CN112675269A - Anticancer and analgesic composition, preparation method and application thereof - Google Patents

Abstract

The invention provides an anticancer and analgesic composition, a preparation method and application thereof, and relates to the technical field of traditional Chinese medicines. The anticancer and analgesic composition comprises the following raw materials: TONGGUANSAN, propolis, cutis Bufonis, squama Manis, Scorpio, and Gekko Swinhonis; has the effects of resisting cancer and relieving pain, and can not cause serious burden to the body after long-term administration, thereby relieving the pain of patients. In addition, the invention also provides a preparation method of the anticancer analgesic composition, which comprises three steps of preparing mixed gelatin blocks, preparing donkey-hide gelatin and mixing into a medicine, wherein the preparation method of the anticancer analgesic composition treats different medicinal materials by adopting different processing methods, ensures that the medicinal materials can fully exert medicinal properties in the processing process, repeatedly implements part of procedures for many times, ensures that impurities in the medicinal materials can be fully removed, ensures the purity of beneficial components in the anticancer analgesic composition, and improves the curative effect of the anticancer analgesic composition.

Description

Anticancer and analgesic composition, preparation method and application thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to an anticancer and analgesic composition, a preparation method and application thereof.

Background

According to data published by the world health organization, the number of cancer patients in the world is rapidly increasing, only 2018 years prove that the number of newly-increased cancer patients in the world reaches 1810 ten thousand, and the number of death patients in the world reaches 960 ten thousand, but the report clearly indicates that more than 1/2 of newly-increased and dead cancer cases in the world come from Asian countries, wherein China is the most number of cancer patients and death patients. Except for the big relation with the population base of China, the aging population, the average life span growth and the change of life and eating habits are all carcinogenic factors. In the last two decades, various cancers have been developed successively due to the aggravation of environmental pollution, overwork, increase of psychological stress and increase of chronic diseases, and the number of cancer patients is increasing.

The treatment of cancer patients is more difficult, especially for patients with advanced cancer, the onset and pain of which is more difficult, and 30-50% of cancer patients are accompanied by pain of different degrees. At present, the medicine is mainly administrated by hospitals according to pain degree: for patients with mild pain, non-opioid analgesics such as acetaminophen, aspirin and ibuprofen are used, and the action mechanism is to relieve peripheral pain; for moderate pain, weak opioid analgesic such as codeine and tramadol sustained release tablet is used; for severe pain patients, strong opioid drugs such as morphine and opiate drugs can inhibit the pain area of the cerebral cortex, have strong analgesic effect, if necessary, drugs such as phenytoin sodium, chlorpheniramine, diazepam, prednisone and the like can be added for adjuvant therapy, the method really relieves the pain of many cancer patients, but the analgesic method has large side effect, easily causes symptoms such as peptic ulcer, dizziness, headache, nausea and vomiting, seriously causes physiological and psychological dependence, needs to further increase the dosage of the drug to achieve the analgesic effect, and the increase of the dosage of the analgesic drug aggravates the damage to the weak body, so the analgesic method needs to be improved.

In conclusion, the analgesic drugs have great side effects and no anticancer effect, and only can add burden to the body after long-term administration, so that the body of a patient is worse and worse, and the body of the patient which is originally weak is frosted.

Disclosure of Invention

The invention aims to provide an anticancer and analgesic composition, which has the effects of resisting cancer and relieving pain, adopts traditional Chinese medicinal materials with mild medicinal properties, does not cause serious burden on a body after long-term administration, and relieves the pain of a patient.

The invention also aims to provide the application of the anticancer and analgesic composition in preparing broad-spectrum anticancer drugs, chemoradiotherapy sensitizers, combined anticancer drugs and/or analgesic drugs.

The invention also aims to provide a preparation method of the anticancer analgesic composition, which adopts different processing methods to process different medicinal materials, ensures that the beneficial components in the medicinal materials can be retained most in the processing process of the medicinal materials, and repeatedly implements part of the working procedures for a plurality of times, ensures that impurities in the medicinal materials can be fully removed, ensures the purity of the beneficial components in the anticancer analgesic composition, and improves the curative effect of the anticancer analgesic composition.

The technical problem to be solved by the invention is realized by adopting the following technical scheme.

In one aspect, the embodiment of the present application provides an anticancer and analgesic composition, which comprises the following raw materials in parts by weight: 150 portions of marsdenia tenacissima, 550 portions of propolis, 450 portions of gecko, 30-70 portions of cutis Bufonis, 550 portions of squama Manis, 350 portions of scorpio, 250 portions of centipede, 250 portions of gecko, 150 portions of Orostachys japonica, 250 portions of earthworm, 350 portions of leech, 150 portions of leech, 350 portions of hiberna, 550 portions of cicada slough, 350 portions of pilose antler, 150 portions of antler, 250 portions of turtle shell, 150 portions of tortoise plastron, 250 portions of frankincense, 150 portions of myrrh, 250 portions of corydalis, 550 portions of greater celandine, 150 portions of chella, 350 portions of borneol, 250 portions of dragon's blood, 350 portions of catechu, 150 portions of sculellaria, 350 portions of notoginseng, 350 portions of oldenlandia, 350 portions of white selfheal, 350 portions of white flower sauce, 350 portions of patrinia, 250 portions of dahurian patrinia, 250 portions of acacia, 250 portions of scorpio, 250 portions of notoginseng, 250 portions of mangnolia, 350 parts of Chinese lobelia, 350 parts of common burreed rhizome, 250 parts of common burreed rhizome, 350 parts of zedoary, 200 parts of Chinese stellera root, 350 parts of platycodon grandiflorum, 250 parts of blister beetle, 150 parts of rhizoma arisaematis, 350 parts of radix scutellariae, 250 parts of aloe and 350 parts of rhubarb.

In another aspect, the present application provides an anticancer and analgesic composition for use in preparing a broad spectrum anticancer drug, a chemoradiotherapy sensitizer, a combination anticancer drug and/or an analgesic drug.

In another aspect, the present application provides a method for preparing an anticancer analgesic composition, comprising the steps of: preparing a mixed rubber block: mixing cornu Cervi, Os bovis Seu Bubali, Os Caprae Seu Ovis, carapax Trionycis and carapax et Plastrum Testudinis with alkali solution, decocting, soaking, decocting in water, concentrating, and collecting paste to obtain mixed gelatin block. Preparation of donkey gelatin: decocting donkey hide in water to melt to obtain colloid solution, adding Alumen, stirring, standing to obtain supernatant, concentrating the supernatant, adding correctant, concentrating, adding yellow wine and crystal sugar to obtain mixture, decocting the mixture, adding sesame oil, stopping heating, taking out, and air drying to obtain donkey gelatin. Mixing to obtain a medicine: decocting TONGGUANGSAN, herba Scutellariae Barbatae, herba Hedyotidis Diffusae, herba Ajugae, herba Patriniae, herba Lobeliae chinensis, rhizoma Sparganii, rhizoma Curcumae, radix Euphorbiae Fischerianae, radix Platycodonis, rhizoma arisaematis, radix Scutellariae, Aloe, radix Et rhizoma Rhei, and herba Chelidonii, concentrating, collecting paste, grinding propolis, cutis Bufonis, squama Manis, Scorpio, Scolopendra, Gekko Swinhonis, herba Orostachyos, Pheretima, Hirudo, Eupolyphaga Seu Steleophaga, periostracum Cicadae, cornu Cervi Pantotrichum, Olibanum, Myrrha, rhizoma corydalis, Borneolum Syntheticum, sanguis Draxonis, Catechu, radix Notoginseng, and Mylabris into powder, adding into the paste, and decocting with mixed gelatin and colla Corii Asini to obtain the anticancer and analgesic composition.

Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:

the embodiment of the application provides an anticancer and analgesic composition, which is prepared by matching reasonable monarch, minister, assistant and guide relations, so that the drug properties of all the medicinal materials are mutually harmonized, the drug effects of all the medicinal materials are concentrated and play a role together, the anticancer and analgesic composition has the anticancer and analgesic effects by cooling blood, removing blood stasis, eliminating dampness, relieving pain, clearing heat, detoxifying and the like, and can relieve sequelae after radiotherapy and chemotherapy.

Wherein the principal drugs include periostracum Cicadae, rhizoma corydalis, Scolopendra, herba Hedyotidis Diffusae and squama Manis. Cicada slough can dispel wind-heat, ventilate lung and relieve spasm. Wu Gong can counteract toxic pathogen and dissipate nodulation, and unblock collaterals and alleviate pain. Oldenlandia diffusa can clear heat and remove toxicity. Squama Manis can dredge collaterals and relieve pain. The five medicinal materials are combined to reduce the size of tumor and inhibit cancer pain by removing blood stasis and relieving pain.

