CN115054556B - Composition for repairing photodamage and application thereof - Google Patents
Composition for repairing photodamage and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention relates to the technical field of cosmetics, in particular to a composition for repairing photodamage, which comprises the following components: carnosine, panthenol, glucosyl rutin, and butterflybush flower extracts; the composition can effectively reduce ROS induced by blue light, thereby repairing skin oxidative damage caused by the blue light, and simultaneously effectively inhibiting inflammatory factor PGE induced by the blue light 2 Further repairing inflammatory injury caused by blue light. Therefore, the composition disclosed by the invention has a synergistic effect of repairing blue light damage, and is excellent in blue light resistance.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a composition for repairing photodamage and application thereof.
Background
Blue light is high-energy visible light with the wavelength of 400-500nm, and is widely used in light emitted by computer screens, electronic books, tablet computers, smart phones, fluorescent lamps, incandescent lamps, LEDs and the like in daily life besides being in sunlight.
Currently, there have been studies showing that exposure of human skin to blue light will increase Reactive Oxygen Species (ROS) production. Excessive active oxygen can cause DNA damage, collagen damage, cell damage, lipid peroxidation, etc., and promote melanin production, thereby causing problems of skin relaxation, wrinkles, hyperpigmentation, etc. In addition, excessive exposure to blue light induces an inflammatory reaction in the skin, which causes the skin to develop symptoms such as redness.
Therefore, how to resist and repair damage to the skin caused by blue light is a highly desirable problem.
Disclosure of Invention
The invention aims to solve the technical problems of resisting and repairing damage of blue light to human skin in daily life, and aims to solve the technical problems by the following technical scheme: there is provided a composition for repairing photodamage comprising the following components: carnosine, panthenol, glucosyl rutin, and butterflybush flower extract.
Preferably, the carnosine content is 0.005-0.2%, the panthenol content is 0.1-4%, the glucosyl rutin content is 0.0001-0.3%, and the buddleja officinalis extract content is 0.01-0.6% based on the total weight of the composition.
When the composition is applied to cosmetics, the influence of blue light on human skin can be resisted and repaired in daily life because the cosmetics belong to daily necessities.
Preferably, in the cosmetic, the carnosine content is 0.005-0.2%, the panthenol content is 0.1-4%, the glucosyl rutin content is 0.0001-0.3%, and the butterflybush flower extract content is 0.01-0.6% based on the total weight of the cosmetic.
In addition, when the composition is applied to cosmetics for sun protection, nourishing, repairing, relieving, anti-wrinkle, tightening and whitening, the influence of blue light on human skin can be resisted and repaired in daily life.
Preferably, in the sun protection milk, the composition comprises the components: carnosine, panthenol, glucosyl rutin, and butterflybush flower extract.
Preferably, the carnosine content is 0.005-0.2%, the panthenol content is 0.1-4%, the glucosyl rutin content is 0.0001-0.3%, and the butterflybush flower extract content is 0.01-0.6% based on the total weight of the sun-protection milk.
Preferably, in the face cream, the above composition components are included: carnosine, panthenol, glucosyl rutin, and butterflybush flower extract.
Preferably, the carnosine content is 0.005-0.2%, the panthenol content is 0.1-4%, the glucosyl rutin content is 0.0001-0.3%, and the buddleja officinalis extract content is 0.01-0.6% based on the total weight of the cream.
The invention has the following effects: the composition of the invention can effectively reduce blue lightThe induced ROS are generated, thereby repairing skin oxidative damage caused by blue light, and simultaneously effectively inhibiting inflammatory factor PGE induced by the blue light 2 Further repairing inflammatory injury caused by blue light. Therefore, the composition provided by the invention has a synergistic effect of repairing blue light damage, and has better blue light resistance.
Detailed Description
The technical solutions of the present invention will be clearly and completely described in conjunction with the embodiments of the present invention, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
It should be understood that the terms "comprises" and "comprising," when used in this specification and the appended claims, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof.
