CN101703248B - 一种含海洋生物活性多糖的肠内营养制剂及其制备方法和用途 - Google Patents
一种含海洋生物活性多糖的肠内营养制剂及其制备方法和用途 Download PDFInfo
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Abstract
本发明公开了一种含海洋生物活性多糖的肠内营养制剂,该制剂包含如下按质量百分比计的组分:海洋生物活性多糖0.5~0.8%,贝鱼肉酶解物25~35%,果蔬粉10~20%,Na-Fe-EDTA 0.05~0.1%,还包括大豆分离蛋白35~45%,海带粉1~5%和魔芋精粉3~5%。本发明还公开了上述含海洋生物活性多糖的肠内营养制剂的制备方法和用途。本发明含海洋生物活性多糖的肠内营养制剂具有高热量、高蛋白、高铁、低脂、含多种维生素且易于消化吸收的优点,充分满足铁需要量高的人群以及白血病患者的营养需求,同时与化疗药物协同作用,可以提高化疗药物的疗效,还可改善胃肠道功能,增强免疫力,减少贫血和并发感染等不良反应,起到良好的辅助治疗作用。
Description
技术领域
本发明涉及食品生产领域,具体涉及一种含海洋生物活性多糖的肠内营养制剂及其制备方法和用途。
背景技术
白血病患者在接受治疗的过程中,由于病情的进展、化疗药物的应用、心理因素等原因,而使患者进食量减少,机体得不到所必需的能量,导致本来极度衰竭的身体继续恶化,形成一种恶性循环。因而,白血病患者加强营养支持是非常重要的。但是白血病患者胃肠道功能较差,尤其是化疗期间,化疗药物抑制胃肠道细胞的生长,引起食欲减退、恶心呕吐、味觉异常及能量消耗增加等不良反应,同时由于免疫功能改变,机体的抵抗能力下降,为了恢复化疗药物损伤的正常细胞,需要将食物配制成高热量、高蛋白、高纤维和低脂的肠内营养制剂,以克服常规饮食营养摄入不足和肠外静脉营养所导致的肠道粘膜结构、吸收功能及免疫功能抑制的缺点,并减少医院传统自制的匀浆膳的卫生难以保证等问题。匀浆膳食易于消化吸收,能显著改善白血病患者的营养状况,提高机体抵抗力,减轻了化疗药物对机体的损害程度,减少了并发症及死亡率,对治疗得以继续进行有积极的意义。
已有研究证明,马氏珠母贝糖胺聚糖对人白血病细胞株HL-60细胞具有明显的抑制作用,且与5-氟尿嘧啶(5-Fu)合用具有协同作用,抑制率可以提高到57%;硫酸软骨素可有效地增强化疗药物对肿瘤细胞的杀伤作用;海带中含有的U-岩藻多糖类化合物能诱导癌细胞自杀,实验证明,将微量U-岩藻多糖类物质注入骨髓性白血病细胞,很快引起细胞内的染色体以自身体内拥有的酶将自己分解,2~3日癌细胞自我消灭,而对正常的细胞则不受伤害。
发明内容
本发明目的在于针对现有技术的不足,提供一种高铁、含多种维生素和营养成分的含海洋生物活性多糖的肠内营养制剂。
本发明另一目的在于提供上述含海洋生物活性多糖的肠内营养制剂的制备方法。
本发明还有一个目的是提供上述含海洋生物活性多糖的肠内营养制剂的用途。
本发明上述目的通过以下技术方案予以实现:
本发明通过将具有抑制白血病肿瘤细胞的海洋生物活性多糖、贝鱼肉酶解物、大豆分离蛋白、海带粉、果蔬粉、魔芋粉和Na-Fe-EDTA混合灭菌后得到的肠内营养制剂。
本发明含海洋生物活性多糖的肠内营养制剂由如下按质量百分数计的组分制成:海洋生物活性多糖0.5~0.8%,贝鱼肉酶解物25~35%,海带粉1~5%,果蔬粉10~20%和Na-Fe-EDTA 0.05~0.1%。
