CN114728974A - 作为btk抑制剂的吡咯并嘧啶类化合物及其应用 - Google Patents
作为btk抑制剂的吡咯并嘧啶类化合物及其应用 Download PDFInfo
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- CN114728974A CN114728974A CN202080078768.4A CN202080078768A CN114728974A CN 114728974 A CN114728974 A CN 114728974A CN 202080078768 A CN202080078768 A CN 202080078768A CN 114728974 A CN114728974 A CN 114728974A
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
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Abstract
本发明公开了一种吡咯并嘧啶类化合物，及其在制备BTK蛋白激酶抑制剂相关疾病的药物中的应用。具体公开了式(III)所示化合物及其药学上可接受的盐。
Description
PCT国内申请，说明书已公开。
Claims (11)
- PCT国内申请，权利要求书已公开。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311079865.7A CN117551103A (zh) | 2019-11-13 | 2020-11-13 | 作为btk抑制剂的吡咯并嘧啶类化合物及其应用 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911109773 | 2019-11-13 | ||
| CN2019111097732 | 2019-11-13 | ||
| CN201911288492 | 2019-12-13 | ||
| CN2019112884928 | 2019-12-13 | ||
| CN202010096582 | 2020-02-17 | ||
| CN2020100965823 | 2020-02-17 | ||
| CN202010711270 | 2020-07-22 | ||
| CN2020107112709 | 2020-07-22 | ||
| PCT/CN2020/128597 WO2021093839A1 (zh) | 2019-11-13 | 2020-11-13 | 作为btk抑制剂的吡咯并嘧啶类化合物及其应用 |
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| CN202311079865.7A Division CN117551103A (zh) | 2019-11-13 | 2020-11-13 | 作为btk抑制剂的吡咯并嘧啶类化合物及其应用 |
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| CN114728974A true CN114728974A (zh) | 2022-07-08 |
| CN114728974B CN114728974B (zh) | 2023-09-19 |
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| CN202080078768.4A Active CN114728974B (zh) | 2019-11-13 | 2020-11-13 | 作为btk抑制剂的吡咯并嘧啶类化合物及其应用 |
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| Country | Link |
|---|---|
| US (1) | US20230357248A1 (zh) |
| EP (1) | EP4059935A4 (zh) |
| JP (1) | JP7473642B2 (zh) |
| KR (1) | KR20220097455A (zh) |
| CN (2) | CN117551103A (zh) |
| WO (1) | WO2021093839A1 (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115894500A (zh) * | 2022-11-02 | 2023-04-04 | 中国药科大学 | 一种作为btk激酶抑制剂的化合物及其制备方法与用途 |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114761410B (zh) * | 2021-04-06 | 2023-08-25 | 广州必贝特医药股份有限公司 | 吡咯并嘧啶酮类化合物及其应用 |
| WO2022213932A1 (zh) * | 2021-04-06 | 2022-10-13 | 广州必贝特医药股份有限公司 | 吡咯并嘧啶酮类化合物及其应用 |
| CN117794934A (zh) * | 2021-05-12 | 2024-03-29 | 浙江龙传生物医药科技有限公司 | 吡咯并嘧啶类化合物的晶型及其制备方法 |
| WO2023110970A1 (en) | 2021-12-14 | 2023-06-22 | Netherlands Translational Research Center Holding B.V | Macrocyclic btk inhibitors |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101594871A (zh) * | 2006-05-26 | 2009-12-02 | 诺瓦提斯公司 | 吡咯并嘧啶化合物及其用途 |
| EP3042903A1 (en) * | 2015-01-06 | 2016-07-13 | Advinus Therapeutics Limited | Substituted hetero-bicyclic compounds, compositions and medicinal applications thereof |
| WO2017111787A1 (en) * | 2015-12-23 | 2017-06-29 | Arqule, Inc. | Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof |
| CN109890821A (zh) * | 2016-08-24 | 2019-06-14 | 艾科尔公司 | 氨基-吡咯并嘧啶酮化合物及其使用方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2018104702A (ru) * | 2012-08-06 | 2019-02-22 | Ацея Байосайенсиз Инк. | Новые соединения пирролопиримидина в качестве ингибиторов протеинкиназ |
-
2020
- 2020-11-13 CN CN202311079865.7A patent/CN117551103A/zh active Pending
- 2020-11-13 EP EP20887944.5A patent/EP4059935A4/en active Pending
- 2020-11-13 WO PCT/CN2020/128597 patent/WO2021093839A1/zh unknown
- 2020-11-13 CN CN202080078768.4A patent/CN114728974B/zh active Active
- 2020-11-13 KR KR1020227018702A patent/KR20220097455A/ko active Search and Examination
- 2020-11-13 US US17/776,873 patent/US20230357248A1/en active Pending
- 2020-11-13 JP JP2022528124A patent/JP7473642B2/ja active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101594871A (zh) * | 2006-05-26 | 2009-12-02 | 诺瓦提斯公司 | 吡咯并嘧啶化合物及其用途 |
| EP3042903A1 (en) * | 2015-01-06 | 2016-07-13 | Advinus Therapeutics Limited | Substituted hetero-bicyclic compounds, compositions and medicinal applications thereof |
| WO2017111787A1 (en) * | 2015-12-23 | 2017-06-29 | Arqule, Inc. | Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof |
| CN109890821A (zh) * | 2016-08-24 | 2019-06-14 | 艾科尔公司 | 氨基-吡咯并嘧啶酮化合物及其使用方法 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115894500A (zh) * | 2022-11-02 | 2023-04-04 | 中国药科大学 | 一种作为btk激酶抑制剂的化合物及其制备方法与用途 |
| CN115894500B (zh) * | 2022-11-02 | 2024-05-28 | 中国药科大学 | 一种作为btk激酶抑制剂的化合物及其制备方法与用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2023506691A (ja) | 2023-02-20 |
| CN114728974B (zh) | 2023-09-19 |
| EP4059935A4 (en) | 2024-02-28 |
| WO2021093839A1 (zh) | 2021-05-20 |
| EP4059935A1 (en) | 2022-09-21 |
| KR20220097455A (ko) | 2022-07-07 |
| US20230357248A1 (en) | 2023-11-09 |
| CN117551103A (zh) | 2024-02-13 |
| JP7473642B2 (ja) | 2024-04-23 |
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