CN110664689A - Eye cream preparation with flexible nano-liposome as carrier and preparation method thereof - Google Patents

Abstract

The invention provides an eye cream preparation taking flexible nano-liposomes as a carrier and a preparation method thereof, wherein the eye cream preparation comprises the following components in percentage by mass, 20-80% of deionized water; 0.5-20% of phospholipid; 3-40% of ethanol; 0-5% of plant essential oil; 0.1 to 10 percent of emulsifier; 0.5 to 20 percent of antioxidant; 0.05-5% of polypeptide; 2-20% of a humectant; 1-20% of plant extract; 0.2 to 2 percent of preservative; 0.1 to 15 percent of thickening agent; 0-1% of essence; the sum of the mass fractions of the components is 100 percent. The invention not only forms a unique component formula aiming at various problems around eyes, but also utilizes the liposome to ensure the stability of active components, and invents the flexible nano liposome which is different from the prior rigid liposome, thereby better realizing the transdermal property of the liposome carrying effective components.

Description

Eye cream preparation with flexible nano-liposome as carrier and preparation method thereof

Technical Field

The invention belongs to the technical field of eye cream products, and particularly relates to an eye cream preparation taking flexible nano-liposomes as a carrier and a preparation method thereof.

Background

The skin around the eyes is weak, is more easily damaged by the external environment, and is one of the most aging parts. As such, consumers tend to be more concerned with eye care than other facial care, and demand for eye care products is also higher. People's functional needs on eye care products are multifaceted and comprehensive. Several important functional directions include 1. reduction of periocular wrinkles 2. reduction of periocular dry lines 3. amelioration of edema 4. amelioration of dark circles. The corresponding mechanism of action is also multi-directional with respect to the requirements of these functionalities. 1. The wrinkles around the eyes occur because collagen and elastic fibers in the dermis are insufficiently supplemented to become thin, the reticular supporting force is lost, the skin loses elasticity, and the skin is difficult to recover after being squeezed, so that the wrinkles are generated. 2. The skin around the eyes is only 0.07mm, has substantially no sebaceous glands distributed, and is therefore prone to lack of sufficient sebum to retain water, resulting in the appearance of dry wrinkles. The dry lines are not classified into different ages, and the young people are easy to have the dry lines. 3. The main causes of ocular edema are local or global poor blood circulation, poor metabolic capability, retention of water in the capillaries, and even infiltration into tissues, which causes edema. Modern living habits such as sedentary and no exercise, long-time watching of mobile phones and computers and the like are easy to cause insufficient blood circulation and eye edema. Also can not eliminate pathological edema caused by liver and kidney dysfunction. 4. The reasons for the black eye are more complex and diversified. The blood vessel type black eye is formed by reinforcing skin and increasing thickness because the skin of the eye is too thin and can not cover blood vessels. Pigmented black eye circles are due to pigmentation caused by sun exposure or overuse, and require a lightening type ingredient to improve pigmentation. Severe eye edema and bags are also prone to color aberration. In conclusion, the excellent eye cream needs to have multiple functions of moisturizing, brightening and whitening, resisting aging, promoting microcirculation, repairing thin epidermis and the like, and has higher requirements on the compounding of effective components. On the other hand, the skin around the eyes is thin and thin, so that sufficient active ingredients are not easy to absorb and retain, sebaceous glands and other glands are lacked, and the ingredients are not easy to permeate and absorb, so that good ingredients are matched with a delivery system which is beneficial to absorption, and the effect can be achieved to the maximum extent. Transdermal flexible nanoliposomes are just one optimal carrier of choice.

Liposomes are bilayer vesicles composed of phospholipids as the major material and were first discovered by british scientists to be structurally similar to biological membranes. In the last 70 th century, liposomes began to become drug carriers, and due to their advantages of biocompatibility, biodegradability, non-toxicity and non-immunogenicity, liposomes have rapidly developed as new pharmaceutical dosage forms, and more than ten liposome preparations have been on the market. In the studies of transdermal action, it has been shown that liposomes having a particle size of 20 to 200nm can be used as active carriers for topical application, penetrating into the epidermis of the living body by the intercellular route. The liposome has the advantages of skin penetration, and the functions of protecting light, heat and oxidation unstable effective components, maintaining activity and stability. In general, in order to maintain stability during storage and circulation in blood, a rigid design is generally adopted, but the design is not favorable for the liposome vesicle to enter deep cells of the skin through the stratum corneum gap.

Disclosure of Invention

In view of the above, the present invention aims to provide an eye cream preparation using a flexible nanoliposome as a carrier and a preparation method thereof, which can comprehensively solve the problems of moisturizing, anti-aging, fine wrinkle removal, dark eye circles, edema improvement, etc. of eye skin, and increase the long-term stability and permeability of active ingredients. The invention not only forms a unique component formula aiming at various problems around eyes, but also utilizes the liposome to ensure the stability of active components, and invents the flexible nano liposome which is different from the prior rigid liposome, thereby better realizing the transdermal property of the liposome carrying effective components.

In order to achieve the purpose, the technical scheme of the invention is realized as follows:

an eye cream preparation taking flexible nano-liposome as a carrier comprises the following components by mass percent, 20-80% of deionized water; 0.5-20% of phospholipid; 3-40% of ethanol; 0-5% of plant essential oil; 0.1 to 10 percent of emulsifier; 0.5 to 20 percent of antioxidant; 0.05-5% of polypeptide; 2-20% of a humectant; 1-20% of plant extract; 0.2 to 2 percent of preservative; 0.1 to 15 percent of thickening agent; 0-1% of essence; the sum of the mass fractions of the components is 100 percent.

Preferably, the cleaning agent comprises the following components, by mass, 20-80% of deionized water; 2% -6% of phospholipid; 5-15% of ethanol; 0.5-1% of plant essential oil; 2-5% of emulsifier; 2-5% of antioxidant; 0.5-2% of polypeptide; 6-10% of a humectant; 1-3% of plant extract; 0.5-1.5% of preservative; 5-10% of a thickening agent; 0-1% of essence; the sum of the mass fractions of the components is 100 percent.

Preferably, the phospholipid is one or more of egg yolk lecithin, soybean lecithin, hydrogenated soybean lecithin, distearoyl phosphatidylcholine, dipalmitoyl lecithin and dimyristoyl lecithin, and preferably egg yolk lecithin and/or hydrogenated soybean lecithin; the polypeptide is one or more than two of glutathione, palmitoyl tripeptide-5, nonapeptide-1, carnosine, hexapeptide, snake venom peptide, oligopeptide-1, human oligopeptide-1, oligopeptide-2, FGF and pentapeptide.

The ethanol is chemically pure ethanol, analytically pure ethanol, dealdehydized ethanol or denatured ethanol, preferably analytically pure ethanol.

Preferably, the plant essential oil is one or more than two of rose essential oil, lavender essential oil, jasmine essential oil, chamomile essential oil, bergamot essential oil, grapefruit essential oil, rosemary essential oil, basil essential oil, citronella essential oil, clary sage essential oil, mint essential oil, rose essential oil, tea tree essential oil, sandalwood essential oil, cypress essential oil, cedar essential oil and frankincense essential oil.

Preferably, the emulsifier is one or more of tween (sorbitan monolaurate) 20, tween 21, tween 40, tween 60, tween 61, tween 65, tween 80, tween 81, tween 85, sorbitan stearate 165, ceteareth PEG20, span (sorbitan monostearate) 20, span 60, span 80, castor oil polyoxyethylene (10/25/40/60/80/90) and poloxamer, and preferably one or more of tween 80, span 80, poloxamer and castor oil polyoxyethylene.

Preferably, the antioxidant is one or more of vitamin C, vitamin E, vitamin A and derivatives thereof, ergothioneine, caffeine, curcumin, tetrahydrocurcumin, beta-carotene, zinc, selenium and plant antioxidant; the plant antioxidant is one or more of rutin, resveratrol, green tea extract, phloretin, salidroside, anthocyanidin, procyanidine, flavone, red wine polyphenol, and grape polyphenol;

the humectant is one or more of butanediol, 1, 2-hexanediol, sodium polyglutamate, sodium hyaluronate, acetyl chitosamine, allantoin, ectoin, water-soluble olive oil, water-soluble lanolin, yeast extract, Tremella polysaccharide, glycerol, and amino acid.

Preferably, the plant extract is one or more of centella asiatica extract, polygonum cuspidatum root extract, scutellaria baicalensis root extract, glycyrrhiza glabra root extract, chamomile flower extract, rosemary leaf extract, ginkgo biloba leaf extract, citrus aurantium fruit extract, chamomile extract, green tea extract, silybum marianum extract, rose extract, arnica montana extract, licorice extract, purslane extract and guarana extract.

