CO2021009078A2 - Pirazolopirimidinas sustituidas y purinas sustituidas y su uso como inhibidores de proteasa procesadora específica de ubiquitina 1 (usp1) - Google Patents

Pirazolopirimidinas sustituidas y purinas sustituidas y su uso como inhibidores de proteasa procesadora específica de ubiquitina 1 (usp1)

Info

Publication number
CO2021009078A2
CO2021009078A2 CONC2021/0009078A CO2021009078A CO2021009078A2 CO 2021009078 A2 CO2021009078 A2 CO 2021009078A2 CO 2021009078 A CO2021009078 A CO 2021009078A CO 2021009078 A2 CO2021009078 A2 CO 2021009078A2
Authority
CO
Colombia
Prior art keywords
usp1
substituted
ubiquitin
inhibitors
specific processing
Prior art date
Application number
CONC2021/0009078A
Other languages
English (en)
Inventor
Jehrod Burnett Brenneman
Elsa Beyer Krall
Michael Schlabach
Andrew Alistair Wylie
Original Assignee
Ksq Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ksq Therapeutics Inc filed Critical Ksq Therapeutics Inc
Publication of CO2021009078A2 publication Critical patent/CO2021009078A2/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La presente descripción proporciona compuestos que tienen la Fórmula I: I y las sales y solvatos farmacéuticamente aceptables de estos, donde X1, X2, X11, X12, R1, R3, R5, R5', R6 y R7 se definen como se indica en la memoria descriptiva. La presente descripción también hace referencia al uso de compuestos de Fórmula I para inhibir una proteína USP1 y/o para tratar un trastorno que responde a la inhibición de proteínas USP1 y la actividad de USP1. Los compuestos de la presente descripción son especialmente útiles para el tratamiento del cáncer.
CONC2021/0009078A 2018-12-20 2021-07-12 Pirazolopirimidinas sustituidas y purinas sustituidas y su uso como inhibidores de proteasa procesadora específica de ubiquitina 1 (usp1) CO2021009078A2 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201862783014P 2018-12-20 2018-12-20
US201962799423P 2019-01-31 2019-01-31
US201962857986P 2019-06-06 2019-06-06
US201962868616P 2019-06-28 2019-06-28
US201962946263P 2019-12-10 2019-12-10
PCT/US2019/067521 WO2020132269A1 (en) 2018-12-20 2019-12-19 Substituted pyrazolopyrimidines and substituted purines and their use as ubiquitin-specific-processing protease 1 (usp1) inhibitors

Publications (1)

Publication Number Publication Date
CO2021009078A2 true CO2021009078A2 (es) 2021-10-29

Family

ID=71100912

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2021/0009078A CO2021009078A2 (es) 2018-12-20 2021-07-12 Pirazolopirimidinas sustituidas y purinas sustituidas y su uso como inhibidores de proteasa procesadora específica de ubiquitina 1 (usp1)

Country Status (14)

Country Link
US (2) US11485736B2 (es)
EP (1) EP3897652A4 (es)
JP (1) JP2022511515A (es)
KR (1) KR20210105887A (es)
CN (1) CN113164485A (es)
AU (1) AU2019405925A1 (es)
BR (1) BR112021010715A2 (es)
CA (1) CA3122108A1 (es)
CL (1) CL2021001575A1 (es)
CO (1) CO2021009078A2 (es)
IL (1) IL284050A (es)
MX (1) MX2021007179A (es)
SG (1) SG11202106232TA (es)
WO (1) WO2020132269A1 (es)

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Also Published As

Publication number Publication date
AU2019405925A1 (en) 2021-07-29
KR20210105887A (ko) 2021-08-27
CL2021001575A1 (es) 2022-06-03
SG11202106232TA (en) 2021-07-29
US11485736B2 (en) 2022-11-01
US11787813B2 (en) 2023-10-17
US20210115049A1 (en) 2021-04-22
TW202039501A (zh) 2020-11-01
EP3897652A1 (en) 2021-10-27
MX2021007179A (es) 2021-09-28
JP2022511515A (ja) 2022-01-31
WO2020132269A1 (en) 2020-06-25
CA3122108A1 (en) 2020-06-25
BR112021010715A2 (pt) 2021-11-16
IL284050A (en) 2021-08-31
CN113164485A (zh) 2021-07-23
US20230203046A1 (en) 2023-06-29
EP3897652A4 (en) 2022-09-14

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