CN113181102A

CN113181102A - Mouthwash with functions of moistening oral cavity and refreshing breath and preparation method thereof

Info

Publication number: CN113181102A
Application number: CN202110256382.4A
Authority: CN
Inventors: 桑苏君
Original assignee: Beijing Shengyong Pharmaceutical Co ltd
Current assignee: Beijing Shengyong Pharmaceutical Co ltd
Priority date: 2021-03-09
Filing date: 2021-03-09
Publication date: 2021-07-30
Anticipated expiration: 2041-03-09
Also published as: CN113181102B

Abstract

The invention discloses mouthwash with the function of moistening oral cavity and refreshing breath and a preparation method thereof, and on one hand, the invention provides mouthwash with the function of moistening oral cavity and refreshing breath, which consists of the following components: cranberry extract, sodium azulene sulfonate, benzalkonium chloride, fluoride, aromatic, sweetener, preservative, honey, traditional Chinese medicine extracting solution, biological lytic enzyme and deionized water; the mouthwash consists of the following components in percentage by mass: cranberry extract: 0.1-2%, sodium azulene sulfonate: 0.01-1%, benzalkonium chloride: 0.01-0.5%, fluoride: 0.01-0.2%, fragrance: 0.01-0.5%, sweetener: 0.01-2%, preservative: 0.01-0.3%, honey: 1-10% of traditional Chinese medicine extracting solution: 0.1-5%, biolytic enzyme: 0.1 to 1 percent; the mouth wash has good antibacterial, anti-inflammatory and hemostatic effects by adopting the traditional Chinese medicine extracting solution containing the components of pseudo-ginseng, honeysuckle, astragalus, Chinese gall, houttuynia cordata and scutellaria baicalensis, and can effectively solve the problems of stomatitis, periodontitis, gingival bleeding and the like of a user.

Description

Mouthwash with functions of moistening oral cavity and refreshing breath and preparation method thereof

Technical Field

The invention relates to the field of daily chemical products, in particular to mouthwash with functions of moistening oral cavities and refreshing breath and a preparation method thereof.

Background

With the development of economic society and the improvement of living standard of people, the dietary structure of people is changed, and various oral diseases corresponding to the dietary structure are more and more common. At present, the incidence rate of oral diseases is extremely high, the types of oral diseases are also various, such as oral ulcer, pharyngitis, laryngitis, tonsillitis, gingivitis and the like, especially recurrent oral ulcer patients have the characteristic of periodic repeated attack, the work and life of the people are seriously affected, and the prevention and treatment of oral diseases and the protection of teeth are particularly important.

The mouth wash is also called as gargle, the main effects are to clean the oral cavity, cover up the bad breath caused by decomposing food residues by bacteria or yeast, and leave a comfortable and refreshing feeling in the oral cavity, during traveling, the tooth brushing is limited at any time and any place, which is inconvenient and unrealistic, and the mouth wash can be used for cleaning the oral cavity at any time and any place by preparing a bottle of mouth wash, so the mouth wash is more and more favored by consumers.

However, the existing gargle has many problems, such as dry mouth, bitter taste and strong irritation to oral mucosa; the antibacterial effect is poor, the stomatitis and the gingival inflammation cannot be effectively relieved, and meanwhile, the hemostatic effect is not achieved, so that the antibacterial agent has great irritation to the oral wound of a user; the sustained effect is poor, and the oral cavity can not be moistened and the breath can not be kept fresh for a long time.

Disclosure of Invention

The invention aims to provide mouthwash with functions of moistening oral cavity and refreshing breath and a preparation method thereof, and aims to solve the problems in the background technology.

In order to achieve the purpose, the invention provides the following technical scheme:

on one hand, the invention provides mouthwash with the function of moistening oral cavity and refreshing breath, which consists of the following components: cranberry extract, sodium azulene sulfonate, benzalkonium chloride, fluoride, aromatic, sweetener, preservative, honey, traditional Chinese medicine extracting solution, biological lytic enzyme and deionized water.

As a further scheme of the invention: the mouthwash consists of the following components in percentage by mass: cranberry extract: 0.1-2%, sodium azulene sulfonate: 0.01-1%, benzalkonium chloride: 0.01-0.5%, fluoride: 0.01-0.2%, fragrance: 0.01-0.5%, sweetener: 0.01-2%, preservative: 0.01-0.3%, honey: 1-10% of traditional Chinese medicine extracting solution: 0.1-5%, biolytic enzyme: 0.1-1% and the balance of deionized water.

As a further scheme of the invention: the mouthwash consists of the following components in percentage by mass: cranberry extract: 0.2%, sodium azulene sulfonate: 0.03%, benzalkonium chloride: 0.02%, fluoride: 0.02%, fragrance: 0.1%, sweetener: 1.2% and preservative: 0.05%, honey: 6% and traditional Chinese medicine extracting solution: 3%, biolytic enzyme: 0.3 percent and the balance of deionized water.

As a further scheme of the invention: the fluoride is sodium fluoride.

As a further scheme of the invention: the aromatic is one or combination of menthol and wintergreen oil.

As a further scheme of the invention: the sweetener is one or combination of xylitol and stevia.

As a further scheme of the invention: the preservative is p-hydroxy methyl formate.

As a further scheme of the invention: the traditional Chinese medicine extracting solution comprises the following components: notoginseng radix, flos Lonicerae, radix astragali, Galla chinensis, herba Houttuyniae, and Scutellariae radix.

As a further scheme of the invention: the pseudo-ginseng, the honeysuckle, the astragalus, the gallnut, the houttuynia cordata and the scutellaria baicalensis are in mass ratio: 5-10: 2-6: 3-8: 2-5: 1-4: 4-7.

As a further scheme of the invention: the preparation method of the traditional Chinese medicine extracting solution comprises the following steps:

s1, weighing the pseudo-ginseng, the honeysuckle, the astragalus membranaceus, the gallnut, the houttuynia cordata and the scutellaria baicalensis according to the formula amount;

s2, fully soaking radix Notoginseng, flos Lonicerae, radix astragali, Galla chinensis, herba Houttuyniae, and radix Scutellariae, removing surface water, putting into an extractor, injecting ethanol solution with volume 8-12 times of the volume of the materials, reflux-extracting for more than 3 times, wherein the reflux-extracting time is 0.2-1h each time, to obtain solid residue and extractive solution;

s3, concentrating the extracting solution under reduced pressure, recovering ethanol to obtain a concentrated solution, and centrifugally separating the concentrated solution to obtain a supernatant;

s4, soaking and washing the solid residues with deionized water, putting the solid residues into a container, adding water with the volume 5-8 times of that of the solid residues into the container, stirring and decocting until the solid-liquid ratio in the container is 1: 2-3, cooling and filtering to obtain a liquid medicine;

s5, mixing the extractive solution with the medicinal liquid to obtain Chinese medicinal extractive solution.

As a still further scheme of the invention: the ethanol concentration of the ethanol solution in the S2 is 70-80%, and the stirring and boiling temperature is 200-230 ℃.

On the other hand, the invention also provides a preparation method of the mouthwash with the function of moistening the oral cavity and refreshing breath, which is used for preparing the mouthwash and comprises the following steps:

the method comprises the following steps: weighing raw materials according to a formula ratio;

step two: adding sodium azulene sulfonate, fluoride, benzalkonium chloride, an aromatic and a sweetening agent into deionized water, heating to 50-60 ℃, and stirring until solid particles are completely dissolved to obtain a mixed solution A;

step three: cooling the mixed solution A to room temperature, adding cranberry extract, Mel, Chinese medicinal extractive solution, and biological lytic enzyme, and stirring for 10-25min to obtain mixed solution B;

step four: and adding the preservative into the mixed solution B, and uniformly stirring to obtain the mouthwash.

Compared with the prior art, the invention has the beneficial effects that:

1. the mouth wash has good antibacterial, anti-inflammatory and hemostatic effects by adopting the traditional Chinese medicine extracting solution containing the components of pseudo-ginseng, honeysuckle, astragalus, Chinese gall, houttuynia cordata and scutellaria baicalensis, and can effectively solve the problems of stomatitis, periodontitis, gingival bleeding and the like of a user.

2. According to the invention, by adding honey, the aromatic containing menthol and/or wintergreen oil and the sweetening agent containing xylitol and/or stevia, the use mouthfeel of the mouthwash can be obviously improved, and meanwhile, the mouthwash can moisten the oral cavity for a long time and keep fresh breath.

