CN113827549A - 一种再生修复冷敷凝胶、其使用方法及应用 - Google Patents
一种再生修复冷敷凝胶、其使用方法及应用 Download PDFInfo
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Abstract
本申请提供了一种再生修复冷敷凝胶、其使用方法及应用，包括乳木果油、乳酸、荷荷巴油、金缕梅提取物、尿素、甘油、泛醇、烟酰胺、四胜肽、苯氧乙醇、三乙醇胺水杨酸酯、D‑樟脑、桉树酚、松节油、胶原蛋白、卡波姆、尿囊素、透明质酸钠、奥替尼啶、葡萄糖酸钙和水。本申请提供的再生修复冷敷凝胶可以增加皮肤屏障密度、促进龟裂皮肤修复、皮肤再生、保持皮肤湿润、改善皮肤光滑度、改善皮肤柔软度、减少致病菌及病毒残留、减轻皮肤炎症及湿疹症状、舒缓皮肤过敏及瘙痒、缓解因风湿、关节炎及肌肉损伤引起的疼痛。
Description
技术领域
本发明涉及一种再生修复冷敷凝胶、其使用方法及应用，属于医疗用品技术领域。
背景技术
皮炎(dermatitis)是指由各种内、外部感染或非感染性因素导致的皮肤炎症性疾患的一个泛称，并非一独立疾病，其病因和临床表现复杂多样，且反复发作，临床治疗较为困难。皮炎和湿疹的概念及分类是皮肤科学术界一直有争论的问题之一，以往曾把二者作为同义语来用，并不严格区分，如有人将异位性皮炎也称为异位性湿疹等。现在多数的观点认为皮炎泛指皮肤的炎症，如接触性致敏、皮肤感染等，而湿疹专指某些非感染性炎症，同时将发病机制或临床特征相对明确者称为“某某皮炎”，而病因暂时不明确者笼统的诊断为“湿疹”。市面上也有一些常见治疗皮炎和湿疹的药物，它们可根据皮损情况选用外用剂型和药物，这些虽然能取得一定效果，但疗效有的很不稳定，作用时间段，还有的甚至会出现病情反复，副作用也不能忽视。
发明内容
基于上述技术问题，本申请提供了一种再生修复冷敷凝胶，包括乳木果油、乳酸、荷荷巴油、金缕梅提取物、尿素、甘油、泛醇、烟酰胺、四胜肽、苯氧乙醇、三乙醇胺水杨酸酯、D-樟脑、桉树酚、松节油、胶原蛋白、卡波姆、尿囊素、透明质酸钠、奥替尼啶、葡萄糖酸钙和水。本申请提供的再生修复冷敷凝胶可以增加皮肤屏障密度、促进龟裂皮肤修复、皮肤再生、保持皮肤湿润、改善皮肤光滑度、改善皮肤柔软度、减少致病菌及病毒残留、减轻皮肤炎症及湿疹症状、舒缓皮肤过敏及瘙痒、缓解因风湿、关节炎及肌肉损伤引起的疼痛。
根据本申请的第一方面，提供了一种再生修复冷敷凝胶，包括乳木果油、乳酸、荷荷巴油、金缕梅提取物、尿素、甘油、泛醇、烟酰胺、四胜肽、苯氧乙醇、三乙醇胺水杨酸酯、D-樟脑、桉树酚、松节油、胶原蛋白、卡波姆、尿囊素、透明质酸钠、奥替尼啶、葡萄糖酸钙和水。
可选地，所述再生修复冷敷凝胶中各组分的质量含量为：
根据本申请的第二方面，提供了一种上述再生修复冷敷凝胶的制备方法，所述制备方法包括：
将含有乳木果油、乳酸、荷荷巴油、金缕梅提取物、尿素、甘油、泛醇、烟酰胺、四胜肽、苯氧乙醇、三乙醇胺水杨酸酯、D-樟脑、桉树酚、松节油、胶原蛋白、卡波姆、尿囊素、透明质酸钠、奥替尼啶、葡萄糖酸钙和水的物料混合，搅拌，即可得到所述再生修复冷敷凝胶。
