CN113413338A - Eye repairing composition and preparation method and application thereof - Google Patents
Eye repairing composition and preparation method and application thereof Download PDFInfo
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- CN113413338A CN113413338A CN202110737721.0A CN202110737721A CN113413338A CN 113413338 A CN113413338 A CN 113413338A CN 202110737721 A CN202110737721 A CN 202110737721A CN 113413338 A CN113413338 A CN 113413338A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9755—Gymnosperms [Coniferophyta]
- A61K8/9767—Pinaceae [Pine family], e.g. pine or cedar
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Biotechnology (AREA)
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- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides an eye repair composition and a preparation method and application thereof. The eye repair composition comprises the following components: hydrolyzed yeast extract, extract of bark of Cedrus deodara, and caffeine silanol; the content of the hydrolytic yeast extract is 0.0001-0.1%, the content of the northern non-cedar bark extract is 0.01-5%, and the content of the caffeine silanol is 0.01-20% based on the total mass of the eye repairing composition being 100%. The eye repairing composition can improve the problems of black eyes and bags in all directions from multiple angles. According to the invention, the effects achieved by compounding the hydrolytic yeast extract, the extract of the bark of the northern non-cedar and the caffeine silanol are obviously superior to those achieved by single or simple combination, and the effects of reducing eye edema, resisting water retention, enhancing skin elasticity, calming and strongly moistening skin and lightening dark circles are realized.
Description
Technical Field
The invention relates to an eye repairing composition and a preparation method and application thereof, in particular to an eye repairing composition capable of improving black eye circles and under-eye puffiness and a preparation method and application thereof, and belongs to the field of cosmetics.
Background
The skin of the eyes is much thinner than the skin of other parts of the face, and is more easily damaged by the outside. Aging is more pronounced in the eye. The ocular sub-skin is rich in connective tissue, with a very rich distribution of capillaries and nerve endings in the fibrous structure. The walls of these capillaries are very thin and permeable, so that connective tissues are easily engorged with blood and water to form edema and hematoma. The skin around the eyes is very thin and very dry and water deficient. Thereby causing wrinkles to easily occur in the skin of the eyes.
The reasons for the formation of dark circles are many, for example: 1. the eyelid can not rest when the eye is not sleeping enough and stays up, the blood vessels around the eyes are continuously tensed and contracted, the blood flow is increased for a long time, and blood stasis and edema of the blood vessels of the subcutaneous tissues of the eye circles are caused, and dark shadows are remained. 2. Inflammation, atopy or allergic contact dermatitis, and dark circles around the eye sockets. 3. The weak subcutaneous tissue around the eye is easy to cause pigmentation and is easy to be exposed on the upper and lower eyelids to form a layer of black circle. 4. Other, for example, overuse of cosmetics, smoking, aging, irregular menstruation and certain liver and kidney diseases may develop dark circles.
The black eye types are divided into three types: the first is a black eye of the melanin type, which is characterized by a tan color with pigmentary abnormalities, primarily due to pigmentation of the eye caused by an insufficiency of melanin production or metabolism. The older the person, the thinner the subcutaneous fat around the eye becomes, so the more visible the dark circles. The second is a blood vessel type black eye ring which is characterized by showing blue, pink and purple color with swelling around the eyes, mainly because of frequent staying up all night, lack of sleep, unstable mood, eye fatigue and aging, too slow blood flow of vein blood vessels, insufficient oxygen supply of red blood cells of skin of eyes, excessive accumulation of carbon dioxide and metabolic waste in the vein blood vessels, formation of chronic hypoxia, darker blood and retention and pigmentation of eyes. The third is a structured black eye characterized by a shadow color with bags under the orbit/on the eyelids, prominent infraorbital grooves, drooping eyelids, bony prominences due to loss of fat or cartilage tissue.