The ministerial drugs comprise TONGGUAN powder, propolis, cutis Bufonis, Scorpio, Gekko Swinhonis, herba Orostachyos, Lumbricus, Hirudo, Eupolyphaga Seu Steleophaga, cornu Cervi Pantotrichum, cornu Cervi, carapax Trionycis, carapax et Plastrum Testudinis, Olibanum, Myrrha, herba Chelidonii, Catechu, herba Scutellariae Barbatae, herba Patriniae, rhizoma Sparganii, Curcumae rhizoma, radix Euphorbiae Fischerianae, Mylabris, rhizoma arisaematis and radix et rhizoma Rhei. The Tongguansan can clear heat, relieve cough, remove toxicity, relieve asthma, promote blood circulation and promote granulation. Propolis has anticancer, antiviral, antiinflammatory, anti-AIDS, cell injury repairing, and immunity enhancing effects. The dried toad skin can clear away heat and toxic material, promote diuresis and relieve distension. Scorpion can counteract toxic pathogen and dissipate nodulation, and dredge collaterals and relieve pain. Gekko Swinhonis has effects in dispersing pathogen accumulation, relieving pain, dispelling pathogenic wind, activating collaterals, tranquilizing mind, and relieving spasm. The herba Orostachyos can clear away heat and toxic materials, stop bleeding, and relieve swelling. Lumbricus can clear heat, calm fright, dredge collaterals and relieve asthma. Leeches can dredge meridians and remove blood stasis. The hibernating insect can remove stasis and accumulation. Cornu Cervi Pantotrichum has effects of strengthening tendons and bones, and invigorating kidney essence. The antler can obviously promote the function of macrophage and inhibit the proliferation capacity of lymphocyte, and obviously inhibit the growth of tumor at lymph position of lung. Carapax Trionycis has effects of nourishing yin, clearing heat, softening and resolving hard mass. The carapax et Plastrum Testudinis has effects of nourishing yin, suppressing yang, invigorating kidney and strengthening bone. Olibanum has effects of regulating blood and qi, relieving pain, and removing toxic substance. Myrrh can dispel blood and resolve stasis, relieve swelling and alleviate pain. The celandine can relieve pain, reduce swelling, clear heat and relieve cough. Catechu has the effects of eliminating dampness and promoting granulation. The barbed skullcap herb can clear away heat and toxic material, remove blood stasis and induce diuresis. The patrinia villosa juss can clear away heat and toxic materials, discharge pus and break stasis. Rhizoma Sparganii has effects of activating qi-flowing, relieving pain, removing blood stasis and removing blood stasis. Zedoary turmeric can promote qi circulation, break blood, remove food retention and alleviate pain. Mylabris has effects of removing blood stasis, sterilizing, removing blood stasis, and resolving hard mass. Rhizoma arisaematis has the effects of eliminating dampness and phlegm, dispelling pathogenic wind and relieving spasm, and resolving hard mass and swelling. Rhubarb can purge heat and unblock intestine, cool blood and remove toxicity, dispel blood stasis and dredge meridians. Multiple ministerial drugs supplement each other, can assist monarch drugs to play the effect, and can also clear away heat and toxic materials and inhibit the activity of cancer cells.

The adjuvant drugs comprise Borneolum Syntheticum, sanguis Draxonis, Notoginseng radix, herba Ajugae and Polyporus, and Borneolum Syntheticum has effects of inducing resuscitation, refreshing mind, clearing heat and relieving pain. Dragon's blood has the functions of dispelling blood stasis, relieving pain, stopping bleeding and promoting granulation. Notoginseng radix has effects of removing blood stasis, stopping bleeding, relieving swelling and relieving pain. The selfheal fruit-spike can clear heat and cool blood, and relieve swelling and remove toxicity. Polyporus umbellatus has effects of promoting diuresis and eliminating dampness. The adjuvant and the adjuvant can assist the monarch drug and the ministerial drug to exert the effects, and can also additionally dissipate blood stasis to stop bleeding and avoid the diffusion of cancer cells.

The Chinese medicinal materials include radix Euphorbiae Fischerianae, radix Platycodi and Aloe, and the radix Euphorbiae Fischerianae has effects of eliminating dampness and phlegm, resolving hard mass and killing parasite. Radix Platycodi has effects of dispersing lung qi, relieving sore throat, eliminating phlegm, and expelling pus. Aloe can clear heat and relieve constipation. The conductant drug combines the drug properties of the monarch drug, the ministerial drug and the adjuvant drug, regulates the drug properties of the monarch drug, the ministerial drug and the adjuvant drug, enables the monarch drug, the ministerial drug and the adjuvant drug to complement each other, and assists the monarch drug, the ministerial drug and the adjuvant drug to exert the drug effect.

In addition, the invention also provides a preparation method of the anticancer analgesic composition, the preparation method adopts different processing methods for different medicinal materials, for example, medicinal materials such as donkey hide and the like are processed in a repeated decoction mode, and medicinal materials such as marsdenia tenacissima and the like are processed in a concentration and paste collection mode, so that the beneficial components of the medicinal materials in the processing and processing process can be kept most, and partial procedures are repeatedly carried out for a plurality of times, for example, water is added for decoction in donkey-hide gelatin preparation, so that impurities in the medicinal materials can be fully removed, the purity of the beneficial components in the anticancer analgesic composition is ensured, and the curative effect of the anticancer analgesic composition is improved.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.

The embodiment of the application provides an anticancer and analgesic composition, which comprises the following raw materials in parts by weight: 150 portions of marsdenia tenacissima, 550 portions of propolis, 450 portions of gecko, 30-70 portions of cutis Bufonis, 550 portions of squama Manis, 350 portions of scorpio, 250 portions of centipede, 250 portions of gecko, 150 portions of Orostachys japonica, 250 portions of earthworm, 350 portions of leech, 150 portions of leech, 350 portions of hiberna, 550 portions of cicada slough, 350 portions of pilose antler, 150 portions of antler, 250 portions of turtle shell, 150 portions of tortoise plastron, 250 portions of frankincense, 150 portions of myrrh, 250 portions of corydalis, 550 portions of greater celandine, 150 portions of chella, 350 portions of borneol, 250 portions of dragon's blood, 350 portions of catechu, 150 portions of sculellaria, 350 portions of notoginseng, 350 portions of oldenlandia, 350 portions of white selfheal, 350 portions of white flower sauce, 350 portions of patrinia, 250 portions of dahurian patrinia, 250 portions of acacia, 250 portions of scorpio, 250 portions of notoginseng, 250 portions of mangnolia, 350 parts of Chinese lobelia, 350 parts of common burreed rhizome, 250 parts of common burreed rhizome, 350 parts of zedoary, 200 parts of Chinese stellera root, 350 parts of platycodon grandiflorum, 250 parts of blister beetle, 150 parts of rhizoma arisaematis, 350 parts of radix scutellariae, 250 parts of aloe and 350 parts of rhubarb.

The anticancer and analgesic composition is prepared by adopting a reasonable monarch, minister, assistant and guide relationship, so that the drug properties of the medicinal materials are mutually harmonized, the drug effects of the medicinal materials are concentrated and play a role together, the anticancer and analgesic composition has the effects of resisting cancer and relieving pain by cooling blood and removing stasis, eliminating dampness and relieving pain, clearing heat and detoxicating and the like, and can relieve sequelae after radiotherapy and chemotherapy.

Wherein the principal drugs include periostracum Cicadae, rhizoma corydalis, Scolopendra, herba Hedyotidis Diffusae and squama Manis. Cicada slough is named as: cicada slough, periostracum Cicadae or cicada skin has 100% of inhibition rate on human cervical cancer JTC-26, and has an inhibition effect on normal fiber cells, and the inhibition rate is 50%. Experiments prove that the cicada slough has an inhibiting effect on mouse sarcoma S180, and experiments in cicada slough water extracts prove that the cicada slough has high anti-tumor activity on Ehrlich ascites carcinoma cells, and the inhibition rate is more than 75%. Rhizoma corydalis is also named as the other name: rhizoma corydalis is used for treating hypochondriac region, abdominal pain, thoracic obstruction, cardialgia, amenorrhea, dysmenorrhea and traumatic injury, and can also be used for relieving various cancer pains. Centipede is named as follows: the foot or Wugong, etc. can counteract toxic substance, dissipate nodulation, dredge collaterals and relieve pain, and has inhibiting effect on metastatic tumor, mouse sarcoma S180, Ehrlich ascites carcinoma, cervical cancer, mouse U14, mouse L160 and Wake cancer W260, the hot water extract has inhibiting rate of 51.4% on mouse sarcoma S180, centipede can inhibit the respiration of human liver cancer cells, and has inhibiting effect on human cervical cancer Hela cells, the hot water extract has inhibiting rate of more than 30% on human cervical cancer JTC-26, the centipede has inhibiting rate of 26% on mouse liver cancer tumor, and has enhancing effect on reticuloendothelial cell function. The alternative name of the oldenlandia is: oldenlandia diffusa, hedyotis diffusa or common house-de-bower and the like, which can clear heat and remove toxicity, contains oldenlandia diffusa element, has the effect of inhibiting and killing mouse ascites hepatoma cells, can completely kill 0.2mL of ascites hepatoma cells within 24 hours by 1mg of oldenlandia diffusa element, has the effect of inhibiting rat Wake cancer W256, mouse cervical cancer U14, mouse sarcoma S180 hepatoma solid type and Ehrlich ascites cancer (ascites type-subcutaneous), has the effect of significantly inhibiting mouse sarcoma S180 by oldenlandia diffusa element, and significantly inhibits tumor cell division phase, especially mitotic phase, so that tumor tissue degeneration and necrosis are realized, and triterpenic acid polysaccharide substances, coumarine and liver cancer solid type substances contained in oldenlandia diffusa have the effect of inhibiting lymphosarcoma No. 1, abdominal cervical cancer U14 and liver cancer solid type sarcoma S180. The first name of the pearl is: squama Manis, etc., it is used as medicine with ungula Sus Domestica for dredging collaterals and relieving pain, and can be used for treating malignant lymphoma, cervical cancer, breast cancer, hepatocarcinoma, esophageal cancer, gastric cancer, intestinal cancer, anal cancer, brain tumor, eyelid cancer, lymph cancer and liposarcoma.

