dogwood and 14g of siegesbeckia orientalis, uniformly stirring, putting into a container with water, steaming for 7 hours, taking out, airing, processing 7g of polygala tenuifolia and 7g of lily with honey, mixing the salvia miltiorrhiza, dogwood and siegesbeckia orientalis steamed with the wine with the polygala tenuifolia and lily with the honey, carrying out water extraction for 3 times, and filtering to obtain a first filtrate;
13g of ruddle is cleaned, calcined on smokeless furnace fire until the ruddle is red, then immediately put into cold vinegar for immersion quenching, pounded, repeatedly calcined and quenched with vinegar for 1 time, dried in the sun and crushed to obtain ruddle powder;
23g of humifuse euphorbia herb, 10g of ligusticum chuanxiong hort, 10g of radix curcumae, 9g of malt, 9g of oriental wormwood, 5g of arisaema cum bile, 7g of semen raphani, 7g of dendrobium officinale and 5g of liquorice are crushed, mixed with ruddle powder and subjected to alcohol extraction and filtration for 3 times to obtain a second filtrate, wherein the mass ratio of the raw materials to the ethanol in the alcohol extraction is 1: 8, extracting with alcohol for 2.0h each time, wherein the malt is fresh malt;
mixing the first filtrate and the second filtrate, concentrating to obtain Chinese medicinal concentrated solution with relative density of 1.15 at 52 deg.C, drying, and making into pill.
Example 2
A traditional Chinese medicine composition for reducing hypertension is prepared by the following steps:
adding 8.8g of yellow wine with the alcohol content of 13 degrees into 15g of salvia miltiorrhiza, 13g of dogwood and 16g of siegesbeckia orientalis, uniformly stirring, putting into a container with water, steaming for 7 hours, taking out, airing, processing honey-fried polygala tenuifolia and 6g of lily, mixing the salvia miltiorrhiza, dogwood and siegesbeckia orientalis steamed with the wine with honey-fried polygala tenuifolia and lily, carrying out water extraction for 3 times, and filtering to obtain a first filtrate;
cleaning 18g of ruddle, calcining the ruddle on smokeless fire until the ruddle is red, immediately putting the ruddle into cold vinegar for immersion quenching, mashing the ruddle, repeatedly carrying out 1-time vinegar calcining quenching, drying the ruddle in the sun and crushing the ruddle to obtain ruddle powder;
27g of humifuse euphorbia herb, 13g of ligusticum chuanxiong hort, 13g of radix curcumae, 9g of malt, 9g of herba artemisiae scopariae, 5g of arisaema cum bile, 9g of semen raphani, 8g of dendrobium officinale and 5g of liquorice are crushed, mixed with ruddle powder and subjected to alcohol extraction and filtration for 3 times to obtain a second filtrate, wherein the mass ratio of the raw materials to the ethanol in the alcohol extraction is 1: 8, extracting with alcohol for 2.0h each time, wherein the malt is fresh malt;
mixing the first filtrate and the second filtrate, concentrating to obtain Chinese medicinal concentrated solution with relative density of 1.15 at 52 deg.C, drying, and making into granule.
Example 3
A traditional Chinese medicine composition for reducing hypertension is prepared by the following steps:
adding 5g of 16-degree yellow wine into 10g of salvia miltiorrhiza, 6g of dogwood and 9g of siegesbeckia orientalis, uniformly stirring, putting into a container with water, steaming for 6 hours, taking out, airing, processing 3g of polygala tenuifolia and 3g of lily with honey, mixing the salvia miltiorrhiza, dogwood and siegesbeckia orientalis steamed with wine with the polygala tenuifolia and lily with honey, carrying out water extraction for 2 times, and filtering to obtain a first filtrate;
cleaning 10g of ruddle, calcining the ruddle on smokeless furnace fire until the ruddle is red, immediately putting the ruddle into cold vinegar for immersion quenching, mashing the ruddle, repeatedly carrying out 1-time vinegar calcining quenching, drying in the sun and crushing to obtain ruddle powder;
20g of humifuse euphorbia, 5g of ligusticum chuanxiong hort, 6g of radix curcumae, 5g of malt, 5g of herba artemisiae scopariae, 3g of arisaema cum bile, 5g of semen raphani, 5g of dendrobium officinale and 3g of liquorice are crushed, mixed with ruddle powder and subjected to 2 times of alcohol extraction and filtration to obtain a second filtrate, wherein the mass ratio of the raw materials to the ethanol in the alcohol extraction is 1: 8, extracting with alcohol for 1.5h each time, wherein the malt is fresh malt;
mixing the first filtrate and the second filtrate, concentrating to obtain Chinese medicinal concentrated solution with relative density of 1.2 at 50 deg.C, drying, and making into tablet.
