CN114917142A - Anti-wrinkle and dark eye circle removing essence and preparation method thereof - Google Patents

Anti-wrinkle and dark eye circle removing essence and preparation method thereof Download PDF

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CN114917142A
CN114917142A CN202210612104.2A CN202210612104A CN114917142A CN 114917142 A CN114917142 A CN 114917142A CN 202210612104 A CN202210612104 A CN 202210612104A CN 114917142 A CN114917142 A CN 114917142A
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wrinkle
black eye
eye
essence
black
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CN114917142B (en
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王小兰
谢智勇
邓昊
王圳
彭蕴
姜浩敏
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Renhe Quanyu Shanghai Great Health Research Institute Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/673Vitamin B group
    • A61K8/675Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/671Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/676Ascorbic acid, i.e. vitamin C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/005Preparations for sensitive skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18

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  • Cosmetics (AREA)

Abstract

The invention discloses an anti-wrinkle and dark eye circle removing essence and a preparation method thereof, wherein the essence comprises the following components in percentage by weight: 0.5-2% of black eye removing component A, 0.05-0.5% of black eye removing component B, 0.1-0.8% of black eye removing component C, 0.2-0.5% of thickening agent, 0.1-1.0% of hyaluronic acid, 0.1-1.0% of skin repair factor, 0.4-0.5% of preservative and the balance of deionized water. The essence prepared by the combination of the black eye removing component A, the black eye removing component B and the black eye removing component C can achieve the effect of synergistically enhancing the black eye removing effect, and has a very good removing effect on black circles caused by different mechanisms. In addition, the essence prepared by the invention also has a good anti-wrinkle effect.

