CN114901360A - 用于递送核酸的新型脂质纳米颗粒 - Google Patents

用于递送核酸的新型脂质纳米颗粒 Download PDF

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CN114901360A
CN114901360A CN202080088512.1A CN202080088512A CN114901360A CN 114901360 A CN114901360 A CN 114901360A CN 202080088512 A CN202080088512 A CN 202080088512A CN 114901360 A CN114901360 A CN 114901360A
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lipid
composition
lipids
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G·纳瓦罗
P·鲍姆霍夫
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Kurewag Europe
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Curevac AG
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN202080088512.1A 2019-12-20 2020-12-18 用于递送核酸的新型脂质纳米颗粒 Pending CN114901360A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EPPCT/EP2019/086825 2019-12-20
EP2019086825 2019-12-20
PCT/EP2020/087254 WO2021123332A1 (en) 2019-12-20 2020-12-18 Lipid nanoparticles for delivery of nucleic acids

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US (1) US12589078B2 (enExample)
EP (1) EP4076647A1 (enExample)
JP (2) JP7846621B2 (enExample)
KR (1) KR20220121246A (enExample)
CN (1) CN114901360A (enExample)
AU (1) AU2020407285A1 (enExample)
BR (1) BR112022011803A2 (enExample)
CA (1) CA3162019A1 (enExample)
IL (1) IL293890A (enExample)
MX (1) MX2022007680A (enExample)
WO (1) WO2021123332A1 (enExample)

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CN115968280A (zh) * 2020-05-18 2023-04-14 世代生物公司 新型脂质及其纳米颗粒组合物
CN116549667A (zh) * 2023-05-29 2023-08-08 四川普锐特药业有限公司 一种pas修饰的脂质纳米粒、包含其的药物制剂，及其制备方法和用途
CN116617414A (zh) * 2023-03-31 2023-08-22 中国农业大学 一种脂质体及其制备方法和应用
WO2024103728A1 (zh) * 2022-11-18 2024-05-23 上海复诺健生物科技有限公司 针对痘病毒的信使核糖核酸疫苗
WO2024140767A1 (zh) 2022-12-29 2024-07-04 仁景(苏州)生物科技有限公司 用于预防或治疗hpv感染相关疾病的多核苷酸分子
WO2025124586A1 (zh) 2023-12-15 2025-06-19 厦门赛诺邦格生物科技股份有限公司 一种含二硫键的可降解阳离子脂质及其应用
WO2025189599A1 (zh) * 2024-03-13 2025-09-18 清华大学 含有生育酚结构的辅助脂质分子、包含其的脂质纳米颗粒及其用途

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