CN113164485A - 被取代的吡唑并嘧啶和被取代的嘌呤以及其作为泛素特异性加工蛋白酶1(usp1)抑制剂的用途 - Google Patents

被取代的吡唑并嘧啶和被取代的嘌呤以及其作为泛素特异性加工蛋白酶1(usp1)抑制剂的用途 Download PDF

Info

Publication number
CN113164485A
CN113164485A CN201980079551.2A CN201980079551A CN113164485A CN 113164485 A CN113164485 A CN 113164485A CN 201980079551 A CN201980079551 A CN 201980079551A CN 113164485 A CN113164485 A CN 113164485A
Authority
CN
China
Prior art keywords
optionally substituted
alkyl
cancer
trifluoromethyl
pyrazolo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201980079551.2A
Other languages
English (en)
Chinese (zh)
Inventor
杰罗德·伯内特·布伦尼曼
埃尔莎·拜尔·克拉尔
迈克尔·施拉巴赫
安德鲁·阿利斯泰尔·维利
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ksq Treatment Co
Original Assignee
Ksq Treatment Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ksq Treatment Co filed Critical Ksq Treatment Co
Publication of CN113164485A publication Critical patent/CN113164485A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
CN201980079551.2A 2018-12-20 2019-12-19 被取代的吡唑并嘧啶和被取代的嘌呤以及其作为泛素特异性加工蛋白酶1(usp1)抑制剂的用途 Pending CN113164485A (zh)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201862783014P 2018-12-20 2018-12-20
US62/783,014 2018-12-20
US201962799423P 2019-01-31 2019-01-31
US62/799,423 2019-01-31
US201962857986P 2019-06-06 2019-06-06
US62/857,986 2019-06-06
US201962868616P 2019-06-28 2019-06-28
US62/868,616 2019-06-28
US201962946263P 2019-12-10 2019-12-10
US62/946,263 2019-12-10
PCT/US2019/067521 WO2020132269A1 (en) 2018-12-20 2019-12-19 Substituted pyrazolopyrimidines and substituted purines and their use as ubiquitin-specific-processing protease 1 (usp1) inhibitors

Publications (1)

Publication Number Publication Date
CN113164485A true CN113164485A (zh) 2021-07-23

Family

ID=71100912

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980079551.2A Pending CN113164485A (zh) 2018-12-20 2019-12-19 被取代的吡唑并嘧啶和被取代的嘌呤以及其作为泛素特异性加工蛋白酶1(usp1)抑制剂的用途

Country Status (16)

Country Link
US (2) US11485736B2 (https=)
EP (1) EP3897652A4 (https=)
JP (2) JP7662519B2 (https=)
KR (1) KR102912147B1 (https=)
CN (1) CN113164485A (https=)
AU (1) AU2019405925B2 (https=)
BR (1) BR112021010715A2 (https=)
CA (1) CA3122108A1 (https=)
CL (1) CL2021001575A1 (https=)
CO (1) CO2021009078A2 (https=)
IL (1) IL284050B2 (https=)
MX (1) MX2021007179A (https=)
PH (1) PH12021551402A1 (https=)
SG (1) SG11202106232TA (https=)
TW (2) TWI895986B (https=)
WO (1) WO2020132269A1 (https=)