本发明含海洋生物活性多糖的肠内营养制剂优选由如下按质量百分数计的组分制成:海洋生物活性多糖0.5~0.8%,贝鱼肉酶解物25~35%,海带粉1~5%,果蔬粉10~20%,Na-Fe-EDTA 0.05~0.1%,魔芋粉3~5%和大豆分离蛋白35~45%,
所述海洋生物活性多糖为马氏珠母贝糖胺聚糖、海参硫酸软骨素或鱼骨硫酸软骨素。其中,马氏珠母贝糖胺聚糖可以参考现有技术来制备得到,例如参考中国专利CN1321469中糖胺聚糖的制备方法,即以马氏珠母贝全脏器为原料,经胃蛋白酶、胰蛋白酶、枯草杆菌中性蛋白酶水解,经脱色、有机溶剂沉淀后用吸附、等电点沉淀、透析、醇沉、CTAB沉淀等法除杂,粗提物再经醇沉、CTAB络合法纯化,得马氏珠母贝糖胺聚糖;鱼骨硫酸软骨素的原料<。)#)))≤是军曹鱼、鱿鱼、鲟鱼或鲨鱼;鱼骨硫酸软骨素和海参硫酸软骨素可以参考现有技术制备,如参考中国专利CN1273497中硫酸软骨素的制备方法,即鱼骨经蒸煮处理、保护或温和浸出、酶解、过滤除蛋白、超滤纯化、真空浓缩、喷雾干燥处理得到,所述的保护剂为亚硫酸钠、亚硫酸钾、亚硝酸钠、亚硝酸钾、硼氢化钠或硼氢化钾,所用的超滤器采用中空纤维超滤器、螺旋卷绕式超滤器、或板式超滤器。
所述贝鱼肉酶解物包括贝肉酶解物、鱼肉酶解物或二者的混合物,其中,贝肉酶解物可以是牡蛎、贻贝、波纹巴非蛤、文蛤、扇贝、珍珠贝等肉酶解物中的一种,这些贝肉酶解物可以参考现有技术制备,例如参考中国发明专利CN1703978中贝肉酶解方法来制备,即先将符合国家贝类食用相关标准贝类洗净,除去贝壳、贝边、内脏等下脚料,然后将贝肉匀浆,经酶解、除臭除腥,后经浓缩、干燥、粉碎,即得贝肉酶解物。所述的酶解可以采用海洋低温碱性蛋白酶、木瓜蛋白酶、胰蛋白酶、枯草杆菌蛋白酶、中性蛋白酶或复合风味酶等中的一种或一种以上,所述的除臭除腥可以采用常规的物理或化学方法进行,例如煮沸法、吸附法或添加柠檬法、甘草等,所述的浓缩、干燥、粉碎步骤均可以采用常规的方法;鱼肉酶解物可以是鳕鱼、军曹鱼、罗非鱼、鲈鱼、带鱼、大黄鱼、金枪鱼或草鱼中的一种或几种的混合物。
所述果蔬粉为番茄粉、胡萝卜粉、菠菜粉、猕猴桃粉、柑橘粉、香蕉粉中的一种或几种的混合物。
本发明含海洋生物活性多糖的肠内营养制剂的制备方法包括以下步骤:
将制备好的海洋生物活性多糖、贝肉酶解物、果蔬粉和Na-Fe-EDTA经混合干燥,粉碎过60目筛,经微波灭菌800kw,2min后即得。
本发明含海洋生物活性多糖的肠内营养制剂的制备方法优选为如下步骤:将制备好的海洋生物活性多糖、贝肉酶解物、果蔬粉、大豆分离蛋白、海带粉、魔芋粉和Na-Fe-EDTA经混合干燥,粉碎过60目筛,经微波灭菌800kw,2min后即得。
本发明肠内营养制剂的营养成分,经分析结果如下:
表1含海洋生物活性多糖的肠内营养制剂的营养分析
本发明含海洋生物活性多糖的肠内营养制剂由于含有丰富的铁,且对白血病细胞有显著的抑制作用,因此本发明营养制剂适用于铁需要量高的人群,尤其因为该营养制剂可以与化疗产生协同作用,因此特别适合化疗期间的急、慢性白血病患者、骨髓移植患者或铁需要量高的患者食用。
与现有技术相比,本发明具有如下有益效果:
(1)本发明肠内营养制剂中含有的海洋活性多糖组分对肿瘤细胞有显著的抑制作用,还可增强化疗药物对肿瘤细胞的杀伤作用,化疗期间的患者食用后可增强化疗的效果;