Description

Anti-wrinkle and dark eye circle removing essence and preparation method thereof
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to an anti-wrinkle and dark eye circle removing essence and a preparation method thereof.
Background
Modern life rhythm is fast, and pressure is big, and young people like staying up night, the influence of natural environment, the radiation of sunlight reinforcing, the skin is easy to appear fine line, phenomenon such as black eye. The products for resisting wrinkles and removing black eyes are also popular among young people, the mechanisms of the black eyes are mainly classified into three types, namely pigment type, blood vessel type and structural type, and the black eyes are caused by a single mechanism or a compound mechanism.
In the existing products for removing dark circles, for example, patent document CN111759762A describes a composition for removing dark circles and an essence for removing dark circles, which comprises 0.2-1.0 part of elderberry extract, 0.1-0.6 part of bark extract of north african cedar, 0.01-0.07 part of hydrolyzed collagen, 0.04-0.2 part of methylsilanol mannitol ester, and 0.75-3.80 parts of sorbitol. The composition for removing dark eye circles can effectively improve the blood supply performance of blood vessels, improve the activity of skin cells and reduce pigmentation, thereby effectively removing dark eye circles, avoiding the formation of dark eye circles and keeping the elasticity and the compactness of skin. Patent document CN112190507A discloses a composition for removing dark circles and wrinkles containing poria cocos wolf extract, which describes that poria cocos wolf contains components such as polysaccharides, pachymic acid, ergosterol, lecithin, etc., and has an effect of improving skin sensitivity. Patent document CN111297764A describes a black eye removing composition prepared from rosemary extract, hydrolyzed prunus cerasifera, turmeric root extract, capsicum frutescens extract, glycyrrhiza glabra extract and nelumbo nucifera root extract, which can achieve a mild black eye removing effect and relieve the bad condition of eye skin by the combination of the components. However, the products have different black eye removing effects on different types of black eyes, and the black eye removing effects on the black eyes generated by the three mechanisms cannot be obvious.
Therefore, it is necessary to develop a universal black eye removal product, which has a significant effect of removing black eyes generated by different mechanisms.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide the anti-wrinkle and black eye circle removing essence and the preparation method thereof.
The purpose of the invention is realized by the following technical scheme:
in a first aspect, the invention provides an anti-wrinkle and dark eye circle removing essence which comprises the following components in percentage by weight:
Figure RE-GDA0003737255460000021
preferably, the black eye removing component A is at least one of nicotinamide and ascorbyl glucoside. The addition of the black eye removing component A mainly aims at the melanin precipitation around eyes caused by pigmented black eyes.
Preferably, the black eye removing component B is at least one of ginseng extract, horse chestnut extract and caffeine. The addition of the black eye removing component B is mainly aimed at local blood circulation disorder caused by blood vessel type black eye.
Preferably, the black eye removing component B is a ginseng extract, a horse chestnut extract and caffeine in a mass ratio of 2:1: 1.
Preferably, the black eye removing component C is peptide, palmitoyl tripeptide-5, palmitoyl pentapeptide-4 and retinol. The addition of the black eye removing component B mainly improves the condition of under-eye puffiness and black eyes caused by the loss of collagen; and it has very good anti-wrinkle effect.
Preferably, the mass ratio of the peptide, the palmitoyl tripeptide-5, the palmitoyl pentapeptide-4 and the retinol is 1-2:4-5:3-5: 10.
Preferably, the mass ratio of the peptide, the palmitoyl tripeptide-5, the palmitoyl pentapeptide-4 and the retinol is 2:4:4: 10.
Preferably, the retinol is added in the form of solubilized water-soluble retinol with a content of 50%.
Preferably, the skin repair factor is one or more of beta-glucan, allantoin, sodium PCA and hydroxyproline.
Preferably, the thickener is carboxymethyl cellulose;
the preservative is p-hydroxyacetophenone.
As a preferred scheme, the anti-wrinkle and black eye circle removing essence comprises the following components in percentage by weight:
Figure RE-GDA0003737255460000031
as a preferred scheme, the anti-wrinkle and black eye circle removing essence comprises the following components in percentage by weight:
Figure RE-GDA0003737255460000032
as a preferred scheme, the anti-wrinkle and black eye circle removing essence comprises the following components in percentage by weight:
Figure RE-GDA0003737255460000041
in a second aspect, the invention provides a preparation method of an anti-wrinkle and dark eye circle removing essence, which comprises the following steps:
s1, weighing the components according to the proportion of the components of the composition for removing the black eye circles;
s2, adding a thickening agent into deionized water, stirring uniformly, then sequentially adding a skin repair factor, hyaluronic acid and a preservative, heating to 80-85 ℃, and preserving heat for 20-40min after all components are fully dissolved;
s3, cooling the mixed emulsion obtained in the step S2 to 38-42 ℃, sequentially adding the black eye removing component A, the black eye removing component B and the black eye removing component C, and uniformly mixing and dissolving;
s4, cooling the mixed emulsion obtained in the step S3 to 28-32 ℃, and obtaining the anti-wrinkle and black eye circle removing essence.