The ministerial drugs comprise TONGGUAN powder, propolis, cutis Bufonis, Scorpio, Gekko Swinhonis, herba Orostachyos, Lumbricus, Hirudo, Eupolyphaga Seu Steleophaga, cornu Cervi Pantotrichum, cornu Cervi, carapax Trionycis, carapax et Plastrum Testudinis, Olibanum, Myrrha, herba Chelidonii, Catechu, herba Scutellariae Barbatae, herba Patriniae, rhizoma Sparganii, Curcumae rhizoma, radix Euphorbiae Fischerianae, Mylabris, rhizoma arisaematis and radix et rhizoma Rhei. Clear and scattered as alternative names: the inhibition rate of glaucescent fissistigma root, custard vine, elecampane or hypogastrium nipponicum stem and the like on solid cancer W256 is 61.6 percent, the inhibition rate on sarcoma S180 mouse cervical cancer U14 liver cancer and ehrlich ascites cancer is 59.7 percent, 65.9 percent, 43.6 percent and 56.9 percent respectively, and the inhibition effect on mouse lymphoma (L1) is also realized. Propolis has anticancer, antiviral, antiinflammatory, anti-AIDS, cell injury repairing, and immunity enhancing effects. The name of the dried toad skin is: clam 34438skin and Chinese forest frog skin, has obvious curative effect on mouse sarcoma S180 and rabbit B.P tumor, can prolong life of mouse with seminoma, ascites carcinoma and liver cancer, and also has inhibiting effect on leukemia cell. The scorpion is also named as follows: the Dubia, the whole worm, the Fuzhuan and the like have obvious inhibition effect on the growth of tumor of a tumor-bearing mouse, the scorpion extract has inhibition effect on colon cancer and human liver cancer cells, and the alcohol preparation can inhibit the respiration of the human liver cancer cells. Gecko is also named as follows: gekko Swinhonis and Gekko Swinhonis have anti-tumor effects, and in vitro experiments show that Gekko Swinhonis extract has effect in inhibiting human hepatocarcinoma cells. The name of the tile pine is: herba Sedi Aizoon, herba Watertiae Wallichii, rhizoma et radix Meretricis Seu Cyclinae, and rhizoma corydalis Thalictrifoliae have certain inhibitory activity on hepatocarcinoma cell and gastric cancer cell. The earthworm is named as the earthworm: the sagittaria, earthworm, etc. have strong antitumor activity, and oral administration has obvious inhibiting effect on mouse sarcoma S180 and liver cancer H22, can obviously reduce tumor, improve general condition of tumor-bearing animal and prolong survival period. Leeches are named as follows: leech, leech and the like, and is mainly used for treating brain tumor, nasopharyngeal carcinoma, tongue cancer, esophageal cancer, lung cancer, liver cancer, digestive tract cancer, abdominal cavity cancer, cancer pain and the like. The jellyfish has another name: eupolyphaga Seu Steleophaga, and Arthrobacter can be used for treating osteosarcoma, hepatocarcinoma, cervical cancer, tongue cancer, leukemia, esophageal cancer and dysphagia. The cornu Cervi Pantotrichum is selected from Cervus Nippon Temminck or Cervus Elaphus L of Cervidae, and is also called: hairy antler, grass antler, antler horn and the like, wherein antler polysaccharide contained in the antler has obvious inhibition effect on mouse sarcoma S180 through intraperitoneal injection. The cornu Cervi is selected from horn of Cervidae such as Cervus Nippon Temminck or Cervus Elaphus, and has effects of remarkably promoting macrophage function, inhibiting proliferation of lymphocyte, and remarkably inhibiting tumor growth in lung lymph position. Turtle shell is also called as: turtle shell and pangolin scales, turtle shell extract I separated from turtle shell extract and turtle shell extract II separated from vinegar extract have obvious inhibition effect on DNA synthesis of liver cancer cells of H22 mice and sarcoma cells of S180 mice, turtle shell powder also has inhibition effect on transplanted parenchymal carcinoma of mice and growth inhibition effect on intestinal cancer cells, and the inhibition effect on the growth of the intestinal cancer cells of the turtle shell and fluorouracil combined medication is more obvious than that of fluorouracil alone. The other name of the tortoise plastron is: tortoise shell, tortoise plastron, etc. the tortoise plastron can raise the antitumor immunity of body, and the tortoise plastron extract has inhibiting effect on S180' S Ehrlich carcinoma and ascites liver cancer. Frankincense with another name: the in vitro test of frankincense shows that the frankincense has an inhibiting effect on tumor cells and mouse sarcoma S180, the inhibiting rate is about 70%, and the inhibiting rate on human cervical cancer cells JTC-26 is between 70 and 90%. The name of myrrh is: the in vitro test of the powder medicine and myrrh shows that it has the function of inhibiting tumor cells, and the myrrh can raise the immunity of human body, promote the transformation of lymphocyte and strengthen the function of reticuloendothelial system. The alternative name of Chelidonium majus: the dose of chelidonine in the chelidonine is 175mg/kg, the chelidonine can effectively inhibit mouse sarcoma S180 and mouse ehrlich ascites carcinoma, and the tumor indexes of the mouse sarcoma S180 and the mouse ehrlich ascites carcinoma are respectively 0.7 and 0.75. The alias of Catechu: catechu, etc. the Catechu has strong effect of killing ascites cancer cell in vitro, and epicatechin contained in Catechu has effect of inhibiting cancer cell activity. The Chinese barbed skullcap herb has the alias: the scutellaria barbata has strong mutation resistance, is one of anticancer mechanisms, and the extract can inhibit the reversion colony number of the aflatoxin B1 and obviously inhibit the combination of the aflatoxin B1 and DNA, thereby generating the anticancer effect. The field of patrinia villosa juss is also named as: herba Patriniae has strong inhibition effect on cancer cells in vitro, and has inhibition rate of S180 sarcoma of mice up to 62.5%, and herba Patriniae extract is injected into mice by intraperitoneal injection, which has direct killing effect on ascetic S180 tumor cells, has inhibition rate of JTC-26 of 50-70%, does not inhibit normal cells at all, but can promote the growth of normal cells (human fibroblasts) by 100%. Three-edged alias: rhizoma Sparganii has inhibitory effect on growth of cancer cells and tumor, and rhizoma Sparganii injection has obvious inhibitory effect on mouse sarcoma S180, human cancer cells, mouse leukemia and L615 solid type hepatocarcinoma. The name of the zedoary is: the anti-cancer action mode of the curcuma zedoary and the immune system of a host act synergistically, the fact that part of cancer tissues are necrotic and shed after the curcuma zedoary injection operation is found in clinical observation, the cervix becomes smooth, and clinical cure is achieved, the morphological changes indicate that the curcuma zedoary has the direct cancer killing effect, and in addition, lymph cells in blood are obviously increased after the curcuma zedoary injection, and the host has obvious immune response. Cantharis is also named as raw material: cantharidin in cantharis can be administrated for 3-4 times to eliminate rabbit cancer induced by tar, so that the anticancer effect is proved, the cantharidin has strong affinity to liver and cancer cells, and the cantharidin with concentration of 01mL and 10g/mL can cause the obvious damage of Hela cells. Rhizoma arisaematis is named as follows: the concentrated preparation of the water extract of the arisaema tuber, the taro, the bract yam, the geranium taro, the typhonium giganteum and the like after alcoholization has the inhibition effect on the activity of human cervical cancer hela cells in vitro, leads the cells to be concentrated into block masses to destroy the normal structures of the cells, and has the obvious tumor inhibition effect on the injection of 0.1ml of the water extract of the arisaema tuber (equivalent to 1g of fresh arisaema tuber) into mice with sarcoma S180 liver cancer solid type and mouse cervical cancer U14. Rhubarb is also named as: rhubarb, and the like, wherein rhubarb has an inhibition effect on mouse transplanted tumors, rhein and emodin in rhubarb both have an anti-tumor effect, particularly have a very strong inhibition effect on melanoma, and also have a certain inhibition effect on breast cancer and ehrlich ascites carcinoma, the inhibition rates of 5mg/kg rhein and emodin on mouse melanoma are 76% and 73% respectively, the emodin concentration at 10mg/mL has an inhibition effect on division of human lung cancer A-549 cells, and has an obvious inhibition effect on biosynthesis of lung cancer A-549 cell DNA, crude extract of rhubarb has an inhibition effect on mouse sarcoma S37 by subcutaneous injection, the inhibition rate of rhein on ehrlich ascites carcinoma is 15%, the inhibition rate of mouse sarcoma S180 is 21%, and the inhibition rate of rhubarb hot water extract on mouse sarcoma S180 is 48.8%.

