CN112772929B - 一种补钙组合物及其制备方法 - Google Patents
一种补钙组合物及其制备方法 Download PDFInfo
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- CN112772929B CN112772929B CN202110130168.4A CN202110130168A CN112772929B CN 112772929 B CN112772929 B CN 112772929B CN 202110130168 A CN202110130168 A CN 202110130168A CN 112772929 B CN112772929 B CN 112772929B
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- maltodextrin
- calcium
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- composition
- stachyose
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Classifications
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- A—HUMAN NECESSITIES
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Abstract
本发明涉及保健品技术领域,具体涉及一种补钙组合物及其制备方法,所述组合物包括如下组分:水苏糖、酪蛋白磷酸肽、碳酸钙、L‑乳酸钙、天门冬氨酸钙、蘑菇粉和麦芽糊精,本发明具有补钙效果好、制备工艺简单、产品稳定性和溶解性能优异的优点。
Description
技术领域
本发明涉及保健品技术领域,具体涉及一种补钙组合物及其制备方法。
背景技术
钙在人体生长发育过程中发挥着重要作用,人体钙的短缺会引发一系列疾病,例如佝偻病、婴幼儿手足抽搐、老年人骨质疏松,同时也会引发高血压、冠心病等,因此钙制剂的研发越来越受到人们的关注。一般钙源的选择有四种,分别为:无机钙、有机酸钙、氨基酸螯合钙以及肽钙复合物。无机钙钙含量较多,但在其吸收过程中会消耗大量胃酸;有机酸钙含钙量低但口感较好;而氨基酸螯合钙和肽钙复合物,两者皆可以整体的形式被小肠吸收,因此成为补钙产品的优选钙源。在补钙产品的研发过程中,除钙源的选择之外,促钙吸收原料的选择也极其重要。研究表明,肠道菌群可使益生元发酵产生有机酸,降低肠道pH值,提高矿物质溶解度,可被适当添加于补钙产品中以促进钙吸收。
食品中的钙以钙盐或钙离子复合物形式进入人体后被胃酸解离成离子形式继而被吸收。约90%的钙离子进入人体后会被小肠吸收。哺乳动物体内钙的吸收途径可分为饱和的跨细胞途径(即主动吸收)和细胞旁路途径(即被动吸收),而钙吸收的主要方式取决于机体钙含量,一般情况下哺乳动物体内两种钙吸收途径会同时进行。当机体对钙的需要量较高或者膳食钙摄入很低时,肠道对钙的跨细胞途径被激活,以促进钙的吸收。在钙的跨细胞途径过程中Ca2+通过瞬时性受体电位通道的瞬时受体阳离子通道亚家族V成员5(TRPV5)和TRPV6进入细胞后,与钙结合蛋白结合扩散到基底外侧膜。在基底外侧膜处,钙离子通过ATP依赖的Ca2+-三磷酸腺苷酶和钠离子/钙离子交换体排出,然后释放到血液或组织液中。
无机钙中的碳酸钙优点是含钙量高,缺点是溶解性差,口服之后,对胃肠有刺激,易出现胃胀、嗳气、便秘等不良反应。
中国专利申请CN111743133A提供了一种补钙益智蛋白组合物,包括以下质量百分含量的组分:20-30份山核桃仁、20-30份钙果、8-10份白砂糖、0.1-1份柠檬酸和0.15-0.25份稳定剂。该专利申请提供的补钙益智蛋白组合物具有独特风味、气味清香、口感顺滑等优势,同时还具有补充钙质、益智等功效;采用该专利申请提供的组合物制备得到的饮料,使得蛋白饮料种类的增加,为蛋白饮料提供了一条新的思路。该专利申请提供的补钙益智蛋白饮料的制备方法进行生产具有无污染,无废渣、废气等有害物质产生的优势,适用于工业化生产。但是该发明的补钙效果有待进一步提高。
中国专利申请CN110101086A提供了一种促进钙吸收的补钙组合物及其制备方法。该组合物包括以下原料:砂仁、肉豆蔻、乳酸钙、酪蛋白磷酸肽、水解蛋黄粉、海藻粉、薏苡仁、茯苓、山药、甘草、白扁豆、桂圆、焦山楂、丁香、陈皮、藿香、黑芝麻和低聚果糖。以上各成分相互协同,能够健脾运,增胃纳,促进食欲,提高小肠钙吸收机体的运行,且改善机体对钙的吸收,从而使该组合物不仅可适用于健康人群,同样还可适用于脾胃不和人群,对其吸收钙有很大帮助。但是该专利申请中的组合物组成复杂,含有多种中药成分,作用机理不明确,不适合儿童补钙。
中国专利申请CN109953981A公开了一种具有补钙作用的药物组合物及其制剂和制备方法。该药物组合物原辅料为:葡萄糖酸钙、葡萄糖酸锌、盐酸赖氨酸、薄荷醇、L天冬氨酸;研究表明,该发明药物组合物具有很好的稳定性,微生物限度检查符合药典的规定。但是该专利的补钙效果有待进一步提高。
因此,开发一种能解决上述技术问题的补钙组合物及其制备方法是非常必要的。
发明内容
本发明的目的是克服现有技术的不足而提供一种补钙效果好、制备工艺简单、产品稳定性和溶解性能优异的、适宜于3岁及以上人群的补钙组合物及其制备方法,是一种口感好、溶解性好、无沉淀、无异味、不含甜味剂、富含膳食纤维、可单独冲服或加入牛奶中混合食用的儿童友好型补钙产品。
本发明是通过以下技术方案予以实现的:
一种组合物,包括如下组分:水苏糖、酪蛋白磷酸肽、碳酸钙、L-乳酸钙、天门冬氨酸钙、蘑菇粉和麦芽糊精。
优选地,所述的组合物,按照重量份数计,包括如下组分:水苏糖15-20份、酪蛋白磷酸肽0.2-0.6份、碳酸钙1-2份、L-乳酸钙0.5-3份、天门冬氨酸钙0.2-1.5份、蘑菇粉0.1-0.4份和麦芽糊精60-100份。
优选地,所述的组合物,按照重量份数计,包括如下组分:水苏糖16-19份、酪蛋白磷酸肽0.3-0.5份、碳酸钙1.2-1.6份、L-乳酸钙1-2.5份、天门冬氨酸钙0.5-1份、蘑菇粉0.2-0.3份和麦芽糊精75-90份。
本发明还涉及上述的组合物的制备工艺,包括如下步骤:
(1)将酪蛋白磷酸肽、碳酸钙、L-乳酸钙、天门冬氨酸钙和蘑菇粉与A部分麦芽糊精预混,再加入B部分麦芽糊精混合,得到预混料A;
(2)依次将C部分麦芽糊精、水苏糖、预混料A、剩余部分麦芽糊精混合,即得。
优选地,所述A部分麦芽糊精为30-35%的麦芽糊精。
优选地,所述B部分麦芽糊精为20-30%的麦芽糊精。
优选地,所述C部分麦芽糊精为20-30%的麦芽糊精。
优选地,步骤(1)中所述预混的时间为10-20min。
优选地,步骤(1)中再加入B部分麦芽糊精混合的时间为20-40min。
优选地,步骤(2)中各物料混合前分别过40-120目筛。