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114181237A (zh) * 2021-12-01 2022-03-15 上海凌凯医药科技有限公司 一种1-异丙基吡唑-5-硼酸频那醇酯的合成方法
CN116496252A (zh) * 2022-04-29 2023-07-28 江苏亚虹医药科技股份有限公司 嘧啶类化合物、其制备方法及其医药用途
WO2023143424A1 (zh) * 2022-01-27 2023-08-03 四川海思科制药有限公司 一种氮杂并环衍生物及其在医药上的应用
WO2023155866A1 (zh) * 2022-02-18 2023-08-24 四川海思科制药有限公司 一种吡唑并吡啶衍生物及其在医药上的应用
CN116768906A (zh) * 2023-05-29 2023-09-19 遵义医科大学珠海校区 一种三并环化合物及其制备方法和应用
CN116925098A (zh) * 2022-04-09 2023-10-24 深圳湾实验室 靶向泛素特异性蛋白酶1(usp1)的小分子抑制剂及其应用
WO2024022266A1 (en) * 2022-07-25 2024-02-01 Guangdong Newopp Biopharmaceuticals Co., Ltd. Heteroaryl compounds as inhibitors of usp1
WO2024022519A1 (zh) * 2022-07-28 2024-02-01 先声再明医药有限公司 杂环并嘧啶类化合物及其应用
WO2024032647A1 (zh) * 2022-08-09 2024-02-15 上海济煜医药科技有限公司 含氮杂环化合物作为泛素-特异性蛋白酶1抑制剂的制备方法、应用及其用途
WO2024041634A1 (zh) * 2022-08-26 2024-02-29 先声再明医药有限公司 三环类化合物及其应用
WO2024046471A1 (zh) * 2022-09-02 2024-03-07 上海齐鲁制药研究中心有限公司 Usp1抑制剂
WO2024051795A1 (zh) * 2022-09-09 2024-03-14 正大天晴药业集团股份有限公司 用作泛素-特异性蛋白酶抑制剂的取代嘌呤酮衍生物
WO2024061213A1 (zh) * 2022-09-20 2024-03-28 正大天晴药业集团股份有限公司 用作泛素-特异性蛋白酶抑制剂的羰基稠合杂环衍生物
WO2024078436A1 (zh) * 2022-10-09 2024-04-18 海南先声再明医药股份有限公司 杂环并嘧啶类化合物、药物组合物及其应用
WO2024094170A1 (zh) * 2022-11-04 2024-05-10 深圳晶泰科技有限公司 泛素特异性蛋白酶1的抑制剂及其应用
CN118215664A (zh) * 2021-10-19 2024-06-18 上海瑛派药业有限公司 取代的三唑并杂芳基化合物作为usp1抑制剂及其应用
WO2024153250A1 (zh) * 2023-01-20 2024-07-25 杭州英创医药科技有限公司 作为usp1抑制剂的化合物
WO2024222880A1 (zh) * 2023-04-27 2024-10-31 西藏海思科制药有限公司 一种吡啶并吡唑衍生物的药物组合物及其在医药上的应用
WO2025007840A1 (zh) * 2023-07-05 2025-01-09 江苏亚虹医药科技股份有限公司 联嘧啶化合物的晶型及其制备方法和用途
WO2025007777A1 (zh) * 2023-07-05 2025-01-09 江苏亚虹医药科技股份有限公司 嘧啶类化合物、其制备方法及其医药用途
WO2025067259A1 (zh) * 2023-09-26 2025-04-03 上海济煜医药科技有限公司 一类氮杂环胺类化合物作为泛素-特异性蛋白酶1抑制剂的制备方法、应用及其用途
WO2025180502A1 (zh) * 2024-03-01 2025-09-04 上海齐鲁制药研究中心有限公司 一种联合用药物组合物及其用途