(2)本发明肠内营养制剂中的贝鱼肉酶解蛋白中含有大量优质蛋白、多肽、功能性短肽、人体必需氨基酸和牛磺酸等多种营养成分,易于吸收和消化,配合大豆分离蛋白可作为蛋白质和能量物质的来源,同时还可提高人体免疫力,增强抵抗力;
(3)本发明肠内营养制剂中的果蔬粉的铁含量高,维生素种类丰富,特别是维生素C的含量高,可以促进铁的吸收;
(4)本发明肠内营养制剂中的海带粉中含有大量人体必需的营养元素,如粗蛋白、海藻胶、淀粉、甘露醇、纤维素等多糖,以及维生素A、胡萝卜素、视黄醇、硫胺素、核黄素、尼克酸和维生素E等多种维生素,同时还含有钙、钾、钠、镁、铁、铜、碘、磷、锌、锰、硒、钴等矿物质,特别是铁的含量尤其丰富,为食用者提供充足的维生素、矿物质和植物蛋白;海带味强碱性食物,能有效防止血液酸化,调节机体的酸碱平衡;
(5)本发明肠内营养制剂中加入的魔芋粉是一种碱性食物,可作为膳食纤维,富含多种氨基酸和微量元素,同时具有助悬河乳化的作用,有利于将粉剂调制成流质,帮助增溶并稳定匀浆;
(6)本发明肠内营养制剂中加入了Na-Fe-EDTA,增加了铁的含量,可改善白血病患者由于失血出现的缺铁性贫血,同时减少放疗时放射元素在体内的残留;
(7)本发明肠内营养制剂的制备方法经微波处理后,不仅可以灭菌,还可使匀浆膳达到良好的色、香、味,有促进患者食欲、易于消化吸收的作用。
具体实施方式
以下结合实施例来进一步解释本发明,但实施例并不对本发明做任何限定。
实施例1
将马氏珠母贝全脏器1kg用高速组织捣碎机捣碎,分别二次用等体积丙酮浸泡24h与0.5h,滤除丙酮后置烘箱中60℃烘干1.5h,粉碎后过60目筛,得丙酮粉,用双酶法水解(胃蛋白酶水解条件:酶用量为4%,酶解温度为50℃,pH值为2.0~2.5,酶解时间为4h;枯草杆菌中性蛋白酶水解条件:酶用量6%,酶解温度为50℃,pH值为7.0,原料∶水为1∶10,酶解时间为6h),煮沸灭酶,用硅藻土∶活性炭为2∶3进行脱色后醇沉,调节pH2.0与pH7.0除蛋白,透析后再用乙醇浓度为50%,pH值为6.5沉淀8h,用无水乙醇洗涤,于40℃真空干燥得糖胺聚糖。
将符合国家食用相关标准的原料牡蛎洗净,除掉下脚料后取牡蛎肉1kg,将其匀浆后采用双酶酶解法水解,同时加入枯草杆菌中性蛋白酶和木瓜蛋白酶,酶解条件∶固液比为1∶4,pH7.0,温度50℃,加酶量2.0%,水解时间为2.5h,然后将酶解物在90℃下煮沸灭酶除臭除腥,70℃条件下真空浓缩3h,经喷雾干燥后即得牡蛎酶解物。
取上述制得的马氏珠母贝糖胺聚糖0.75g,牡蛎酶解物2g,从深圳市泰尔氨基酸生物制品有限公司购得鱼肉酶解物23g,从安阳漫天雪食品制造有限公司购得大豆分离蛋白45g,从青岛世展科技有限公司购得海带粉5g、从新疆富源果蔬制品有限公司购得番茄粉10g和猕猴桃粉10g,从襄樊惠葡生化科技工程有限公司购得魔芋精粉4.2g,从北京维他公司购得Na-Fe-EDTA0.05g。
将上述各原料由小量的逐渐加到量大的用搅拌混合器混合均匀,60℃真空干燥,粉碎过60目筛,经微波800KW,2min灭菌即得。
实施例2
将鱿鱼喉软骨除去非软骨成分,洗净,得到干净的软骨,粉碎,用2%浓度的碱液提取,温度50℃,料液比为1∶4,然后过滤取滤液,加入2%酶量的木瓜蛋白酶,酶解温度为55℃,酶解时间8h,而后醇沉,沉淀物经真空冷冻干燥即得鱿鱼硫酸软骨素。