优选地,步骤(2)各物料混合工艺为先将C部分麦芽糊精和水苏糖混合,再在5-9min后投入预混料A,10-15min后投入剩余麦芽糊精,最后将所有物料一起混合16-20min。
优选地,步骤(2)中C部分麦芽糊精过40-60目筛,预混料A过60-80目筛,水苏糖过80-120目筛,剩余部分麦芽糊精过60-100目筛。
更优选地,所述组合物的制备工艺,包括如下步骤:
(1)将酪蛋白磷酸肽、碳酸钙、L-乳酸钙、天门冬氨酸钙和蘑菇粉与30-35%的麦芽糊精预混10-20min,再加入20-30%的麦芽糊精混合20-40min,得到预混料A;
(2)依次将20-30%的麦芽糊精过40-60目筛,水苏糖过80-120目筛,预混料A过60-80目筛,剩余部分麦芽糊精过60-100目筛后混合,各物料混合工艺为先将20-30%的麦芽糊精和水苏糖混合,再在5-9min后投入预混料A,10-15min后投入剩余麦芽糊精,最后将所有物料一起混合16-20min,即得。
本发明还涉及一种制剂,包括上述的组合物或上述的制备工艺制备得到的组合物。
本发明还涉及上述的组合物或上述的制备工艺制备得到的组合物或上述的制剂在制备适用于补钙的食品或保健品中的应用。
本发明的有益效果是:
本发明优化了补钙组合物的组成以及各组分的用量配比,尤其是通过研究钙源的复配和辅料的组成,改善了肠道健康,促进了钙的吸收,补钙效果显著,且口感优异。
本发明优化了补钙组合物的制备工艺,比如优化了原料的添加顺序以及混合粒径,制备得到的组合物质量稳定,溶解性能优异,补钙效果进一步提高。
本发明制备得到的产品用于3岁及以上人群均补钙效果显著,无副作用,避免了碳酸钙引起的便秘等不良后果。
具体实施方式
下面结合具体实施例来进一步描述本发明,本发明的优点和特点将会随着描述而更为清楚。但这些实施例仅是范例性的,并不对本发明的范围构成任何限制。本领域技术人员应该理解的是,在不偏离本发明的精神和范围下可以对本发明技术方案的细节和形式进行修改或替换,但这些修改和替换均落入本发明的保护范围内。
本发明各实施例和对比例中的酪蛋白磷酸肽,购自上海普洛钦国际贸易有限公司,型号HCP-102;
本发明各实施例和对比例中的蘑菇粉购自北京勤聪驰达健康科技有限公司,型号维生素D含量5000IU/g;
本发明各实施例和对比例中的麦芽糊精购自保龄宝生物股份有限公司,型号普通型。
实施例1
一种组合物,按照重量份数计,包括如下组分:水苏糖15份、酪蛋白磷酸肽0.2份、碳酸钙1份、L-乳酸钙0.5份、天门冬氨酸钙0.2份、蘑菇粉0.1份和麦芽糊精60份。
所述组合物的制备工艺,包括如下步骤:
(1)将酪蛋白磷酸肽、碳酸钙、L-乳酸钙、天门冬氨酸钙和蘑菇粉与30%的麦芽糊精预混10min,再加入20%的麦芽糊精混合20min,得到预混料A;
(2)依次将20%的麦芽糊精过40目筛,水苏糖过80目筛,预混料A过60目筛,剩余部分麦芽糊精过60目筛后混合,各物料混合工艺为先将20%的麦芽糊精和水苏糖混合,再在5min后投入预混料A,10min后投入剩余麦芽糊精,最后将所有物料一起混合16min,即得。
实施例2
一种组合物,按照重量份数计,包括如下组分:水苏糖20份、酪蛋白磷酸肽0.6份、碳酸钙2份、L-乳酸钙1.5份、天门冬氨酸钙1.5份、蘑菇粉0.4份和麦芽糊精100份。
所述组合物的制备工艺,包括如下步骤:
(1)将酪蛋白磷酸肽、碳酸钙、L-乳酸钙、天门冬氨酸钙和蘑菇粉与35%的麦芽糊精预混20min,再加入30%的麦芽糊精混合40min,得到预混料A;