The adjuvant drugs are borneol, dragon's blood, pseudo-ginseng, Ajuga decumbens and grifola, and the borneol is also called as another name: borneol, borneol. Dragon's blood is also named as: sanguis Draxonis, etc., hot water extract of sanguis Draxonis has strong inhibiting effect on mouse sarcoma S180 after alcoholization. The alias of pseudo-ginseng is as follows: the experiments in vivo show that the panax notoginseng has the inhibiting effect on mouse sarcoma S180, the saponin contained in the panax notoginseng has the obvious inhibiting effect on mouse lymphocyte leukemia P388 and L1210 and human nasopharyngeal epithelial cancer cells, and the panax notoginseng has the effects of resisting cancer and bacteria and enhancing the activity of reticuloendothelial cells. The common selfheal fruit-spike is also called as follows: animal experiments prove that the anti-tumor luteolin contained in the common selfheal fruit-spike has a certain inhibiting effect on NK/LY ascites cancer cells. The other name of the polyporus umbellatus is: the alcohol extract of the polyporus umbellatus has obvious tumor inhibiting effect on mouse S180, polyporus umbellatus polysaccharide in the polyporus umbellatus can inhibit DNA synthesis and CAMP-phosphodiesterase activity in mouse S180 ascites carcinoma cells, and the polyporus umbellatus polysaccharide can improve the killing activity of spleen lymphoid cells on tumor cells and promote the proliferation of mouse bone marrow stem cells.

The guiding drugs are radix euphorbiae ebracteolatae, platycodon grandiflorum and aloe, and the radix euphorbiae ebracteolatae is also called as the other name: experiments prove that the radix euphorbiae lantu intraperitoneal injection and oral administration of the radix euphorbiae lantu can inhibit Lewis lung cancer, has an inhibiting effect on mouse transplantation tumor S180 and cervical cancer U14 liver cancer, and has low toxicity. Platycodon grandiflorum is also named as: the betulin in the platycodon grandiflorum can inhibit the tumor activity of W256 of rat Wake cancer, the suppression rate of the ethanol extract of the platycodon grandiflorum to mouse sarcoma (ascites type) is 72.9%, and the suppression rate of the water extract is 37.4%. The aloe is also named as: the aloe extract and aloin A separated from the aloe extract have anti-tumor effects, the aloe extract can inhibit the growth of cancer cells in liver cancer, ehrlich ascites carcinoma, sarcoma S180 and ehrlich abdominal carcinoma, and the aloesin in the aloe has inhibitory effect on solid tumor.

In some embodiments of the present invention, the anticancer analgesic composition comprises the following raw materials in parts by weight: 200 parts of marsdenia tenacissima, 500 parts of propolis, 50 parts of dried toad skin, 500 parts of pangolin scales, 300 parts of scorpion, 300 parts of centipede, 200 parts of gecko, 200 parts of herba orostachyos, 300 parts of earthworm, 200 parts of leech, 300 parts of hibernating insect, 500 parts of cicada slough, 300 parts of pilose antler, 200 parts of turtle shell, 200 parts of tortoise plastron, 200 parts of frankincense, 200 parts of myrrh, 500 parts of corydalis tuber, 200 parts of celandine, 300 parts of borneol, 200 parts of dragon's blood, 300 parts of catechu, 200 parts of sculellaria barbata, 300 parts of pseudo-ginseng, 300 parts of oldenlandia diffusa, 300 parts of common selfheal fruit-spike, 300 parts of patrinia villosa, 300 parts of Chinese lobelia, 300 parts of rhizoma sparganii, 300 parts of curcuma zedoary, 150 parts of radix euphorbiae lantu, 300 parts.

The above embodiment is a formulation with better effect of the anticancer analgesic composition, and the formulation can better exert the drug effect in the medicinal materials, so that the prepared anticancer analgesic composition has better effect in the inhibition treatment of various cancers, tumors, pains, lumps, chronic swellings and various cancer metastases, and can also better cooperate with the treatment of sequelae caused by radiotherapy and chemotherapy of various cancers.

In some embodiments of the present invention, the anticancer analgesic composition further comprises the following raw materials in parts by weight: 10000 portions of ox bone 20000 portions, 10000 portions of sheep bone 20000 portions, 10000 portions of deer bone 20000 portions, 45000 portions of donkey skin 55000 portions, 1500 portions of yellow wine 2250 portions, 1750 portions of crystal sugar 2250 portions, 1000 portions of sesame oil 1500 portions, 200 portions of alum and 300 portions of flavoring agent 200 portions. The beef bone, the sheep bone and the deer bone are decocted with the tortoise plastron, the turtle shell and other medicinal materials to form the gel, so that the nutritional value and the efficacy of the anticancer and analgesic composition can be improved. The Os Cervi is selected from bone of Cervidae animals such as Cervus Nippon Temminck or Cervus Elaphus L. The donkey hide can be made into donkey gelatin, which has effects of replenishing blood and invigorating qi, and can exert the effects of consolidating body constitution and cultivating primordial qi. The yellow wine and the crystal sugar can improve the taste of the anticancer and analgesic composition, increase a little sweet taste and have certain effects of promoting blood circulation and tonifying qi. The sesame oil can improve the odor of the anticancer and analgesic composition, and unsaturated fatty acids such as linoleic acid and palmitic acid contained in the composition also have the effect of protecting blood vessels. The alum can adsorb impurities, so that the impurities are settled and are convenient to remove. The taste and smell of the anticancer and analgesic composition can be improved by the flavoring agent, and the administration compliance of patients is improved.

In some embodiments of the present invention, the anticancer analgesic composition comprises the following raw materials in parts by weight: 15000 parts of ox bone, 15000 parts of sheep bone, 15000 parts of deer bone, 50000 parts of donkey skin, 1750 parts of yellow wine, 2000 parts of rock candy, 1250 parts of sesame oil, 250 parts of alum and 250 parts of flavoring agent.

The above examples are formulations in which the effects of the above raw materials are better, and the effects of the above raw materials can be more effectively exhibited.

On the other hand, the embodiment of the application also provides the application of the anticancer and analgesic composition in preparing broad-spectrum anticancer drugs, chemoradiotherapy sensitizers, combined anticancer drugs and/or analgesic drugs.

In another aspect, the present application provides a method for preparing an anticancer analgesic composition, comprising the following steps: preparing a mixed rubber block: mixing cornu Cervi, Os bovis Seu Bubali, Os Caprae Seu Ovis, carapax Trionycis and carapax et Plastrum Testudinis with alkali solution, decocting, soaking, decocting in water, concentrating, and collecting paste to obtain mixed gelatin block. Preparation of donkey gelatin: adding water into donkey hide, decocting into colloidal solution, adding Alumen, stirring, standing to obtain supernatant, heating and concentrating the supernatant, adding correctant, concentrating, adding yellow wine and crystal sugar to obtain a first mixture, decocting the first mixture, adding sesame oil, stopping heating, taking out of a pot to obtain a second mixture, and drying the second mixture to obtain donkey hide glue. Mixing to obtain a medicine: decocting TONGGUANGSAN, herba Scutellariae Barbatae, herba Hedyotidis Diffusae, herba Ajugae, herba Patriniae, herba Lobeliae chinensis, rhizoma Sparganii, rhizoma Curcumae, radix Euphorbiae Fischerianae, radix Platycodonis, rhizoma arisaematis, radix Scutellariae, Aloe, radix Et rhizoma Rhei, and herba Chelidonii, concentrating, collecting paste, grinding propolis, cutis Bufonis, squama Manis, Scorpio, Scolopendra, Gekko Swinhonis, herba Orostachyos, Pheretima, Hirudo, Eupolyphaga Seu Steleophaga, periostracum Cicadae, cornu Cervi Pantotrichum, Olibanum, Myrrha, rhizoma corydalis, Borneolum Syntheticum, sanguis Draxonis, Catechu, radix Notoginseng, and Mylabris into powder, adding into the paste, and decocting with mixed gelatin and colla Corii Asini to obtain the anticancer and analgesic composition. In the preparation of the mixed gel block, decocting with alkali liquor for 5-15 min, decocting with water for 22-24h, and repeating for 5-8 times. In the preparation of donkey-hide gelatin, donkey skin is cut into 4 × 5cm pieces before decocting in water, and the pieces are conveniently decocted to form gelatin, and soaked in clear water for 2-3 days with water changed 1-2 times per day. Adding Alumen, stirring, and standing for 4-5 hr. The flavoring agent is added about 2h before the concentration is completed. The yellow wine is added after it is warm. Heating until the mixture is soaked, decocting until a little is picked up by a shovel and continuously falls into pieces, and adding sesame oil. Adding sesame oil, stopping heating, taking out, pouring into a rubber plate coated with sesame oil, cutting into small pieces with length of 10cm, width of 4-5cm and thickness of 0.8-1.6cm, and air drying. In the mixing process, the decoction time is 15-25 minutes, and the relative density of the concentrated and paste-collected materials is 1.0-1.1 at 60 ℃. Decocting the mixed gelatin block, donkey-hide gelatin and concentrated ointment for 4-5 hr. In the preparation of the mixed gelatin block, the preparation of donkey-hide gelatin and the mixed synthetic medicine, the decoction is carried out by adopting slow fire decoction.

