PH12021551402A1 - Substituted pyrazolopyrimidines and substituted purines and their use as ubiquitin-specific-processing protease 1 (usp1) inhibitors - Google Patents
Substituted pyrazolopyrimidines and substituted purines and their use as ubiquitin-specific-processing protease 1 (usp1) inhibitorsInfo
- Publication number
- PH12021551402A1 PH12021551402A1 PH1/2021/551402A PH12021551402A PH12021551402A1 PH 12021551402 A1 PH12021551402 A1 PH 12021551402A1 PH 12021551402 A PH12021551402 A PH 12021551402A PH 12021551402 A1 PH12021551402 A1 PH 12021551402A1
- Authority
- PH
- Philippines
- Prior art keywords
- usp1
- substituted
- ubiquitin
- inhibitors
- specific
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Hospice & Palliative Care (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862783014P | 2018-12-20 | 2018-12-20 | |
| US201962799423P | 2019-01-31 | 2019-01-31 | |
| US201962857986P | 2019-06-06 | 2019-06-06 | |
| US201962868616P | 2019-06-28 | 2019-06-28 | |
| US201962946263P | 2019-12-10 | 2019-12-10 | |
| PCT/US2019/067521 WO2020132269A1 (en) | 2018-12-20 | 2019-12-19 | Substituted pyrazolopyrimidines and substituted purines and their use as ubiquitin-specific-processing protease 1 (usp1) inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH12021551402A1 true PH12021551402A1 (en) | 2023-05-03 |
Family
ID=71100912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH1/2021/551402A PH12021551402A1 (en) | 2018-12-20 | 2019-12-19 | Substituted pyrazolopyrimidines and substituted purines and their use as ubiquitin-specific-processing protease 1 (usp1) inhibitors |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11485736B2 (https=) |
| EP (1) | EP3897652A4 (https=) |
| JP (2) | JP7662519B2 (https=) |
| KR (1) | KR102912147B1 (https=) |
| CN (1) | CN113164485A (https=) |
| AU (1) | AU2019405925B2 (https=) |
| BR (1) | BR112021010715A2 (https=) |
| CA (1) | CA3122108A1 (https=) |
| CL (1) | CL2021001575A1 (https=) |
| CO (1) | CO2021009078A2 (https=) |
| IL (1) | IL284050B2 (https=) |
| MX (1) | MX2021007179A (https=) |
| PH (1) | PH12021551402A1 (https=) |
| SG (1) | SG11202106232TA (https=) |
| TW (2) | TWI895986B (https=) |
| WO (1) | WO2020132269A1 (https=) |
Families Citing this family (60)
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| US10189841B2 (en) | 2015-11-20 | 2019-01-29 | Forma Therapeutics, Inc. | Purinones as ubiquitin-specific protease 1 inhibitors |
| BR112021010715A2 (pt) | 2018-12-20 | 2021-11-16 | Ksq Therapeutics Inc | Pirazolopirimidinas substituídas e purinas substituídas e seu uso como inibidores de protease de processamento ubiquitina-específica 1 (usp1) |
| JP7253640B2 (ja) | 2019-01-31 | 2023-04-06 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| ES3025474T3 (en) * | 2020-01-15 | 2025-06-09 | Ksq Therapeutics Inc | Compositions of substituted pyrazolopyrimidines and uses thereof |
| CA3168009A1 (en) * | 2020-02-14 | 2021-08-19 | KSQ Therapeutics, Inc. | Therapeutic combinations comprising ubiquitin-specific-processing protease 1 (usp1) inhibitors and poly (adp-ribose) polymerase (parp) inhibitors |
| EP4161494A4 (en) * | 2020-06-02 | 2024-07-17 | KSQ Therapeutics, Inc. | NITROGEN-CONTAINING FUSED BICYCLIC COMPOUNDS AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS |
| WO2022053998A1 (en) * | 2020-09-10 | 2022-03-17 | Universidade Do Porto | New pharmaceutical compounds, methods and uses thereof |
| KR20230098186A (ko) * | 2020-10-30 | 2023-07-03 | 케이에스큐 세러퓨틱스 인코포레이티드 | 치환된 피라졸로피리미딘의 고체 상태 형태 및 이의 용도 |
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| EP4430041A4 (en) * | 2021-11-12 | 2025-09-24 | Insilico Medicine Ip Ltd | SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 1 (USP1) AND THEIR USES |
| CN114181237B (zh) * | 2021-12-01 | 2024-02-23 | 上海凌凯医药科技有限公司 | 一种1-异丙基吡唑-5-硼酸频那醇酯的合成方法 |
| IL312982A (en) * | 2021-12-09 | 2024-07-01 | Ksq Therapeutics Inc | Methods for the preparation of converted pyrazolopyrimidines |
