CN1136222C - 3-(2-氧-[1,3′]二吡咯烷基-3-基亚基甲基)-头孢 - Google Patents

3-(2-氧-[1,3′]二吡咯烷基-3-基亚基甲基)-头孢 Download PDF

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Publication number
CN1136222C
CN1136222C CNB998073474A CN99807347A CN1136222C CN 1136222 C CN1136222 C CN 1136222C CN B998073474 A CNB998073474 A CN B998073474A CN 99807347 A CN99807347 A CN 99807347A CN 1136222 C CN1136222 C CN 1136222C
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China
Prior art keywords
hydrogen
oxo
compound
ocor
compounds
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Expired - Lifetime
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CNB998073474A
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English (en)
Chinese (zh)
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CN1305484A (zh
Inventor
�������ɭ
保罗·哈贝森
�ٰ�������ʩΤ����
克里斯蒂安·胡布施韦尔朗
�ˡ����˶�������˹
琼－吕克·施佩克林
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Basilea Pharmaceutica International AG
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Basilea Pharmaceutica AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/48—Methylene radicals, substituted by hetero rings
    • C07D501/56—Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CNB998073474A 1998-06-15 1999-06-07 3-(2-氧-[1,3′]二吡咯烷基-3-基亚基甲基)-头孢 Expired - Lifetime CN1136222C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP98110888 1998-06-15
EP98110888.9 1998-06-15
EP98117099.6 1998-09-10
EP98117099 1998-09-10

Publications (2)

Publication Number Publication Date
CN1305484A CN1305484A (zh) 2001-07-25
CN1136222C true CN1136222C (zh) 2004-01-28

Family

ID=26149347

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB998073474A Expired - Lifetime CN1136222C (zh) 1998-06-15 1999-06-07 3-(2-氧-[1,3′]二吡咯烷基-3-基亚基甲基)-头孢

Country Status (28)

Country Link
EP (1) EP1087980B1 (enExample)
JP (1) JP3872955B2 (enExample)
KR (1) KR100411915B1 (enExample)
CN (1) CN1136222C (enExample)
AR (1) AR018675A1 (enExample)
AT (1) ATE231871T1 (enExample)
AU (1) AU754732B2 (enExample)
BE (1) BE2014C034I2 (enExample)
BR (2) BRPI9911178B8 (enExample)
CA (1) CA2334568C (enExample)
CO (1) CO5080758A1 (enExample)
DE (1) DE69905162T2 (enExample)
DK (1) DK1087980T3 (enExample)
ES (1) ES2190222T3 (enExample)
FR (1) FR14C0044I2 (enExample)
GT (1) GT199900084A (enExample)
HU (1) HUP0105426A3 (enExample)
ID (1) ID27686A (enExample)
IL (1) IL139872A0 (enExample)
LU (1) LU92564I2 (enExample)
MA (1) MA26650A1 (enExample)
NO (1) NO20006350D0 (enExample)
PA (1) PA8475701A1 (enExample)
PE (1) PE20000645A1 (enExample)
PL (1) PL344994A1 (enExample)
SV (1) SV1999000075A (enExample)
TN (1) TNSN99114A1 (enExample)
WO (1) WO1999065920A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6267100A (en) * 1999-07-07 2001-01-30 F. Hoffmann-La Roche Ag Vinylpyrrolidinone derivatives with substituted thiazole ring
DE60123513T2 (de) 2000-04-19 2007-05-10 Basilea Pharmaceutica Ag Verfahren zur Herstellung von D-Asparaginderivaten
US6504025B2 (en) 2000-05-24 2003-01-07 Basilea Pharmaceutica Ag Process for the preparation of vinyl-pyrrolidinone cephalosporin derivatives
JP5230934B2 (ja) * 2003-03-27 2013-07-10 バジリア ファルマスーチカ アーゲー 結晶形態のセファロスポリン
EP1656930A1 (en) * 2004-11-10 2006-05-17 Basilea Pharmaceutica AG Stabilized freeze-dried formulation for cephalosporin derivatives
AR071318A1 (es) 2008-04-15 2010-06-09 Basilea Pharmaceutica Ag Benzhidril ester del acido (6r,7r)-7-{2-(5-amino-[1,2,4]tiadiazol-3-il)-2-[(z)-tritiloxiimino]-acetilamino}-3-[(r)-1'-terc-butoxicarbonil-2-oxo-[1,3']bipirrolidinil-(3e)-ilidenometil]-8-oxo-5-tia-1-aza-biciclo[4.2.0]oct-2-eno-2-carboxilico cristalino; su elaboracion y uso
WO2010072672A1 (en) 2008-12-24 2010-07-01 Basilea Pharmaceutica Ag New crystal polymorphs of ceftobiprole
ES2565205T3 (es) * 2009-05-25 2016-04-01 Sandoz Ag Método para la producción de ceftobiprol medocaril
AU2011252135B2 (en) 2010-05-10 2014-04-03 Basilea Pharmaceutica International Ltd. Oxidation process for preparing 3-formyl-cephem derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0841339T3 (da) * 1996-11-06 2007-07-02 Basilea Pharmaceutica Ag Vinylpyrrolidinon-cephalosporinderivater
TW415949B (en) * 1996-12-19 2000-12-21 Hoffmann La Roche Vinyl pyrrolidine cephalosporin derivatives with basic substituents

Also Published As

Publication number Publication date
LU92564I2 (fr) 2014-12-01
FR14C0044I1 (enExample) 2014-07-18
KR100411915B1 (ko) 2003-12-18
BR9911178A (pt) 2001-03-13
EP1087980A1 (en) 2001-04-04
ID27686A (id) 2001-04-19
CO5080758A1 (es) 2001-09-25
JP3872955B2 (ja) 2007-01-24
BE2014C034I2 (en) 2018-08-24
FR14C0044I2 (fr) 2015-02-20
BRPI9911178B8 (pt) 2017-03-07
NO20006350L (no) 2000-12-13
WO1999065920A1 (en) 1999-12-23
PE20000645A1 (es) 2000-07-26
AR018675A1 (es) 2001-11-28
SV1999000075A (es) 2000-05-02
PL344994A1 (en) 2001-11-19
MA26650A1 (fr) 2004-12-20
ES2190222T3 (es) 2003-07-16
CA2334568A1 (en) 1999-12-23
CN1305484A (zh) 2001-07-25
JP2002518401A (ja) 2002-06-25
DE69905162T2 (de) 2003-12-24
HUP0105426A3 (en) 2002-12-28
AU754732B2 (en) 2002-11-21
ATE231871T1 (de) 2003-02-15
GT199900084A (es) 2000-12-05
BR9911178B1 (pt) 2013-10-29
IL139872A0 (en) 2002-02-10
AU4508199A (en) 2000-01-05
TNSN99114A1 (fr) 2005-11-10
CA2334568C (en) 2009-02-24
DE69905162D1 (de) 2003-03-06
PA8475701A1 (es) 2000-09-29
NO20006350D0 (no) 2000-12-13
EP1087980B1 (en) 2003-01-29
BRPI9911178C1 (pt) 2021-05-25
KR20010052866A (ko) 2001-06-25
DK1087980T3 (da) 2003-05-26
HUP0105426A2 (hu) 2002-05-29

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: BASILE PHARMACEUTICAL CO., LTD.

Free format text: FORMER OWNER: HOFFMAN-LALUOAI LTD.

Effective date: 20011210

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20011210

Address after: Swiss Binnigen

Applicant after: Basilea Pharmaceutica AG

Address before: Basel

Applicant before: F. Hoffmann-La Roche AG

C14 Grant of patent or utility model
GR01 Patent grant
TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20180928

Address after: Basel

Patentee after: Basilea Pharmaceutica International Ltd.

Address before: Swiss Binnigen

Patentee before: Basilea Pharmaceutica AG

EE01 Entry into force of recordation of patent licensing contract
EE01 Entry into force of recordation of patent licensing contract

Application publication date: 20010725

Assignee: SHENZHEN CHINA RESOURCES GOSUN PHARMACEUTICAL CO., LTD.

Assignor: Basilea Pharmaceutica International Ltd.

Contract record no.: 2019990000040

Denomination of invention: 3-(2-oxo[1,3']bihyrrolidinyl-3-ylidenemethyl)-cephems

Granted publication date: 20040128

License type: Exclusive License

Record date: 20190201

CX01 Expiry of patent term
CX01 Expiry of patent term

Granted publication date: 20040128