Preferably, the preservative is one or more than two of sodium benzoate, potassium sorbate, phenoxyethanol, nipagin ester, cason, benzyl alcohol, phenethyl alcohol and salicylic acid; the thickener is one or more of xanthan gum, carrageenan, carbomer, poloxamer, hydroxymethyl cellulose and hydroxyethyl cellulose, preferably phenoxyethanol.

The present invention also provides a method for preparing the eye cream preparation as described above, comprising the steps of,

1) mixing deionized water, water-soluble emulsifier, water-soluble antioxidant, polypeptide, water-soluble humectant and water-soluble plant extract, heating to 40-80 deg.C, and magnetically stirring at 100-. Keeping the temperature and stirring for 10-30 minutes continuously to obtain a water phase;

2) mixing phospholipid, ethanol, an alcohol-soluble emulsifier, an alcohol-soluble antioxidant, essential oil, an alcohol-soluble humectant, an alcohol-soluble plant extract and an alcohol-soluble essence, heating to the same temperature of the water phase in the step 1), and magnetically stirring or stirring with a stirring paddle at a speed of 600r/min for 100-; keeping the temperature and stirring for 10-30 minutes continuously to obtain an organic phase;

3) slowly injecting the mixed organic phase into the water phase, simultaneously keeping the temperature control at 30-80 ℃, rapidly mixing the two phases by magnetic stirring at the speed of 100-600r/min, stirring by a stirring paddle or high-speed shearing to form a liposome system, and continuously stirring for 2-30 minutes at the controlled temperature after the organic phase is completely injected to ensure the uniformity and stability of the system to obtain an emulsified phase;

4) homogenizing the emulsified phase into flexible nano liposome with average particle size below 100 nm and all particles below 150 nm, which is the initial finished product;

5) adding a proper amount of preservative and thickener into the initial finished product in the step 4), controlling the temperature to be 30-80 ℃, uniformly mixing at the speed of 100-600r/min to obtain a final product, and continuously controlling the temperature and uniformly mixing for more than 10 minutes to ensure that the final product is uniform and stable;

wherein, one or both of the water-soluble emulsifier and the alcohol-soluble emulsifier are optionally added, and when one of the water-soluble emulsifier and the alcohol-soluble emulsifier is not added, the corresponding step is not added; optionally adding one or both of water-soluble antioxidant and alcohol-soluble antioxidant, and when one of the water-soluble antioxidant and the alcohol-soluble antioxidant is not added, not adding the corresponding step; optionally adding one or both of the water-soluble humectant and the alcohol-soluble humectant, wherein when one of the water-soluble humectant and the alcohol-soluble humectant is not added, the corresponding step is not added; one or both of the water-soluble plant extract and the alcohol-soluble plant extract are optionally added, and when one of the water-soluble plant extract and the alcohol-soluble plant extract is not added, the corresponding step is not added.

The invention also provides the eye cream preparation using the flexible nano liposome as the carrier or the application of the eye cream prepared by the preparation method in the preparation of the eye cream or the eye cream product.

Since the skin around the eyes is weak and is only as thick as the facial skin 1/4, the use of heavy oily eye cream is liable to cause a burden, which aggravates the eye problems. The liposome is an aqueous matrix, has no mineral oil, vegetable oil or synthetic oil, and can supplement nutrition without causing burden. The skin around the eyes has almost no sebaceous glands and sweat glands, the common skin care product is more difficult to permeate, and the flexible nano liposome can enhance the transdermal absorption of nutrient substances. The eye cream of the present invention contains some components specific to the eye cream, such as plant extracts such as caffeine, guarana extract and horse chestnut extract.

Specifically, the flexible nanoliposome carrying caffeine or guarana extract (containing high-concentration caffeine) can permeate into the stratum corneum gaps around eyes, enhance metabolism and improve microcirculation, thereby improving the problems of dark circles and edema; the flexible nanometer liposome carrying horse chestnut extract (containing aescin) has effects of relieving edema, resisting exudation, protecting vascular wall permeability, and preventing hyaluronidase from decomposing proteoglycan, thereby improving edema and fine lines around eyes. Therefore, the invention can better absorb the effective components, has multiple functions of better moisturizing, resisting aging, removing dark eye circles, removing edema and the like, and achieves the full-effect nursing effect.