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10189841B2 (en) 2015-11-20 2019-01-29 Forma Therapeutics, Inc. Purinones as ubiquitin-specific protease 1 inhibitors
BR112021010715A2 (pt) 2018-12-20 2021-11-16 Ksq Therapeutics Inc Pirazolopirimidinas substituídas e purinas substituídas e seu uso como inibidores de protease de processamento ubiquitina-específica 1 (usp1)
JP7253640B2 (ja) 2019-01-31 2023-04-06 武田薬品工業株式会社 複素環化合物およびその用途
ES3025474T3 (en) * 2020-01-15 2025-06-09 Ksq Therapeutics Inc Compositions of substituted pyrazolopyrimidines and uses thereof
CA3168009A1 (en) * 2020-02-14 2021-08-19 KSQ Therapeutics, Inc. Therapeutic combinations comprising ubiquitin-specific-processing protease 1 (usp1) inhibitors and poly (adp-ribose) polymerase (parp) inhibitors
EP4161494A4 (en) * 2020-06-02 2024-07-17 KSQ Therapeutics, Inc. NITROGEN-CONTAINING FUSED BICYCLIC COMPOUNDS AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS
WO2022053998A1 (en) * 2020-09-10 2022-03-17 Universidade Do Porto New pharmaceutical compounds, methods and uses thereof
KR20230098186A (ko) * 2020-10-30 2023-07-03 케이에스큐 세러퓨틱스 인코포레이티드 치환된 피라졸로피리미딘의 고체 상태 형태 및 이의 용도
US20240182481A1 (en) * 2021-02-15 2024-06-06 Tango Therapeutics, Inc. Pyrrolo[3,2-d]pyrimidine compounds and methods of use in the treatment of cancer
AU2022238886A1 (en) * 2021-03-17 2023-09-14 Medivir Ab Purine derivatives as anticancer agents
MX2023011709A (es) * 2021-04-07 2023-10-12 Forma Therapeutics Inc Inhibidor de la proteasa 1 especifica de ubiquitina (usp1).
CN117337290B (zh) * 2021-05-03 2026-01-02 轩竹生物科技股份有限公司 三并环类泛素特异性蛋白酶1抑制剂及其用途
WO2022253188A1 (en) * 2021-05-31 2022-12-08 Impact Therapeutics (Shanghai) , Inc Nitrogen-containing fused heteroaromatic bicyclic compounds as usp1 inhibitors and the use thereof
GB202114863D0 (en) 2021-10-18 2021-12-01 Syngenta Crop Protection Ag Improvements in or relating to organic compounds
CN114031556B (zh) * 2021-11-08 2023-03-31 温州大学 一种绿色的一锅法制备5-氨基-n-芳基-3-芳基吡唑类化合物的合成方法
GEAP202416531A (en) * 2021-11-12 2024-10-28 Insilico Medicine Ip Ltd Small molecule inhibitors of ubiquitin specific protease 1 (usp1) and uses thereof
CR20240191A (es) * 2021-11-12 2024-09-13 Insilico Medicine Ip Ltd Inhibidores de molécula pequeña de proteasa 1 específica de ubiquitina (usp1) y usos de los mismos
EP4430041A4 (en) * 2021-11-12 2025-09-24 Insilico Medicine Ip Ltd SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 1 (USP1) AND THEIR USES
IL312982A (en) * 2021-12-09 2024-07-01 Ksq Therapeutics Inc Methods for the preparation of converted pyrazolopyrimidines
US20250163049A1 (en) * 2022-02-03 2025-05-22 Exelixis, Inc. Fused bicyclic heterocyclyl compounds as usp1 inhibitors
IL315748A (en) * 2022-04-08 2024-11-01 Ksq Therapeutics Inc Therapeutic combinations containing ubiquitin-specific processing protease 1 (USP1) inhibitors and chemotherapy agents
EP4543890A1 (en) * 2022-06-23 2025-04-30 Forma Therapeutics, Inc. Usp1 inhibitors and uses thereof
WO2024006879A1 (en) * 2022-06-29 2024-01-04 Zentaur Therapeutics Usa Inc. Usp1 inhibitors and uses thereof
CN117263944B (zh) * 2022-08-24 2025-10-17 轩竹生物科技股份有限公司 泛素特异性蛋白酶1抑制剂及其用途
CN117384187B (zh) * 2022-09-30 2026-01-30 轩竹生物科技股份有限公司 泛素特异性蛋白酶1抑制剂
WO2024086790A1 (en) 2022-10-21 2024-04-25 Exelixis, Inc. 4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-c]PYRIDINE COMPOUNDS AND DERIVATIVES AS USP1 INHIBITORS
CN120513237A (zh) 2023-01-12 2025-08-19 先正达农作物保护股份公司 除草咪唑化合物
WO2024233605A1 (en) 2023-05-08 2024-11-14 Tango Therapeutics, Inc. Compounds and their use against cancer
WO2024233665A1 (en) 2023-05-08 2024-11-14 Tango Therapeutics, Inc. Compounds and their use against cancer
WO2025010245A1 (en) 2023-07-06 2025-01-09 Exelixis, Inc. Fused pyrazole derivatives as usp1 inhibitors
WO2025015905A1 (en) * 2023-07-14 2025-01-23 Laekna Therapeutics Shanghai Co., Ltd. Pyrimidine compounds and their use as usp1 inhibitors
WO2025095751A1 (ko) * 2023-10-30 2025-05-08 현대약품 주식회사 신규한 화합물, 및 이를 포함하는 암의 예방 또는 치료용 약학적 조성물
TW202535865A (zh) 2023-10-31 2025-09-16 美商必治妥美雅史谷比公司 泛素特異性加工蛋白酶1 (usp1) 化合物
WO2025096487A1 (en) 2023-10-31 2025-05-08 Bristol-Myers Squibb Company Ubiquitin specific processing protease 1 (usp1) compounds
WO2025096488A1 (en) 2023-10-31 2025-05-08 Bristol-Myers Squibb Company Ubiquitin specific processing protease 1 (usp1) compounds
WO2025102016A1 (en) 2023-11-10 2025-05-15 Vrise Therapeutics, Inc. Novel molecules as inhibitors of dna damage repair pathway
WO2025151705A1 (en) 2024-01-10 2025-07-17 Vrise Therapeutics, Inc. Novel inhibitors of dna damage repair pathway
KR20250138136A (ko) * 2024-03-12 2025-09-19 현대약품 주식회사 신규한 화합물, 및 이를 포함하는 암의 예방 또는 치료용 약학적 조성물