3. In the invention, when the cranberry extract, the traditional Chinese medicine extracting solution and the benzalkonium chloride are used at the same time, a synergistic antibacterial effect is generated, and the antibacterial rate of the mouthwash is greatly improved.

Detailed Description

In order to make the technical problems, technical solutions and advantageous effects to be solved by the present invention more apparent, the present invention will be further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

It will be understood that when an element is referred to as being "secured to" or "disposed on" another element, it can be directly on the other element or be indirectly on the other element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or be indirectly connected to the other element.

It will be understood that the terms "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are used merely to facilitate describing the invention and to simplify the description, and do not indicate or imply that the referenced devices or elements must be constructed and operated in a particular orientation within the specification and are not to be considered limiting of the invention.

Furthermore, the terms "first", "second", "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature.

In one aspect of the invention, the invention provides mouthwash with the function of moistening oral cavity and refreshing breath, which consists of the following components: cranberry extract, sodium azulene sulfonate, benzalkonium chloride, fluoride, aromatic, sweetener, preservative, honey, traditional Chinese medicine extracting solution, biological lytic enzyme and deionized water.

The cranberry extract contains procyanidin as main ingredient, and has effects of strengthening capillary vessel, artery and vein vessel, relieving swelling, and removing blood stasis, and releasing a compound called histamine when human body is inflamed, wherein procyanidin can inhibit enzyme required for producing histamine, and prevent histamine generation, thereby relieving inflammation. Procyanidin is a well-known inhibitor of histamine, but it does not block other enzymes, so cranberry extract is effective in preventing and treating oral inflammation and periodontal inflammation.

The sodium azulene sulfonate is an anti-inflammatory and anti-ulcer medicine with little side effect, has good treatment effect on common oral diseases, and can effectively eliminate symptoms such as edema, hyperemia, abscess, gingival bleeding, halitosis, odontoseisis and the like caused by the common oral diseases. Pharmacological research on sodium azulene sulfonate shows that the sodium azulene sulfonate has a non-steroidal anti-inflammatory effect and an anti-adhesive film ulcer effect, and the main pharmacology is as follows: diminish inflammation, promote mucosa metabolism and epidermis formation, but has weak antibacterial effect. The sodium azulene sulfonate is added into the common toothpaste to be used in the oral cavity, which does not destroy the normal oral cavity flora balance and has good treatment effect on inflammatory reactions such as red, swelling, heat, pain and the like in the oral cavity.

Benzalkonium chloride is an effective antibacterial agent that kills bacteria in the mouth that cause bad breath, tooth decay, and reduces plaque formation to some extent.

The mouthwash consists of the following components in percentage by mass: cranberry extract: 0.1-2%, sodium azulene sulfonate: 0.01-1%, benzalkonium chloride: 0.01-0.5%, fluoride: 0.01-0.2%, fragrance: 0.01-0.5%, sweetener: 0.01-2%, preservative: 0.01-0.3%, honey: 1-10% of traditional Chinese medicine extracting solution: 0.1-5%, biolytic enzyme: 0.1-1% and the balance of deionized water.

The mouthwash consists of the following components in percentage by mass: cranberry extract: 0.2%, sodium azulene sulfonate: 0.03%, benzalkonium chloride: 0.02%, fluoride: 0.02%, fragrance: 0.1%, sweetener: 1.2% and preservative: 0.05%, honey: 6% and traditional Chinese medicine extracting solution: 3%, biolytic enzyme: 0.3 percent and the balance of deionized water.

The fluoride is sodium fluoride.

Sodium fluoride not only inhibits bacterial growth, but also strengthens tooth enamel, and is beneficial to preventing decayed teeth and tooth decay.

The aromatic is one or combination of menthol and wintergreen oil.

The mouth feel of the mouthwash can be obviously improved by adding the flavoring agent containing menthol and/or wintergreen oil.

The sweetener is one or combination of xylitol and stevia.

By adding a sweetening agent containing xylitol and/or stevia and matching with the use of an aromatic and honey, the taste sense of the mouthwash can be further improved, the bitter taste of traditional Chinese medicine extracting solution and other components in the formula can be covered, meanwhile, the halitosis can be covered, the breath can be kept fresh, and the positive effect on inhibiting the bacterial reproduction in the oral cavity can be achieved.

The preservative is p-hydroxy methyl formate.

The preservative can prevent the mouth wash from going bad and prolong the service life of the mouth wash.