Compared with the prior art, the eye cream preparation taking the flexible nano liposome as the carrier and the preparation method thereof have the following advantages:

1. the invention relates to a multi-effect eye cream taking flexible nano-liposomes as a carrier, which takes a plurality of functions of moisturizing, anti-aging, removing dark eye circles, removing edema and the like into consideration from the formula of effective components so as to achieve the full-effect nursing effect. Meanwhile, the flexible nano liposome is innovatively adopted as a carrier of the active ingredients, so that transdermal delivery of the active ingredients can be realized, and the active ingredients which are easy to inactivate can be protected for a long time.

2. The finished product of the invention has stable properties, is white, light yellow, light brown, transparent or semitransparent liquid with certain viscosity, is stable and not layered after being heated and placed for 6 hours at 60 ℃, and is stable and not layered after being placed at room temperature and 4 ℃ for half a year. The product is fine and smooth in whole, does not precipitate granular insoluble substances, is easy to spread and coat uniformly on the skin, can be almost completely absorbed within minutes after being thinly coated, has no odor, and can have slight phospholipid peculiar smell or peculiar smell from plant extracts. The finished product is water-soluble as a whole, so that the finished product is light, thin, breathable and non-sticky, the flexible nano liposome can be absorbed by the skin, the skin can be moisturized for a long time, and the active ingredients are effectively released subcutaneously.

3. The finished product is an oil-in-water system, the liposome is a bilayer vesicle which is mainly composed of phospholipid, the whole system is a water phase, the bilayer is an organic phase or called an oil phase, and fat-soluble components are carried in the bilayer. The liposome vesicle is internally provided with a second water phase, and the water-soluble active ingredients are wrapped in the vesicle and released into subcutaneous cells along with the transdermal absorption and cell fusion processes of the vesicle to play various roles. An important characteristic of the finished product is that the average particle diameter of all the liposomes is not more than 100 nanometers, the particle diameter is not more than 150 nanometers, and only the flexible nanoliposomes which are less than the two standards can be absorbed into the subcutaneous part for playing a role through the intercellular spaces of the stratum corneum of 30 to 50 nanometers.

Drawings

FIG. 1 is a photographic image of the finished product of example 3;

the flexible nano liposome eye cream is a uniform liquid without layering, precipitation and semi-transparency;

FIG. 2 is a graph showing a particle size distribution in example 3;

the average particle diameter of the flexible nano liposome in the eye cream is 85 nanometers, the average particle diameter is between 70 nanometers and 100 nanometers, the distribution is concentrated and uniform, and the flexible nano liposome is a good nano dispersion system.

Detailed Description

Unless defined otherwise, technical terms used in the following examples have the same meanings as commonly understood by one of ordinary skill in the art to which the present invention belongs. The test reagents used in the following examples, unless otherwise specified, are all conventional biochemical reagents; the experimental methods are conventional methods unless otherwise specified.

The present invention will be described in detail with reference to examples.

Example one

Weighing and mixing 486g of deionized water, 2020 g of tween, 10g of caffeine, 15g of resveratrol, 2g of pentapeptide, 55g of glycerin and 10g of liquorice extract, heating to 40 ℃, and magnetically stirring at 300r/min until all components in the water phase are completely dissolved. Stirring for 30 minutes under constant temperature to form an aqueous phase. Mixing distearyl phosphatidyl choline 100g, anhydrous ethanol 150g, span 2011 g, retinol 5g, butanediol 50g, and flos Matricariae Chamomillae extract 10g, heating to 40 deg.C, and magnetically stirring at 600r/min until the components are completely dissolved. The mixture was stirred for 10 minutes with constant temperature to form an organic phase. Slowly injecting the mixed organic phase into the water phase, keeping the temperature controlled at 40 ℃, stirring and uniformly mixing the two phases by a 600r/min stirring paddle to form a liposome system, and continuously controlling the temperature and stirring for 10 minutes after the organic phase is completely injected to ensure that the system is uniform and stable to form an emulsified phase. The emulsion phase is further homogenized into an initial finished product by ultrasonic crushing and high-pressure mean value. Adding 10g of methyl hydroxybenzoate and 66g of xanthan gum into the initial finished product, controlling the temperature at 80 ℃, stirring and uniformly mixing by a stirring paddle at the speed of 100r/min to obtain a final product, and continuously controlling the temperature and uniformly mixing for more than 10 minutes to ensure uniformity and stability of the final product.

