CN114980904A - 硫酸乙酰肝素(hs)低聚糖在肝缺血再灌注损伤中的影响 - Google Patents

硫酸乙酰肝素(hs)低聚糖在肝缺血再灌注损伤中的影响 Download PDF

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Publication number
CN114980904A
CN114980904A CN202080092829.2A CN202080092829A CN114980904A CN 114980904 A CN114980904 A CN 114980904A CN 202080092829 A CN202080092829 A CN 202080092829A CN 114980904 A CN114980904 A CN 114980904A
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Chinese (zh)
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凯特琳·阿诺尔德
刘健
拉法尔·波林斯基
布赖恩·库利
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University of North Carolina at Chapel Hill
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University of North Carolina at Chapel Hill
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
CN202080092829.2A 2019-11-13 2020-11-13 硫酸乙酰肝素(hs)低聚糖在肝缺血再灌注损伤中的影响 Pending CN114980904A (zh)

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Application Number Priority Date Filing Date Title
US201962934845P 2019-11-13 2019-11-13
US62/934,845 2019-11-13
PCT/US2020/060581 WO2021097345A1 (en) 2019-11-13 2020-11-13 Heparan sulfate (hs) oligosaccharides effect in liver ischemia reperfusion injury

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CN114980904A true CN114980904A (zh) 2022-08-30

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US (1) US12569512B2 (https=)
EP (1) EP4041251A4 (https=)
JP (1) JP7801217B2 (https=)
CN (1) CN114980904A (https=)
WO (1) WO2021097345A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12397016B2 (en) 2017-11-03 2025-08-26 The University Of North Carolina At Chapel Hill Sulfated oligosaccharides having anti-inflammatory activity
US12539311B2 (en) 2017-03-10 2026-02-03 The University Of North Carolina At Chapel Hill Short-acting heparin-based anticoagulant compounds and methods
US12569512B2 (en) 2019-11-13 2026-03-10 The University Of North Carolina At Chapel Hill Heparan sulfate (HS) oligosaccharides effect in liver ischemia reperfusion injury

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WO2019010216A1 (en) 2017-07-03 2019-01-10 The University Of North Carolina At Chapel Hill ENZYMATIC SYNTHESIS OF HOMOGENEOUS CHONDROITIN SULFATE OLIGOSACCHARIDES
CN112437667B (zh) 2018-06-20 2024-05-28 北卡罗来纳大学查珀尔希尔分校 细胞保护方法和组合物
US20250019465A1 (en) * 2021-11-12 2025-01-16 The Board Of Regents Of The University Of Texas System Compositions and methods for rare heparan sulfate glycan-targeted cancer treatment
WO2024054682A2 (en) * 2022-09-09 2024-03-14 The University Of North Carolina At Chapel Hill Ultralow molecular weight heparin
CN116987212B (zh) * 2023-09-25 2023-12-26 山东大学 低分子量硫酸乙酰肝素及其衍生物和制备方法与应用

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Cited By (3)

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Publication number Priority date Publication date Assignee Title
US12539311B2 (en) 2017-03-10 2026-02-03 The University Of North Carolina At Chapel Hill Short-acting heparin-based anticoagulant compounds and methods
US12397016B2 (en) 2017-11-03 2025-08-26 The University Of North Carolina At Chapel Hill Sulfated oligosaccharides having anti-inflammatory activity
US12569512B2 (en) 2019-11-13 2026-03-10 The University Of North Carolina At Chapel Hill Heparan sulfate (HS) oligosaccharides effect in liver ischemia reperfusion injury

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US12569512B2 (en) 2026-03-10
EP4041251A4 (en) 2023-11-29
WO2021097345A1 (en) 2021-05-20
JP7801217B2 (ja) 2026-01-16
JP2023501568A (ja) 2023-01-18
EP4041251A1 (en) 2022-08-17
US20220265699A1 (en) 2022-08-25

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