根据本申请的第三方面，提供了一种上述再生修复冷敷凝胶的使用方法，所述使用方法包括以下步骤：
取所述再生修复冷敷凝胶涂抹于肌肤即可。
可选地，所述再生修复冷敷凝胶使用前，需要清洁皮肤。
可选地，所述肌肤选自手部肌肤。
根据本申请的第四方面，提供了一种上述再生修复冷敷凝胶在职业性皮炎、手部湿疹、日常手部护理、抗菌、抗病毒、修复受损皮肤、改善天然皮肤屏障中的应用。
本申请能够产生的有益效果包括：
本申请提供的再生修复冷敷凝胶在增加皮肤屏障密度、促进龟裂皮肤修复、皮肤再生、保持皮肤湿润、改善皮肤光滑度、改善皮肤柔软度、减少致病菌及病毒残留、减轻皮肤炎症及湿疹症状、舒缓皮肤过敏及瘙痒、缓解因风湿、关节炎及肌肉损伤引起的疼痛中的应用。
具体实施方式
下面结合实施例详述本发明，但本发明并不局限于这些实施例。
如无特别说明，本发明的实施例中的原料和试剂均通过商业途径购买。
本申请实施例中使用的透明质酸钠的分子量为80万～200万道尔顿；胶原蛋白为I型胶原蛋白。
实施例1-3
按表1中各组分的质量含量称取乳木果油、乳酸、荷荷巴油、金缕梅提取物、尿素、甘油、泛醇、烟酰胺、四胜肽、苯氧乙醇、三乙醇胺水杨酸酯、D-樟脑、桉树酚、松节油、胶原蛋白、卡波姆、尿囊素、透明质酸钠、奥替尼啶、葡萄糖酸钙和水，搅拌混合均匀，即可得到再生修复冷敷凝胶(总质量均为10g)。
表1
实施例4临床验证
(1)病例：手部湿疹、皮肤炎症
(2)实验组：51例，男性25例，女性26例，年龄15～45岁，随机分成三组；
对照组：20例，男性10例，女性10例，年龄15～45岁，分成两组，
使用方法：实验组分别涂敷实施例1-3制得的再生修复冷敷凝胶，每日三次，对照组不涂敷再生修复冷敷凝胶，总共观察15天。
疗效判断：
痊愈：湿疹消失，炎症消失；
显效：湿疹消退至少85％，炎症症状明显好转；
有效：湿疹消退30～85％，炎症症状有改善；
无效果：湿疹消退小于30％，炎症症状无改善。
统计结果如表2所示：
表2
| 痊愈 | 显效 | 有效 | 无效 | |
| 实施例1 | 14 | 2 | 1 | 0 |
| 实施例2 | 13 | 3 | 1 | 0 |
| 实施例3 | 12 | 3 | 2 | 0 |
| 不涂覆 | 0 | 0 | 0 | 20 |
从上述结果来看，本发明制备得到的再生修复冷敷凝胶对湿疹、炎症的治疗效果比较好，非常有效。
实施例5杀菌性能测试
1.实验器具
1.1实验菌种：金黄色葡萄球菌、铜绿假单胞菌和白色念珠菌。
1.2实验试剂：胰酪大豆胨琼脂培养基、沙氏葡萄糖琼脂培养基、0.9％的无菌生理盐水。
1.3设备与耗材：微量移液器、一次性枪头、试管、立式高压蒸汽灭菌器、生物洁净安全柜、电动混合仪、智能生化培养箱、霉菌培养箱。
2.实验步骤：
2.1配制消毒液，即实施例1中的再生修复冷敷凝胶。
2.2菌悬液制备：
表3
按照表3的接种物要求，金黄色葡萄球菌、铜绿假单胞菌、白色念珠菌离心收集菌体，用0.9％无菌生理盐水逐级稀释并制成每lm l含菌数约为1.0×105cfu-1.0×106cfu的菌悬液。
菌液制备后若在室温下放置，应在2小时内使用；若保存在2-8℃，可在24小时内使用。
