CN111631977A - Children eye cream based on quinoa peptide and preparation method thereof - Google Patents
Children eye cream based on quinoa peptide and preparation method thereof Download PDFInfo
- Publication number
- CN111631977A CN111631977A CN202010405347.XA CN202010405347A CN111631977A CN 111631977 A CN111631977 A CN 111631977A CN 202010405347 A CN202010405347 A CN 202010405347A CN 111631977 A CN111631977 A CN 111631977A
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- Prior art keywords
- quinoa
- parts
- eye cream
- peptide
- children
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- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims abstract description 36
- 239000002994 raw material Substances 0.000 claims abstract description 29
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- 108010007119 flavourzyme Proteins 0.000 claims description 7
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical compound C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 claims description 7
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 7
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 6
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- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims description 4
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 3
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- 235000005473 carotenes Nutrition 0.000 abstract description 3
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
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- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to the technical field of skin care product manufacturing, in particular to a quinoa peptide-based eye cream for children and a preparation method thereof, wherein the raw material components of the eye cream comprise quinoa, vitamin E, vitamin A, curcumin, coenzyme Q10, an emulsifier, a humectant, a stabilizer and a lipid solvent, wherein the lipid solvent is a lipid mixture prepared by mixing glycerol, silicone oil and horse oil according to a ratio of 5-7: 2-3: 1, and the humectant is a mixture prepared by mixing physiological lipid, propylene glycol and vaseline according to a ratio of 2:1: 6; according to the children eye cream provided by the invention, 70% -80% of free radicals around eyes can be removed by utilizing the small molecular peptides of quinoa proteolysis and the produced eye cream, and the oxidation problem of inflammatory cells of the free radicals around the eyes is solved to the maximum extent by compounding materials such as carotene, vitamin E, vitamin A curcumin and the like, so that the effect of improving the problem of the visual deterioration of the eyes of children is achieved.
Description
Technical Field
The invention relates to the technical field of skin care product manufacturing, and particularly relates to quinoa peptide-based children eye cream and a preparation method thereof.
Background
In recent years, the eyesight of children is on the decline trend under the influence of the screen of a television, a computer and a mobile phone. The damage of blue light by the screen and the generation of free radicals are the main causes of vision deterioration. The attack of free radicals on the human body is first initiated by the cell membrane. The cell membrane is very elastic and flexible, which is determined by its loose chemical structure, and because of this, its electrons are easily lost, and thus the cell membrane is very vulnerable to free radical attack. Once electrons are abstracted by free radicals, the cell membrane loses elasticity and loses function. The damage caused by free radical attack on cells is mainly the oxidation of lipids: if lipid on the cell membrane is oxidized, the cell membrane is changed in a circulating way, and nutrients cannot enter the cell to cause cell necrosis. If the cell membrane is destroyed at a rate greater than the rate of cell regeneration, the function of the tissue and organ is affected and aging occurs. Attack protein, make protein lose function, or form macromolecule, and even break, cause pathological changes. Collagen tissue occurring under the skin can cause the skin to lose elasticity and the muscles and bones to be stiff. Furthermore, oxidative stress caused by free radicals may also cause inflammation.
The quinoa is rich in plant protein, and by decomposing the quinoa protein contained in the quinoa into quinoa peptide, the micromolecule protein polypeptide can promote the synthesis of collagen in skin cells, so that the problem of oxidizing free radical inflammatory cells around eyes can be solved.
Disclosure of Invention
Aiming at the problems, the invention provides the children eye cream based on the quinoa peptide and the preparation method thereof, 70-80% of free radicals around eyes can be eliminated by utilizing the quinoa proteolytic small molecular peptide and the produced eye cream, and the oxidation problem of inflammatory cells of the free radicals around the eyes is solved to the maximum extent by compounding carotene, vitamin E, vitamin A, curcumin and other materials, so that the effect of improving the visual deterioration problem of the eyes of children is achieved.
In order to achieve the purpose, the invention is realized by the following technical scheme:
the children eye cream based on the quinoa peptide comprises the following raw material components in parts by weight: 70-95 parts of quinoa, 7-15 parts of vitamin E, 7-15 parts of vitamin A, 6-16 parts of curcumin, 108-20 parts of coenzyme Q, 5-12 parts of an emulsifier, 13-26 parts of a humectant, 4-9 parts of a stabilizer, 35-50 parts of a lipid solvent and the balance of water.
Preferably, the lipid solvent is a lipid mixture prepared by blending glycerol, silicone oil and horse oil according to the proportion of 5-7: 2-3: 1.
Preferably, the humectant is a mixture prepared by mixing physiological lipid, propylene glycol and vaseline at a ratio of 2:1:6, wherein the physiological lipid can be one or more of nicotinamide, cholesterol, ceramide and free fatty acid.
Preferably, the stabilizer is a mixture prepared from sodium lactate, stearic acid and imidazoline.
Preferably, the emulsifier is any one of fatty acid soap, lecithin, acacia, sodium alkyl benzene sulfonate or tween 80.
Further, the specific method for preparing the quinoa peptide from the quinoa raw material comprises the following steps:
a: cleaning quinoa raw materials, grinding the cleaned quinoa raw materials to 60-120 meshes by using a grinder, and then pouring quinoa powder into clear water with the weight ratio of 4-6 times to soak for 2 hours;
b: adding mixed enzyme into the quinoa powder solution, adjusting the pH of the solution to 6-8, raising the temperature of the solution to 45-55 ℃, and carrying out enzymolysis reaction for 60-100 min under slow stirring;
c: after enzymolysis, raising the temperature of the solution to 90-95 ℃ to carry out inactivation reaction on the enzyme for 10min, cooling the solution, and filtering the solution by using a polysulfone roll-type ultrafiltration membrane under 0.3MPa to obtain chenopodium quinoa ultrafiltrate;
d: placing the quinoa ultrafiltrate into a spray dryer, and carrying out atomization drying on the filtrate by using a pressure spray drying method to finally obtain dry powder, namely the quinoa peptide powder.
Preferably, the addition amount of the enzyme in the enzymolysis process in the step b is 3-6% of the weight of the quinoa wheat flour, wherein the mixed enzyme is a double-enzyme preparation consisting of papain and flavourzyme.
Further, the preparation method of the quinoa peptide-based children eye cream comprises the following steps:
s1: vitamin E, vitamin A, curcumin and coenzyme Q10 in parts by weight are stirred and dispersed in a lipid solvent by a dispersion machine at 35 ℃;
s2: uniformly stirring and dissolving quinoa peptide powder prepared from quinoa in a deionized water solution with the weight ratio of 3-5 times at normal temperature;
s3: putting the products obtained in S1 and S2, an emulsifier, a humectant, a stabilizer and a proper amount of water into a high-viscosity vacuum mixing stirrer, and organically mixing the materials under a vacuum condition;
s4: and keeping the temperature in the stirring tank at 42-50 ℃ and continuously stirring for 3h, and fully stirring and mixing to obtain a product, namely the quinoa peptide eye cream for children.
Compared with the prior art, the invention has the following beneficial effects:
the children eye protection cream provided by the invention can remove 70% -80% of free radicals around eyes by utilizing the small molecular peptide of quinoa proteolysis and the produced eye protection cream, and can solve the problem of oxidation of inflammatory cells of free radicals around eyes to the maximum extent by compounding materials such as carotene, vitamin E, vitamin A curcumin and the like, and the humectant component consisting of physiological lipid, propylene glycol and vaseline is added in the components, so that the moisturizing effect on the skin of eyes can be enhanced, and the water loss of the stratum corneum of the skin can be reduced. The effects of anti-inflammation, anti-allergy and aging slowing of skin cells are realized by eliminating and reducing free radicals, so that the effect of improving the visual deterioration of the eyes of children is achieved.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1:
the children eye cream based on the quinoa peptide comprises the following raw material components in parts by weight: 70 parts of quinoa, 7 parts of vitamin E, 15 parts of vitamin A, 16 parts of curcumin, 109 parts of coenzyme Q, 5 parts of an emulsifier, 13 parts of a humectant, 9 parts of a stabilizer, 50 parts of a lipid solvent and the balance of water.
Wherein the lipid solvent is a lipid mixture prepared by mixing glycerol, silicone oil and horse oil according to the proportion of 7:2: 1.
The humectant is a mixture prepared by mixing physiological lipid, propylene glycol and vaseline according to the proportion of 2:1:6, wherein the physiological lipid is a mixed component consisting of nicotinamide and cholesterol.
Wherein the stabilizer is a mixture prepared from sodium lactate, stearic acid and imidazoline.
Wherein the emulsifier is fatty acid soap.
The specific method for preparing the quinoa peptide from the quinoa raw material comprises the following steps:
a: cleaning quinoa raw materials, grinding the cleaned quinoa raw materials to 80 meshes by using a grinder, and then pouring the quinoa powder into clear water with the weight ratio of 5 times to soak the quinoa powder for 2 hours;
b: adding mixed enzyme into quinoa powder solution, adjusting pH of the solution to 7, raising the temperature of the solution to 45 deg.C, and performing enzymolysis reaction for 75min under slow stirring;
c: after the enzymolysis is finished, raising the temperature of the solution to 90 ℃ to carry out inactivation reaction on the enzyme for 10min, and filtering the solution by utilizing a polysulfone roll-type ultrafiltration membrane under 0.3MPa after the solution is cooled to obtain chenopodium quinoa ultrafiltrate;
d: placing the quinoa ultrafiltrate into a spray dryer, and carrying out atomization drying on the filtrate by using a pressure spray drying method to finally obtain dry powder, namely the quinoa peptide powder.
Preferably, the addition amount of the enzyme in the enzymolysis process of the step b is 3 percent of the weight of the quinoa wheat flour, wherein the mixed enzyme is a double-enzyme preparation consisting of papain and flavourzyme.
Further, the preparation method of the quinoa peptide-based children eye cream comprises the following steps:
s1: vitamin E, vitamin A, curcumin and coenzyme Q10 in parts by weight are stirred and dispersed in a lipid solvent by a dispersion machine at 35 ℃;
s2: uniformly stirring quinoa peptide powder prepared from quinoa at normal temperature and dissolving in deionized water solution with weight ratio of 4 times;
s3: putting the products obtained in S1 and S2, an emulsifier, a humectant, a stabilizer and a proper amount of water into a high-viscosity vacuum mixing stirrer, and organically mixing the materials under a vacuum condition;
s4: and keeping the temperature in the stirring tank at 42 ℃ and continuously stirring for 3h, and fully stirring and mixing to obtain a product, namely the quinoa peptide eye cream for children.
Example 2:
the children eye cream based on the quinoa peptide comprises the following raw material components in parts by weight: 95 parts of quinoa, 12 parts of vitamin E, 14 parts of vitamin A, 16 parts of curcumin, 1012 parts of coenzyme Q, 5 parts of an emulsifier, 13 parts of a humectant, 9 parts of a stabilizer, 50 parts of a lipid solvent and the balance of water.
Wherein the lipid solvent is a lipid mixture prepared by mixing glycerol, silicone oil and horse oil according to the proportion of 7:3: 1.
The humectant is a mixture prepared by mixing physiological lipid, propylene glycol and vaseline according to the ratio of 2:1:6, wherein the physiological lipid is free fatty acid.
Wherein the stabilizer is a mixture prepared from sodium lactate, stearic acid and imidazoline.
Wherein the emulsifier is sodium alkyl benzene sulfonate.