The traditional Chinese medicine extracting solution comprises the following components: notoginseng radix, flos Lonicerae, radix astragali, Galla chinensis, herba Houttuyniae, and Scutellariae radix.

Wherein, the pseudo-ginseng and the gallnut have the efficacies of removing blood stasis, stopping bleeding, promoting blood circulation and relieving pain;

the honeysuckle has the effects of clearing away heat and toxic materials, diminishing inflammation and relieving swelling;

the astragalus has the effects of expelling toxin, expelling pus, promoting granulation and the like, and can accelerate the healing of wounds in the oral cavity;

the scutellaria has the effects of clearing heat, drying dampness, purging fire, removing toxin and the like, has strong clinical antibacterial property, does not generate drug resistance, and can effectively kill harmful bacteria in the oral cavity.

The pseudo-ginseng, the honeysuckle, the astragalus, the gallnut, the houttuynia cordata and the scutellaria baicalensis are in mass ratio: 5-10: 2-6: 3-8: 2-5: 1-4: 4-7.

The preparation method of the traditional Chinese medicine extracting solution comprises the following steps:

The ethanol concentration of the ethanol solution in the S2 is 70-80%, and the stirring and boiling temperature is 200-230 ℃.

Example 1:

weighing: cranberry extract: 0.2 part, sodium azulene sulfonate: 0.03 part of benzalkonium chloride: 0.02 part, fluoride: 0.02 part of aromatic: 0.1 part of sweetening agent: 1.2 parts of preservative: 0.05 part of honey: 6 parts of traditional Chinese medicine extracting solution: 3 parts of a biological lytic enzyme: 0.3 part, weighing deionized water to make the total mass to 100 parts.

Example 2:

weighing: cranberry extract: 0.5 part, sodium azulene sulfonate: 0.05 part, benzalkonium chloride: 0.015 parts, fluoride: 0.03 part of aromatic: 0.15 part of sweetening agent: 1 part of preservative: 0.08 part of honey: 8 parts of traditional Chinese medicine extracting solution: 4 parts of a biological lytic enzyme: 0.6 part, weighing deionized water to 100 parts of the total mass.

Comparative example 1:

this comparative example differs from example 1 in that cranberry extract was not added to the formulation.

Comparative example 2:

the difference between the comparative example and the example 1 is that the traditional Chinese medicine extracting solution is not added in the formula.

Comparative example 3:

this comparative example differs from example 1 in that benzalkonium chloride was not added to the formulation.

Comparative example 4:

the difference between the comparative example and the example 1 is that the traditional Chinese medicine extracting solution and benzalkonium chloride are not added in the formula.

Comparative example 5:

this comparative example differs from example 1 in that no honey, aroma and sweetener were added to the formulation.

Comparative example 6:

this comparative example used a commercially available brand of mouthwash.

Performance test:

1. and (3) sterilizing effect test:

(1) the bacterial species: the bacteria used were all international standard strains including Streptococcus mutans (ATCC 25175), Actinomyces viscosus (ATCC 19246), Porphyromonas gingivalis (ATCC 33277), and Candida albicans (ATCC 76615).

(2) The test method comprises the following steps: the same amount of the mouthwashes of examples 1 to 2 and comparative examples 1 to 6 was used as an experimental group, and the bacteriostatic effect test was performed according to QB/T2738-2012, and the bacteriostatic rate (%) after 1 hour was observed and recorded, and the results were obtained

Table 1:

TABLE 1

As can be seen from table 1, the cranberry extract, the traditional Chinese medicine extract and the benzalkonium chloride all have certain antibacterial effects, and when the cranberry extract, the traditional Chinese medicine extract and the benzalkonium chloride are used at the same time, a synergistic antibacterial effect is generated, so that the antibacterial rate of the mouthwash is greatly improved.