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102014631A (zh) * 2008-03-03 2011-04-13 泰格尔医药科技公司 酪氨酸激酶抑制剂
US20110130384A1 (en) * 2008-06-25 2011-06-02 Takeda Pharmaceutical Company Limited Amide compound
US20110144134A1 (en) * 2004-11-19 2011-06-16 The Regents Of The University Of California Anti-Inflammatory Pyrazolopyrimndines
US20130079512A1 (en) * 2007-10-05 2013-03-28 Verastem Pyrimidine substituted purine derivatives
US20130253005A1 (en) * 2010-04-30 2013-09-26 The Brigham And Women's Hospital, Inc. Small molecule inhibitors of usp1 deubiquitinating enzyme activity
WO2017026718A1 (ko) * 2015-08-07 2017-02-16 한국과학기술연구원 Ret 키나아제 저해제인 신규 3-(이속사졸-3-일)-피라졸로[3,4-디]피리미딘-4-아민 화합물
CN108473495A (zh) * 2015-11-20 2018-08-31 福马治疗有限公司 作为泛素-特异性蛋白酶1抑制剂的嘌呤酮

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5010175A (en) 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
EP0786469B1 (en) 1990-06-11 2006-03-01 Gilead Sciences, Inc. Methods of use of nucleic acid ligands
AU672790B2 (en) 1992-07-15 1996-10-17 Novartis Ag Variants of parathyroid hormone and its fragments
AU3204895A (en) 1995-02-01 1996-08-21 University Of Massachusetts Medical Center Methods of selecting a random peptide that binds to a target protein
EP0934526B1 (en) 1996-10-08 2003-01-08 U-BISys B.V. Methods and means for selecting peptides and proteins having specific affinity for a target
US6453242B1 (en) 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
WO2007149484A2 (en) 2006-06-20 2007-12-27 Dana-Farber Cancer Institute Inhibitors of usp1 deubiquitinating enzyme complex
AU2007325900A1 (en) 2006-10-20 2008-06-05 Dnar, Inc. DNA damage repair inhibitors and methods for treating cancer
US7964356B2 (en) 2007-01-16 2011-06-21 Somalogic, Inc. Method for generating aptamers with improved off-rates
GB0917934D0 (en) * 2009-10-13 2009-11-25 Syngenta Ltd Herbicidal compounds
CA2896731A1 (en) 2012-12-28 2014-07-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Inhibitors of the usp1/uaf1 deubiquitinase complex and uses thereof
EP3760719A1 (en) 2013-11-18 2021-01-06 CRISPR Therapeutics AG Crispr-cas system materials and methods
JP2017510628A (ja) * 2014-03-13 2017-04-13 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 縮合ピリミジン系ヒドロキサメート誘導体
BR112021010715A2 (pt) 2018-12-20 2021-11-16 Ksq Therapeutics Inc Pirazolopirimidinas substituídas e purinas substituídas e seu uso como inibidores de protease de processamento ubiquitina-específica 1 (usp1)
US20240182481A1 (en) 2021-02-15 2024-06-06 Tango Therapeutics, Inc. Pyrrolo[3,2-d]pyrimidine compounds and methods of use in the treatment of cancer

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110144134A1 (en) * 2004-11-19 2011-06-16 The Regents Of The University Of California Anti-Inflammatory Pyrazolopyrimndines
US20130079512A1 (en) * 2007-10-05 2013-03-28 Verastem Pyrimidine substituted purine derivatives
CN102014631A (zh) * 2008-03-03 2011-04-13 泰格尔医药科技公司 酪氨酸激酶抑制剂
US20110130384A1 (en) * 2008-06-25 2011-06-02 Takeda Pharmaceutical Company Limited Amide compound
US20130253005A1 (en) * 2010-04-30 2013-09-26 The Brigham And Women's Hospital, Inc. Small molecule inhibitors of usp1 deubiquitinating enzyme activity
WO2017026718A1 (ko) * 2015-08-07 2017-02-16 한국과학기술연구원 Ret 키나아제 저해제인 신규 3-(이속사졸-3-일)-피라졸로[3,4-디]피리미딘-4-아민 화합물
CN108473495A (zh) * 2015-11-20 2018-08-31 福马治疗有限公司 作为泛素-特异性蛋白酶1抑制剂的嘌呤酮

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JIA HONG等: "Discovery of (S)-1-(1-(imidazo[1, 2-a]pyridin-6-yl)ethyl)-6-(1-methyl-1Hpyrazol-4-yl)-1H-[1, 2, 3]triazolo[4, 5-b]pyrazine (Volitinib) as a Highly Potent and Selective Mesenchymal-Epithelial Transition Factor(c-Met) Inhibitor in Clinical Development for Treatment of Cancer", JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, no. 18, pages 7583 *
YE LIANBAO等: "Design and Synthesis of Some Novel 3H-[1, 2, 3]triazolo[4, 5-d]pyrimidines as Potential c-Met Inhibitors", INTERNATIONAL JOURNAL FOR PHARMACEUTICAL RESEARH SCHOLARS, vol. 3, no. 1, pages 415 *
YE LIANBAO等: "Design, synthesis and molecular docking analysis of some novel 7-[(quinolin-6-yl) methyl] purines as potential c-Met inhibitors", MEDICINAL CHEMISTRY RESEARCH, vol. 24, no. 8, pages 3329 *