The specific method for preparing the quinoa peptide from the quinoa raw material comprises the following steps:
a: cleaning quinoa raw materials, grinding the cleaned quinoa raw materials to 60 meshes by using a grinder, and then pouring the quinoa powder into clear water with the weight ratio of 4 times to soak the quinoa powder for 2 hours;
b: adding mixed enzyme into quinoa powder solution, adjusting pH of the solution to 6, raising the temperature of the solution to 45 deg.C, and performing enzymolysis reaction for 60min under slow stirring;
c: after the enzymolysis is finished, raising the temperature of the solution to 90 ℃ to carry out inactivation reaction on the enzyme for 10min, and filtering the solution by utilizing a polysulfone roll-type ultrafiltration membrane under 0.3MPa after the solution is cooled to obtain chenopodium quinoa ultrafiltrate;
d: placing the quinoa ultrafiltrate into a spray dryer, and carrying out atomization drying on the filtrate by using a pressure spray drying method to finally obtain dry powder, namely the quinoa peptide powder.
Preferably, the enzyme is added in an amount of 5% by weight of the quinoa flour in the enzymolysis process in the step b, wherein the mixed enzyme is a double-enzyme preparation consisting of papain and flavourzyme.
Further, the preparation method of the quinoa peptide-based children eye cream comprises the following steps:
s1: vitamin E, vitamin A, curcumin and coenzyme Q10 in parts by weight are stirred and dispersed in a lipid solvent by a dispersion machine at 35 ℃;
s2: uniformly stirring quinoa peptide powder prepared from quinoa at normal temperature and dissolving in deionized water solution with the weight ratio of 3 times;
s3: putting the products obtained in S1 and S2, an emulsifier, a humectant, a stabilizer and a proper amount of water into a high-viscosity vacuum mixing stirrer, and organically mixing the materials under a vacuum condition;
s4: and keeping the temperature in the stirring tank at 46 ℃ and continuously stirring for 3h, and fully stirring and mixing to obtain a product, namely the quinoa peptide eye cream for children.
Example 3:
the children eye cream based on the quinoa peptide comprises the following raw material components in parts by weight: 80 parts of quinoa, 12 parts of vitamin E, 10 parts of vitamin A, 6 parts of curcumin, 1011 parts of coenzyme Q, 12 parts of emulsifier, 13 parts of humectant, 7 parts of stabilizer, 45 parts of lipid solvent and the balance of water.
Wherein the lipid solvent is a lipid mixture prepared by mixing glycerol, silicone oil and horse oil according to the proportion of 6:3: 1.
The humectant is a mixture prepared by mixing physiological lipid, propylene glycol and vaseline according to the proportion of 2:1:6, wherein the physiological lipid is a mixed component consisting of ceramide and free fatty acid.
Wherein the stabilizer is a mixture prepared from sodium lactate, stearic acid and imidazoline.
Wherein the emulsifier is lecithin.
The specific method for preparing the quinoa peptide from the quinoa raw material comprises the following steps:
a: cleaning quinoa raw materials, grinding the cleaned quinoa raw materials to 80 meshes by using a grinder, and then pouring the quinoa powder into clear water with the weight ratio of 6 times to soak for 2 hours;
b: adding mixed enzyme into quinoa powder solution, adjusting pH of the solution to 8, raising the temperature of the solution to 45 deg.C, and performing enzymolysis reaction for 70min under slow stirring;
c: after the enzymolysis is finished, raising the temperature of the solution to 90 ℃ to carry out inactivation reaction on the enzyme for 10min, and filtering the solution by utilizing a polysulfone roll-type ultrafiltration membrane under 0.3MPa after the solution is cooled to obtain chenopodium quinoa ultrafiltrate;
d: placing the quinoa ultrafiltrate into a spray dryer, and carrying out atomization drying on the filtrate by using a pressure spray drying method to finally obtain dry powder, namely the quinoa peptide powder.
Preferably, the addition amount of the enzyme in the enzymolysis process of the step b is 3 percent of the weight of the quinoa wheat flour, wherein the mixed enzyme is a double-enzyme preparation consisting of papain and flavourzyme.