In some embodiments of the present invention, the preparation of the mixed gelatin block further comprises removing bone marrow from deer bone, cow bone and sheep bone, and mixing with lye for decoction. Remove bone marrow to avoid affecting drug property.

In some embodiments of the present invention, the soaking step is to rinse the raw materials mixed and decocted with the alkali solution with clear water for 6-8 days, air-dry for 12-18 days, dry and pulverize into pieces, and rinse with clear water for 7-9 days. Cleaning the raw materials, air drying, pulverizing, removing impurities in the raw materials, and decocting the raw materials into gel more conveniently.

In some embodiments of the invention, the boiling in the preparation of donkey hide glue comprises the following steps of adding clear water to soak for 2-3 days after boiling for 10-20min, filtering, repeating for 5-6 times until donkey hide is dissolved to form a colloid solution, wherein the weight ratio of the single time of clear water to the donkey hide is (4-6): 1. The donkey hide is fully decocted to ensure that the donkey hide is completely dissolved to form a colloid solution, so that the preparation of the donkey hide is more convenient, and sufficient clear water is added for soaking to ensure that impurities in the donkey hide can be completely removed.

In some embodiments of the invention, the air-drying comprises the following steps of placing the mixture II on a net rack for spreading and air-drying, turning over once every 2-3 days, placing the mixture II in a wooden box for sealing and flattening after 7-8 days, and taking out the mixture II when the appearance becomes soft; drying and repeating for 2-3 times. Spreading and drying in the air, turning over to prevent the prepared donkey-hide gelatin from sticking together, sealing, and flattening to solidify the donkey-hide gelatin into colloid.

The features and properties of the present invention are described in further detail below with reference to examples.

Example 1

The embodiment of the application provides an anticancer and analgesic composition, which comprises: 150g of marsdenia tenacissima, 450g of propolis, 30g of dried toad skin, 450g of pangolin scales, 250g of scorpion, 250g of centipede, 150g of gecko, 150g of herba orostachyos, 250g of earthworm, 150g of leech, 250g of hibernating insect, 450g of cicada slough, 250g of pilose antler, 150g of turtle shell, 150g of tortoise plastron, 150g of frankincense, 150g of myrrh, 450g of rhizoma corydalis, 150g of celandine, 250g of borneol, 150g of dragon's blood, 250g of catechu, 150g of sculellaria barbata, 250g of pseudo-ginseng, 250g of oldenlandia diffusa, 250g of selfheal, 250g of patrinia villosa, 250-g of Chinese lobelia herb, 250g of rhizoma sparganii, 250g of curcuma zedoary, 100g of radix euphorbiae lantu, 250g of platyc.

The anticancer analgesic composition is prepared by the following method: removing residual meat and tendon on deer horn, 10000g of deer bone, 10000g of cattle bone, 10000g of sheep bone, turtle shell and tortoise plastron, removing bone marrow in the deer bone, the cattle bone and the sheep bone, mixing with alkali liquor, decocting for 5min, taking out, rinsing the raw materials mixed and decocted with the alkali liquor with clear water for 6 days, air-drying for 12 days, drying and crushing into blocks, rinsing with clear water for 7 days, taking out, adding water, decocting for 22h, repeating for 5 times, concentrating and collecting paste to obtain the mixed glue block. Weighing 45000g of donkey skin, cutting into 4 × 5cm pieces, soaking in clear water for 2 days, changing water for 1 time per day, decocting the small pieces in water for 10min, adding clear water, soaking for 2 days, and filtering, wherein the weight ratio of the clear water to the donkey skin is 4: 1. Repeating for 5 times until the donkey skin is dissolved to form a colloid solution. Adding 200g of alum into the colloid solution, stirring uniformly and standing for 4h, filtering impurities at the bottom to obtain a supernatant, heating and concentrating the supernatant, adding 200g of a flavoring agent 2h before the concentration is finished, adding 1500g of warm yellow wine and 1750g of crystal sugar after the concentration is finished to obtain a mixture, heating the mixture until the mixture is steeped, decocting, adding 1000g of sesame oil when the mixture is picked up by a shovel to be broken and continuously flaky, stopping heating and taking out of a pot, immediately pouring the mixture into a rubber plate coated with the sesame oil, cutting the mixture into small blocks with the length of 10cm, the width of 4cm and the thickness of 0.8cm, placing the small blocks on a net rack for spreading and airing, turning over once every 2 days, spreading and airing for 7 days, placing the small blocks in a wooden box for sealing and flattening, taking out the small blocks when the appearance is soft, spreading and airing the small blocks until the operation is sealed and flattened is repeated for 2 times. Decocting TONGGUANGSAN, herba Scutellariae Barbatae, herba Hedyotidis Diffusae, herba Ajugae, herba Patriniae, herba Lobeliae chinensis, rhizoma Sparganii, rhizoma Curcumae, radix Euphorbiae Fischerianae, radix Platycodonis, rhizoma arisaematis, radix Scutellariae, Aloe, radix Et rhizoma Rhei, and herba Chelidonii for 15min, concentrating, collecting paste until the relative density is 1.0 at 60 deg.C, making into concentrated paste, grinding propolis, cutis Bufonis, squama Manis, Scorpio, Scolopendra, Gekko Swinhonis, herba Orostachyos, Pheretima, Hirudo, Eupolyphaga Seu Steleophaga, periostracum Cicadae, cornu Cervi Pantotrichum, Olibanum, Myrrha, rhizoma corydalis, Borneolum Syntheticum, sanguis Draxonis, Catechu, radix Notoginseng, and Mylabris into powder, adding into the concentrated paste, and decocting with the mixed gel block and colla Corii Asini for 4h to obtain.

Example 2

The embodiment of the application provides an anticancer and analgesic composition, which comprises: 250g of marsdenia tenacissima, 550g of propolis, 70g of dried toad skin, 550g of pangolin scales, 350g of scorpion, 350g of centipede, 250g of gecko, 250g of herba orostachyos, 350g of earthworm, 250g of leech, 350g of hibernating insect, 550g of cicada slough, 350g of pilose antler, 250g of turtle shell, 250g of tortoise plastron, 250g of frankincense, 250g of myrrh, 550g of corydalis tuber, 250g of celandine, 350g of borneol, 250g of dragon blood, 350g of catechu, 250g of barbed skullcap herb, 350g of pseudo-ginseng, 350g of oldenlandia diffusa, 350g of hairy selfheal, 350g of patrinia villosa, 350g of Chinese lobelia herb, 350g of rhizoma sparganii, 350g of zedoary, 200g of radix euphorbiae lantu, 350g of platycodon root, 250g of cantha.