| CN118525022A (zh) * | 2022-01-27 | 2024-08-20 | 西藏海思科制药有限公司 | 一种氮杂并环衍生物及其在医药上的应用 |
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| IL315748A (en) * | 2022-04-08 | 2024-11-01 | Ksq Therapeutics Inc | Therapeutic combinations containing ubiquitin-specific processing protease 1 (USP1) inhibitors and chemotherapy agents |
| CN116925098B (zh) * | 2022-04-09 | 2026-02-17 | 深圳湾实验室 | 靶向泛素特异性蛋白酶1(usp1)的小分子抑制剂及其应用 |
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| CN119522224A (zh) * | 2022-08-09 | 2025-02-25 | 上海济煜医药科技有限公司 | 含氮杂环化合物作为泛素-特异性蛋白酶1抑制剂的制备方法、应用及其用途 |
| CN117263944B (zh) * | 2022-08-24 | 2025-10-17 | 轩竹生物科技股份有限公司 | 泛素特异性蛋白酶1抑制剂及其用途 |
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| WO2024086790A1 (en) | 2022-10-21 | 2024-04-25 | Exelixis, Inc. | 4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-c]PYRIDINE COMPOUNDS AND DERIVATIVES AS USP1 INHIBITORS |
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| CN120513237A (zh) | 2023-01-12 | 2025-08-19 | 先正达农作物保护股份公司 | 除草咪唑化合物 |
| CN120603835A (zh) * | 2023-01-20 | 2025-09-05 | 杭州英创医药科技有限公司 | 作为usp1抑制剂的化合物 |
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| TW202530229A (zh) * | 2023-09-26 | 2025-08-01 | 大陸商上海濟煜醫藥科技有限公司 | 氮雜環胺類化合物作為泛素-特異性蛋白酶１抑制劑的製備方法、應用及其用途 |
| WO2025095751A1 (ko) * | 2023-10-30 | 2025-05-08 | 현대약품 주식회사 | 신규한 화합물, 및 이를 포함하는 암의 예방 또는 치료용 약학적 조성물 |
| TW202535865A (zh) | 2023-10-31 | 2025-09-16 | 美商必治妥美雅史谷比公司 | 泛素特異性加工蛋白酶1 (usp1) 化合物 |
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| BR112021010715A2 (pt) | 2018-12-20 | 2021-11-16 | Ksq Therapeutics Inc | Pirazolopirimidinas substituídas e purinas substituídas e seu uso como inibidores de protease de processamento ubiquitina-específica 1 (usp1) |
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2019
- 2019-12-19 BR BR112021010715A patent/BR112021010715A2/pt unknown
- 2019-12-19 TW TW113105437A patent/TWI895986B/zh active
- 2019-12-19 PH PH1/2021/551402A patent/PH12021551402A1/en unknown
- 2019-12-19 JP JP2021531985A patent/JP7662519B2/ja active Active
- 2019-12-19 SG SG11202106232TA patent/SG11202106232TA/en unknown
- 2019-12-19 AU AU2019405925A patent/AU2019405925B2/en active Active
- 2019-12-19 CN CN201980079551.2A patent/CN113164485A/zh active Pending
- 2019-12-19 IL IL284050A patent/IL284050B2/en unknown
- 2019-12-19 US US16/721,079 patent/US11485736B2/en active Active
- 2019-12-19 MX MX2021007179A patent/MX2021007179A/es unknown
- 2019-12-19 EP EP19897934.6A patent/EP3897652A4/en active Pending
- 2019-12-19 KR KR1020217017482A patent/KR102912147B1/ko active Active
- 2019-12-19 WO PCT/US2019/067521 patent/WO2020132269A1/en not_active Ceased
- 2019-12-19 TW TW108146728A patent/TWI834784B/zh active
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2021
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2022
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2024
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Also Published As
| Publication number | Publication date |
|---|---|
| AU2019405925A1 (en) | 2021-07-29 |
| SG11202106232TA (en) | 2021-07-29 |
| AU2019405925B2 (en) | 2025-07-03 |
| US11787813B2 (en) | 2023-10-17 |
| JP2022511515A (ja) | 2022-01-31 |
| TW202039501A (zh) | 2020-11-01 |
| CN113164485A (zh) | 2021-07-23 |
| US11485736B2 (en) | 2022-11-01 |
| CA3122108A1 (en) | 2020-06-25 |
| TWI895986B (zh) | 2025-09-01 |
| EP3897652A4 (en) | 2022-09-14 |
| KR20210105887A (ko) | 2021-08-27 |
| JP7662519B2 (ja) | 2025-04-15 |
| IL284050A (en) | 2021-08-31 |
| IL284050B1 (en) | 2025-09-01 |
| KR102912147B1 (ko) | 2026-01-13 |
| EP3897652A1 (en) | 2021-10-27 |
| US20230203046A1 (en) | 2023-06-29 |
| CO2021009078A2 (es) | 2021-10-29 |
| BR112021010715A2 (pt) | 2021-11-16 |
| MX2021007179A (es) | 2021-09-28 |
| JP2024150464A (ja) | 2024-10-23 |
| IL284050B2 (en) | 2026-01-01 |
| TWI834784B (zh) | 2024-03-11 |
| TW202421630A (zh) | 2024-06-01 |
| CL2021001575A1 (es) | 2022-06-03 |
| US20210115049A1 (en) | 2021-04-22 |
| WO2020132269A1 (en) | 2020-06-25 |
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