(2)依次将30%的麦芽糊精过60目筛,水苏糖过120目筛,预混料A过80目筛,剩余部分麦芽糊精过100目筛后混合,各物料混合工艺为先将30%的麦芽糊精和水苏糖混合,再在9min后投入预混料A,15min后投入剩余麦芽糊精,最后将所有物料一起混合20min,即得。
实施例3
一种组合物,按照重量份数计,包括如下组分:水苏糖18份、酪蛋白磷酸肽0.4份、碳酸钙1.4份、L-乳酸钙3份、天门冬氨酸钙0.6份、蘑菇粉0.3份和麦芽糊精80份。
所述组合物的制备工艺,包括如下步骤:
(1)将酪蛋白磷酸肽、碳酸钙、L-乳酸钙、天门冬氨酸钙和蘑菇粉与32%的麦芽糊精预混15min,再加入25%的麦芽糊精混合30min,得到预混料A;
(2)依次将25%的麦芽糊精过50目筛,水苏糖过100目筛,预混料A过70目筛,剩余部分麦芽糊精过80目筛后混合,各物料混合工艺为先将25%的麦芽糊精和水苏糖混合,再在7min后投入预混料A,12min后投入剩余麦芽糊精,最后将所有物料一起混合18min,即得。
对比例1
与实施例3的区别仅在于碳酸钙、L-乳酸钙和天门冬氨酸钙的总质量不变,三者用量配比不同,其余条件均相同,具体如下:
一种组合物,按照重量份数计,包括如下组分:水苏糖18份、酪蛋白磷酸肽0.4份、碳酸钙1.4份、L-乳酸钙1.0份、天门冬氨酸钙2.6份、蘑菇粉0.3份和麦芽糊精80份。
对比例2
与实施例3的区别仅在于L-乳酸钙替换为等质量的葡萄糖酸钙,其余条件均相同。
对比例3
与实施例3的区别仅在于水苏糖、酪蛋白磷酸肽和蘑菇粉的总质量不变,三者用量配比不同,其余条件均相同,具体如下:
一种组合物,按照重量份数计,包括如下组分:水苏糖14.9份、酪蛋白磷酸肽1.5份、碳酸钙1.4份、L-乳酸钙1.5份、天门冬氨酸钙0.8份、蘑菇粉2.3份和麦芽糊精80份。
对比例4
与实施例3的区别仅在于组合物制备过程中,步骤(2)的麦芽糊精一次性加入,并且原料混合顺序不同,其余条件均相同,具体如下:
(1)将酪蛋白磷酸肽、碳酸钙、L-乳酸钙、天门冬氨酸钙和蘑菇粉与32%的麦芽糊精预混15min,再加入25%的麦芽糊精混合30min,得到预混料A;
(2)依次将25%的麦芽糊精过50目筛,剩余部分麦芽糊精过80目筛,水苏糖过100目筛,预混料A过70目筛后混合,各物料混合工艺为先将25%的麦芽糊精、剩余部分麦芽糊精和水苏糖混合12min,再在7min后投入预混料A,最后将所有物料一起混合18min,即得。
对比例5
与实施例3的区别仅在于组合物制备过程中,步骤(2)的原料过筛粒径不同,其余条件均相同,具体如下:
(2)依次将25%的麦芽糊精过80目筛,水苏糖过70目筛,预混料A过100目筛,剩余部分麦芽糊精过50目筛后混合,各物料混合工艺为先将25%的麦芽糊精和水苏糖混合,再在7min后投入预混料A,12min后投入剩余麦芽糊精,最后将所有物料一起混合18min,即得。
测试例1
实施例1-3和对比例1-5制备得到的组合物在体外胃肠模拟体系中进行稳定性比较,进一步推测各实施例和对比例的补钙效果,以及各组分的口感评分,结果如表1所示。口感评分表如表2所示,总分10分。
钙吸收测试方法:比较实施例1-3和对比例1-5中组合物的消化稳定性。
将实施例1-3和对比例1-5的组合物分别配成0.5%的溶液,用6M HCL调pH至2.0,加入2%胃液在37℃水浴中酶解2h后取出样品,测定组合物经胃液消化后液体中的结合钙含量(mg/L)。胃液消化后,继续用6M NaOH调pH至7.6,加入2%肠液,37℃水浴继续酶解,2h后取出样品,测定样品经胃肠液共同消化后液体中的游离钙、结合钙及沉淀钙含量(mg/L)。