Compared with the prior art, the invention has the following beneficial effects:
1. the essence prepared by the combination of the black eye removing component A, the black eye removing component B and the black eye removing component C can achieve the effect of synergistically enhancing the black eye removing effect, and has a very good removing effect on black circles caused by different mechanisms. In addition, the essence prepared by the invention also has a good anti-wrinkle effect.
2. The invention further selects the combination of the ginseng extract, the horse chestnut extract and the caffeine as the black eye removing component B, and selects the combination of the peptide, the palmitoyl tripeptide-5, the palmitoyl pentapeptide-4 and the retinol as the black eye removing component C, so that the black eye removing effect of the prepared essence is better.
Detailed Description
The present invention will be described in detail with reference to specific examples. The following examples will aid those skilled in the art in further understanding the present invention, but are not intended to limit the invention in any manner. It should be noted that variations and modifications can be made by persons skilled in the art without departing from the concept of the invention. All falling within the scope of the present invention.
The raw material components adopted in the embodiment of the invention are all commercially available raw materials; wherein the retinol is added as solubilized water-soluble retinol with the content of 50%.
Example 1
The present example provides an anti-wrinkle and black eye removal essence, and the raw material compositions and weight percentage contents are shown in table 1. The preparation method of the anti-wrinkle black eye removing essence comprises the following steps:
1) sequentially weighing black eye removing component A (nicotinamide, ascorbic acid glucoside), black eye removing component B (Ginseng radix extract, horse chestnut extract, caffeine), and black eye removing component C (peptide, palmitoyl tripeptide-5, palmitoyl pentapeptide-4, and retinol) according to the proportion of black eye removing component.
2) Adding carboxymethyl cellulose into deionized water, stirring, sequentially adding skin repair factor (beta-dextran), hyaluronic acid and p-hydroxyacetophenone, heating to 85 deg.C, dissolving the components completely, and keeping the temperature for half an hour.
3) Cooling to 40 ℃, adding the components of the component A without black eye circles, and stirring and dissolving uniformly; then adding the component B for removing the black eye, and stirring and dissolving uniformly; then adding the component C for removing the black eye, and mixing and dissolving uniformly.
4) Cooling to 30 ℃, and obtaining the anti-wrinkle and dark eye circle removing essence after passing inspection.
Example 2
The embodiment provides an anti-wrinkle and black eye circle removing essence, and the raw materials and the weight percentage content are shown in table 1. The preparation method of the anti-wrinkle and anti-blackeye essence is the same as that of example 1.
Example 3
The present example provides an anti-wrinkle and black eye removal essence, and the raw material compositions and weight percentage contents are shown in table 1. The anti-wrinkle and anti-blackeye essence is prepared in the same manner as in example 1.
Example 4
The embodiment provides an anti-wrinkle and black eye circle removing essence, and the raw materials and the weight percentage content are shown in table 1. The preparation method of the anti-wrinkle and anti-blackeye essence is the same as that of example 1.
Example 5
The embodiment provides an anti-wrinkle and black eye circle removing essence, and the raw materials and the weight percentage content are shown in table 1. The anti-wrinkle and anti-blackeye essence is prepared in the same manner as in example 1.
Example 6
The embodiment provides an anti-wrinkle and black eye circle removing essence, and the raw materials and the weight percentage content are shown in table 1. The preparation method of the anti-wrinkle and anti-blackeye essence is the same as that of example 1.
Example 7
The embodiment provides an anti-wrinkle and black eye circle removing essence, and the raw materials and the weight percentage content are shown in table 1. The anti-wrinkle and anti-blackeye essence is prepared in the same manner as in example 1.
Example 8
The embodiment provides an anti-wrinkle and black eye circle removing essence, and the raw materials and the weight percentage content are shown in table 1. The preparation method of the anti-wrinkle and anti-blackeye essence is the same as that of example 1.
Example 9
The present example provides an anti-wrinkle and black eye removal essence, and the raw material compositions and weight percentage contents are shown in table 1. The anti-wrinkle and anti-blackeye essence is prepared in the same manner as in example 1.
Example 10
The embodiment provides an anti-wrinkle and black eye circle removing essence, and the raw materials and the weight percentage content are shown in table 1. The anti-wrinkle and anti-blackeye essence is prepared in the same manner as in example 1.
TABLE 1
Figure RE-GDA0003737255460000061
Figure RE-GDA0003737255460000071
And (3) black eye removing efficacy verification:
30 subjects, which were 20 to 65 years old and had no history of skin disease and skin allergy, were selected, and had a black eye problem caused by at least one of pigmentary, vascular and structural causes.
The using method comprises the following steps: when a subject nurses skin in the early morning and at night, the similar products in the original skin care step are replaced by the test samples, and the essence liquids prepared in the embodiments 1 to 10 of the invention are used as the test samples and are uniformly smeared on the parts around eyes until being absorbed. The Skin around the eyes was examined using a colorimeter Skin-Glossimeter GL200 for 56 consecutive days before and after the test samples were used for 56 days.
Before each test, subjects should use a laboratory-supplied facial cleanser to cleanse their faces and then wait for 30 minutes in a resting waiting area at a temperature of 21 + -1 deg.C and a relative humidity of 50 + -5% RH.
The ITA ° values (calculated from L and b measured by colorimeter) test results are shown in table 2. The higher the ITA degree value is measured, the brighter and whiter the skin color is, and the better the black eye removing effect is; otherwise, the darker the skin, the worse the black eye circle removing effect. The rates of change in table 2 refer to: (ITA-values after use of samples-ITA-values before use of samples)/ITA-values before use of samples × 100%
TABLE 2 ITA-value results of periocular skin
Figure RE-GDA0003737255460000072
Figure RE-GDA0003737255460000081
As can be seen from the results of table 2 above, in example 4, compared with example 2, the ITA ° value change rate of example 4 is smaller than that of example 2 due to the absence of horse chestnut extract, i.e., the black eye removal effect of example 4 is worse than that of example 2; examples 5 and 6 compared with example 2, the content ratios of ginseng extract, horse chestnut extract and caffeine were adjusted, resulting in that the ITA ° value change rates of examples 5 and 6 were all less than example 2, i.e. the black eye removal effects of examples 5 and 6 were also inferior to example 2. The results of examples 4-6 and example 2 demonstrate that ginseng extract, horse chestnut extract and caffeine, formulated in a black eye removing composition B in specific amounts, exert a synergistic effect to further improve the black eye removing effect.
As can be seen from the results of table 2 above, examples 7 and 8 adjusted the content ratios of victimide, palmitoyl tripeptide-5, palmitoyl pentapeptide-4 and retinol compared to example 1, resulting in a smaller rate of change in ITA ° values than example 1 for examples 7 and 8, i.e., the black eye removing effect is worse for examples 7 and 8 than for example 1; example 9 compared to example 1, the ITA ° value change rate of example 9 was less than that of example 1 due to no peptide addition, i.e., the black eye removal effect of example 9 was also worse than that of example 1; example 10 compared to example 1, the use of palmitoyl tetrapeptide-7 instead of palmitoyl tripeptide-5 resulted in example 10 having an ITA ° value change rate less than that of example 1, i.e., example 10 also had a poorer black eye removal effect than example 1. The results of examples 7 to 10 and example 1 show that the combination C for removing dark circles can exert a synergistic effect by using peptides, palmitoyl tripeptide-5, palmitoyl pentapeptide-4 and retinol as the combination C for removing dark circles and further using a specific content ratio to further improve the effect of removing dark circles.
Feedback on use of partial subject cases
In a certain plum, a woman in 28 years old has a long-term overnight habit, so that the black eye circles are obvious, and after the anti-wrinkle and black eye circle removing essence prepared in the embodiment 1 of the invention is used for 30 days, the black eye circle removing effect is obvious.
For a woman in 55 years old, the periphery of the eyes of the woman has obvious black eyes caused by melanin deposition, and after 45 days of the anti-wrinkle and black eye removing essence prepared in the embodiment 1 of the invention, the melanin begins to obviously fade, fine lines of the eyes are reduced, and the black eye removing effect is obvious.
After the anti-wrinkle and black eye removal essence prepared in the embodiment 1 of the invention is used for 56 days, the eye bags are obviously improved, the melanin is obviously lightened, and the black eye removal effect is obvious.
And (3) verification of anti-aging efficacy:
the subject is a healthy female subject of 25-55 years of age.
The using method comprises the following steps: the skin care product is used in the morning and evening, the similar products in the original skin care step are replaced by the test samples, and a proper amount of the test samples (essence prepared by the embodiments and the comparative examples of the invention) are taken and evenly smeared on the parts around the eyes until the absorption. For 56 consecutive days, skin wrinkle analysis was performed using VISIA-CR before, 11 days after, 28 days after, and 56 days after each test sample was used. Before each test, subjects should use a laboratory-supplied facial cleanser to cleanse their faces and then wait for 30 minutes in a resting waiting area at a temperature of 21 + -1 deg.C and a relative humidity of 50 + -5% RH.
The detection results of canthus wrinkles are shown in table 3. Wherein the rate of change refers to: (test value after using sample-test value before using sample)/test value before using sample X100%
TABLE 3 canthus wrinkle area detection results
Figure RE-GDA0003737255460000101
The detection results in table 3 show that the essence prepared by the invention can reduce the wrinkle area of the eye corner by 9.25-11.48% after being used for 56 days, which indicates that the essence has a certain anti-wrinkle effect.
The invention has many applications and the above description is only a preferred embodiment of the invention. It should be noted that the above examples are only for illustrating the present invention, and are not intended to limit the scope of the present invention. It will be apparent to those skilled in the art that various modifications can be made without departing from the spirit of the invention, and these modifications should be construed as within the scope of the invention.

