AU2020355240A1 - Extracellular vesicle compositions - Google Patents
Extracellular vesicle compositions Download PDFInfo
- Publication number
- AU2020355240A1 AU2020355240A1 AU2020355240A AU2020355240A AU2020355240A1 AU 2020355240 A1 AU2020355240 A1 AU 2020355240A1 AU 2020355240 A AU2020355240 A AU 2020355240A AU 2020355240 A AU2020355240 A AU 2020355240A AU 2020355240 A1 AU2020355240 A1 AU 2020355240A1
- Authority
- AU
- Australia
- Prior art keywords
- composition
- concentration
- aspects
- potassium phosphate
- sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 738
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 380
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims description 318
- 210000001808 exosome Anatomy 0.000 claims description 194
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- 239000005720 sucrose Substances 0.000 claims description 163
- 235000011009 potassium phosphates Nutrition 0.000 claims description 158
- 229910000160 potassium phosphate Inorganic materials 0.000 claims description 157
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- 235000019796 monopotassium phosphate Nutrition 0.000 claims description 152
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical group [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 claims description 149
- 239000001488 sodium phosphate Substances 0.000 claims description 148
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- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 148
- 229910000162 sodium phosphate Inorganic materials 0.000 claims description 147
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- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 69
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 69
- PYLIXCKOHOHGKQ-UHFFFAOYSA-L disodium;hydrogen phosphate;heptahydrate Chemical group O.O.O.O.O.O.O.[Na+].[Na+].OP([O-])([O-])=O PYLIXCKOHOHGKQ-UHFFFAOYSA-L 0.000 claims description 67
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- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims description 4
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| EP2200639B1 (en) | 2007-09-24 | 2016-03-30 | Government of the USA, as Represented by the Secretary, Department of Health and Human Services | Immunostimulatory combinations of tlr3 ligands with tlr2 and tlr9 agonists and methods of use |
| US9370558B2 (en) | 2008-02-13 | 2016-06-21 | President And Fellows Of Harvard College | Controlled delivery of TLR agonists in structural polymeric devices |
| CA2732437C (en) | 2008-08-01 | 2017-11-21 | Ventirx Pharmaceuticals, Inc. | Toll-like receptor agonist formulations and their use |
| EP2486134B1 (en) | 2009-10-06 | 2014-01-08 | Panacela Labs, Inc. | Use of toll-like receptor and agonist for treating cancer |
| WO2011041897A1 (en) * | 2009-10-06 | 2011-04-14 | Angiochem Inc. | Compositions and methods for the transport of therapeutic agents |
| KR101866893B1 (ko) | 2010-10-01 | 2018-06-14 | 벤티알엑스 파마슈티칼스 인코포레이티드 | Tlr 아고니스트의 치료적 용도 및 병용 요법 |
| EP2858722B8 (en) | 2012-06-08 | 2018-02-21 | Aduro BioTech, Inc. | Compostions and methods for cancer immunotherapy |
| SG11201502796RA (en) | 2012-12-13 | 2015-05-28 | Aduro Biotech Inc | Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use |
| JP2016524593A (ja) | 2013-04-29 | 2016-08-18 | メモリアル スローン−ケタリング キャンサー センター | セカンドメッセンジャーのシグナル伝達を変えるための組成物及び方法 |
| CN105377867B (zh) | 2013-05-03 | 2019-11-12 | 加利福尼亚大学董事会 | I型干扰素的环状二核苷酸诱导 |
| EP2996472B1 (en) | 2013-05-18 | 2019-03-27 | Aduro Biotech, Inc. | Compositions and methods for inhibiting "stimulator of interferon gene" dependent signalling |
| CU24377B1 (es) | 2013-05-18 | 2018-12-05 | Aduro Biotech Inc | Dinucléotidos de purina cíclicos y composiciones de los mismos útiles para inducir la producción de interferón de tipo i dependientes de sting |
| US10176292B2 (en) | 2013-07-31 | 2019-01-08 | Memorial Sloan-Kettering Cancer Center | STING crystals and modulators |
| JP2016538344A (ja) | 2013-11-19 | 2016-12-08 | ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ | 癌処置としてのｓｔｉｎｇアゴニストの使用 |
| EP3152217B1 (en) | 2014-06-04 | 2018-08-01 | GlaxoSmithKline Intellectual Property Development Limited | Cyclic di-nucleotides as modulators of sting |
| DK3233882T3 (da) | 2014-12-16 | 2020-01-27 | Kayla Therapeutics | Fluorinerede cykliske dinukleotider til cytokininduktion |
| EP3233191A1 (en) | 2014-12-16 | 2017-10-25 | Invivogen | Combined use of a chemotherapeutic agent and a cyclic dinucleotide for cancer treatment |
| GB201501462D0 (en) | 2015-01-29 | 2015-03-18 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| TWI706958B (zh) | 2015-03-10 | 2020-10-11 | 美商艾杜諾生物科技公司 | 活化「干擾素基因刺激因子」依賴性訊息傳導之組合物及方法 |
| CN108137641B (zh) | 2015-08-13 | 2022-04-01 | 默沙东公司 | 作为sting激动剂的环状双核苷酸化合物 |
| KR20180066241A (ko) | 2015-10-28 | 2018-06-18 | 아두로 바이오테크, 인코포레이티드 | “인터페론 유전자의 자극제”-의존성 신호전달을 활성화시키기 위한 조성물 및 방법 |
| NZ742327A (en) * | 2015-11-18 | 2020-01-31 | Aruna Biomedical Inc | Neural cell extracellular vessicles |
| IL280430B2 (en) | 2016-03-18 | 2023-11-01 | Univ Texas | Cyclic dinucleotide compounds and methods of use |
| SG10201900628RA (en) | 2016-04-07 | 2019-02-27 | Glaxosmithkline Ip Dev Ltd | Heterocyclic amides useful as protein modulators |
| WO2017175156A1 (en) | 2016-04-07 | 2017-10-12 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides useful as protein modulators |
| WO2018070939A1 (en) * | 2016-10-12 | 2018-04-19 | Agency For Science, Technology And Research | Method for lyophilising an exosome |
| US20180193270A1 (en) * | 2016-11-29 | 2018-07-12 | PureTech Health LLC | Exosomes for delivery of therapeutic agents |
| WO2018100558A2 (en) | 2016-12-01 | 2018-06-07 | Takeda Pharmaceutical Company Limited | Cyclic dinucleotide |
| KR20240033086A (ko) | 2017-08-25 | 2024-03-12 | 코디악 바이오사이언시즈, 인크. | 막 단백질을 사용한 치료용 엑소좀의 제조 |
| US20190151456A1 (en) | 2017-11-17 | 2019-05-23 | Codiak Biosciences, Inc. | Compositions of Engineered Exosomes and Methods of Loading Luminal Exosome Payloads |
| US20190175506A1 (en) * | 2017-11-17 | 2019-06-13 | Codiak Biosciences, Inc. | Loading of Extracellular Vesicles through Imparting of Mechanical Shear |
| EP3731849A4 (en) * | 2017-12-28 | 2021-12-01 | Codiak BioSciences, Inc. | EXOSOME FOR IMMUNONCOLOGICAL AND ANTI-INFLAMMATORY THERAPY |
| GB201802163D0 (en) * | 2018-02-09 | 2018-03-28 | Evox Therapeutics Ltd | Compositions for EV storage and formulation |
| EP3752615B1 (en) * | 2018-02-12 | 2025-08-27 | Lonza Sales AG | Methods and compositions for macrophage polarization |
| TW202003032A (zh) * | 2018-03-23 | 2020-01-16 | 美商科迪亞克生物科學公司 | 包含ｓ ｔ ｉ ｎ ｇ 促效劑之胞外囊泡 |
| EP4059510B1 (en) | 2018-11-16 | 2025-05-21 | Lonza Sales AG | Engineered extracellular vesicles and uses thereof |
| EP3941607A1 (en) * | 2019-03-21 | 2022-01-26 | Codiak BioSciences, Inc. | Process for preparing extracellular vesicles |
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- 2020-09-25 EP EP20790126.5A patent/EP4034081A1/en active Pending
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- 2020-09-25 US US17/763,996 patent/US20240099973A1/en active Pending
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| US20240099973A1 (en) | 2024-03-28 |
| CA3152478A1 (en) | 2021-04-01 |
| MX2022003570A (es) | 2022-07-11 |
| CN114727947A (zh) | 2022-07-08 |
| IL291690A (en) | 2022-05-01 |
| KR20220092654A (ko) | 2022-07-01 |
| JP2022549328A (ja) | 2022-11-24 |
| BR112022005614A2 (pt) | 2022-07-12 |
| EP4034081A1 (en) | 2022-08-03 |
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