取上述制得的鱿鱼硫酸软骨素0.8g,从广东兴亿海洋生物工程有限公司购得文蛤酶解物10g,从梁山科泰生物制品有限公司购得鱼肉酶解物25g,从天津云海国际贸易有限公司购得大豆分离蛋白40g,从宁波超星海洋生物制品有限公司购得海带粉3.12g,从天津市真如果食品工业有限公司购得胡萝卜粉18g,从嘉华进出口贸易公司购得魔芋精粉3g,从北京维他公司购得Na-Fe-EDTA0.08g。
将上述各原料由小量的逐渐加到量大的用搅拌混合器混合均匀,60℃真空干燥,粉碎过60目筛,经微波800KW,2min灭菌即得本发明的肠内营养制剂。
实施例3
根据实施例2的方法制得鲨鱼硫酸软骨素0.5g,根据实施例1的方法制得波纹巴非蛤酶解物30g,从安阳市得天力食品有限责任公司购得大豆分离蛋白45g,从青岛金友国际贸易有限公司购得海带粉2.4g,从北京宝得瑞食品有限公司购得菠菜粉8.5g和柑橘粉8.5g,从郑州联创食品商贸有限公司购得魔芋精粉5g,从北京维他公司购得Na-Fe-EDTA0.1g。
将上述各原料由小量的逐渐加到量大的用搅拌混合器混合均匀,60℃真空干燥,粉碎过60目筛,经微波800KW,2min灭菌即得本发明的肠内营养制剂。
实施例4
根据实施例2的方法制得军曹鱼硫酸软骨素0.7g,从广东兴亿海洋生物工程有限公司购得扇贝酶解物15g,从石岛集团有限公司购得鱼肉酶解物20g,从南宁庞博生物工程有限公司购得大豆分离蛋白40g,从山东鸿洋神水产科技有限公司购得海带粉1g,从廊坊市隆源食品添加剂有限公司购得番茄粉10g和香蕉粉10g,从郑州世纪美添食化贸易有限公司购得魔芋精粉3.2g,从北京维他公司购得Na-Fe-EDTA0.1g。
将上述各原料由小量的逐渐加到量大的用搅拌混合器混合均匀,60℃真空干燥,粉碎过60目筛,经微波800KW,2min灭菌即得本发明的肠内营养制剂。
实施例5
根据实施例2的方法制得鲟鱼硫酸软骨素0.6g,从广东兴亿海洋生物工程有限公司购得贻贝酶解物10g,从湖州珍露生物制品有限公司购得鱼肉酶解物25g,从乐清市百川食品有限公司购得大豆分离蛋白45g,从天津同春和坊食品有限公司购得海带粉5g,从甘肃玉门绿地生物制品有限公司购得胡萝卜粉10g,从郑州元丰食品添加剂有限公司购得魔芋精粉4.3g,从北京维他公司购得Na-Fe-EDTA0.1g。
将上述各原料由小量的逐渐加到量大的用搅拌混合器混合均匀,60℃真空干燥,粉碎过60目筛,经微波800KW,2min灭菌即得本发明的肠内营养制剂。
实施例6
根据实施例2的方法制得海参硫酸软骨素0.8g,从广东兴亿海洋生物工程有限公司购得珍珠贝酶解物10g,从上海西王淀粉糖有限公司购得鱼肉酶解物20g,从康普达生物科技有限公司购得大豆分离蛋白45g,从青岛利施科技有限公司购得海带粉4.55g,从新疆富源果蔬制品有限责任公司购得番茄粉8g和猕猴桃粉8g,从郑州元丰食品添加剂有限公司购得魔芋精粉3.6g,从北京维他公司购得Na-Fe-EDTA0.05g。
将上述各原料由小量的逐渐加到量大的用搅拌混合器混合均匀,60℃真空干燥,粉碎过60目筛,经微波800KW,2min灭菌即得本发明的肠内营养制剂。
实施例7
根据实施例1的方法制得马氏珠母贝糖胺聚糖0.7g,从深圳市科迪尔生物科技有限公司购得鱼肉酶解物30g,从安阳漫天雪食品制造有限公司购得大豆分离蛋白45g,从青岛世展科技有限公司购得海带粉5g,从廊坊市隆源食品添加剂有限公司购得番茄粉7.5g和香蕉粉7.5g,从郑州世纪美添食化贸易有限公司购得魔芋精粉4.2g,从北京维他公司购得Na-Fe-EDTA0.1g。