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118215664A (zh) * 2021-10-19 2024-06-18 上海瑛派药业有限公司 取代的三唑并杂芳基化合物作为usp1抑制剂及其应用
CN114181237A (zh) * 2021-12-01 2022-03-15 上海凌凯医药科技有限公司 一种1-异丙基吡唑-5-硼酸频那醇酯的合成方法
CN114181237B (zh) * 2021-12-01 2024-02-23 上海凌凯医药科技有限公司 一种1-异丙基吡唑-5-硼酸频那醇酯的合成方法
WO2023143424A1 (zh) * 2022-01-27 2023-08-03 四川海思科制药有限公司 一种氮杂并环衍生物及其在医药上的应用
WO2023155866A1 (zh) * 2022-02-18 2023-08-24 四川海思科制药有限公司 一种吡唑并吡啶衍生物及其在医药上的应用
CN116925098A (zh) * 2022-04-09 2023-10-24 深圳湾实验室 靶向泛素特异性蛋白酶1(usp1)的小分子抑制剂及其应用
WO2023208130A1 (zh) * 2022-04-29 2023-11-02 江苏亚虹医药科技股份有限公司 嘧啶类化合物、其制备方法及其医药用途
CN116496252A (zh) * 2022-04-29 2023-07-28 江苏亚虹医药科技股份有限公司 嘧啶类化合物、其制备方法及其医药用途
CN116496252B (zh) * 2022-04-29 2025-07-22 江苏亚虹医药科技股份有限公司 嘧啶类化合物、其制备方法及其医药用途
WO2024022266A1 (en) * 2022-07-25 2024-02-01 Guangdong Newopp Biopharmaceuticals Co., Ltd. Heteroaryl compounds as inhibitors of usp1
WO2024022519A1 (zh) * 2022-07-28 2024-02-01 先声再明医药有限公司 杂环并嘧啶类化合物及其应用
WO2024032647A1 (zh) * 2022-08-09 2024-02-15 上海济煜医药科技有限公司 含氮杂环化合物作为泛素-特异性蛋白酶1抑制剂的制备方法、应用及其用途
WO2024041634A1 (zh) * 2022-08-26 2024-02-29 先声再明医药有限公司 三环类化合物及其应用
WO2024046471A1 (zh) * 2022-09-02 2024-03-07 上海齐鲁制药研究中心有限公司 Usp1抑制剂
WO2024051795A1 (zh) * 2022-09-09 2024-03-14 正大天晴药业集团股份有限公司 用作泛素-特异性蛋白酶抑制剂的取代嘌呤酮衍生物
WO2024061213A1 (zh) * 2022-09-20 2024-03-28 正大天晴药业集团股份有限公司 用作泛素-特异性蛋白酶抑制剂的羰基稠合杂环衍生物
WO2024078436A1 (zh) * 2022-10-09 2024-04-18 海南先声再明医药股份有限公司 杂环并嘧啶类化合物、药物组合物及其应用
WO2024094170A1 (zh) * 2022-11-04 2024-05-10 深圳晶泰科技有限公司 泛素特异性蛋白酶1的抑制剂及其应用
WO2024153250A1 (zh) * 2023-01-20 2024-07-25 杭州英创医药科技有限公司 作为usp1抑制剂的化合物
WO2024222880A1 (zh) * 2023-04-27 2024-10-31 西藏海思科制药有限公司 一种吡啶并吡唑衍生物的药物组合物及其在医药上的应用
CN116768906B (zh) * 2023-05-29 2024-04-09 遵义医科大学珠海校区 一种三并环化合物及其制备方法和应用
CN116768906A (zh) * 2023-05-29 2023-09-19 遵义医科大学珠海校区 一种三并环化合物及其制备方法和应用
WO2025007840A1 (zh) * 2023-07-05 2025-01-09 江苏亚虹医药科技股份有限公司 联嘧啶化合物的晶型及其制备方法和用途
WO2025007777A1 (zh) * 2023-07-05 2025-01-09 江苏亚虹医药科技股份有限公司 嘧啶类化合物、其制备方法及其医药用途
WO2025067259A1 (zh) * 2023-09-26 2025-04-03 上海济煜医药科技有限公司 一类氮杂环胺类化合物作为泛素-特异性蛋白酶1抑制剂的制备方法、应用及其用途
WO2025180502A1 (zh) * 2024-03-01 2025-09-04 上海齐鲁制药研究中心有限公司 一种联合用药物组合物及其用途