The anticancer analgesic composition is prepared by the following method: removing meat and meat residue on cornu Cervi, 20000g Os bovis Seu Bubali, 20000g Os Caprae Seu Ovis, carapax Trionycis and carapax et Plastrum Testudinis, removing bone marrow from Os Cervi, Os bovis Seu Bubali and Os Caprae Seu Ovis, mixing with alkali solution, decocting for 15min, taking out, rinsing with clear water for 8 days, air drying for 18 days, oven drying, pulverizing into pieces, rinsing with clear water for 7 days, decocting with water for 24 hr, repeating for 8 times, concentrating, and collecting paste to obtain mixed gel block. Weighing 55000g donkey skin, cutting into 4 × 5cm small blocks, soaking in clear water for 3 days, changing water for 2 times per day, adding the small blocks into the water, decocting for 20min, adding clear water, soaking for 3 days, filtering the clear water, and the weight ratio of the added clear water to the donkey skin is 6: 1. Repeating for 6 times until the donkey skin is dissolved to form a colloid solution. Adding 300g of alum into the colloid solution, stirring uniformly and standing for 5h, filtering impurities at the bottom to obtain a supernatant, heating and concentrating the supernatant, adding 300g of a flavoring agent 2h before the concentration is finished, adding 2000g of warm yellow wine and 2250g of rock sugar after the concentration is finished to obtain a mixture, heating the mixture until the mixture is steeped, decocting, adding 1500g of sesame oil when the mixture is lifted by a shovel to a small amount and drops into pieces, stopping heating and taking out the mixture, pouring the mixture into a rubber plate coated with the sesame oil, cutting the mixture into small blocks with the length of 10cm, the width of 5cm and the thickness of 1.6cm, placing the small blocks on a net rack for spreading and airing, turning over the small blocks once every 3 days, placing the small blocks into a wooden box for sealing and flattening after the spreading and airing for 8 days, taking out the small blocks when the appearance is soft, and repeating the operation for 3 times during the sealing and flattening to obtain the donkey. Decocting TONGGUANGSAN, herba Scutellariae Barbatae, herba Hedyotidis Diffusae, herba Ajugae, herba Patriniae, herba Lobeliae chinensis, rhizoma Sparganii, rhizoma Curcumae, radix Euphorbiae Fischerianae, radix Platycodonis, rhizoma arisaematis, radix Scutellariae, Aloe, radix Et rhizoma Rhei, and herba Chelidonii for 25min, concentrating, collecting paste until the relative density is 1.1 at 60 deg.C, making into concentrated paste, grinding propolis, cutis Bufonis, squama Manis, Scorpio, Scolopendra, Gekko Swinhonis, herba Orostachyos, Pheretima, Hirudo, Eupolyphaga Seu Steleophaga, periostracum Cicadae, cornu Cervi Pantotrichum, Olibanum, Myrrha, rhizoma corydalis, Borneolum Syntheticum, sanguis Draxonis, Catechu, radix Notoginseng, and Mylabris into powder, adding into the concentrated paste, and decocting with the mixed gel block and colla Corii Asini for 5h to obtain.

Example 3

The embodiment of the application provides an anticancer and analgesic composition, which comprises: 200g of marsdenia tenacissima, 500g of propolis, 50g of dried toad skin, 500g of pangolin scales, 300g of scorpion, 300g of centipede, 200g of gecko, 200g of herba orostachyos, 300g of earthworm, 200g of leech, 300g of hibernating insect, 500g of cicada slough, 300g of pilose antler, 200g of turtle shell, 200g of tortoise plastron, 200g of frankincense, 200g of myrrh, 500g of corydalis tuber, 200g of celandine, 300g of borneol, 200g of dragon's blood, 300g of catechu, 200g of sculellaria barbata, 300g of pseudo-ginseng, 300g of oldenlandia diffusa, 300g of selfheal, 300g of patrinia villosa, 300g of Chinese lobelia herb, 300g of rhizoma sparganii, 300g of curcuma zedoary, 150g of radix euphorbiae lantu, 300g of platycodon.

The anticancer analgesic composition is prepared by the following method: removing residual meat and tendon on deer horn, 15000g deer bone, 15000g cattle bone, 15000g sheep bone, turtle shell and tortoise plastron, removing bone marrow in the deer bone, the cattle bone and the sheep bone, mixing with alkali liquor, decocting for 10min, taking out, rinsing the materials mixed and decocted with the alkali liquor with clear water for 7 days, air drying for 15 days, drying and crushing into blocks, rinsing with clear water for 7 days, taking out, adding water, decocting for 23h, repeating for 6 times, concentrating, and collecting paste to obtain the mixed rubber block. Weighing 50000g donkey hide, cutting into 4 × 5cm pieces, soaking in clear water for 3 days, changing water for 2 times per day, decocting the small pieces in water for 15min, adding clear water, soaking for 3 days, filtering, and mixing the clear water with donkey hide at a weight ratio of 5: 1. Repeating for 6 times until the donkey skin is dissolved to form a colloid solution. Adding 250g of alum into the colloidal solution, stirring uniformly and standing for 4.5h, filtering impurities at the bottom to obtain a supernatant, heating and concentrating the supernatant, adding 250g of a flavoring agent 2h before the concentration is finished, adding 17500g of warm yellow wine and 2000g of rock sugar after the concentration is finished to obtain a mixture, heating the mixture until the mixture is steeped, decocting, adding 1250g of sesame oil when the mixture is picked up by a shovel to be slightly broken and continuously flaky, taking out the mixture from a pot while stopping heating, immediately pouring the mixture into a glue tray coated with the sesame oil, cutting the mixture into small blocks with the length of 10cm, the width of 4.5cm and the thickness of 1.2cm, placing the small blocks on a net rack for spreading and airing, turning over once every 3 days, placing the small blocks in a wood box for sealing and flattening after the spreading and airing for 8 days, taking out the small blocks when the appearance is soft, and repeating the operation for 3 times during the sealing and flattening to obtain the. Decocting TONGGUANGSAN, herba Scutellariae Barbatae, herba Hedyotidis Diffusae, herba Ajugae, herba Patriniae, herba Lobeliae chinensis, rhizoma Sparganii, rhizoma Curcumae, radix Euphorbiae Fischerianae, radix Platycodonis, rhizoma arisaematis, radix Scutellariae, Aloe, radix Et rhizoma Rhei, and herba Chelidonii for 20min, concentrating, collecting paste until the relative density is 1.05 at 60 deg.C, making into concentrated paste, grinding propolis, cutis Bufonis, squama Manis, Scorpio, Scolopendra, Gekko Swinhonis, herba Orostachyos, Pheretima, Hirudo, Eupolyphaga Seu Steleophaga, periostracum Cicadae, cornu Cervi Pantotrichum, Olibanum, Myrrha, rhizoma corydalis, Borneolum Syntheticum, sanguis Draxonis, Catechu, radix Notoginseng, and Mylabris into powder, adding into the concentrated paste, and decocting with the mixed gel block and colla Corii Asini for 4.5h to obtain.

Example 4

The embodiment of the application provides an anticancer and analgesic composition, which comprises: 190g of marsdenia tenacissima, 490g of propolis, 40g of dried toad skin, 490g of pangolin scales, 290g of scorpion, 290g of centipede, 190g of gecko, 190g of herba orostachyos, 290g of earthworm, 190g of leech, 290g of hibernating insect, 490g of cicada slough, 290g of pilose antler, 190g of turtle shell, 190g of tortoise plastron, 190g of frankincense, 190g of myrrh, 490g of corydalis tuber, 190g of celandine, 290g of borneol, 190g of dragon's blood, 290g of catechu, 190g of barbed skullcap herb, 290g of pseudo-ginseng, 290g of oldenlandia diffusa, 290g of common selfheal fruit-spike, 290g of patrinia scandens scabiosaefolia, 290g of Chinese lobelia herb, 290g of common burreed rhizome, 290g of zedoary, 140g of Chinese wolfsbane root, 290.

The anticancer analgesic composition is prepared by the following method: removing residual meat and tendon on deer horn, 14000g of deer bone, 14000g of cattle bone, 14000g of sheep bone, turtle shell and tortoise plastron, removing bone marrow in the deer bone, the cattle bone and the sheep bone, mixing with alkali liquor, decocting for 9min, taking out, rinsing the materials mixed and decocted with the alkali liquor with clear water for 7 days, air-drying for 14 days, drying and crushing into blocks, rinsing with clear water for 7 days, taking out, adding water, decocting for 22.5h, repeating for 6 times, concentrating and collecting paste to obtain the mixed rubber block. Weighing 49000g donkey hide, cutting into 4 × 5cm pieces, soaking in clear water for 3 days, changing water for 2 times per day, decocting the small pieces in water for 14min, adding clear water, soaking for 3 days, and filtering, wherein the weight ratio of the clear water to the donkey hide is 4.5: 1. Repeating for 6 times until the donkey skin is dissolved to form a colloid solution. Adding 240g of alum into the colloidal solution, stirring uniformly and standing for 4.3h, filtering impurities at the bottom to obtain a supernatant, heating and concentrating the supernatant, adding 240g of a flavoring agent 2h before the concentration is finished, adding 16500g of warm yellow wine and 1900g of rock sugar after the concentration is finished to obtain a mixture, heating the mixture until the mixture is steeped, decocting, adding 1150g of sesame oil when the mixture is picked up by a shovel to be slightly broken and continuously flaked, stopping heating and taking out of a pot, immediately pouring the mixture into a rubber plate coated with the sesame oil, cutting the mixture into small blocks with the length of 10cm, the width of 4.3cm and the thickness of 1.1cm, placing the small blocks on a net rack for spreading and airing, turning over once every 3 days, placing the small blocks in a wood box for sealing and flattening after the surfaces are softened, taking out again when the surfaces are sealed and flattened, and repeating the operation for 3 times to obtain the donkey glue. Decocting TONGGUANGSAN, herba Scutellariae Barbatae, herba Hedyotidis Diffusae, herba Ajugae, herba Patriniae, herba Lobeliae chinensis, rhizoma Sparganii, rhizoma Curcumae, radix Euphorbiae Fischerianae, radix Platycodonis, rhizoma arisaematis, radix Scutellariae, Aloe, radix Et rhizoma Rhei, and herba Chelidonii for 18min, concentrating, collecting paste until the relative density is 1.03 at 60 deg.C, making into concentrated paste, grinding propolis, cutis Bufonis, squama Manis, Scorpio, Scolopendra, Gekko Swinhonis, herba Orostachyos, Pheretima, Hirudo, Eupolyphaga Seu Steleophaga, periostracum Cicadae, cornu Cervi Pantotrichum, Olibanum, Myrrha, rhizoma corydalis, Borneolum Syntheticum, sanguis Draxonis, Catechu, radix Notoginseng, and Mylabris into powder, adding into the concentrated paste, and decocting with the mixed gel block and colla Corii Asini for 4.3h to obtain.