Example two

528g of deionized water, 8050 g of tween, 12g of poloxamer, 4g of red wine polyphenol, 12g of dipotassium glycyrrhizinate, 12g of oligopeptide, 1g of hexapeptide, 8g of tremella polysaccharide, 5g of sodium hyaluronate, 20g of sodium polyglutamate and 16g of arnica montana extract are weighed and mixed, heated to 60 ℃, stirred by a stirring paddle at 250r/min until all components in a water phase are completely dissolved. Stirring for 15 min under constant temperature to obtain water phase. Weighing and mixing 125g of soybean lecithin, 180g of denatured ethanol, 15g of green tea extract, 1g of clary sage essential oil and 5g of silybum marianum extract, heating to 60 ℃, and magnetically stirring at 150r/min until all the components are completely dissolved. The mixture was stirred for 30 minutes under constant temperature to form an organic phase. And slowly injecting the mixed organic phase into the water phase, keeping the temperature of 60 ℃, rapidly shearing at high speed, and rapidly mixing the two phases to form a liposome system, and continuously shearing at controlled temperature for 5 minutes after the organic phase is completely injected to ensure that the system is uniform and stable to form an emulsified phase. The emulsified phase is further homogenized by microfluidization to form a primary product. Adding 10g of phenoxyethanol and 6g of hydroxyethyl cellulose into the initial finished product, controlling the temperature to be 50 ℃, stirring by a stirring paddle at the speed of 500r/min, grinding by a colloid mill, uniformly mixing to obtain a final product, and continuously controlling the temperature to be uniformly mixed for more than 10 minutes to ensure the uniformity and stability of the final product.

EXAMPLE III

Weighing and mixing 520g of deionized water, 8048 g of tween, 20g of ascorbic acid, 5g of hexapeptide, 2g of glutathione, 5g of sodium hyaluronate, 20g of allantoin, 18g of ectoin, 50g of yeast extract, 35g of guarana extract and 10g of roselle extract, heating to 50 ℃, and magnetically stirring at 300r/min until all components in a water phase are completely dissolved. Stirring for 10 min under constant temperature to obtain water phase. Weighing and mixing yolk lecithin 100g, anhydrous ethanol 85g, span 805 g, lemon fruit essential oil 2g, herba Silybi Mariani extract 3g, herba Rosmarini officinalis extract 6g, and menthol 6g, heating to 50 deg.C, stirring with stirring paddle at 100r/min until all components are completely dissolved. The mixture was stirred for 20 minutes with constant temperature to form an organic phase. Slowly injecting the mixed organic phase into the water phase, simultaneously keeping the temperature control at 50 ℃, rapidly shearing at high speed and uniformly mixing the two phases to form a liposome system, and continuously shearing at the controlled temperature for 10 minutes after the organic phase is completely injected to ensure that the system is uniform and stable to form an emulsified phase. Homogenizing the emulsified phase with a high pressure homogenizer for 2 minutes to obtain a further homogenized product. Adding 10g of phenoxyethanol and 50g of carbomer into the initial finished product, controlling the temperature to be 60 ℃, uniformly grinding the mixture by using a colloid mill to obtain a final product, and continuously grinding the mixture for more than 10 minutes at a controlled temperature to ensure that the final product is uniform and stable.

The products obtained in the first to third examples were tested separately.

1. Macroscopically observing the finished product, wherein the initial state of the synthesis, the stable state after being heated and placed for 6 hours at 60 ℃, the stable state of the product after being placed for half a year at room temperature and 4 ℃ and the absorption state of the product on the skin are observed, and the results are shown in the following table 1.

TABLE 1

2. And (5) microscopic observation of a finished product.

The finished products obtained in the first to third embodiments are oil-in-water systems, wherein the liposome is a bilayer vesicle composed of phospholipids as main materials, the whole system is a water phase, the bilayer is an organic phase, or called an oil phase, and lipid-soluble components are carried in the bilayer. The liposome vesicle is internally provided with a second water phase, and the water-soluble active ingredients are wrapped in the vesicle and released into subcutaneous cells along with the transdermal absorption and cell fusion processes of the vesicle to play various roles.

The particle diameter distribution of the flexible nano-liposome is tested by using a Nicomp 380Z3000 nano-particle size instrument, and the result is shown in figure 2, which shows that the particle size of the product reaches the standard.