It is also to be understood that the terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used in this specification and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.
It should be further understood that the term "and/or" as used in the present specification and the appended claims refers to any and all possible combinations of one or more of the associated listed items, and includes such combinations.
Furthermore, the terms "substantially," "essentially," and the like, are intended to be limited to the precise form disclosed herein and are not necessarily intended to be limiting. For example: the term "substantially equal" does not merely mean absolute equal, but is difficult to achieve absolute equal during actual production and operation, and generally has a certain deviation. Thus, in addition to absolute equality, "approximately equal to" includes the above-described case where there is a certain deviation. In other cases, the terms "substantially", "essentially" and the like are used in a similar manner to those described above unless otherwise indicated.
In order to reduce the influence of blue light on skin caused by factors such as computer screens, sunlight irradiation, mobile phone screens, illumination lights and the like in daily life, the invention provides a composition for repairing photodamage, which comprises the following components: carnosine, panthenol, glucosyl rutin, and butterflybush flower extract.
Wherein, based on the total weight of the composition, the carnosine content is 0.005-0.2%, the panthenol content is 0.1-4%, the glucosyl rutin content is 0.0001-0.3%, and the butterflybush flower extract content is 0.01-0.6%. Wherein, the carnosine has the functions of resisting oxidation, reducing ROS, promoting collagen generation and the like; panthenol has effects of improving skin redness and relieving inflammation; glucosyl rutin has effects of resisting oxidation, protecting skin cells, protecting collagen, etc.; the flos Buddlejae extract has effects of inhibiting lipid peroxidation, relieving inflammation, and preventing pigmentation.
The composition of the invention can be added into cosmetics, and the cosmetics belong to daily necessities, and are one of articles commonly used in daily life. Therefore, the composition can resist and repair the influence of blue light on the skin in daily life by taking cosmetics as carriers.
Accordingly, in cosmetics, the components of the composition of the present invention are included: carnosine, panthenol, glucosyl rutin and butterflybush flower extract, specifically, carnosine content is 0.005-0.2%, panthenol content is 0.1-4%, glucosyl rutin content is 0.0001-0.3%, butterflybush flower extract content is 0.01-0.6% based on total weight of the cosmetic.
The composition provided by the invention can be added into skin care products belonging to cosmetics to achieve the adverse effect of repairing blue light on skin in the skin care processes of sun protection, skin care and the like.
For example, in a sun block, components in the composition of the present invention are included: carnosine, panthenol, glucosyl rutin and butterflybush flower extract, specifically, carnosine content is 0.005-0.2%, panthenol content is 0.1-4%, glucosyl rutin content is 0.0001-0.3%, butterflybush flower extract content is 0.01-0.6% based on total weight of sun-screening milk.
In a face cream, components of the composition of the invention are included: carnosine, panthenol, glucosyl rutin and butterflybush flower extract, specifically, carnosine content is 0.005-0.2%, panthenol content is 0.1-4%, glucosyl rutin content is 0.0001-0.3%, butterflybush flower extract content is 0.01-0.6% based on total weight of the cream.
The effects of the composition of the present invention on the treatment of skin damage by blue light will be described below with reference to specific examples and comparative examples
Example 1
In this example, the following components were contained in the cell culture medium in an in vitro test based on the total weight of the cell culture medium: carnosine 0.1%, panthenol 4%, glucosyl rutin 0.2%, and Buddleja officinalis extract 0.5%.
Example 2
Based on the total weight of the cell culture broth, the contents of the components are as follows: carnosine 0.01%, panthenol 2%, glucosyl rutin 0.3%, and Buddleja officinalis extract 0.01%.
Example 3
Based on the total weight of the cell culture fluid composition, the contents of the components are as follows: carnosine 0.2%, panthenol 0.1%, glucosyl rutin 0.0001%, and Buddleja officinalis extract 0.3%.
Comparative example 1
Based on the total weight of the cell culture broth, the contents of the components are as follows: carnosine 0.1%, panthenol 4%, glucosyl rutin 0.2%, and no extract of Buddleja officinalis.
Comparative example 2
Based on the total weight of the cell culture broth, the contents of the components are as follows: 4.2% panthenol, 0.1% glucosyl rutin, and no carnosine or butterflybush flower extract.
Comparative example 3
Based on the total weight of the cell culture broth, the contents of the components are as follows: carnosine 0.1%, glucosyl rutin 0.2%, and no panthenol and butterflybush flower extract.
Comparative example 4
Based on the total weight of the cell culture broth, the contents of the components are as follows: carnosine 0.1%, glucosyl rutin 0.2%, dipotassium glycyrrhizinate 4%, and no panthenol and flos Buddlejae extract.
Comparative example 5
Based on the total weight of the cell culture broth, the contents of the components are as follows:
0.1% of decarboxylated carnosine, 4% of panthenol, 0.2% of glucosyl rutin, 0.5% of butterflybush flower extract, 0.2% of baical skullcap root extract, 0.1% of sage extract and 0.3% of kuh-seng root extract.
The following are the composition tables of each example and comparative example
Table 1 composition table of examples and comparative examples
In order to verify the repairing effect of each example and comparative example on blue light damage, the invention performs cell model test on each example and comparative example, and the specific method, principle, using reagent and equipment are as follows:
principle of testing
The skin can generate Reactive Oxygen Species (ROS) in the skin after exposure to blue light, and can induce oxidative stress injury when ROS are generated beyond self-scavenging ability, and oxidative stress injury can further activate inflammatory reaction, so that various inflammation related factors such as PGE 2 Thereby inducing the occurrence of clinical phenomena such as redness of the skin.
Thus, based on keratinocytes, keratinocytes can be irradiated with a dose of blue light to build upIn the three-dimensional blue light injury cell model, after a sample to be tested (namely each example and comparative example) acts on the blue light injury model, the ROS content and PGE (polymerase chain reaction) content are detected 2 The secretion amount is comprehensively evaluated, and the efficacy of repairing oxidative damage and inflammatory damage induced by blue light is comprehensively evaluated.
Primary cells and agents
And (3) cells: keratinocytes (bosch organism); reagent: KC2500 cell culture (Boxi organism), PBS (Boshide), MTT (Sigma), DMSO (Sigma), ROS kit (Biyun Tian), PGE 2 ELISA kit (Abcam).
Main equipment
CO 2 Incubator (Thermo, 150 i), ultra clean bench (Suzhou Antai, SW-CJ-1F), flow cytometer (Beckmann, cytoFLEX), microplate reader (BioTek, epoch)
Test method
1) Cell inoculation: cells were seeded at 1.8E5/well density into 6-well plates, incubators (37 ℃, 5% CO 2 ) Incubate overnight.
2) Test grouping: a blank control group (BC), a negative control group (NC) and a sample group were experimentally set, and 3 duplicate wells were set per group.
3) Preparing liquid: according to the proportion of each embodiment, based on the total amount of cell culture fluid (composition: cell basal culture fluid, epidermal cell growth factor, VC, insulin and the like), each composition is added into the cell culture fluid to prepare a sample group working fluid.
4) Administration: and (3) when the cell plating rate in the 6-hole plate reaches 40% -60%, administration is carried out. Adding 2mL of cell culture solution into each hole of the blank control group and the negative control group; 2mL of culture solution containing the test substance with the corresponding concentration after 4 times dilution (safe concentration) is added into each hole of the sample group; after the completion of the administration, the 6-well plate was placed in an incubator (37 ℃, 5% CO) 2 ) Is cultured.
Reactive Oxygen Species (ROS) test
1) Loading an active oxygen detection probe: after 24h of cell administration culture, PBS washes cells, 1mL of probe DCFH-DA is added to each hole according to the instruction of the kit, and the cells are incubated for 20min at 37 ℃; the DCFH-DA-containing culture solution was discarded and the cells were washed three times with PBS.
2) Blue light irradiation: after PBS washes cells, the total dose received by the negative control group, the positive control group and the sample group is 10J/cm 2 At the same time, the blank was placed in the same environment, but without blue light irradiation. After the irradiation, fresh culture was replaced, and the 6-well plate was placed in an incubator (37 ℃ C., 5% CO) 2 ) Culture medium and incubation for 30min.
3) And (3) detection: after incubation for 30min, the supernatant was discarded, the cells were digested with pancreatin and collected, washed 1 time with PBS, resuspended with 500. Mu.LPBS, and assayed. And opening a flow cytometer, establishing an FSC/SSC double-parameter scatter diagram to select cells, and simultaneously establishing a FITC single-parameter histogram. Resuspended cells of different groups of samples were assayed on-press and FITC channel fluorescence signal intensity (MFI) was recorded for each group.
ROS inhibition of each sample group = (NC group MFI value-sample group MFI value)/NC group MFI value ×100%
PGE 2 Testing
Cell culture supernatants were collected according to PGE 2 ELISA kit instructions, standard preparation, plate arrangement according to the number of samples, standard and samples added to corresponding wells, followed by PGE in sequence 2 Treating antibody, pNpp substrate solution and stop solution, reading OD value at 405nm and 570nm with enzyme-labeled instrument, and finally drawing OD value and PGE 2 Standard curve corresponding to content, and performing sample group PGE according to the standard curve 2 And (5) calculating the content.
PGE of each sample group 2 Inhibition ratio= (NC group PGE 2 Content-sample group PGE 2 content)/NC group PGE 2 Content of 100%
Based on the above cell model test, the test results of each example and comparative example are shown in the following table:
TABLE 2 results of cell model test for examples and comparative examples
| Example 1 | Example 2 | Example 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 | Comparative example 4 | Comparative example 5 | |
| ROS inhibition rate | 63.7％ | 56.1％ | 54.9％ | 53.4％ | 46.9％ | 45.4％ | 35.4％ | 50.1％ |
| PGE 2 Inhibition rate | 51.1％ | 50.9％ | 50.6％ | 50.8％ | 41.4％ | 45.4％ | 38.3％ | 18.7％ |
In examples 1-3 (compositions of the present invention), carnosine, glucosyl rutin, buddleja officinalis extract can play a role in repairing oxidative damage by resisting oxidation, scavenging ROS, and inhibiting lipid peroxidation; the panthenol and the buddleja officinalis extract can play a role in resisting inflammation, relieving and improving redness by inhibiting inflammatory factors.
As can be seen from the above table, example 1 is useful for inhibiting ROS (reactive oxygen species), repairing blue light-induced oxidative damage, and inhibiting inflammatory factor PGE 2 The effect of repairing the inflammation injury caused by the blue light is obviously better than that of comparative examples 1-3, which shows that the combination of 4 components of the invention has the synergistic effect of repairing the blue light injury. ROS inhibition and PGE of comparative example 1 2 The inhibition rates were lower than in example 1, indicating that the butterflybush flower extract plays an important role in inhibiting oxidative damage and inhibiting inflammatory damage; meanwhile, the ROS inhibition ratio and PGE of comparative example 1 2 The inhibition rates were higher than those of comparative examples 2 and 3, indicating that carnosine and panthenol play an important role in the inhibition of oxidative damage and the inhibition of inflammatory damage. In addition, examples 2 and 3 are useful in inhibiting ROS and PGE 2 Is significantly better than comparative examples 2 and 3, but is likely to be closer to comparative example 1 due to the lower amount of additive.
In addition, example 1 and comparative example 1 are useful for inhibiting ROS, repairing blue light-induced oxidative damage, and inhibiting inflammatory factor PGE 2 The efficacy of repairing the inflammation injury caused by blue light is obviously better than that of comparative example 4, which shows that the effect of panthenol in the component of the invention is better than that of other anti-inflammatory components (dipotassium glycyrrhizinate).
In particular, example 1 is directed to inhibiting ROS, repairing blue light-induced oxidative damage, and inhibiting inflammatory factor PGE 2 The efficacy of repairing inflammation damage caused by blue light is obviously better than that of comparative example 5, and comparative example 5 is a composition commonly used in the prior art, namely the blue light resistance of the composition of the invention is shownThe efficacy is better than the prior art.
Based on the above results, the invention also provides specific applications of the composition in sun protection emulsions, creams and foundation solutions.
A. Sun block containing the composition of the present invention
The specific formulation is shown in the following table:
TABLE 3 formula list of sunscreens containing compositions of the present invention
The preparation process of the sun protection emulsion containing the composition comprises the following steps:
1) Sequentially weighing 1-6, heating at 80deg.C, stirring, cooling to 40deg.C, adding 7-12, and stirring to obtain phase A;
2) Sequentially weighing 13-18, heating at 80deg.C for dissolving, and stirring to obtain phase B;
3) Sequentially weighing phase C19-24, stirring thoroughly, dispersing, homogenizing for 5min, transferring to phase B, mixing, homogenizing for 5min again to obtain phase BC;
4) Sequentially weighing phase D25-28, stirring thoroughly, dispersing, homogenizing for 5min, transferring to phase BC, mixing, homogenizing for 5min again to obtain BCD phase;
5) Weighing the E phase 29 and the E phase 30 to the BCD phase, stirring and dispersing, and homogenizing for 5min to obtain a BCDE phase;
6) Adding phase A into BCDE phase, stirring, emulsifying, homogenizing for 5min, and discharging.
B. Face cream containing the composition of the invention
The specific formulation is shown in the following table:
TABLE 4 formulation of creams containing compositions of the invention
The preparation process of the face cream containing the composition of the invention comprises the following steps:
1) Weighing 1-7, heating to 80 ℃, uniformly stirring, cooling to 40 ℃, adding 8-11, and uniformly stirring for later use;
2) Weighing 13-18, heating to 80deg.C, stirring and dissolving uniformly;
3) Mixing the components 1) and 2), homogenizing and emulsifying for 5min, adding 12 dissolved in water after the emulsification is completed, stirring for 15min, and sampling.
C. Foundation liquid containing composition of the invention
The specific formulation is shown in the following table:
TABLE 5 Foundation liquid formulation Table containing compositions of the present invention
The preparation process of the foundation liquid containing the composition of the invention comprises the following steps:
1) Weighing 1-6, heating to 80deg.C, and stirring to obtain phase A;
2) Weighing 7-13 in turn, heating to 80deg.C, and completely dissolving to obtain phase B;
3) Weighing the C phases 14 and 15, sequentially adding the C phases into the B phase, and homogenizing at a high speed until the toner and gel raw materials are completely dispersed to obtain a BC phase;
4) And (3) slowly and uniformly adding the phase A into the BC phase under the condition of 80 ℃ water bath and 3000rpm homogenization, homogenizing for 5min at 4500rpm, cooling to 40 ℃, adding the phase D into the BC phase, stirring uniformly, homogenizing for 5min, and discharging.
While the invention has been described with reference to certain preferred embodiments, it will be understood by those skilled in the art that various changes and substitutions of equivalents may be made and equivalents will be apparent to those skilled in the art without departing from the scope of the invention. Therefore, the protection scope of the invention is subject to the protection scope of the claims.
Claims (6)
1. A composition for repairing photodamage comprising the following components: carnosine, panthenol, glucosyl rutin, and butterflybush flower extracts; the carnosine content is 0.005-0.2%, the panthenol content is 0.1-4%, the glucosyl rutin content is 0.0001-0.3%, and the butterflybush flower extract content is 0.01-0.6%, based on the total weight of the composition.
2. Use of a composition for repairing photodamage according to claim 1 in the preparation of a cosmetic.
3. A cosmetic for repairing photodamage, comprising the following components: carnosine, panthenol, glucosyl rutin, and butterflybush flower extracts; the content of carnosine is 0.005-0.2%, the content of panthenol is 0.1-4%, the content of glucosyl rutin is 0.0001-0.3%, and the content of Buddleja officinalis extract is 0.01-0.6% based on the total weight of the cosmetic.
4. Use of a composition for repairing photodamage according to claim 3 in the preparation of a cosmetic, characterized in that: the composition is applied to cosmetics for sun protection, nourishing, repairing, relieving, anti-wrinkle, tightening and whitening.
5. A sun protection emulsion for repairing photodamage, which is characterized by comprising the following components: carnosine, panthenol, glucosyl rutin, and butterflybush flower extracts; the content of carnosine is 0.005-0.2%, the content of panthenol is 0.1-4%, the content of glucosyl rutin is 0.0001-0.3%, and the content of Buddleja officinalis extract is 0.01-0.6% based on the total weight of the sunscreen lotion.
6. A facial cream for repairing photodamage, comprising the following components: carnosine, panthenol, glucosyl rutin, and butterflybush flower extracts; the content of carnosine is 0.005-0.2%, the content of panthenol is 0.1-4%, the content of glucosyl rutin is 0.0001-0.3%, and the content of Buddleja officinalis extract is 0.01-0.6% based on the total weight of the cream.
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| US20070274932A1 (en) * | 2006-05-15 | 2007-11-29 | The Procter & Gamble Company | Water in oil emulsion compositions containing sunscreen actives and siloxane elastomers |
| EP2789369B1 (en) * | 2013-04-14 | 2018-06-06 | Symrise AG | A composition for lightening skin and hair |
| AU2017342344A1 (en) * | 2016-10-13 | 2019-05-02 | Lubrizol Advanced Materials, Inc. | Compounds useful for the treatment and/or care of the skin, hair, nails and/or mucous membranes |
| KR20200125628A (en) * | 2018-02-26 | 2020-11-04 | 다니스코 유에스 인크. | Compositions and methods of use to provide skin care benefits |
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| CN110448511B (en) * | 2019-09-06 | 2022-09-02 | 广州一一生物技术有限公司 | Anti-makeup and anti-blue-light skin conditioner, skin cream and preparation method thereof |
| CN110575410A (en) * | 2019-09-16 | 2019-12-17 | 安婕妤化妆品科技股份有限公司 | Cosmetic containing blue light-shielding component |
| CN112294667A (en) * | 2020-11-09 | 2021-02-02 | 西安润玉医疗科技有限公司 | Composition with broad-spectrum light protection effect and application thereof |
| CN113925809A (en) * | 2021-10-08 | 2022-01-14 | 广州葆妍生物科技有限公司 | Blue light resistant composition and preparation method and application thereof |
| CN114569479B (en) * | 2021-12-01 | 2023-04-07 | 凡可生物技术(广州)有限公司 | Panthenol-containing composition and skin care product |
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| CN108524372A (en) * | 2018-06-26 | 2018-09-14 | 湖南御家化妆品制造有限公司 | A kind of composition and its application in preparing the cosmetics with safeguard function |
| CN110384637A (en) * | 2019-08-30 | 2019-10-29 | 上海科颜生物科技有限公司 | A kind of sunlight screening skin-protecting product substituting ultraviolet absorbing agent |
| CN111265449A (en) * | 2020-03-30 | 2020-06-12 | 西安润玉医疗科技有限公司 | Isolation protection composition and preparation method thereof |
| CN113181090A (en) * | 2021-04-19 | 2021-07-30 | 广东梵蜜琳生物科技有限公司 | Essence containing anti-aging composition and preparation method thereof |
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