Example 5

The embodiment of the application provides an anticancer and analgesic composition, which comprises: 210g of marsdenia tenacissima, 510g of propolis, 60g of dried toad skin, 510g of pangolin scales, 310g of scorpion, 310g of centipede, 210g of gecko, 210g of herba orostachyos, 310g of earthworm, 210g of leech, 310g of hibernating insect, 510g of cicada slough, 310g of pilose antler, 210g of turtle shell, 210g of tortoise plastron, 210g of frankincense, 210g of myrrh, 510g of corydalis tuber, 210g of celandine, 310g of borneol, 210g of dragon's blood, 310g of catechu, 210g of sculellaria barbata, 310g of pseudo-ginseng, 310g of oldenlandia diffusa, 310g of selfheal, 310g of patrinia villosa, 310g of Chinese lobelia herb, 310g of common burreed rhizome, 310g of zedoary, 160g of radix euphorbiae lantu, 310g of platycodon.

The anticancer analgesic composition is prepared by the following method: removing residual meat and tendon on deer horn, 16000g deer bone, 16000g cow bone, 16000g sheep bone, turtle shell and tortoise plastron, removing bone marrow in deer bone, cow bone and sheep bone, mixing with alkali liquor, decocting for 12min, taking out, rinsing with clear water for 7 days, air drying for 16 days, oven drying, pulverizing into blocks, rinsing with clear water for 7 days, decocting with water for 23.5h, repeating for 7 times, concentrating, and collecting paste to obtain mixed gelatin block. Weighing 51000g donkey hide, cutting into 4 × 5cm pieces, soaking in clear water for 3 days, changing water for 2 times per day, decocting the small pieces in water for 16min, adding clear water, soaking for 3 days, filtering, and adding clear water at a weight ratio of 5.5: 1. Repeating for 6 times until the donkey skin is dissolved to form a colloid solution. Adding 260g of alum into the colloidal solution, stirring uniformly and standing for 4.7h, filtering impurities at the bottom to obtain a supernatant, heating and concentrating the supernatant, adding 260g of a flavoring agent 2h before the concentration is finished, adding 18500g of warm yellow wine and 2100g of crystal sugar after the concentration is finished to obtain a mixture, heating the mixture until the mixture is steeped, decocting, adding 1350g of sesame oil when the mixture is picked up by a shovel to be broken and continuously flaked, stopping heating and taking out of a pot, immediately pouring the mixture into a rubber plate coated with the sesame oil, cutting the mixture into small blocks with the length of 10cm, the width of 4.6cm and the thickness of 1.3cm, placing the small blocks on a net rack for spreading and airing, turning over once every 3 days, placing the small blocks in a wooden box for sealing and flattening after the spreading and airing for 8 days, taking out the small blocks when the appearance is soft, and repeating the operation for 3 times during the sealing and flattening to obtain the donkey glue. Decocting TONGGUANGSAN, herba Scutellariae Barbatae, herba Hedyotidis Diffusae, herba Ajugae, herba Patriniae, herba Lobeliae chinensis, rhizoma Sparganii, rhizoma Curcumae, radix Euphorbiae Fischerianae, radix Platycodonis, rhizoma arisaematis, radix Scutellariae, Aloe, radix Et rhizoma Rhei, and herba Chelidonii for 22min, concentrating, collecting paste until the relative density is 1.06 at 60 deg.C, making into concentrated paste, grinding propolis, cutis Bufonis, squama Manis, Scorpio, Scolopendra, Gekko Swinhonis, herba Orostachyos, Pheretima, Hirudo, Eupolyphaga Seu Steleophaga, periostracum Cicadae, cornu Cervi Pantotrichum, Olibanum, Myrrha, rhizoma corydalis, Borneolum Syntheticum, sanguis Draxonis, Catechu, radix Notoginseng, and Mylabris into powder, adding into the concentrated paste, and decocting with the mixed gel block and colla Corii Asini for 4.8h to obtain.

Test example 1

30 BALB/C mice aged 10-15 weeks, with an average body weight of 27g, were selected, and the anti-cancer analgesic composition prepared in examples 1-5 was administered as follows: water ═ 1 g: 10ml of the solution is prepared, and the concentration is 1X 10¹⁰The S180 tumor cells of mice/ml were injected into 30 mice, and after normal culture in an incubator for 20 days, 5 of the mice were gavaged with the solution prepared in example 1 and numbered group A, 5 of the mice were gavaged with the solution prepared in example 2 and numbered group B, 5 of the mice were gavaged with the solution prepared in example 3 and numbered group C, 5 of the mice were gavaged with the solution prepared in example 4 and numbered group D, 5 of the mice were gavaged with the solution prepared in example 5 and numbered group E, and finally 5 of the mice were gavaged with physiological saline as a control group. The method comprises the following steps of (1) intragastrically irrigating 0.2mL every day, killing the mice after continuously irrigating the stomach for 14 days, taking out tumors in the mice, and calculating the proliferation inhibition rate of tumor cells, wherein the test method of the proliferation inhibition rate of the tumor cells comprises the following steps: measuring the longest diameter (a) and the shortest diameter (b) of the tumor by using a vernier caliper, and calculating the volume V of the transplanted tumor by using a formula V (mm) ═ pi ab/6; the tumor suppression rate of the transplanted tumor is calculated by the formula of percent (% of tumor suppression rate of transplanted tumor) V (mean volume of tumor of control mice-mean volume of tumor of A/B/C/D/E group mice)/V (mean volume of tumor of control mice) x 100%. The average proliferation inhibition results for each group are shown in table 1:

TABLE 1 proliferation inhibition rate of tumor cells

As shown in the results of Table 1, the anticancer effects of examples 3-5 were significantly superior to those of examples 1 and 2, and the anticancer effect of example 3 was slightly superior to those of examples 4 and 5, so that the anticancer analgesic composition prepared in example 3 had the best anticancer effect.

In conclusion, the anticancer and analgesic composition provided by the embodiment of the invention has a great inhibiting effect on mouse S180 sarcoma cells, and is effective and significant in anticancer. In addition, the anticancer and analgesic composition is prepared by adopting a reasonable monarch, minister, assistant and guide relationship, so that the drug properties of the medicinal materials are mutually harmonized, the drug effects of the medicinal materials are concentrated and play a role together, the anticancer and analgesic composition has the effects of resisting cancer and relieving pain by cooling blood and removing stasis, eliminating dampness and relieving pain, clearing heat and detoxicating and the like, and sequelae after radiotherapy and chemotherapy can be relieved.

Wherein the principal drugs include periostracum Cicadae, rhizoma corydalis, Scolopendra, herba Hedyotidis Diffusae and squama Manis. Periostracum Cicadae has effects of dispelling wind heat, dispersing lung qi and relieving spasm, and is mainly used for treating meningioma. Rhizoma corydalis has effects of promoting blood circulation, activating qi-flowing and relieving pain, and can be used for treating various cancer pains. Scolopendra has effects in removing toxic substance, resolving hard mass, dredging collaterals, and relieving pain, and can be used for treating nasopharyngeal carcinoma, carcinoma of maxillary sinus, nasal cavity cancer, paranasal sinus cancer, brain tumor, laryngeal carcinoma, esophageal cancer, gastric cancer, hepatocarcinoma, digestive tract cancer, breast cancer, squamous cell carcinoma of head, malignant lymphoma, skin cancer, malignant tumor, and stomach cancer pain. Herba Hedyotidis Diffusae has effects of clearing away heat and toxic materials, and can be used for treating various malignant cancers such as gastric cancer, esophageal cancer, rectal cancer, breast cancer, cervical cancer, lung cancer, nasopharyngeal cancer, hepatocarcinoma, pancreatic cancer, digestive tract cancer, leukemia and malignant lymphoma. Squama Manis can be used for dredging collaterals and relieving pain, and can be used for treating malignant lymphoma, cervical cancer, breast cancer, hepatocarcinoma, esophageal cancer, gastric cancer, intestinal cancer, anal cancer, brain tumor, eyelid cancer, lymphoma, liposarcoma, etc.