Example 4
A traditional Chinese medicine composition for reducing hypertension is prepared by the following steps:
adding 10.6g of yellow wine with the alcohol content of 10 degrees into 20g of salvia miltiorrhiza, 15g of dogwood and 18g of siegesbeckia orientalis, uniformly stirring, putting into a container with water, steaming for 8 hours, taking out, airing, processing the polygala tenuifolia and 9g of lily with honey, mixing the salvia miltiorrhiza, dogwood and siegesbeckia orientalis steamed with the wine with the polygala tenuifolia and lily with the honey, carrying out water extraction for 4 times, and filtering to obtain a first filtrate;
20g of ruddle is cleaned, calcined on smokeless furnace fire until the ruddle is red, then immediately put into cold vinegar for immersion and quenching, pounding, repeatedly carrying out vinegar calcination and quenching for 2 times, drying in the sun and crushing to obtain ruddle powder;
30g of humifuse euphorbia, 14g of ligusticum chuanxiong hort, 18g of radix curcumae, 12g of malt, 12g of oriental wormwood, 8g of arisaema cum bile, 10g of semen raphani, 10g of dendrobium officinale and 7g of liquorice are crushed, mixed with ruddle powder and subjected to alcohol extraction and filtration for 4 times to obtain a second filtrate, wherein the mass ratio of the raw materials to the ethanol in the alcohol extraction is 1: 7, extracting the mixture with alcohol for 2.5 hours each time, wherein the malt is raw malt;
mixing the first filtrate and the second filtrate, concentrating to obtain Chinese medicinal concentrated solution with relative density of 1.1 at 55 deg.C, drying, and making into granule.
Example 5
A traditional Chinese medicine composition for reducing hypertension is prepared by the following steps:
adding 10.2g of yellow wine with the alcohol content of 15 degrees into 17g of salvia miltiorrhiza, 14g of dogwood and 15g of siegesbeckia orientalis, uniformly stirring, putting into a container with water, steaming for 7 hours, taking out, airing, processing with honey by using 4g of polygala tenuifolia and 6g of lily, mixing the salvia miltiorrhiza, dogwood and siegesbeckia orientalis steamed with the wine with the honey by using the polygala tenuifolia and the lily, carrying out water extraction for 3 times, and filtering to obtain a first filtrate;
cleaning 16g of ruddle, calcining the ruddle on smokeless fire until the ruddle is red, immediately putting the ruddle into cold vinegar for immersion quenching, mashing the ruddle, repeatedly carrying out 1-time vinegar calcining quenching, drying the ruddle in the sun and crushing the ruddle to obtain ruddle powder;
25g of humifuse euphorbia herb, 12g of ligusticum chuanxiong hort, 14g of radix curcumae, 7g of malt, 8g of oriental wormwood, 6g of arisaema cum bile, 8g of semen raphani, 8g of dendrobium officinale and 4g of liquorice are crushed, mixed with ruddle powder and subjected to alcohol extraction and filtration for 3 times to obtain a second filtrate, wherein the mass ratio of the raw materials to the ethanol in the alcohol extraction is 1: 8, extracting the mixture with alcohol for 1.8h each time, wherein the malt is raw malt;
mixing the first filtrate and the second filtrate, concentrating to obtain Chinese medicinal concentrated solution with relative density of 1.12 at 53 deg.C, drying, and making into pill.
Comparative example 1
Compared with example 1, the malt was cooked malt, and the rest steps were identical.
Comparative example 2
Compared with the embodiment 1, the dosage of the raw medicinal materials is 20g of dogwood, 23g of siegesbeckia orientalis, 23g of ruddle, 18g of malt, 16g of oriental wormwood, 16g of humifuse euphorbia herb, 15g of salvia miltiorrhiza, 12g of ligusticum chuanxiong hort, 12g of radix curcumae, 5g of arisaema cum bile, 8g of semen raphani, 8g of bulbus dendrobii, 5g of polygala tenuifolia, 5g of lily and 5g of liquorice, and the other steps are the same.
Comparative example 3
Compared with the example 1, the dosage of the raw medicinal materials is 15g of arisaema cum bile, 20g of semen raphani, 18g of bulbus dendrobii, 15g of humifuse euphorbia herb, 14g of salvia miltiorrhiza, 12g of ligusticum chuanxiong hort, 12g of radix curcumae, 8g of dogwood, 8g of herba siegesbeckiae, 10g of ruddle, 8g of malt, 8g of oriental wormwood, 6g of polygala tenuifolia, 6g of lily and 5g of liquorice, and the other steps are the same.
Examples of the experiments
140 cases of 45-65-year-old hypertensive patients are selected as study objects, wherein 77 males and 63 females have inclusion standards that the diastolic pressure of the patients is more than or equal to 90mmHg, and the systolic pressure of the patients is more than or equal to 140 mmHg; belonging to essential hypertension; meets the relevant requirements of the 'traditional Chinese medicine disease diagnosis curative effect standard', namely the main clinical symptoms of headache, dizziness, nausea, vomiting, insomnia, white and greasy tongue coating, wiry and slippery pulse and the like of the patient; eliminate serious dysfunction of liver and kidney. Randomly dividing 140 patients into 7 groups, wherein each group comprises 20 patients, wherein 1-3 groups take the traditional Chinese medicine composition prepared in the embodiment 1-3 of the invention respectively, 4-6 groups take the traditional Chinese medicine composition prepared in the comparative example 1-3 respectively, and each group takes 3 times per day, avoids eating spicy food, does not take other medicines and keeps good life and diet habits; group 7 orally administered nifedipine controlled release tablet (manufactured by Bayer medicinal health promotion Limited company) 30mg each time and 1 time per day, patients should adhere to good dietary habits, and should not take other medicines during the treatment period. After each group was continuously administered for 3 months, the clinical efficacy of each group was observed.
The criteria for therapeutic effect are as follows:
the effect is shown: the headache, dizziness and other clinical symptoms of the patient basically disappear, and the blood pressure is reduced by more than 20 mmHg;
the method has the following advantages: the clinical symptoms of headache, dizziness and the like of a patient are effectively improved, and the blood pressure is reduced by 10-20 mmHg;
and (4) invalidation: the clinical symptoms of the patients do not change obviously, and the blood pressure is reduced by less than 10 mmHg.
The total effective rate (effective + effective)/total people number x 100%, and the therapeutic effect is shown in table 1.
TABLE 1
Figure BDA0003400049120000141
Figure BDA0003400049120000151
As can be seen from Table 1, after the continuous treatment for 3 months, the total effective rate of the patients treated by the medicaments prepared in the embodiments 1 to 3 of the invention can reach more than 85 percent, compared with the conventional western medicament treatment, the treatment effect is more obvious, the treatment effect is reduced by adopting the cooked malt in the comparative example 1 because the raw malt has better effect of soothing the liver and regulating the flow of qi, in the comparative example 2, cornus officinalis, siegesbeckia orientalis, hematite, malt and oriental wormwood are used as monarch drugs, humifuse euphorbia herb, salvia miltiorrhiza, ligusticum chuanxiong hort and radix curcumae are used as ministerial drugs, in comparative example 3, arisaema cum bile, radish seed and bulbus dendrobii are used as monarch drugs, humifuse euphorbia herb, salvia miltiorrhiza, ligusticum chuanxiong hort and radix curcumae are used as ministerial drugs, dogwood, siegesbeckia orientalis, ruddle, malt, oriental wormwood, polygala tenuifolia and lily are used as adjuvant drugs, although the raw materials are the same, the final effects are also greatly different because of different addition proportions and different compatibility.