Also Published As

Publication number Publication date
AU2019405925A1 (en) 2021-07-29
SG11202106232TA (en) 2021-07-29
AU2019405925B2 (en) 2025-07-03
US11787813B2 (en) 2023-10-17
JP2022511515A (ja) 2022-01-31
TW202039501A (zh) 2020-11-01
US11485736B2 (en) 2022-11-01
CA3122108A1 (en) 2020-06-25
TWI895986B (zh) 2025-09-01
EP3897652A4 (en) 2022-09-14
KR20210105887A (ko) 2021-08-27
JP7662519B2 (ja) 2025-04-15
IL284050A (en) 2021-08-31
IL284050B1 (en) 2025-09-01
KR102912147B1 (ko) 2026-01-13
EP3897652A1 (en) 2021-10-27
US20230203046A1 (en) 2023-06-29
CO2021009078A2 (es) 2021-10-29
BR112021010715A2 (pt) 2021-11-16
MX2021007179A (es) 2021-09-28
JP2024150464A (ja) 2024-10-23
IL284050B2 (en) 2026-01-01
TWI834784B (zh) 2024-03-11
TW202421630A (zh) 2024-06-01
PH12021551402A1 (en) 2023-05-03
CL2021001575A1 (es) 2022-06-03
US20210115049A1 (en) 2021-04-22
WO2020132269A1 (en) 2020-06-25

Similar Documents

Publication Publication Date Title
CN113164485A (zh) 被取代的吡唑并嘧啶和被取代的嘌呤以及其作为泛素特异性加工蛋白酶1(usp1)抑制剂的用途
KR102891608B1 (ko) Irak 분해제 및 이의 용도
EP4667458A1 (en) Pharmaceutical composition for treatment of cancer, comprising sos1 inhibitor and anticancer drug
WO2020239077A1 (zh) 含氮杂环类衍生物调节剂、其制备方法和应用
KR20210049090A (ko) A2a/a2b 억제제로서 융합된 피라진 유도체
IL311187B1 (en) Process for the synthesis of fused cyclic chemical compounds and intermediates therefor
TW202400576A (zh) 嘧啶類化合物、其製備方法及其醫藥用途
TW201811797A (zh) 細胞代謝過程之抑制劑
JPWO2013051639A1 (ja) ピラゾロキノリン誘導体
TW201542520A (zh) 炔基醇及其使用方法
US20230219965A1 (en) Nitrogen-containing fused bicyclic compounds and their use as ubiquitin-specific-processing protease 1 (usp1) inhibitors
WO2019196720A1 (zh) 一类精氨酸甲基转移酶抑制剂及其药物组合物和用途
CN113227095A (zh) 作为irak4抑制剂的新三环化合物
WO2021249417A1 (zh) 杂环化合物及其衍生物
CN112279837B (zh) 吡嗪化合物和其用途
CN111747954B (zh) 吡嗪化合物和其用途
RU2833222C2 (ru) Замещенные пиразолопиримидины и замещенные пурины и их применение в качестве ингибиторов убиквитин-специфической процессирующей протеазы 1 (usp1)
TWI915372B (zh) 含氮稠合二環化合物及其作為泛素特異性加工蛋白酶１（ｕｓｐ１）抑制劑之用途
HK40074500A (en) Pyrazine compounds and uses thereof
CN119019362A (zh) 杂芳环类化合物、其药物组合物及其应用
HK40037929A (en) Pyrazine compounds and uses thereof
HK40037929B (en) Pyrazine compounds and uses thereof
CN117062817A (zh) 用于抑制sgk-1的吡唑并[3,4-d]嘧啶-6-基-磺酰胺衍生物
HK40045062A (en) Pyrazine compounds and uses thereof
HK40045062B (en) Pyrazine compounds and uses thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination