CN1150206C - 含有n-取代甘氨酸的血管舒缓激肽拮抗剂肽 - Google Patents

含有n-取代甘氨酸的血管舒缓激肽拮抗剂肽 Download PDF

Info

Publication number
CN1150206C
CN1150206C CNB951930176A CN95193017A CN1150206C CN 1150206 C CN1150206 C CN 1150206C CN B951930176 A CNB951930176 A CN B951930176A CN 95193017 A CN95193017 A CN 95193017A CN 1150206 C CN1150206 C CN 1150206C
Authority
CN
China
Prior art keywords
arg
pro
gly
hyp
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB951930176A
Other languages
English (en)
Chinese (zh)
Other versions
CN1148393A (zh
Inventor
V��S���ŷ���
V·S·古费罗
M·V·马拉特
E·T·瓦利
�Ƴ�
T·D·菲茨帕特里克
K·G·库尔曼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cortech Inc
Original Assignee
Cortech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cortech Inc filed Critical Cortech Inc
Publication of CN1148393A publication Critical patent/CN1148393A/zh
Application granted granted Critical
Publication of CN1150206C publication Critical patent/CN1150206C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/18—Kallidins; Bradykinins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNB951930176A 1994-03-09 1995-03-07 含有n-取代甘氨酸的血管舒缓激肽拮抗剂肽 Expired - Fee Related CN1150206C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20811594A 1994-03-09 1994-03-09
US08/208115 1994-03-09
US08/208,115 1994-03-09

Publications (2)

Publication Number Publication Date
CN1148393A CN1148393A (zh) 1997-04-23
CN1150206C true CN1150206C (zh) 2004-05-19

Family

ID=22773240

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB951930176A Expired - Fee Related CN1150206C (zh) 1994-03-09 1995-03-07 含有n-取代甘氨酸的血管舒缓激肽拮抗剂肽

Country Status (12)

Country Link
US (1) US5700779A (cg-RX-API-DMAC7.html)
EP (1) EP0813544B1 (cg-RX-API-DMAC7.html)
JP (1) JPH09511500A (cg-RX-API-DMAC7.html)
KR (1) KR100360639B1 (cg-RX-API-DMAC7.html)
CN (1) CN1150206C (cg-RX-API-DMAC7.html)
AT (1) ATE280777T1 (cg-RX-API-DMAC7.html)
AU (1) AU696429B2 (cg-RX-API-DMAC7.html)
CA (1) CA2184824A1 (cg-RX-API-DMAC7.html)
DE (1) DE69533704D1 (cg-RX-API-DMAC7.html)
TW (1) TW408133B (cg-RX-API-DMAC7.html)
WO (1) WO1995024422A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA951974B (cg-RX-API-DMAC7.html)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648336A (en) * 1994-11-18 1997-07-15 University Of Colorado Bradykinin antagonist peptides containing indane-substituted amino acids
EP0832106A2 (en) * 1995-06-05 1998-04-01 Cortech, Inc. Compounds having bradykinin antagonistic activity and mu-opioid agonistic activity
US5849863A (en) * 1995-09-08 1998-12-15 University Of Colorado Cytolytic bradykinin antagonists
DE19612067A1 (de) * 1996-03-27 1997-10-02 Hoechst Ag Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung von chronisch fibrogenetischen Lebererkrankungen und akuten Lebererkrankungen
FR2756566B1 (fr) * 1996-12-04 1999-01-08 Fournier Ind & Sante Peptides agonistes du recepteur b2 de la bradykinine, procede de preparation et utilisation en therapeutique
US6849605B1 (en) 1999-03-05 2005-02-01 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of viral infections
WO2000051625A1 (en) * 1999-03-05 2000-09-08 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of herpes viruses
WO2000051624A2 (en) 1999-03-05 2000-09-08 The Trustees Of University Technology Corporation Methods and compositions useful in inhibiting apoptosis
WO2000051623A2 (en) 1999-03-05 2000-09-08 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions
US7105172B1 (en) 1999-11-18 2006-09-12 Bolla John D Treatment of rosacea
US6699486B1 (en) 1999-11-18 2004-03-02 Bolla Corporation Treatment or prevention of photoaging and skin cancer
US7211566B2 (en) * 2003-04-01 2007-05-01 Universite De Sherbrooke Selective bradykinin (BK) B1 peptidic receptor antagonists and uses thereof
US20040220242A1 (en) * 2003-05-02 2004-11-04 Leland Shapiro Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions
US7605120B2 (en) * 2003-10-22 2009-10-20 Amgen Inc. Antagonists of the brandykinin B1 receptor
US7932228B2 (en) * 2004-08-19 2011-04-26 Societe de Commercialisation des Produits de la Recherche Applique Socpra Sciences Sante et Humaines S.E.C. Method of treating bone or prostate cancer with selective bradykinin B1 receptor antagonists
MX2007013213A (es) * 2005-04-25 2007-12-12 Amgen Inc Composiciones de liberacion prolongada de peptidos biodegradables que contienen porogenos.
US7403325B2 (en) * 2006-05-19 2008-07-22 Xerox Corporation Electrophoretic display device
US8476408B2 (en) * 2008-06-13 2013-07-02 Alize Pharma Sas Unacylated ghrelin and analogs as therapeutic agents for vascular remodeling in diabetic patients and treatment of cardiovascular disease
FR2974182B1 (fr) * 2011-04-14 2013-04-26 Univ Grenoble 1 Diagnostic et traitement de l'angioedeme
CN102295711A (zh) * 2011-08-23 2011-12-28 湖北宝迪农业科技有限公司 从猪肺中提取肝素钠并联产多肽蛋白粉的工艺
WO2013043669A1 (en) * 2011-09-21 2013-03-28 The Board Of Regents Of The University Of Texas System Peptoid compositions for the treatment of alzheimer's disease and polyglutamine expansion disorder
CA3001065A1 (en) 2015-10-14 2017-04-20 Xiaoxi WEI Compositions and methods for reducing ice crystal formation
CN116554267A (zh) * 2022-01-30 2023-08-08 江苏众红生物工程创药研究院有限公司 聚乙二醇修饰的激肽或其变体和药物应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT387393B (de) * 1978-07-18 1989-01-10 Kabi Ab Verfahren zur herstellung von neuen tripeptidderivaten
US4693993A (en) * 1985-06-13 1987-09-15 Stewart John M Bradykinin antagonist peptides
DE4013270A1 (de) * 1990-04-26 1991-10-31 Hoechst Ag Peptide mit bradykinin-antagonistischer wirkung
IE63490B1 (en) * 1988-11-24 1995-05-03 Hoechst Ag Peptides having bradykinin antagonist action
AU1914592A (en) * 1991-04-19 1992-11-17 Nova Technology Limited Partnership Bradykinin type peptides
HUT63060A (en) * 1991-08-22 1993-07-28 Hoechst Ag Process for producing pharmaceutical compositions locally applicable on nose and eye, comprising bradykinin antagonists
WO1993011789A1 (en) * 1991-12-12 1993-06-24 Scios Nova Inc. Modified position (7) bradykinin antagonist peptides
TW258739B (cg-RX-API-DMAC7.html) * 1992-04-04 1995-10-01 Hoechst Ag
ATE191486T1 (de) * 1993-09-09 2000-04-15 Scios Inc Pseudo-oder nicht peptidartige bradykinin rezeptor antagoniste