将上述各原料由小量的逐渐加到量大的用搅拌混合器混合均匀,60℃真空干燥,粉碎过60目筛,经微波800KW,2min灭菌即得本发明的肠内营养制剂。
实施例8
肠内营养制剂体外辅助抑制HL-60肿瘤细胞的作用:
实验设8组:空白对照组;马氏珠母贝糖胺聚糖浓度分别为0.25、0.5、1.0g·L-1;5-氟尿嘧啶0.005、0.025g·L-1两个浓度组;5-氟尿嘧啶0.005g·L-1+马氏珠母贝糖胺聚糖0.25、0.5g·L-1两个浓度组。
将对数生长期的HL-60细胞调整细胞悬液的浓度为5×104个·mL-1,以每孔450ul接种到24孔培养板中,同时加入各浓度的实验肠内营养制剂50ul,对照组加入等量的三蒸水,每组设8个平行孔,置37℃,5%CO2培养箱培养。24h后,每孔加台盼蓝染液200ul,吹打均匀后取100ul滴于计数板上,计数活细胞,结果见表2,用下列公式计算抑瘤率。
肿瘤抑瘤率=(对照组活细胞数-实验组活细胞数)/对照组活细胞数×100%
表2肠内营养制剂对HL-60的细胞的抑制作用(x±s)
实验结果表明,该肠内营养制剂中马氏珠母贝各浓度组作用HL-60细胞24h都有不同程度的抑制作用,且与5-氟尿嘧啶合用具有显著的增效作用。
实施例9
肠内营养制剂对H22荷瘤小鼠免疫功能的影响:
取ICR小鼠,体重18.0±2.0g,单一性别,每组10只。实验设:空白对照组,灌喂生理盐水;实验I组,灌喂低浓度(0.25g·L-1)的本发明肠内营养制剂;实验II组,灌喂中浓度(0.5g·L-1)的本发明肠内营养制剂;实验III组,灌喂高浓度(1.0g·L-1)的本发明肠内营养制剂,每日灌胃一次,各组小鼠连续给予受试物30d后,测定各项指标。
1.肠内营养制剂对正常小鼠胸腺、脾脏质量的影响
由表3可见,经口给予小鼠不同剂量的受试物30d后,与对照组比较,各剂量组胸腺、脾脏/体重比值均无显著差异(p>0.05)。
表3肠内营养制剂对正常小鼠胸腺、脾脏质量的影响(x±s)
2.2肠内营养制剂对小鼠细胞免疫的影响
由表4可见,经口给予小鼠不同剂量的受试物30d后,与对照组比较,高剂量组的淋巴细胞增殖能力及足趾肿胀度分别提高87.31%(p<0.05)和84.46%(p<0.05)。
表4肠内营养制剂对小鼠细胞免疫的影响(x±s)
#单位为光密度值;
*与对照组比较有显著性差异(p<0.05)。
2.3肠内营养制剂对小鼠体液免疫的影响
由表5可见,经口给予小鼠不同剂量的受试物30d后,与对照组比较,高剂量组的HC50提高156.95%(p<0.05),各剂量组的PFC无显著差异(p>0.05)。
表5肠内营养制剂对小鼠体液免疫的影响(x±s)
#单位为log10空斑数/全脾;
*与对照组比较有显著性差异(p<0.05)。
2.4肠内营养制剂对小鼠吞噬细胞吞噬功能的影响
由表6可见,经口给予小鼠不同剂量的受试物30d后,与对照组比较,各剂量组的碳廓清指数无显著差异(P>0.05)。高剂量组的吞噬率和吞噬指数分别提高了91.80%(p<0.05)和84.25%(p<0.05)。
表6肠内营养制剂对正常小鼠的碳廓清的影响(x±s)
*与对照组比较有显著性差异(p<0.05)。