The following are some typical cases:
liu Yi, female, 50 years old, often restlessness, impatience, dryness, spontaneous sweating, dry throat and tongue, soreness and weakness of waist and knees, dark red tongue with thin and white coating, cun, wiry, thready and weak pulse, and 157/98mmHg blood pressure measured. After taking the medicine prepared in the embodiment 1 of the invention for 3 months, the clinical symptoms basically disappear, the blood pressure is kept at 138/88mmHg, the tongue is pale red and has little coating, and the pulse is wiry and thready.
Li Yi, male, age 62 years old, found hypertension for 1 year, was untreated, recently felt dizziness, neck pain, debilitation, spontaneous sweating, short breath, anorexia, pale and tender tongue with thin and white coating, deep, thready and weak pulse, blood pressure was measured at 160/95 mmHg. After taking the medicine prepared in the embodiment 2 of the invention for 3 months, the clinical symptoms are relieved, and the blood pressure is measured at 147/90mmHg in the same tongue pulse.
In the case of male, 56 years old, hypertension is 2 years old, western medicines are intermittently taken, the patient often feels dizzy and dizzy, and the patient is particularly tired and suffers from palpitation, insomnia, anorexia, pale tongue, white fur, thready or weak pulse, and the blood pressure fluctuation is 147-156/87-96 mmHg. After taking the medicine prepared in the embodiment 2 of the invention for 3 months, dizziness is greatly reduced, the rest symptoms are also reduced, and the blood pressure is kept at 134/82 mmHg.
In conclusion, the invention provides a traditional Chinese medicine composition for reducing hypertension, which is prepared by adopting humifuse euphorbia herb, salvia miltiorrhiza, ligusticum chuanxiong hort, radix curcumae, dogwood, herba siegesbeckiae, ruddle, malt, oriental wormwood, arisaema cum bile, radish seed, bulbus dendrobii, polygala tenuifolia, lily and liquorice as raw materials, and aims at hypertension, wherein the traditional Chinese medicine composition mainly has the effects of promoting blood circulation and removing blood stasis, warming and nourishing liver and kidney, and clearing heat and eliminating phlegm, and calming the heart and tranquilizing the mind.
In addition, the invention also provides a preparation method of the traditional Chinese medicine composition for reducing the hypertension, the preparation method has simple and convenient flow, the wine-steamed salvia miltiorrhiza, dogwood and siegesbeckia orientalis can moderate the medicine property and enhance the effect of promoting blood circulation and removing obstruction in channels, the polygala tenuifolia and lily are fried with honey to make the medicine property milder, the ruddle vinegar is convenient to crush after being calcined and quenched, the effective components are fully dissolved and decocted, the medicine effect is enhanced, more beneficial substances in the raw medicinal materials can be extracted after water extraction and alcohol extraction are respectively carried out, the proportion of the beneficial substances in the finished product is improved, the concentrated traditional Chinese medicine concentrated solution is convenient to be subsequently prepared into pills, granules, tablets and the like, the carrying and the taking are convenient, and the prepared medicine has good treatment effect.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims (10)

1. The traditional Chinese medicine composition for reducing hypertension is characterized by comprising the following raw materials in parts by weight: 20-30 parts of humifuse euphorbia, 10-20 parts of salvia miltiorrhiza, 5-14 parts of ligusticum chuanxiong hort, 6-18 parts of radix curcumae, 6-15 parts of dogwood, 9-18 parts of siegesbeckia orientalis, 10-20 parts of ruddle, 5-12 parts of malt, 5-12 parts of oriental wormwood, 3-8 parts of arisaema cum bile, 5-10 parts of radish seed, 5-10 parts of dendrobium, 3-9 parts of polygala tenuifolia, 3-9 parts of lily and 3-7 parts of liquorice.
