CN114761377A - 一种l-鸟氨酸复合盐及其制备方法、应用 - Google Patents

一种l-鸟氨酸复合盐及其制备方法、应用 Download PDF

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Publication number
CN114761377A
CN114761377A CN202080082487.6A CN202080082487A CN114761377A CN 114761377 A CN114761377 A CN 114761377A CN 202080082487 A CN202080082487 A CN 202080082487A CN 114761377 A CN114761377 A CN 114761377A
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China
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ornithine
chamber
acid
solution
salt
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Pending
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CN202080082487.6A
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English (en)
Inventor
苏海霞
熊宗华
朱程军
杨磊
舒敏
鲁凡
邢盼盼
皮莉
王炯
李敬
左江
黄治华
刘梦洁
陈磊
郝成伟
蔡成平
梅雪臣
黄佳琪
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Wuhan Grand Hoyo Co ltd
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Wuhan Grand Hoyo Co ltd
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Publication of CN114761377A publication Critical patent/CN114761377A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C07C227/42—Crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid

Abstract

提供一种L‑鸟氨酸复合盐的制备方法，其包括以下步骤：(1)以L‑鸟氨酸盐溶液为原料，通过双极膜电渗析装置制备游离的L‑鸟氨酸溶液；(2)游离的L‑鸟氨酸溶液与物质A混合反应，得L‑鸟氨酸复合盐溶液；物质A为L‑门冬氨酸、α‑酮戊二酸或者R‑(+)‑硫辛酸；(3)L‑鸟氨酸复合盐溶液结晶即可获得L‑鸟氨酸复合盐。利用所述制备方法制备L‑鸟氨酸复合盐，含水量低于2％，无副产物生成，无废盐和废水等污染，绿色、环保，收率可观。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN202080082487.6A 2019-11-28 2020-11-27 一种l-鸟氨酸复合盐及其制备方法、应用 Pending CN114761377A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2019/121473 2019-11-28
CN2019121473 2019-11-28
PCT/CN2020/132161 WO2021104432A1 (zh) 2019-11-28 2020-11-27 一种l-鸟氨酸复合盐及其制备方法、应用

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CN114761377A true CN114761377A (zh) 2022-07-15

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WO (1) WO2021104432A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113336663B (zh) * 2021-06-04 2023-08-22 无锡晶海氨基酸股份有限公司 一种利用鸟氨酸催化液制备门冬氨酸鸟氨酸的方法
CN116283494A (zh) * 2023-04-04 2023-06-23 南通百川新材料有限公司 一种三羟甲基丙烷绿色化生产工艺

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1887882A (zh) * 2006-08-08 2007-01-03 武汉远大制药集团有限公司 右旋硫辛酸氨基酸盐及其制备方法
JP2008156282A (ja) * 2006-12-25 2008-07-10 Hamari Chemicals Ltd α−リポ酸Ｌ−オルニチン塩およびその製造法
CN102373245A (zh) * 2010-08-18 2012-03-14 上海汉飞生化科技有限公司 一种L-鸟氨酸-α-酮戊二酸盐的制备方法
CN102924311A (zh) * 2011-08-12 2013-02-13 北京四环制药有限公司 一种l-天门冬氨酸-l-鸟氨酸盐的制备方法
CN102964261A (zh) * 2012-04-17 2013-03-13 肖文辉 门冬氨酸鸟氨酸的一种制备方法
CN103014086A (zh) * 2012-12-12 2013-04-03 武汉圣佳化工有限公司 一种酶固定化连续生产l-鸟氨酸复合盐的方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1887882A (zh) * 2006-08-08 2007-01-03 武汉远大制药集团有限公司 右旋硫辛酸氨基酸盐及其制备方法
JP2008156282A (ja) * 2006-12-25 2008-07-10 Hamari Chemicals Ltd α−リポ酸Ｌ−オルニチン塩およびその製造法
CN102373245A (zh) * 2010-08-18 2012-03-14 上海汉飞生化科技有限公司 一种L-鸟氨酸-α-酮戊二酸盐的制备方法
CN102924311A (zh) * 2011-08-12 2013-02-13 北京四环制药有限公司 一种l-天门冬氨酸-l-鸟氨酸盐的制备方法
CN102964261A (zh) * 2012-04-17 2013-03-13 肖文辉 门冬氨酸鸟氨酸的一种制备方法
CN103014086A (zh) * 2012-12-12 2013-04-03 武汉圣佳化工有限公司 一种酶固定化连续生产l-鸟氨酸复合盐的方法

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Title
陈艳等: "电渗析技术在氨基酸生产中的应用" *

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