The diameters of the particles are shown in table 2.

TABLE 2

	Example one	Example two	EXAMPLE III
				Average diameter (nanometer)	97.8	105.1	85.3

Effect verification:

the eye cream of the third example is used by 10 testers with skin conditions to be improved around the eyes, the age range is 28-55 years, and the skin problems around the eyes comprise one or more of black eyes, loose eyes, dry wrinkles and edema. The composition is applied twice a day in the morning and evening with 1mL, and massaged by looping until absorption, and the effect is observed for 2 weeks. According to the feedback, 5 of 10 testers had black eye problems, and all the 5 testers are considered to have obvious improvement; among 10 subjects, 8 of them had a relaxation problem, 6 of them considered a significant improvement, and 2 of them considered no significant improvement; among 10 testers, 9 testers had the dry streak problem, 8 testers considered the obvious improvement, and 1 tester considered the little improvement; of the 10 subjects, 3 had edema problems, 2 had no significant improvement, and 1 had no significant improvement. All people think that the eye cream has fresh texture and is not sticky and is suitable for being used around eyes. In conclusion, the two-week effect test shows that the eye cream can obviously improve various skin undesirable conditions around the eyes, has fresh texture and good user compliance.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims (10)

1. An eye cream preparation taking flexible nano-liposome as a carrier is characterized in that: comprises the following components in percentage by mass, 20-80% of deionized water; 0.5-20% of phospholipid; 3-40% of ethanol; 0-5% of plant essential oil; 0.1 to 10 percent of emulsifier; 0.5 to 20 percent of antioxidant; 0.05-5% of polypeptide; 2-20% of a humectant; 1-20% of plant extract; 0.2 to 2 percent of preservative; 0.1 to 15 percent of thickening agent; 0-1% of essence; the sum of the mass fractions of the components is 100 percent.

2. The eye cream formulation using flexible nanoliposomes as carriers of claim 1, wherein: comprises the following components in percentage by mass, 20-80% of deionized water; 2% -6% of phospholipid; 5-15% of ethanol; 0.5-1% of plant essential oil; 2-5% of emulsifier; 2-5% of antioxidant; 0.5-2% of polypeptide; 6-10% of a humectant; 1-3% of plant extract; 0.5-1.5% of preservative; 5-10% of a thickening agent; 0-1% of essence; the sum of the mass fractions of the components is 100 percent.

3. The eye cream formulation using flexible nanoliposomes as carriers according to claim 1 or 2, wherein: the phospholipid is one or more of egg yolk lecithin, soybean lecithin, hydrogenated soybean lecithin, distearoyl phosphatidylcholine, dipalmitoyl lecithin and dimyristoyl lecithin, preferably egg yolk lecithin and/or hydrogenated soybean lecithin; the polypeptide is one or more than two of glutathione, palmitoyl tripeptide-5, nonapeptide-1, carnosine, hexapeptide, snake venom peptide, oligopeptide-1, human oligopeptide-1, oligopeptide-2, FGF and pentapeptide.

4. The eye cream formulation using flexible nanoliposomes as carriers according to claim 1 or 2, wherein: the plant essential oil is one or more of rose essential oil, lavender essential oil, jasmine essential oil, chamomile essential oil, bergamot essential oil, grapefruit essential oil, rosemary essential oil, basil essential oil, citronella essential oil, clary sage essential oil, mint essential oil, rose essential oil, tea tree essential oil, sandalwood essential oil, cypress essential oil, cedar essential oil and frankincense essential oil.

5. The eye cream formulation using flexible nanoliposomes as carriers according to claim 1 or 2, wherein: the emulsifier is one or more of tween (sorbitan monolaurate) 20, tween 21, tween 40, tween 60, tween 61, tween 65, tween 80, tween 81, tween 85, sorbitan stearate 165, ceteareth PEG20, span (sorbitan monostearate) 20, span 60, span 80, castor oil polyoxyethylene (10/25/40/60/80/90) and poloxamer, and preferably one or more of tween 80, span 80, poloxamer and castor oil polyoxyethylene.