The pouch is mainly classified into a pseudo pouch and a true pouch. If the eye is not fatty and is naturally hypertrophic, the eye is called false eye pouch; in addition, occasional tiredness and edema of the eyes may cause eye puffiness, but recovery after resting and massaging is a false pouch. The real pouch refers to the formation of the real pouch due to the loss of elasticity of the skin and the loose face which causes the fat to diffuse out.
With the acceleration of the pace of life, the increase of the pressure of life, the pollution of the living environment and the popularization of mobile phones and computers, many people often have the condition of overuse of eyes, and the eyes are very tired, so that the eyes generate a plurality of problems such as black eyes, pouches and the like. At present, a plurality of eye care products are sold in the market and are popular with people, but the eye care products have uneven quality (for example, some eye care products have poor absorption, some eye care products have unobvious effect, and some eye care products can grow fat grains or have allergy phenomenon), the using effect cannot be guaranteed, and people can not select the eye care products easily.
Therefore, how to develop an eye repair composition for effectively improving dark circles and bags under the eyes becomes a technical problem to be solved urgently.
Disclosure of Invention
Problems to be solved by the invention
In view of the disadvantages of the prior art, for example: the eye repairing composition has the advantages of being poor in absorption of effective components, allergic, unobvious in effect, rebound in effect and the like, and one of the purposes of the invention is to provide the eye repairing composition which can effectively solve the problems of black eyes and eye bags.
Furthermore, the invention also provides a preparation method of the eye repair composition, and the preparation method is simple and feasible, and raw materials are easy to obtain.
Means for solving the problems
The invention provides an eye-repairing composition, which comprises the following components:
the yeast extract is hydrolyzed to obtain a hydrolyzed yeast extract,
extract of the bark of Cedrus deodara, and
caffeine silanol;
the content of the hydrolytic yeast extract is 0.0001-0.1%, the content of the northern non-cedar bark extract is 0.01-5%, and the content of the caffeine silanol is 0.01-20% based on the total mass of the eye repairing composition being 100%.
The eye repair composition according to the present invention comprises 0.0005% to 0.01% of the hydrolyzed yeast extract, 0.1% to 3% of the extract of the bark of the northern non-cedar, and 0.5% to 18% of the caffeine silanol, based on 100% of the total weight of the eye repair composition.
The eye repairing composition comprises 0.001% -0.008% of hydrolyzed yeast extract, 0.5% -2% of northern non-cedar bark extract and 1% -15% of caffeine silanol, wherein the total mass of the eye repairing composition is 100%.
The eye repair composition comprises a hydrolytic yeast extract, a northern cedar bark extract and caffeine silanol, wherein the mass ratio of the hydrolytic yeast extract to the northern cedar bark extract to the caffeine silanol is 1: 10-1000: 50-10000.
The eye repairing composition provided by the invention further comprises one or more of a humectant, a chelating agent, a preservative and a solvent; the addition amount of the humectant is 1-50% based on 100% of the total mass of the eye repairing composition; the addition amount of the chelating agent is 0.01-1%; the addition amount of the preservative is 0.1-1%, and the addition amount of the solvent is 13-95%.
The eye-repairing composition according to the present invention, wherein the humectant comprises one or a combination of two or more of 1, 3-propanediol, propylene glycol, pentanediol, hexanediol, sorbitol, glycerol, dipropylene glycol, 1, 3-butanediol, trehalose, xylitol, erythritol, glyceryl polyether-26, β -glucan, methyl glucitol polyether-20, methyl glucitol polyether-10, erythrulose, biogum-1, betaine, rhamnose, oat β -glucan, chitosamine, polyethylene glycols, water-soluble oils and fats, water-soluble silicone oils, and sodium hyaluronate.
The eye-repairing composition according to the present invention, wherein the chelating agent comprises EDTA-2Na and/or EDTA-4 Na; and/or
The antiseptic is one or more of p-hydroxyacetophenone, phenoxyethanol, chlorphenesin, sorbitan caprylate, benzyl alcohol, benzoic acid, gluconolactone, sodium benzoate, ethylhexyl glycerol, methyl hydroxybenzoate, and propyl hydroxybenzoate.