2. The traditional Chinese medicine composition for reducing hypertension according to claim 1, wherein the raw materials are used in the following amounts in parts by weight: 23 parts of humifuse euphorbia, 13 parts of salvia miltiorrhiza, 10 parts of ligusticum chuanxiong hort, 10 parts of radix curcumae, 10 parts of dogwood, 14 parts of siegesbeckia orientalis, 13 parts of ruddle, 9 parts of malt, 9 parts of oriental wormwood, 5 parts of arisaema cum bile, 7 parts of radish seed, 7 parts of dendrobium, 7 parts of polygala tenuifolia, 7 parts of lily and 5 parts of liquorice.
3. The traditional Chinese medicine composition for reducing hypertension according to claim 1, wherein the raw materials are used in the following amounts in parts by weight: 27 parts of humifuse euphorbia, 15 parts of salvia miltiorrhiza, 13 parts of ligusticum chuanxiong hort, 13 parts of radix curcumae, 13 parts of dogwood, 16 parts of siegesbeckia orientalis, 18 parts of ruddle, 9 parts of malt, 9 parts of oriental wormwood, 5 parts of arisaema cum bile, 9 parts of radish seed, 8 parts of bulbus dendrobii, 6 parts of polygala tenuifolia, 6 parts of lily and 5 parts of liquorice.
4. The antihypertensive traditional Chinese medicine composition according to any one of claims 1 to 3, wherein the malt is a raw malt.
5. The method for preparing the antihypertensive traditional Chinese medicine composition according to any one of claims 1 to 4, comprising the following steps:
steaming Saviae Miltiorrhizae radix, Corni fructus and Siegesbeckiae herba with wine, processing cortex et radix Polygalae and Bulbus Lilii with honey, mixing Saviae Miltiorrhizae radix, Corni fructus and Siegesbeckiae herba steamed with wine with honey, extracting with water for 2-4 times, and filtering to obtain first filtrate;
calcining and quenching ruddle with vinegar, drying in the sun and crushing to obtain ruddle powder;
pulverizing herba Euphorbiae Humifusae, rhizoma Ligustici Chuanxiong, radix Curcumae, fructus Hordei Germinatus, herba Artemisiae Scopariae, Arisaema cum bile, Raphani semen, herba Dendrobii and Glycyrrhrizae radix, mixing with Haematitum powder, extracting with ethanol for 2-4 times, and filtering to obtain second filtrate;
mixing the first filtrate and the second filtrate, concentrating to obtain Chinese medicinal concentrated solution, and making into common dosage forms.
6. The preparation method of the traditional Chinese medicine composition for reducing hypertension according to claim 5, wherein the specific steps of wine steaming are as follows: mixing Saviae Miltiorrhizae radix, Corni fructus and Siegesbeckiae herba with yellow wine, steaming in water container for 6-8 hr, taking out, and air drying.
7. The method for preparing the traditional Chinese medicine composition for reducing the hypertension according to claim 6, wherein when the wine is steamed, the mass ratio of the salvia miltiorrhiza, the dogwood, the siegesbeckia orientalis and the yellow wine is 1: (4.5-5), and the degree of the yellow wine is 10-16 degrees.
8. The preparation method of the traditional Chinese medicine composition for reducing hypertension according to claim 5, which is characterized in that the vinegar calcining and quenching comprises the following specific steps: cleaning Haematitum, calcining on smokeless furnace to red, soaking and quenching in cold vinegar liquid, mashing, and repeatedly calcining and quenching vinegar for 1-2 times.
9. The preparation method of the traditional Chinese medicine composition for reducing hypertension according to claim 5, wherein the mass ratio of the raw materials to the ethanol in the ethanol extraction is 1: (7-8), and extracting with alcohol for 1.5-2.5h each time.
10. The method for preparing the traditional Chinese medicine composition for reducing the hypertension according to claim 5, wherein the relative density of the traditional Chinese medicine concentrated solution is 1.1-1.2 at 50-55 ℃.
CN202111495828.5A 2021-12-08 2021-12-08 Traditional Chinese medicine composition for reducing hypertension and preparation method thereof Withdrawn CN114099628A (en)

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Application publication date: 20220301