Claims (10)

1. The anti-wrinkle and dark eye circle removal essence is characterized by comprising the following components in percentage by weight:
Figure FDA0003672276640000011
2. the anti-wrinkle and anti-black eye essence according to claim 1, wherein the black eye component A is at least one of niacinamide and ascorbyl glucoside.
3. The anti-wrinkle and black eye removal essence according to claim 1, wherein the black eye removal component B is at least one of ginseng extract, horse chestnut extract and caffeine.
4. The essence with the effects of resisting wrinkles and removing black eyes as claimed in claim 3, wherein the component B with the effect of removing black eyes is ginseng extract, horse chestnut extract and caffeine in a mass ratio of 2:1: 1.
5. The anti-wrinkle and anti-dark-eye essence according to claim 1, wherein the dark-eye component C is vicpetide, palmitoyl tripeptide-5, palmitoyl pentapeptide-4 and retinol.
6. The anti-wrinkle and black eye removal essence according to claim 5, wherein the mass ratio of the peptide, the palmitoyl tripeptide-5, the palmitoyl pentapeptide-4 and the retinol is 1-2:4-5:3-5: 10.
7. The anti-wrinkle and anti-dark eye essence according to claim 6, wherein the mass ratio of the victimide, the palmitoyl tripeptide-5, the palmitoyl pentapeptide-4 and the retinol is 2:4:4: 10.
8. The anti-wrinkle and anti-dark-eye-circle essence according to claim 1, wherein the skin repair factor is one or more of beta-glucan, allantoin, sodium PCA and hydroxyproline.
9. The anti-wrinkle and anti-dark-eye essence according to claim 1, wherein the thickener is carboxymethyl cellulose;
the preservative is p-hydroxyacetophenone.
10. The preparation method of the anti-wrinkle and black eye removal essence according to any one of claims 1 to 8, comprising the following steps of:
s1, weighing each component according to the proportion of each component of the composition for removing the black eye;
s2, adding a thickening agent into deionized water, stirring uniformly, then sequentially adding a skin repair factor, hyaluronic acid and a preservative, heating to 80-85 ℃, and preserving heat for 20-40min after all components are fully dissolved;
s3, cooling the mixed emulsion obtained in the step S2 to 38-42 ℃, sequentially adding the black eye removing component A, the black eye removing component B and the black eye removing component C, and uniformly mixing and dissolving;
s4, cooling the mixed emulsion obtained in the step S3 to 28-32 ℃ to obtain the anti-wrinkle and black eye circle removing essence.
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CN109276509A (en) * 2018-12-18 2019-01-29 珠海水信生物科技有限公司 A kind of compact eye cream of multiple-effect
CN110151632A (en) * 2019-06-26 2019-08-23 广东芭薇生物科技股份有限公司 A kind of cosmetic composition and preparation method thereof for nursing eye skin
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