The present invention also provides a process for the preparation of the eye repair composition according to the invention comprising the step of mixing the components of the eye repair composition.
The invention also provides the use of an eye-rejuvenating composition according to the invention for the preparation of an eye-care product; preferably, the eye care product is one of eye cream, eye gel, eye mask, eye essence and eye patch.
The use according to the invention, wherein the eye-rejuvenating composition is added in an amount of 1% to 90%.
ADVANTAGEOUS EFFECTS OF INVENTION
The eye repairing composition can improve the problems of black eyes and bags in all directions from multiple angles. According to the invention, the effects achieved by compounding the hydrolytic yeast extract, the extract of the bark of the northern non-cedar and the caffeine silanol are obviously superior to those achieved by single or simple combination, and the effects of reducing eye edema, resisting water retention, enhancing skin elasticity, calming and strongly moistening skin and lightening dark circles are realized.
In addition, the preparation method of the eye repairing composition is simple and feasible, the raw materials are easy to obtain, and the eye repairing composition is suitable for mass production.
The eye care product containing the eye repairing composition prepared by the invention is safe and non-irritant, can effectively solve the problems of black eye and pouch, and is suitable for people of all ages.
Detailed Description
The present invention will be described in detail below. The technical features described below are explained based on typical embodiments and specific examples of the present invention, but the present invention is not limited to these embodiments and specific examples.
Furthermore, in the following detailed description, numerous specific details are set forth in order to provide a better understanding of the present invention. It will be understood by those skilled in the art that the present invention may be practiced without some of these specific details. In other instances, methods, means, devices and steps which are well known to those skilled in the art have not been described in detail so as not to obscure the invention.
It should be noted that:
in the present specification, the meaning of "may" or "may" includes both the meaning of performing a certain process and the meaning of not performing a certain process.
In the present specification, the numerical range represented by "numerical value a to numerical value B" means a range including the end point numerical value A, B.
All units used in the present invention are international standard units unless otherwise stated, and numerical values and numerical ranges appearing in the present invention should be understood to include errors allowed in industrial production.
In the present specification, reference to "some particular/preferred embodiments," "other particular/preferred embodiments," "embodiments," and the like, means that a particular element (e.g., feature, property, and/or characteristic) described in connection with the embodiment is included in at least one embodiment described herein, and may or may not be present in other embodiments. In addition, it is to be understood that the described elements may be combined in any suitable manner in the various embodiments.
In the present specification, if "room temperature" or the like appears, the meaning may be "10 to 40 ℃.
<First aspect>
A first aspect of the invention provides an eye-repair composition comprising the following components:
the yeast extract is hydrolyzed to obtain a hydrolyzed yeast extract,
extract of the bark of Cedrus deodara, and
caffeine silanol;
the content of the hydrolytic yeast extract is 0.0001-0.1%, the content of the northern non-cedar bark extract is 0.01-5%, and the content of the caffeine silanol is 0.01-20% based on the total mass of the eye repairing composition being 100%.
In the invention, the raw materials of each component are mild to human body, safe and non-irritant. The invention uses the compatibility of the hydrolytic yeast extract, the extract of the bark of the northern non-cedar and the caffeine silanol, and the three play the role of synergy.
Hydrolyzed yeast extract
In the present invention, the hydrolyzed yeast extract is an active ingredient obtained by extracting a fermentation product of marine microorganism Penicillium notatum by biotechnology. The hydrolyzed yeast extract of the present invention can reduce vascular permeability. The present inventors have found that hydrolyzed yeast extract can improve the symptoms of dark circles and bags due to accumulation of liquid by reducing the rate of liquid exudation. The hydrolyzed yeast extract also promotes the degradation of bilirubin, and by reducing the residual accumulation of colored by-products, the decrease in pigmentation that leads to the formation of dark circles under the eyes can increase the synthesis of type I collagen and elastin by dermal fibroblasts. Therefore, the hydrolytic yeast extract can restore the elasticity and compactness of skin, brighten the skin color, and has various effects of lightening dark eye circles, relieving eye edema, refining wrinkles and the like.