经口给予小鼠不同剂量的该肠内营养制剂30d天后,高剂量组的淋巴细胞增殖能力提高87.31%(p<0.05),足趾肿胀度提高84.46%(p<0.05)。HC50提高156.95%(p<0.05),巨噬细胞吞噬率和吞噬指数分别提高91.80%(p<0.05)和84.25%(p<0.05),实验前后,胸腺/体重比值、脾脏/体重比值、抗体生成细胞数量、碳廓清指数均无显著差异(p>0.05)。
实施例10
肠内营养制剂改善缺铁性贫血的实验观察
取ICR小鼠60只,体重18.0±2.0g,雌雄各半,喂饲低铁基础饲料,饮去离子水,三周后从小鼠尾部采血,用氰化高铁血红蛋白法测定每只小鼠血红蛋白(Hb)含量,选出48只Hb含量为(9.1±1.2g)/100ml的贫血小鼠,将这些小鼠随机分为空白对照组、血宝组(阳性对照)和肠内营养制剂组,每组16只,实验开始后三组均喂饲普通基础饲料,对照组饮用自来水,血宝组、匀浆膳组分别用血宝、匀浆膳代替水饮用,连服14d,实验第15d测定每只小鼠血红蛋白含量,结果如表7所示。
表7肠内营养制剂对小鼠Hb含量的影响(x±s)
#与对照组及本实验前比较有显著性差异(p<0.05);
*与血宝组比较无显著性差异(p>0.1)。
实施例11
用于白血病患者的肠内营养制剂的临床观察如下:
营养评价:选取急性粒细胞性白血病患者共30例,年龄为15~50岁,其中男20例,女10例,30例患者均采用相同的治疗方案,随机分为对照组及治疗组各20例,对照组给予常规饮食,治疗组给予本发明肠内营养制剂,两组患者在病种、性别、年龄、病情方面差异无显著性。根据患者的身高、体重及营养状况制定营养计划,从化疗前7d开始实施至化疗结束,约14d,每日热量供给45kcal/kg,进行各阶段营养指标评定,结果见表8。
表8两组病例营养状况比较(x±s)
疗效分析:试验组的病人胃肠道不良反应如食欲减退、恶心呕吐和味觉异常等症状较对照组有显著的改善。体重和氮平衡大幅度升高,试验组由负氮平衡转为正氮平衡。红细胞计数、血红蛋白、总蛋白也有显著性差异,说明该肠内营养制剂能有效改善机体的营养状况,提高免疫力,特别是能改善由于失血造成的贫血,增强化疗的耐受性和敏感性。
Claims (4)
1.一种含海洋生物活性多糖的肠内营养制剂,其特征在于所述营养制剂包括如下按质量百分数计的组分:海洋生物活性多糖0.5~0.8%,贝鱼肉酶解物25~35%,果蔬粉10~20%,Na-Fe-EDTA 0.05~0.1%,大豆分离蛋白35~45%,海带粉1~5%和魔芋粉3~5%;
所述海洋生物活性多糖为马氏珠母贝糖胺聚糖、海参硫酸软骨素或鱼骨硫酸软骨素;
所述鱼骨硫酸软骨素的原料鱼是军曹鱼、鱿鱼、鲟鱼或鲨鱼;
所述贝鱼肉酶解物为牡蛎、贻贝、波纹巴非蛤、文蛤、扇贝、珍珠贝、鳕鱼、军曹鱼、罗非鱼、鲈鱼、带鱼、大黄鱼、金枪鱼或草鱼的肉酶解物中的一种或几种的混合物;
所述用于酶解贝鱼肉的酶为海洋低温碱性蛋白酶、木瓜蛋白酶、胰蛋白酶、枯草芽孢杆菌蛋白酶、中性蛋白酶、复合风味酶中的一种或几种的混合物;
所述果蔬粉为番茄粉、胡萝卜粉、菠菜粉、猕猴桃粉、柑橘粉、香蕉粉中的一种或几种的混合物。
2.权利要求1所述的含海洋生物活性多糖的肠内营养制剂的制备方法,其特征在于所述方法是将原料经混合干燥后,粉碎过60目筛,微波灭菌800kw,2min后即得。
3.权利要求1所述的含海洋生物活性多糖的肠内营养制剂的用途,其特征在于所述营养制剂用于作为铁需要量高的人群的食物。
4.根据权利要求3所述的含海洋生物活性多糖的肠内营养制剂的用途,其特征在于所述营养制剂用于作为白血病患者、骨髓移植患者或铁需要量高的患者的食物。
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1199050A (zh) * | 1997-05-08 | 1998-11-18 | 张偲 | 马氏珠母贝氨基多糖的制备方法 |
CN1961746A (zh) * | 2006-11-28 | 2007-05-16 | 中国科学院南海海洋研究所 | 一种海洋生物临床肠内营养剂 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1988001861A1 (en) * | 1986-09-17 | 1988-03-24 | Baxter Travenol Laboratories, Inc. | Nutritional support or therapy for individuals at risk or under treatment for atherosclerotic, vascular, cardiovascular, and/or thrombotic diseases |
US6194379B1 (en) * | 1998-05-01 | 2001-02-27 | Abbott Laboratories | Elemental enteral formula |
CN1321469A (zh) * | 2000-04-30 | 2001-11-14 | 湛江海洋大学 | 具抗肿瘤活性的马氏珠母贝全脏器糖蛋白、糖胺聚糖及其提取工艺 |
CN101019652B (zh) * | 2007-03-09 | 2011-01-05 | 广州腾健海洋生物科技有限公司 | 一种促进少年儿童生长发育的海洋保健功能食品 |
CN101544686A (zh) * | 2008-03-28 | 2009-09-30 | 李勇 | 糖肽合剂在制备肿瘤辅助治疗药物、保健食品中的用途 |
CN101361804B (zh) * | 2008-09-25 | 2011-04-27 | 中国科学院南海海洋研究所 | 一种用于肿瘤患者的肠内营养乳剂 |
-
2009
- 2009-10-23 CN CN2009101932727A patent/CN101703248B/zh active Active
- 2009-12-30 WO PCT/CN2009/076236 patent/WO2011047518A1/zh active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1199050A (zh) * | 1997-05-08 | 1998-11-18 | 张偲 | 马氏珠母贝氨基多糖的制备方法 |
CN1961746A (zh) * | 2006-11-28 | 2007-05-16 | 中国科学院南海海洋研究所 | 一种海洋生物临床肠内营养剂 |
Non-Patent Citations (2)
Title |
---|
吴园涛等.海洋生物型肠内营养制剂的研究进展.《肠外与肠内营养》.2007,第14卷(第5期),301-304. * |
王长云等.海洋功能食品研究现状和展望.《海洋科学》.1997,(第2期),20-23. * |
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