6. The eye cream formulation using flexible nanoliposomes as carriers according to claim 1 or 2, wherein: the antioxidant is one or more of vitamin C, vitamin E, vitamin A and its derivatives, caffeine, ergothioneine, curcumin, tetrahydrocurcumin, beta-carotene, zinc, selenium, and plant antioxidant; the plant antioxidant is one or more of rutin, resveratrol, green tea extract, phloretin, salidroside, anthocyanidin, procyanidine, flavone, red wine polyphenol, and grape polyphenol;

the humectant is one or more of butanediol, 1, 2-hexanediol, sodium polyglutamate, sodium hyaluronate, acetyl chitosamine, allantoin, ectoin, water-soluble olive oil, water-soluble lanolin, yeast extract, Tremella polysaccharide, glycerol, and amino acid.

7. The eye cream formulation using flexible nanoliposomes as carriers according to claim 1 or 2, wherein: the plant extract is one or more of herba Centellae extract, rhizoma Polygoni Cuspidati extract, radix Scutellariae extract, radix Glycytthizae extract, flos Matricariae Chamomillae extract, herba Rosmarini officinalis leaf extract, folium Ginkgo extract, fructus Citri Junoris extract, flos Matricariae Chamomillae extract, green tea extract, herba Silybi Mariani extract, flos Rosae Rugosae extract, Arnica herb extract, radix Glycyrrhizae extract, herba Portulacae extract, and guarana extract.

8. The eye cream formulation using flexible nanoliposomes as carriers according to claim 1 or 2, wherein: the preservative is one or more than two of sodium benzoate, potassium sorbate, phenoxyethanol, nipagin ester, cason, benzyl alcohol, phenethyl alcohol and salicylic acid; the thickener is one or more of xanthan gum, carrageenan, carbomer, poloxamer, hydroxymethyl cellulose and hydroxyethyl cellulose.

9. A method of preparing an eye cream formulation according to any one of claims 1 to 8, wherein: comprises the following steps of (a) carrying out,

1) mixing deionized water, water-soluble emulsifier, water-soluble antioxidant, polypeptide, water-soluble humectant and water-soluble plant extract, heating to 40-80 deg.C, and magnetically stirring at 100-. Keeping the temperature and stirring for 10-30 minutes continuously to obtain a water phase;

2) mixing phospholipid, ethanol, an alcohol-soluble emulsifier, an alcohol-soluble antioxidant, essential oil, an alcohol-soluble humectant, an alcohol-soluble plant extract and an alcohol-soluble essence, heating to the same temperature of the water phase in the step 1), and magnetically stirring or stirring with a stirring paddle at a speed of 600r/min for 100-; keeping the temperature and stirring for 10-30 minutes continuously to obtain an organic phase;

3) slowly injecting the mixed organic phase into the water phase, simultaneously keeping the temperature control at 30-80 ℃, rapidly mixing the two phases by magnetic stirring at the speed of 100-600r/min, stirring by a stirring paddle or high-speed shearing to form a liposome system, and continuously stirring for 2-30 minutes at the controlled temperature after the organic phase is completely injected to ensure the uniformity and stability of the system to obtain an emulsified phase;

4) homogenizing the emulsified phase into flexible nano liposome with average particle size below 100 nm and all particles below 150 nm, which is the initial finished product;

5) adding a proper amount of preservative and thickener into the initial finished product in the step 4), controlling the temperature to be 30-80 ℃, uniformly mixing at the speed of 100-600r/min to obtain a final product, and continuously controlling the temperature and uniformly mixing for more than 10 minutes to ensure that the final product is uniform and stable;

wherein, one or both of the water-soluble emulsifier and the alcohol-soluble emulsifier are optionally added, and when one of the water-soluble emulsifier and the alcohol-soluble emulsifier is not added, the corresponding step is not added; optionally adding one or both of water-soluble antioxidant and alcohol-soluble antioxidant, and when one of the water-soluble antioxidant and the alcohol-soluble antioxidant is not added, not adding the corresponding step; optionally adding one or both of the water-soluble humectant and the alcohol-soluble humectant, wherein when one of the water-soluble humectant and the alcohol-soluble humectant is not added, the corresponding step is not added; one or both of the water-soluble plant extract and the alcohol-soluble plant extract are optionally added, and when one of the water-soluble plant extract and the alcohol-soluble plant extract is not added, the corresponding step is not added.

10. Use of the eye cream preparation with flexible nanoliposomes as carriers according to any one of claims 1 to 8 or the eye cream prepared by the preparation method according to claim 9 in the preparation of eye creams or eye cream products.

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