In the present invention, the content of the hydrolyzed yeast extract is 0.0001% to 0.1%, preferably 0.0005% to 0.01%, more preferably 0.001% to 0.008%, based on 100% by mass of the total eye-rejuvenating composition. When the content of the hydrolyzed yeast extract is less than 0.0001%, the corresponding effect cannot be obtained, and when the content of the hydrolyzed yeast extract is more than 0.1%, the cost is too high.
Extract of bark of Cedar tree
The extract of the bark of the northern non-cedar is prepared by extracting the bark of the northern non-cedar serving as a raw material. The extract of Cedar bark can improve vascular tension and reduce excessive formation of blood vessel. Therefore, the extract of the bark of Cedrus deodara can prevent the oxidative damage of blood vessels and relieve local inflammation. In the invention, the extract of the bark of the northern non-cedar can provide sufficient nutrient components for the skin and has the functions of lightening dark eye circles, eye bags and eye puffiness.
In the present invention, the content of the extract of the bark of Cedrus deodara is 0.01% to 5%, preferably 0.1% to 3%, more preferably 0.5% to 2%, based on 100% by mass of the total eye-repairing composition. When the content of the extract of the northern non-cedar bark is less than 0.01 percent, the corresponding effects of lightening dark circles and under-eye bags cannot be achieved, and when the content of the extract of the hydrolytic yeast is more than 5 percent, the cost is too high.
Caffeine silanol
Caffeine silanol may also be referred to as caffeine silanol C, which is a complex of caffeine and silicone triol alginate. Caffeine silanol C is a silanol that can be built up by caffeine and a siloxane triol alginate. It is soluble in water, has a very rich hydroxyl function, and is obtained by condensing some characteristic roots, so that it has both its own biological function and the special function brought by the roots made of natural substances.
The caffeine silanol promotes the lipolysis by the activation of cyclic adenosine monophosphate by silicon element, and reduces the formation and accumulation of triglyceride by the inhibitory action on the lipoprotein. Meanwhile, the skin tissue is reconstructed, and the effects of skin firming, anti-inflammation and the like are achieved. The lipolytic action of caffeine silanol can be manifested by two mechanisms: the compound is expressed by a stimulation function of cyclic adenosine monophosphate and an inhibition function of lipoprotein lipase. In the present invention, the caffeine silanol can promote blood circulation and improve dark circles and under-eye puffiness.
In the present invention, the content of the caffeine silanol is 0.01% to 20%, preferably 0.5% to 18%, more preferably 1% to 15%, based on 100% by mass of the total eye-repairing composition. When the content of the caffeine silanol is less than 0.01%, the corresponding black eye and eye pouch lightening effect cannot be achieved, and when the content of the caffeine silanol is more than 20%, the cost is too high.
In the invention, the components compounded by the hydrolytic yeast extract and the extract of the northern non-cedar bark have synergistic effect, improve the tension of blood vessels, reduce the generation of blood vessels, reduce the permeability of the blood vessels, promote the generation of collagen, and more effectively reduce the melanin deposition around the eyes and improve the bags under the eyes. And caffeine silanol is added to promote blood circulation and enhance the effects of removing dark eye circles and eye bags. The obtained effect is obviously superior to that of single or simple combination, and the effects of reducing eye edema, increasing the synthesis of collagen and elastin and lightening dark circles are realized.
