CN115803328A - 哌嗪-2,3-二酮衍生物及其在医药上的应用 - Google Patents
哌嗪-2,3-二酮衍生物及其在医药上的应用 Download PDFInfo
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- CN115803328A CN115803328A CN202180046901.2A CN202180046901A CN115803328A CN 115803328 A CN115803328 A CN 115803328A CN 202180046901 A CN202180046901 A CN 202180046901A CN 115803328 A CN115803328 A CN 115803328A
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- methylpyridin
- isopropyl
- methyl
- kras
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/499—Spiro-condensed pyrazines or piperazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
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- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
本申请公开了新型哌嗪‑2，3‑二酮衍生物或者其药物可接受的盐或立体异构体、其药物组合物以及其在制备KRAS G12C抑制剂中的应用，该化合物可改善疗效，同时降低毒副作用。
Description
PCT国内申请，说明书已公开。
Claims (3)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2020113274819 | 2020-11-24 | ||
| CN202011327481 | 2020-11-24 | ||
| PCT/CN2021/132804 WO2022111527A1 (zh) | 2020-11-24 | 2021-11-24 | 哌嗪-2,3-二酮衍生物及其在医药上的应用 |
Publications (2)
| Publication Number | Publication Date |
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| CN115803328A true CN115803328A (zh) | 2023-03-14 |
| CN115803328B CN115803328B (zh) | 2024-07-23 |
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| Country | Link |
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| WO (1) | WO2022111527A1 (zh) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230107642A1 (en) | 2020-12-18 | 2023-04-06 | Erasca, Inc. | Tricyclic pyridones and pyrimidones |
| US20240293558A1 (en) | 2021-06-16 | 2024-09-05 | Erasca, Inc. | Kras inhibitor conjugates |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017058805A1 (en) * | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| CN110267957A (zh) * | 2017-02-02 | 2019-09-20 | 安斯泰来制药株式会社 | 喹唑啉化合物 |
| WO2019213516A1 (en) * | 2018-05-04 | 2019-11-07 | Amgen Inc. | Kras g12c inhibitors and methods of using the same |
| WO2019217307A1 (en) * | 2018-05-07 | 2019-11-14 | Mirati Therapeutics, Inc. | Kras g12c inhibitors |
| WO2021219090A1 (zh) * | 2020-04-29 | 2021-11-04 | 北京泰德制药股份有限公司 | 喹喔啉二酮衍生物作为kras g12c突变蛋白的不可逆抑制剂 |
-
2021
- 2021-11-24 WO PCT/CN2021/132804 patent/WO2022111527A1/zh active Application Filing
- 2021-11-24 CN CN202180046901.2A patent/CN115803328B/zh active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017058805A1 (en) * | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| CN110267957A (zh) * | 2017-02-02 | 2019-09-20 | 安斯泰来制药株式会社 | 喹唑啉化合物 |
| WO2019213516A1 (en) * | 2018-05-04 | 2019-11-07 | Amgen Inc. | Kras g12c inhibitors and methods of using the same |
| WO2019217307A1 (en) * | 2018-05-07 | 2019-11-14 | Mirati Therapeutics, Inc. | Kras g12c inhibitors |
| WO2021219090A1 (zh) * | 2020-04-29 | 2021-11-04 | 北京泰德制药股份有限公司 | 喹喔啉二酮衍生物作为kras g12c突变蛋白的不可逆抑制剂 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN115803328B (zh) | 2024-07-23 |
| WO2022111527A1 (zh) | 2022-06-02 |
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Effective date of registration: 20240730 Address after: No. 433, Anxian Road, Section 3, Qiqi Avenue, Wenjiang District, Chengdu, Sichuan 610000 Patentee after: Kangbaida (Sichuan) Biopharmaceutical Technology Co.,Ltd. Country or region after: China Address before: 611130 b7-10 / F, Tianfu Life Science Park, 88 Keyuan South Road, high tech Zone, Chengdu, Sichuan Patentee before: CHENGDU BAIYU PHARMACEUTICAL Co.,Ltd. Country or region before: China |