2.3供试品接种：取包装完整的再生修复冷敷凝胶一支，直接接种试验菌。用微量移液枪吸取1.0mL相应浓度的金黄色葡萄球菌、铜绿假单胞菌和白色念珠菌菌悬液于无菌试管内，每种菌悬液分别吸取1.0mL置无菌试管中，然后向试验菌试管中加入再生修复冷敷凝胶0.5g，充分混合，使供试品中的试验菌均匀分布，并做好标记。然后用微量移液枪吸取混合液置90mm无菌平皿中，按活菌计数方法测定存活菌数。
2.4阳性对照：同时用稀释液代替样品，进行平行试验，作为阳性对照。
2.5计数培养：用倾注法注入15-20mL温度不超过45℃熔化的胰酪大豆胨琼脂和沙氏葡萄糖琼脂培养基，混匀，凝固，倒置培养。胰酪大豆胨琼脂培养金黄色葡萄球菌、铜绿假单胞菌并置于生化培养箱20-25℃，培养24小时观察结果，沙氏葡萄糖琼脂培养白色念珠菌并置于霉菌培养箱30-35℃，培养48小时观察结果。
2.6试验重复3次，计算各组的活菌浓度(cfu/mL)，并换算为对数值(N)，然后按下式计算杀灭对数值：
杀灭对数值(KL)＝对照组平均活菌浓度的对数值(No)一试验组活菌浓度对数
根据存活菌数测定结果，计算每个平皿的菌落数及所加再生修复冷敷凝胶前后菌落数，并换算成lg值。
3.结果判断
测试结果见表4“减少的lg值”是指每个平皿的菌落数在加入抗感染喷剂的前后的菌落数的相差值。
表4
综上所知，再生修复冷敷凝胶对金黄色葡萄球菌、铜绿假单胞菌和真菌类白色念珠菌都有明显的杀菌作用。
以上所述，仅是本发明的几个实施例，并非对本发明做任何形式的限制，虽然本发明以较佳实施例揭示如上，然而并非用以限制本发明，任何熟悉本专业的技术人员，在不脱离本发明技术方案的范围内，利用上述揭示的技术内容做出些许的变动或修饰均等同于等效实施案例，均属于技术方案范围内。
Claims (7)
1.一种再生修复冷敷凝胶，其特征在于，包括乳木果油、乳酸、荷荷巴油、金缕梅提取物、尿素、甘油、泛醇、烟酰胺、四胜肽、苯氧乙醇、三乙醇胺水杨酸酯、D-樟脑、桉树酚、松节油、胶原蛋白、卡波姆、尿囊素、透明质酸钠、奥替尼啶、葡萄糖酸钙和水。
2.根据权利要求1所述的再生修复冷敷凝胶，其特征在于，所述再生修复冷敷凝胶中各组分的质量含量为：
其余为水。
3.权利要求1或2所述的再生修复冷敷凝胶的制备方法，其特征在于，所述制备方法包括：
将含有乳木果油、乳酸、荷荷巴油、金缕梅提取物、尿素、甘油、泛醇、烟酰胺、四胜肽、苯氧乙醇、三乙醇胺水杨酸酯、D-樟脑、桉树酚、松节油、胶原蛋白、卡波姆、尿囊素、透明质酸钠、奥替尼啶、葡萄糖酸钙和水的物料混合，搅拌，即可得到所述再生修复冷敷凝胶。
4.权利要求1或2所述的再生修复冷敷凝胶的使用方法，其特征在于，所述使用方法包括以下步骤：
取所述再生修复冷敷凝胶涂抹于肌肤即可。
5.根据权利要求4所述的使用方法，其特征在于，所述再生修复冷敷凝胶使用前，需要清洁皮肤。
6.根据权利要求4所述的使用方法，其特征在于，所述肌肤选自手部肌肤。
7.权利要求1或2所述的再生修复冷敷凝胶在职业性皮炎、手部湿疹、日常手部护理、抗菌、抗病毒、修复受损皮肤、改善天然皮肤屏障中的应用。
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