In some specific embodiments, the mass ratio of the hydrolyzed yeast extract, the extract of the northern cedar bark, and the caffeine silanol is 1:10 to 1000:50 to 10000. When the mass ratio of the hydrolytic yeast extract to the northern non-cedar bark extract to the caffeine silanol is 1: 10-1000: 50-10000, the effects of reducing melanin deposition around eyes and improving pouches can be achieved on the premise of saving cost. Specifically, the mass ratio of the hydrolytic yeast extract to the northern cedar bark extract to the caffeine silanol can be 1: 20-900: 100-9000, can be 1: 30-800: 200-8000, can be 1: 40-700: 300-6000, can be 1: 50-600: 400-5000, can be 1: 60-500: 500-5000, can be 1: 70-400: 600-4000, can be 1: 80-300: 500-3000, can be 1: 90-200: 600-2000, can be 1: 100-150: 500-1800 and the like.
Other Components
In the present invention, the eye-repairing composition further comprises one or a combination of two or more of a humectant, a chelating agent, a preservative, a solvent and the like; the addition amount of the humectant is 1-50% based on 100% of the total mass of the eye repairing composition; the addition amount of the chelating agent is 0.01-1%; the addition amount of the preservative is 0.1-1%, and the addition amount of the solvent is 13-95%.
The eye repairing composition has excellent moisturizing performance on the basis of improving black eye circles and bags under the eyes by adding the moisturizing agent. In the invention, the adding amount of the humectant is 1-50%, preferably 1-25%, more preferably 1-20% based on 100% of the total mass of the composition for removing dark circles and bags under the eyes; in order to further exert the efficacy of the humectant, the humectant can be added in an amount of 1-18%, 3-16%, 5-14% or 6-12%. For example: may be 2%, 3%, 6%, 8%, 10%, 12%, 15%, 17%, 19%, etc.
Specifically, the humectant comprises one or a combination of more than two of 1, 3-propylene glycol, pentanediol, hexanediol, sorbitol, glycerol, dipropylene glycol, 1, 3-butanediol, trehalose, xylitol, erythritol, glycerol polyether-26, beta-glucan, methyl glucitol polyether-20, methyl glucitol polyether-10, erythrulose, biogum-1, betaine, rhamnose, oat beta-glucan, acetyl chitosamine, polyethylene glycols, water-soluble oil and fat, water-soluble silicone oil and sodium hyaluronate.
Further, in the present invention, as the chelating agent and the preservative, the present invention is not particularly limited, and may be a chelating agent and a preservative commonly used in the art. The addition amount of the chelating agent is 0.01-1%, preferably 0.01-0.1% based on the total mass of the eye repairing composition being 100%; the addition amount of the preservative is 0.1-1%.
For example, the chelating agent includes EDTA-2Na and/or EDTA-4 Na. The antiseptic is one or more of p-hydroxyacetophenone, phenoxyethanol, chlorphenesin, sorbitan caprylate, benzyl alcohol, benzoic acid, gluconolactone, sodium benzoate, ethylhexyl glycerol, methyl hydroxybenzoate, and propyl hydroxybenzoate.
The eye repairing composition provided by the invention has multiple functional components, except that a compound combination of a hydrolytic yeast extract, a northern cedar bark extract and caffeine silanol is used as a main functional component, one or more than two combinations of a humectant, a chelating agent and a preservative are also related components, and can be used as a whole to play a synergistic cooperation role with each other, so that the eye repairing composition capable of effectively improving the problems of black eyes and under-eye puffiness is prepared.
In addition, the eye-repairing composition of the present invention further comprises a solvent. The solvent may be water or the like. The "water" as referred to herein may be water usable in the cosmetic field such as deionized water, double distilled water, ion-exchanged water, reverse osmosis water, purified water, etc. Specifically, in the present invention, the solvent may be added in an amount of 13% to 95%, preferably 57% to 93%, more preferably 71% to 90%, etc., based on 100% by mass of the total eye-repairing composition. For example: the amount of solvent added may be 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 75%, 80%, 85%, etc.
The eye repairing composition has the effects of moisturizing, fading fine wrinkles, fading dark circles and astringing pouches, and the effective components can penetrate into the bottoms of eye muscles to protect the skin of the eyes.
<Second aspect of the invention>
A second aspect of the invention provides a method of preparing an eye-repair composition comprising the step of mixing the components of the eye-repair composition. The preparation method of the composition for removing dark circles and bags under the eyes is simple and easy to implement, the raw materials are easy to obtain, and the composition is suitable for mass production.
In some specific embodiments, the method of preparing the ocular repair composition comprises the steps of:
1) adding the optional humectant, the optional chelating agent, the optional preservative and the optional water into an emulsifying pot, heating to 80-85 ℃, and stirring for dissolving;
2) cooling the emulsifying pot to 42-48 deg.C, adding hydrolyzed yeast extract, extract of bark of Cedrus deodara, caffeine silanol and optionally preservative, and stirring to obtain eye repairing composition.
Further, the present invention also provides a use of the eye-repairing composition according to the present invention for preparing an eye-care product, preferably, the eye-care product is one of eye cream, eye gel, eye mask, eye essence, and eye patch.
Specifically, the eye-rejuvenating composition is added in an amount of 1% to 99% based on the total mass of the eye-care product, for example: 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, etc.
Specifically, when the eye care product is eye cream, eye essence, eye gel and the like, the addition amount of the composition for removing black eye circles and eye bags is 1-50% based on the total mass of the eye care product; when the eye care product is an eye mask, an eye patch or the like, the addition amount of the composition for removing black eye circles and bags under the eyes is 1% -20%.
Examples
Embodiments of the present invention will be described in detail below with reference to examples, but those skilled in the art will appreciate that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products commercially available.
In the examples, the manufacturer of the hydrolytic yeast extract was: spanish Lipotec corporation;
the manufacturers of the extract of the bark of the northern non-cedar comprise: french Olvic corporation;
the manufacturer of caffeine silanol C is: french Eisen Mei Co.
Examples 1 to 10
Eye-repairing compositions of examples 1-10 were prepared according to the following table 1-2, in terms of the mass percentages of the components.
The preparation method of the eye repairing composition comprises the following steps:
1) adding sterilized deionized water into main pot, adding hyaluronic acid, glycerol, 1, 3-propylene glycol, betaine, EDTA-2NA, and methyl hydroxybenzoate under stirring, heating to 82 deg.C, homogenizing at 3000rpm for 3min, stirring to remove lumps, and keeping the temperature for 20 min.
2) Cooling to 45 deg.C, adding hydrolyzed yeast extract, cortex Centellae extract, caffeine silanol C, and phenoxyethanol, stirring, cooling to 35 deg.C, inspecting, and discharging.
Table 1 eye-repair compositions of examples 1-5
Wherein, in the embodiment 1, the mass ratio of the hydrolytic yeast extract to the extract of the bark of the northern cedar to the caffeine silanol C is 1:100: 100;
in example 2, the mass ratio of the hydrolyzed yeast extract, the extract of the bark of Cedar Africa and the caffeine silanol C is 1:40: 200;
in example 3, the mass ratio of the hydrolyzed yeast extract, the extract of the bark of Cedar Africa, and the caffeine silanol C was 1:50: 200;
in example 4, the mass ratio of the hydrolyzed yeast extract, the extract of the bark of Cedar Africa, and the caffeine silanol C was about 1:50: 333;
in example 5, the mass ratio of the hydrolyzed yeast extract, the extract of the bark of Cedar, and the caffeine silanol C was about 1:83: 556.
Table 2 eye-repair compositions of examples 6-10
Wherein, in example 6, the mass ratio of the hydrolytic yeast extract to the extract of the bark of the northern cedar to the caffeine silanol C is 1:150: 1000;
in example 7, the mass ratio of the hydrolyzed yeast extract, the extract of the bark of Cedar Africa, and the caffeine silanol C was 1:150: 1000;
in example 8, the mass ratio of the hydrolyzed yeast extract, the extract of the bark of Cedar, and the caffeine silanol C was 1:187.5: 1250;
in example 9, the mass ratio of the hydrolyzed yeast extract, the extract of the bark of Cedar Africa, and the caffeine silanol C was 1:240: 1600;
in example 10, the mass ratio of the hydrolyzed yeast extract, the extract of northern cedar bark, and the caffeine silanol C was 1:187.5: 1500.
Comparative examples 1 to 7
According to the mass percentages of the components in the following table 3, the compositions for removing black eye and removing pouch of the comparative examples 1 to 7 are prepared according to the preparation methods of the examples 1 to 10.
TABLE 3 Ocular repair compositions of comparative examples 1-7
Performance testing
Detection method
80 subjects with deep black eye and large bags were screened and divided into 16 groups of 5 persons each, and women aged 25-50 years were used as trial subjects. The subjects were allowed to rest in a constant temperature and humidity environment (21. + -.1 ℃ C.) and humidity environment (50. + -.10)% and the same periocular skin (under-eye and eye lines) was selected as the measurement area, and the periocular skin (under-eye and eye lines) was measured twice a day in the morning and evening, about 0.2g each time, using a skin melanin and hemoglobin tester MDD4-Mexameter MX 18 and a skin rapid optical imaging system PRIMOS lite.
The above tests were carried out on the compositions of examples 1 to 10 of the present invention and the compositions of comparative examples 1 to 6. The subjects continued to use the product for 28 days according to the above requirements. The test was performed on day 0, 14 and 28, respectively, and the test procedure was repeated with the results averaged.
Second, analysis method
1. Determination of melanin: the skin was tested periocular (under the eye) using a skin melanin and heme tester MDD4-Mexameter MX 18. The instrument is based on the principle of spectral absorption, and the content of melanin and heme in skin is determined by measuring the reflection quantity of light with specific wavelength irradiated on the skin of a human body. The smaller the melanin number, the whiter the skin, and conversely, the darker the skin, as shown in Table 4 below.
TABLE 4
As can be seen from the results in Table 4, the black eye improvement tendency was improved in examples 1 to 10 as the mass percentage of the hydrolyzed yeast extract, the extract of North African cedar bark, and the caffeine silanol C in the formulation was increased. From example 4 and comparative examples 5-7, it is seen that the combination of the hydrolyzed yeast extract, the extract of Cedar bark, and the caffeine silanol C achieves an effect significantly better than that achieved by single or simple combination, and effects of lightening melanin and improving dark circles are achieved.
2. Testing of pouch volume: the skin fast optical imaging system PRIMOS lite detects the eye pouch volume. The smaller the value of the pouch volume, the smaller the pouch volume, and the results are shown in Table 5 below.
TABLE 5
As is clear from the results in Table 5, the improvement of the pouches was observed in examples 1 to 10 as the mass percentage of the hydrolyzed yeast extract, the extract of the bark of Cedrus deodara, and the caffeine silanol C in the formulation was increased. It is seen from example 4 and comparative examples 5-7 that the combination of the hydrolyzed yeast extract, the extract of Cedar bark, and the caffeine silanol C achieves an effect significantly better than that achieved by single or simple combination, and achieves the effects of reducing eye edema and lightening pouches.
The results prove that: as seen from example 4 and comparative examples 5 to 7, the hydrolyzed yeast extract, the extract of North Africa cedar bark, and caffeine silanol C are synergistic, and have excellent skin-lightening, dark under-eye and under-eye-bag improving properties. The eye circles and bags are obviously gradually reduced after the use for 14 days and 28 days, and the result is far better than that of a comparative example. The result shows that the composition for removing the black eye circles and the under-eye puffiness can provide quick and synergistic effects for improving the black eye circles and the under-eye puffiness.
Therefore, the composition of the present invention can improve the black eye and the pouch.
The above examples of the present invention are merely examples for clearly illustrating the present invention and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the claims of the present invention.
Claims (10)
1. An eye-care composition comprising the following components:
the yeast extract is hydrolyzed to obtain a hydrolyzed yeast extract,
extract of the bark of Cedrus deodara, and
caffeine silanol;
the content of the hydrolytic yeast extract is 0.0001-0.1%, the content of the northern non-cedar bark extract is 0.01-5%, and the content of the caffeine silanol is 0.01-20% based on the total mass of the eye repairing composition being 100%.
2. The eye-repairing composition according to claim 1, wherein said hydrolyzed yeast extract is contained in an amount of 0.0005% to 0.01%, said extract of the bark of Cedrus deodara is contained in an amount of 0.1% to 3%, and said caffeine silanol is contained in an amount of 0.5% to 18%, based on 100% by mass of said eye-repairing composition.
3. The eye-repairing composition according to claim 1 or 2, wherein said hydrolyzed yeast extract is contained in an amount of 0.001% to 0.008%, said north non cedar bark extract is contained in an amount of 0.5% to 2%, and said caffeine silanol is contained in an amount of 1% to 15% based on 100% by mass of the total eye-repairing composition.
4. The eye-rejuvenating composition according to any one of claims 1 to 3 wherein the mass ratio of the hydrolyzed yeast extract, the extract of Cedar bark and the caffeine silanol is from 1:10 to 1000:50 to 10000.
5. The ocular repair composition of any one of claims 1 to 4 further comprising one or a combination of two or more of a humectant, a chelating agent, a preservative, and a solvent; the addition amount of the humectant is 1-50% based on 100% of the total mass of the eye repairing composition; the addition amount of the chelating agent is 0.01-1%; the addition amount of the preservative is 0.1-1%, and the addition amount of the solvent is 13-95%.
6. The eye-rejuvenating composition according to claim 5 wherein the humectant comprises one or a combination of two or more of 1, 3-propanediol, propylene glycol, pentanediol, hexanediol, sorbitol, glycerol, dipropylene glycol, 1, 3-butanediol, trehalose, xylitol, erythritol, glyceryl polyether-26, β -glucan, methyl gluceth-20, methyl gluceth-10, erythrulose, biogum-1, betaine, rhamnose, oat β -glucan, acetyl chitosamine, polyethylene glycols, water-soluble fats and oils, water-soluble silicone oils and sodium hyaluronate.
7. The ocular repair composition of claim 5 or 6, wherein the chelating agent comprises EDTA-2Na and/or EDTA-4 Na; and/or
The antiseptic is one or more of p-hydroxyacetophenone, phenoxyethanol, chlorphenesin, sorbitan caprylate, benzyl alcohol, benzoic acid, gluconolactone, sodium benzoate, ethylhexyl glycerol, methyl hydroxybenzoate, and propyl hydroxybenzoate.
8. A method of preparing an ocular repair composition according to any one of claims 1 to 7 comprising the step of mixing the components of the ocular repair composition.
9. Use of an eye-rejuvenating composition according to any one of claims 1 to 7 for the preparation of an eye-care product; preferably, the eye care product is one of eye cream, eye gel, eye mask, eye essence and eye patch.
10. The use according to claim 9, wherein the eye-rejuvenating composition is added in an amount of from 1% to 90%.
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| CN106580762A (en) * | 2016-12-22 | 2017-04-26 | 广州睿森生物科技有限公司 | Skincare product composition with wrinkle smoothing and preventing effects, eye cream with wrinkle smoothing and preventing effects, and production method of eye cream |
| CN109602655A (en) * | 2018-12-25 | 2019-04-12 | 广州葆妍生物科技有限公司 | It is a kind of with it is crease-resistant, remove black eye, the composition for going eye pouch effect and its preparation method and application |
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