Further, the preparation method of the quinoa peptide-based children eye cream comprises the following steps:
s1: vitamin E, vitamin A, curcumin and coenzyme Q10 in parts by weight are stirred and dispersed in a lipid solvent by a dispersion machine at 35 ℃;
s2: uniformly stirring quinoa peptide powder prepared from quinoa at normal temperature and dissolving in deionized water solution with the weight ratio of 5 times;
s3: putting the products obtained in S1 and S2, an emulsifier, a humectant, a stabilizer and a proper amount of water into a high-viscosity vacuum mixing stirrer, and organically mixing the materials under a vacuum condition;
s4: and keeping the temperature in the stirring tank at a constant temperature of 50 ℃, continuously stirring for 3h, and fully stirring and mixing to obtain a product, namely the quinoa peptide eye cream for children.
Example 4:
the children eye cream based on the quinoa peptide comprises the following raw material components in parts by weight: 75 parts of quinoa, 15 parts of vitamin E, 12 parts of vitamin A, 14 parts of curcumin, 1016 parts of coenzyme Q, 12 parts of an emulsifier, 17 parts of a humectant, 9 parts of a stabilizer, 46 parts of a lipid solvent and the balance of water.
Wherein the lipid solvent is a lipid mixture prepared by mixing glycerol, silicone oil and horse oil according to the proportion of 7:3: 1.
The humectant is a mixture prepared by mixing physiological lipid, propylene glycol and vaseline according to the proportion of 2:1:6, wherein the physiological lipid is a mixed component consisting of nicotinamide and free fatty acid.
Wherein the stabilizer is a mixture prepared from sodium lactate, stearic acid and imidazoline.
Wherein the emulsifier is Tween 80.
The specific method for preparing the quinoa peptide from the quinoa raw material comprises the following steps:
a: cleaning quinoa raw materials, grinding the cleaned quinoa raw materials to 100 meshes by using a grinding machine, and then pouring quinoa powder into clear water with the weight ratio of 4 times to soak the quinoa powder for 2 hours;
b: adding mixed enzyme into quinoa powder solution, adjusting pH of the solution to 6, raising the temperature of the solution to 45 deg.C, and performing enzymolysis reaction for 60min under slow stirring;
c: after the enzymolysis is finished, raising the temperature of the solution to 90 ℃ to carry out inactivation reaction on the enzyme for 10min, and filtering the solution by utilizing a polysulfone roll-type ultrafiltration membrane under 0.3MPa after the solution is cooled to obtain chenopodium quinoa ultrafiltrate;
d: placing the quinoa ultrafiltrate into a spray dryer, and carrying out atomization drying on the filtrate by using a pressure spray drying method to finally obtain dry powder, namely the quinoa peptide powder.
Preferably, the addition amount of the enzyme in the enzymolysis process of the step b is 3 percent of the weight of the quinoa wheat flour, wherein the mixed enzyme is a double-enzyme preparation consisting of papain and flavourzyme.
Further, the preparation method of the quinoa peptide-based children eye cream comprises the following steps:
s1: vitamin E, vitamin A, curcumin and coenzyme Q10 in parts by weight are stirred and dispersed in a lipid solvent by a dispersion machine at 35 ℃;
s2: uniformly stirring quinoa peptide powder prepared from quinoa at normal temperature and dissolving in deionized water solution with the weight ratio of 3 times;
s3: putting the products obtained in S1 and S2, an emulsifier, a humectant, a stabilizer and a proper amount of water into a high-viscosity vacuum mixing stirrer, and organically mixing the materials under a vacuum condition;
s4: and keeping the temperature in the stirring tank at 46 ℃ and continuously stirring for 3h, and fully stirring and mixing to obtain a product, namely the quinoa peptide eye cream for children.
Example 5:
the children eye cream based on the quinoa peptide comprises the following raw material components in parts by weight: 77 parts of quinoa, 7 parts of vitamin E, 9 parts of vitamin A, 12 parts of curcumin, 1015 parts of coenzyme Q, 5 parts of emulsifier, 26 parts of humectant, 9 parts of stabilizer, 48 parts of lipid solvent and the balance of water.
Wherein the lipid solvent is a lipid mixture prepared by mixing glycerol, silicone oil and horse oil according to the proportion of 5:2: 1.
The humectant is a mixture prepared by mixing physiological lipid, propylene glycol and vaseline at a ratio of 2:1:6, wherein the physiological lipid is ceramide.
Wherein the stabilizer is a mixture prepared from sodium lactate, stearic acid and imidazoline.
Wherein the emulsifier is acacia gum.
The specific method for preparing the quinoa peptide from the quinoa raw material comprises the following steps:
a: cleaning quinoa raw materials, grinding the cleaned quinoa raw materials to 90 meshes by using a grinding machine, and then pouring quinoa powder into clear water with the weight ratio of 6 times to soak for 2 hours;
b: adding mixed enzyme into the quinoa powder solution, adjusting the pH of the solution to 6-8, raising the temperature of the solution to 55 ℃, and carrying out enzymolysis reaction for 85min under slow stirring;
c: after the enzymolysis is finished, raising the temperature of the solution to 95 ℃ to carry out inactivation reaction on the enzyme for 10min, and filtering the solution by utilizing a polysulfone roll-type ultrafiltration membrane under 0.3MPa after the solution is cooled to obtain chenopodium quinoa ultrafiltrate;
d: placing the quinoa ultrafiltrate into a spray dryer, and carrying out atomization drying on the filtrate by using a pressure spray drying method to finally obtain dry powder, namely the quinoa peptide powder.
Preferably, the enzyme is added in 6% of the chenopodium quinoa powder weight in the enzymolysis process of step b, wherein the mixed enzyme is a double-enzyme preparation consisting of papain and flavourzyme.
Further, the preparation method of the quinoa peptide-based children eye cream comprises the following steps:
s1: vitamin E, vitamin A, curcumin and coenzyme Q10 in parts by weight are stirred and dispersed in a lipid solvent by a dispersion machine at 35 ℃;
s2: uniformly stirring quinoa peptide powder prepared from quinoa at normal temperature and dissolving in deionized water solution with weight ratio of 4 times;
s3: putting the products obtained in S1 and S2, an emulsifier, a humectant, a stabilizer and a proper amount of water into a high-viscosity vacuum mixing stirrer, and organically mixing the materials under a vacuum condition;
s4: and keeping the temperature in the stirring tank at 46 ℃ and continuously stirring for 3h, and fully stirring and mixing to obtain a product, namely the quinoa peptide eye cream for children.
And (3) product effect detection:
the average molecular weight of the quinoa peptide powder obtained in the preparation process in the embodiments 1-5 of the invention is detected by using a CEM protein tester, and the detection result is that the average molecular weight of the protein peptide prepared in the 5 groups of embodiments is 537, which is a small molecular protein peptide suitable for effective absorption by human body.
5-10 g of the eye protection cream prepared in the embodiment 3 of the invention is applied to 50 past male and female children with no allergic symptoms in the morning and evening of each day in the age of 6-16 years, and the using effect of the product is detected. After 21 days, the skin cutin tester is used for testing the skin moisturizing effect, and the skin hydration is increased by 12.7 percent and the skin is healthier and more moist. A small amount of cells or blood around the eyes of a subject are taken before and after a test experiment by using an oxidative stress free radical detection analyzer FRAS5, cell oxidative stress evaluation comparison is carried out, and the content of free radicals in skin cells around the eyes is reduced by 70-80% after 21 days, so that the effect of eliminating cell oxidation is obvious.
In the test period of 21 days, all children to be tested do not have irritation and anaphylactic reaction caused by the product of the invention, and the product effect is safe and stable.