钙含量参照《GB/T 5009.268-2016食品中多元素的测定》中电感耦合等离子体法进行检测。游离钙在小肠弱碱性环境中易生成不溶性物质,会抑制钙的吸收,结合钙可以直接被小肠上皮细胞吸收。
其中,“总Ca含量”为各组合物中的钙元素含量。
表1补钙效果和口感测试结果
表2口感评分表
上述详细说明是针对本发明其中之一可行实施例的具体说明,该实施例并非用以限制本发明的专利范围,凡未脱离本发明所为的等效实施或变更,均应包含于本发明技术方案的范围内。
Claims (7)
1.一种组合物,其特征在于,按照重量份数计,包括如下组分:水苏糖15-20份、酪蛋白磷酸肽0.2-0.6份、碳酸钙1-2份、L-乳酸钙0.5-3份、天门冬氨酸钙0.2-1.5份、蘑菇粉0.1-0.4份和麦芽糊精60-100份;
所述的组合物的制备工艺,包括如下步骤:
(1)将酪蛋白磷酸肽、碳酸钙、L-乳酸钙、天门冬氨酸钙和蘑菇粉与A部分麦芽糊精预混,再加入B部分麦芽糊精混合,得到预混料A;
(2)依次将C部分麦芽糊精、水苏糖、预混料A、剩余部分麦芽糊精混合,即得;
所述A部分麦芽糊精为30-35%的麦芽糊精,所述B部分麦芽糊精为20-30%的麦芽糊精,所述C部分麦芽糊精为20-30%的麦芽糊精;
步骤(2)各物料混合工艺为先将C部分麦芽糊精和水苏糖混合,再在5-9min后投入预混料A,10-15min后投入剩余麦芽糊精,最后将所有物料一起混合16-20min;
步骤(2)中C部分麦芽糊精过40-60目筛,预混料A过60-80目筛,水苏糖过80-120目筛,剩余部分麦芽糊精过60-100目筛。
2.根据权利要求1所述的组合物,其特征在于,按照重量份数计,包括如下组分:水苏糖16-19份、酪蛋白磷酸肽0.3-0.5份、碳酸钙1.2-1.6份、L-乳酸钙1-2.5份、天门冬氨酸钙0.5-1份、蘑菇粉0.2-0.3份和麦芽糊精75-90份。
3.一种权利要求1-2任一所述的组合物的制备工艺,其特征在于,包括如下步骤:
(1)将酪蛋白磷酸肽、碳酸钙、L-乳酸钙、天门冬氨酸钙和蘑菇粉与A部分麦芽糊精预混,再加入B部分麦芽糊精混合,得到预混料A;
(2)依次将C部分麦芽糊精、水苏糖、预混料A、剩余部分麦芽糊精混合,即得;
所述A部分麦芽糊精为30-35%的麦芽糊精,所述B部分麦芽糊精为20-30%的麦芽糊精,所述C部分麦芽糊精为20-30%的麦芽糊精;
步骤(2)各物料混合工艺为先将C部分麦芽糊精和水苏糖混合,再在5-9min后投入预混料A,10-15min后投入剩余麦芽糊精,最后将所有物料一起混合16-20min;
步骤(2)中C部分麦芽糊精过40-60目筛,预混料A过60-80目筛,水苏糖过80-120目筛,剩余部分麦芽糊精过60-100目筛。
4.根据权利要求3所述的制备工艺,其特征在于,步骤(1)中所述预混的时间为10-20min;再加入B部分麦芽糊精混合的时间为20-40min。
5.一种制剂,其特征在于,包括权利要求1-2任一所述的组合物或权利要求3-4任一所述的制备工艺制备得到的组合物。
6.权利要求1-2任一所述的组合物或权利要求3-4任一所述的制备工艺制备得到的组合物或权利要求5所述的制剂在制备用于补钙的食品中的应用。
7.权利要求1-2任一所述的组合物或权利要求3-4任一所述的制备工艺制备得到的组合物或权利要求5所述的制剂在制备用于补钙的保健品中的应用。
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