Also Published As

Publication number Publication date
AU696429B2 (en) 1998-09-10
JPH09511500A (ja) 1997-11-18
ZA951974B (en) 1995-12-11
CA2184824A1 (en) 1995-09-14
CN1148393A (zh) 1997-04-23
TW408133B (en) 2000-10-11
WO1995024422A1 (en) 1995-09-14
EP0813544B1 (en) 2004-10-27
EP0813544A4 (cg-RX-API-DMAC7.html) 1998-01-07
ATE280777T1 (de) 2004-11-15
DE69533704D1 (de) 2004-12-02
AU1932595A (en) 1995-09-25
KR100360639B1 (ko) 2003-01-30
EP0813544A1 (en) 1997-12-29
US5700779A (en) 1997-12-23

Similar Documents

Publication Publication Date Title
CN1150206C (zh) 含有n-取代甘氨酸的血管舒缓激肽拮抗剂肽
CN1171118A (zh) 纤连蛋白粘附抑制剂
CN1181091C (zh) 因子Xa抑制剂
CN1114961A (zh) 细胞粘连肽抑制剂
CN1195778C (zh) 细胞粘附抑制剂
CN1203087C (zh) 因子VIIa抑制剂
CN1041950A (zh) 新型肽酶抑制剂
CN1171116A (zh) 作为因子Xa抑制剂的N－取代甘氨酸衍生物
CN1159196A (zh) 白介素-1β转化酶抑制剂
CN1313863A (zh) 尿激酶和血管形成的抑制剂
CN1571796A (zh) 黑皮素受体配体
CN1894274A (zh) 丙肝病毒ns3丝氨酸蛋白酶的大环抑制剂
CN1332734A (zh) 新颖的丙二酸衍生物、其制备方法、其用途和含有它们的药物组合物(Xa因子活性抑制作用
CN1918131A (zh) 新的谷氨酰胺酰基环化酶抑制剂
CN1867579A (zh) 丙肝病毒的新的肽模拟物ns3－丝氨酸蛋白酶抑制剂
HK1045846A1 (zh) 低分子量补体蛋白酶抑制剂
CN101029080A (zh) 用于对iap抑制卡斯蛋白酶进行去阻遏的方法及组合物
CN1491942A (zh) N-[n-n-(4-（哌啶-4-基)丁酰基)-n-乙基甘氨酰基]化合物的不吸湿的稳定结晶形式
CN1116305C (zh) 肽衍生物
CN1575299A (zh) 导向多肽
CN1054857C (zh) 具有胃肠道运动刺激活性的胃动素样多肽
CN1086825A (zh) 三环和四环化合物
CN1893967A (zh) 白细胞内化的肽－药物偶联物
CN1742997A (zh) 白介素－8的模拟物及其在疾病预防、治疗、诊断中的用途
CN1278734A (zh) 用于治疗类风湿性关节炎的方法和组合物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee