CN114133454A - 多特异性抗原结合分子及其用途 - Google Patents

多特异性抗原结合分子及其用途 Download PDF

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Publication number
CN114133454A
CN114133454A CN202111438717.0A CN202111438717A CN114133454A CN 114133454 A CN114133454 A CN 114133454A CN 202111438717 A CN202111438717 A CN 202111438717A CN 114133454 A CN114133454 A CN 114133454A
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binding
antigen
multispecific antigen
molecule
binding molecule
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Chinese (zh)
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N·J·帕帕多普洛斯
A·J·莫菲
A·N·艾科诺米德斯
K·D·希纳尔
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
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CN202111438717.0A 2012-03-14 2013-03-13 多特异性抗原结合分子及其用途 Pending CN114133454A (zh)

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US201261610494P 2012-03-14 2012-03-14
US61/610,494 2012-03-14
US201261721831P 2012-11-02 2012-11-02
US61/721,831 2012-11-02
US201361751286P 2013-01-11 2013-01-11
US61/751,286 2013-01-11
CN201380020750.9A CN104302664B (zh) 2012-03-14 2013-03-13 多特异性抗原结合分子及其用途

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CN201380020750.9A Active CN104302664B (zh) 2012-03-14 2013-03-13 多特异性抗原结合分子及其用途

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