2. Sensory test:

the test method comprises the following steps: selecting 80 patients who often suffer from oral inflammation, gum swelling and pain and various oral problems as trial objects, randomly dividing the trial objects into 8 groups, using the mouth washes of examples 1-2 and comparative examples 2-6 for 10 persons in each group, wherein the use frequency is once every morning, evening and the use period is 2 weeks, and then scoring the used mouth washes, wherein the scoring items are as follows: mouthfeel, hemostatic effect, inflammation-improving effect, and breath-freshening lasting effect; the score value is 0-5, wherein 0 indicates basic invalidity \ very unsatisfying, 5 indicates remarkable effect \ very satisfactory, and the average score of each mouthwash is shown in table 2:

TABLE 2

The data of comparative example 4 and comparative example 1 are compared and observed to show that the mouthwash added with traditional Chinese medicine extract and benzalkonium chloride has good bactericidal and bacteriostatic effects, and hemostatic effects are good, and stomatitis can be significantly alleviated, and breath freshness can be maintained, and meanwhile, the data of comparative example 5 and comparative example 1 are compared to show that the use mouthfeel of the mouthwash can be significantly improved by adding honey, the aromatic containing menthol and/or wintergreen oil, and the sweetener containing xylitol and/or stevia rebaudiana can be maintained, and meanwhile, the oral cavity is moistened for a long time, and breath freshness can be maintained.

Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that various changes in the embodiments and/or modifications of the invention can be made, and equivalents and modifications of some features of the invention can be made without departing from the spirit and scope of the invention.

Claims

1. A mouth wash with functions of moistening oral cavity and refreshing breath is characterized in that: the composition consists of the following components: cranberry extract, sodium azulene sulfonate, benzalkonium chloride, fluoride, aromatic, sweetener, preservative, honey, traditional Chinese medicine extracting solution, biological lytic enzyme and deionized water.

2. The mouthwash having the function of moistening and refreshing breath, according to claim 1, wherein: the composite material comprises the following components in percentage by mass: cranberry extract: 0.1-2%, sodium azulene sulfonate: 0.01-1%, benzalkonium chloride: 0.01-0.5%, fluoride: 0.01-0.2%, fragrance: 0.01-0.5%, sweetener: 0.01-2%, preservative: 0.01-0.3%, honey: 1-10% of traditional Chinese medicine extracting solution: 0.1-5%, biolytic enzyme: 0.1-1% and the balance of deionized water.

3. The mouthwash having the function of moistening and refreshing breath, according to claim 2, wherein: the composite material comprises the following components in percentage by mass: cranberry extract: 0.2%, sodium azulene sulfonate: 0.03%, benzalkonium chloride: 0.02%, fluoride: 0.02%, fragrance: 0.1%, sweetener: 1.2% and preservative: 0.05%, honey: 6% and traditional Chinese medicine extracting solution: 3%, biolytic enzyme: 0.3 percent and the balance of deionized water.

4. The mouthwash having the function of moistening and refreshing breath, according to claim 1, wherein: the fluoride is sodium fluoride.

5. The mouthwash having the function of moistening and refreshing breath, according to claim 1, wherein: the aromatic is one or combination of menthol and wintergreen oil.

6. The mouthwash having the function of moistening and refreshing breath, according to claim 1, wherein: the sweetener is one or combination of xylitol and stevia.

7. The mouthwash having the function of moistening and refreshing breath, according to claim 1, wherein: the preservative is p-hydroxy methyl formate.

8. The mouthwash having the function of moistening and refreshing breath, according to claim 1, wherein: the traditional Chinese medicine extracting solution comprises the following components: notoginseng radix, flos Lonicerae, radix astragali, Galla chinensis, herba Houttuyniae, and Scutellariae radix.

9. The mouthwash having the function of moistening and refreshing breath, according to claim 8, wherein: the pseudo-ginseng, the honeysuckle, the astragalus, the gallnut, the houttuynia cordata and the scutellaria baicalensis are in mass ratio: 5-10: 2-6: 3-8: 2-5: 1-4: 4-7.

10. The mouthwash having the function of moistening and refreshing breath, according to claim 9, wherein: the preparation method of the traditional Chinese medicine extracting solution comprises the following steps:

11. The mouthwash having the function of moistening and refreshing breath, according to claim 10, wherein: the ethanol concentration of the ethanol solution in the S2 is 70-80%, and the stirring and boiling temperature is 200-230 ℃.

12. A method for preparing a mouth wash having a function of moistening and refreshing breath, which is used for preparing the mouth wash as claimed in any one of claims 1 to 11, comprising the steps of:

step two: adding sodium azulene sulfonate, fluoride, benzalkonium chloride, aromatic and sweetening agent into deionized water,

heating to 50-60 ℃, and stirring until the solid particles are completely dissolved to obtain a mixed solution A;