CN114727947A - 细胞外囊泡组合物 - Google Patents

细胞外囊泡组合物 Download PDF

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Publication number
CN114727947A
CN114727947A CN202080078588.6A CN202080078588A CN114727947A CN 114727947 A CN114727947 A CN 114727947A CN 202080078588 A CN202080078588 A CN 202080078588A CN 114727947 A CN114727947 A CN 114727947A
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composition
concentration
aspects
phosphate
sucrose
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Chinese (zh)
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康林·奥尼尔
雷蒙德·布尔多
拉内·哈里森
迈克·多尔蒂
亚伦·诺伊斯
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Lhasa Sales Co ltd
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Codiak Biosciences Inc
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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    • A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
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    • A61K38/00—Medicinal preparations containing peptides
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Oil, Petroleum & Natural Gas (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Inorganic Chemistry (AREA)
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  • Dermatology (AREA)
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  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN202080078588.6A 2019-09-25 2020-09-25 细胞外囊泡组合物 Pending CN114727947A (zh)

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Application Number Priority Date Filing Date Title
US201962906018P 2019-09-25 2019-09-25
US62/906,018 2019-09-25
US201962906485P 2019-09-26 2019-09-26
US62/906,485 2019-09-26
PCT/US2020/052935 WO2021062317A1 (en) 2019-09-25 2020-09-25 Extracellular vesicle compositions

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EP (1) EP4034081A1 (cg-RX-API-DMAC10.html)
JP (1) JP2022549328A (cg-RX-API-DMAC10.html)
KR (1) KR20220092654A (cg-RX-API-DMAC10.html)
CN (1) CN114727947A (cg-RX-API-DMAC10.html)
AU (1) AU2020355240A1 (cg-RX-API-DMAC10.html)
BR (1) BR112022005614A2 (cg-RX-API-DMAC10.html)
CA (1) CA3152478A1 (cg-RX-API-DMAC10.html)
IL (1) IL291690A (cg-RX-API-DMAC10.html)
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CA3213989A1 (en) * 2021-04-01 2022-10-06 Conlin O'NEIL Extracellular vesicle compositions
AR128774A1 (es) * 2022-03-18 2024-06-12 Merck Patent Gmbh Métodos y composiciones para purificar pequeñas vesículas extracelulares
WO2023195976A1 (en) * 2022-04-05 2023-10-12 Babak Ghalili Exosome systems, products and methods
CN119855597A (zh) * 2022-06-30 2025-04-18 隆萨销售股份有限公司 使用靶向stat6的细胞外囊泡-aso的方法
JP7730003B2 (ja) * 2023-02-10 2025-08-27 中国▲医▼薬大学 細胞外小胞／エクソソーム保存溶液及びその混合溶液
TW202506990A (zh) * 2023-03-30 2025-02-16 艾萬霖生技股份有限公司 放射性標記的外泌體及其製備方法和套組

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Publication number Priority date Publication date Assignee Title
CN115282065A (zh) * 2022-08-11 2022-11-04 顾帅 一种含间充质干细胞外泌体的冻干粉及其制备方法和应用
CN115282065B (zh) * 2022-08-11 2024-03-15 顾帅 一种含间充质干细胞外泌体的冻干粉及其制备方法和应用

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AU2020355240A1 (en) 2022-04-21
CA3152478A1 (en) 2021-04-01
MX2022003570A (es) 2022-07-11
IL291690A (en) 2022-05-01
KR20220092654A (ko) 2022-07-01
JP2022549328A (ja) 2022-11-24
BR112022005614A2 (pt) 2022-07-12
EP4034081A1 (en) 2022-08-03

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