The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (8)
1. The children eye cream based on quinoa peptide is characterized by comprising the following raw material components in parts by weight: 70-95 parts of quinoa, 7-15 parts of vitamin E, 7-15 parts of vitamin A, 6-16 parts of curcumin, 108-20 parts of coenzyme Q, 5-12 parts of an emulsifier, 13-26 parts of a humectant, 4-9 parts of a stabilizer, 35-50 parts of a lipid solvent and the balance of water.
2. The quinoa peptide-based eye cream for children according to claim 1, wherein: the lipid solvent is a lipid mixture prepared by blending glycerol, silicone oil and horse oil according to a ratio of 5-7: 2-3: 1.
3. The quinoa peptide-based eye cream for children according to claim 1, wherein: the humectant is a mixture prepared by mixing physiological lipid, propylene glycol and vaseline at a ratio of 2:1:6, wherein the physiological lipid can be one or more of nicotinamide, cholesterol, ceramide and free fatty acid.
4. The quinoa peptide-based eye cream for children according to claim 1, wherein: the stabilizer is a mixture prepared from sodium lactate, stearic acid and imidazoline.
5. The quinoa peptide-based eye cream for children according to claim 1, wherein: the emulsifier is any one of fatty acid soap, lecithin, acacia, sodium alkyl benzene sulfonate or tween 80.
6. The children eye cream based on quinoa peptide as claimed in claim 1, wherein the specific method for preparing the quinoa peptide from the quinoa raw material comprises:
a: cleaning quinoa raw materials, grinding the cleaned quinoa raw materials to 60-120 meshes by using a grinder, and then pouring quinoa powder into clear water with the weight ratio of 4-6 times to soak for 2 hours;
b: adding mixed enzyme into the quinoa powder solution, adjusting the pH of the solution to 6-8, raising the temperature of the solution to 45-55 ℃, and carrying out enzymolysis reaction for 60-100 min under slow stirring;
c: after enzymolysis, raising the temperature of the solution to 90-95 ℃ to carry out inactivation reaction on the enzyme for 10min, cooling the solution, and filtering the solution by using a polysulfone roll-type ultrafiltration membrane under 0.3MPa to obtain chenopodium quinoa ultrafiltrate;
d: placing the quinoa ultrafiltrate into a spray dryer, and carrying out atomization drying on the filtrate by using a pressure spray drying method to finally obtain dry powder, namely the quinoa peptide powder.
7. The quinoa peptide-based eye cream for children according to claim 6, wherein: and c, in the enzymolysis process of the step b, the addition amount of the enzyme is 3-6% of the weight of the quinoa wheat flour, wherein the mixed enzyme is a double-enzyme preparation consisting of papain and flavourzyme.
8. A method for preparing the quinoa peptide-based eye cream for children according to any one of claims 1 to 7, comprising: the preparation method comprises the following steps:
s1: vitamin E, vitamin A, curcumin and coenzyme Q10 in parts by weight are stirred and dispersed in a lipid solvent by a dispersion machine at 35 ℃;
s2: uniformly stirring and dissolving quinoa peptide powder prepared from quinoa in a deionized water solution with the weight ratio of 3-5 times at normal temperature;
s3: putting the products obtained in S1 and S2, an emulsifier, a humectant, a stabilizer and a proper amount of water into a high-viscosity vacuum mixing stirrer, and organically mixing the materials under a vacuum condition;
s4: and keeping the temperature in the stirring tank at 42-50 ℃ and continuously stirring for 3h, and fully stirring and mixing to obtain a product, namely the quinoa peptide eye cream for children.
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| CN112646194B (en) * | 2020-12-17 | 2022-05-13 | 宜宾惠美纤维新材料股份有限公司 | Quinoa protein liquid for fiber compounding and preparation method of quinoa protein fiber |
| CN112826781A (en) * | 2021-02-07 | 2021-05-25 | 上海彩藜科技有限公司 | Preparation method of quinoa essence with anti-wrinkle and anti-aging effects, quinoa essence and cosmetic applying quinoa essence |
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