The ministerial drugs comprise TONGGUAN powder, propolis, cutis Bufonis, Scorpio, Gekko Swinhonis, herba Orostachyos, Lumbricus, Hirudo, Eupolyphaga Seu Steleophaga, cornu Cervi Pantotrichum, cornu Cervi, carapax Trionycis, carapax et Plastrum Testudinis, Olibanum, Myrrha, herba Chelidonii, Catechu, herba Scutellariae Barbatae, herba Patriniae, rhizoma Sparganii, Curcumae rhizoma, radix Euphorbiae Fischerianae, Mylabris, rhizoma arisaematis and radix et rhizoma Rhei. The TONG GUO SAN has effects of clearing heat, relieving cough, removing toxic substance, relieving asthma, promoting blood circulation and promoting granulation, and can be used for treating esophageal cancer, cardia cancer, cervical cancer, Hodgkin's disease, gastric cancer, hepatocarcinoma, digestive tract cancer, osteosarcoma and malignant lymphoma. Propolis has anticancer, antiviral, antiinflammatory, anti-AIDS, cell injury repairing, and immunity enhancing effects. The dried cutis Bufonis has effects of clearing away heat and toxic materials, promoting diuresis, and relieving flatulence, and can be used for treating malignant tumor or cancer pain such as esophageal cancer, gastric cancer, hepatocarcinoma, rectal cancer, colon cancer, cervical cancer, leukemia, Hodgkin's disease, etc. Scorpio has effects in removing toxic substance, resolving hard mass, dredging collaterals and relieving pain, and can be used for treating tongue cancer, malignant tumor of paranasal sinuses and nasal sinuses, nasopharyngeal carcinoma, brain tumor, breast cancer, lung cancer, esophageal carcinoma, intestinal cancer bleeding, choriocarcinoma and skin cancer. Gekko Swinhonis has effects in resolving hard mass, relieving pain, dispelling pathogenic wind, activating collaterals, tranquilizing mind, and relieving spasm, and can be used for treating esophageal cancer, carcinoma of gastric cardia, gastric cancer, nasopharyngeal carcinoma, lymph node metastasis cancer, chorioepithelioma, leukemia, breast cancer and malignant tumor. Herba Orostachyos has effects of clearing away heat and toxic materials, stopping bleeding, and relieving swelling, and can be used for treating cervical cancer and breast cancer. Lumbricus has effects in clearing away heat, arresting convulsion, dredging collaterals, and relieving asthma, and can be used for treating brain tumor, nasopharyngeal carcinoma, tongue cancer, esophageal cancer, lung cancer, hepatocarcinoma, digestive tract cancer, abdominal cavity cancer or various cancer pain. Hirudo has effects of dredging channels and removing blood stasis, and can be used for treating brain tumor, nasopharyngeal carcinoma, tongue cancer, esophageal cancer, lung cancer, hepatocarcinoma, digestive tract cancer, abdominal cavity cancer and cancer pain. The Eupolyphaga Seu Steleophaga has effects of removing blood stasis and resolving food stagnation, and can be used for treating osteosarcoma, hepatocarcinoma, cervical cancer, tongue cancer, leukemia, esophageal cancer and dysphagia. Cornu Cervi Pantotrichum has effects of strengthening tendons and bones, and invigorating kidney essence, and can be used for treating cervical cancer and breast cancer. The antler can obviously promote the function of macrophage and inhibit the proliferation capacity of lymphocyte, and obviously inhibit the growth of tumor at lymph position of lung. Carapax Trionycis has effects in nourishing yin, clearing heat, softening and resolving hard mass, and can be used for treating ovarian cancer, abdominal cancer, lung cancer hematemesis, hepatocarcinoma, gastric adenocarcinoma, and cervical cancer. The carapax et Plastrum Testudinis has effects of nourishing yin, suppressing yang, invigorating kidney, and strengthening bone, and can be used for treating various cancers such as lung cancer, breast cancer, hepatocarcinoma, intestinal cancer and gastric cancer. Olibanum has effects of regulating blood and activating qi-flowing, relieving pain and removing toxic substance, and can be used for treating breast cancer, skin cancer, lip cancer and gastric cancer. Myrrha can dissipate blood stasis, relieve swelling and alleviate pain, and is mainly used for treating leukemia, cervical cancer and uterine cancer. Herba Chelidonii has effects of relieving pain and swelling, clearing heat and relieving cough, and can be used for treating gastric cancer, esophageal cancer, lung cancer and skin cancer. Catechu has effects of eliminating dampness and promoting granulation, and can be used for treating gastric cancer and squamous cell carcinoma of tonsil. The sculellaria barbata can clear away heat and toxic materials, remove blood stasis and induce diuresis, and is mainly used for treating various cancers such as nasopharyngeal carcinoma, gastric cancer, esophageal cancer, lung cancer, rectal cancer, liver cancer, oral squamous carcinoma, cervical cancer, mediastinal lymphosarcoma, chorioepithelioma, malignant hydatidiform mole, choriocarcinoma, ovarian cancer, acute cellular leukemia, breast tumor, fibroadenoma of breast, malignant pleural tumor, rhabdomyosarcoma and the like. Herba Patriniae has effects of clearing away heat and toxic materials, promoting pus discharge, and dispelling blood stasis, and can be used for treating various cancers such as appendiceal tumor, hepatocarcinoma, gastric cancer, intestinal cancer, leukemia and cervical cancer. Rhizoma Sparganii has effects of activating qi-flowing, relieving pain, removing blood stasis, and treating abdominal cancer, ovarian cancer, cervical cancer and infantile neuroblastoma liver metastasis. Zedoary turmeric has effects of promoting qi circulation, removing blood stasis, resolving food stagnation and relieving pain, and can be used for treating cervical cancer, abdominal cancer, skin cancer, esophageal cancer and cardia cancer. Mylabris has effects of removing blood stasis, removing toxic substances, and resolving hard mass, and can be used for treating hepatocarcinoma, gastric cancer, esophageal cancer, digestive tract cancer, nasopharyngeal carcinoma, lung cancer, breast cancer, cervical cancer, bladder cancer, skin cancer, etc. Rhizoma arisaematis has effects of eliminating dampness and phlegm, dispelling pathogenic wind and relieving spasm, resolving hard mass and detumescence, and can be used for treating cervical cancer, esophageal cancer, nasopharyngeal cancer, gastric cancer pain, breast cancer, hepatocarcinoma, nervous system malignant tumor and malignant lymphoma. The rhubarb has the effects of purging heat and promoting bowel movement, cooling blood and removing toxicity, and removing blood stasis and stimulating the menstrual flow, and is mainly used for treating colorectal cancer, leukemia, ovarian cancer, gastric cancer, breast cancer, cervical cancer, liver cancer, multiple myeloma and the like.

The adjuvant drugs include Borneolum Syntheticum, sanguis Draxonis, Notoginseng radix, herba Ajugae and Polyporus, and the Borneolum Syntheticum has effects of inducing resuscitation, refreshing mind, clearing heat and relieving pain, and can be used for treating breast cancer, hepatocarcinoma pain, lung cancer, breast cancer pain and lymphoma or cancer pain. Sanguis Draxonis has effects in dispelling blood stasis, relieving pain, stopping bleeding, and promoting granulation, and can be used for treating breast cancer, malignant lymphoma, hemangioma, skin cancer, and penile cancer. Notoginseng radix has effects of removing blood stasis, stopping bleeding, relieving swelling and pain, and can be used for treating gastric cancer, esophageal cancer and brain tumor. The Ajuga decumbens can clear heat and cool blood, relieve swelling and remove toxicity, and is mainly used for treating lung cancer, nasopharyngeal carcinoma, laryngeal cancer, breast cancer, liver cancer and the like. Polyporus umbellatus has effects of promoting diuresis and eliminating dampness, and can be used for treating various cancers such as lung cancer, colon cancer, papillary carcinoma of bladder, adenocarcinoma, infiltrative cancer, non-epithelial tumor and gastric cancer.

The Chinese medicinal materials include radix Euphorbiae Fischerianae, radix Platycodi and Aloe, and the radix Euphorbiae Fischerianae has effects of eliminating phlegm, resolving hard mass and killing parasite, and can be used for treating various cancers such as lung cancer, breast cancer, carcinoma of large intestine, brain glioma, gastric cancer, lung cancer, hepatocarcinoma and thyroid cancer. Radix Platycodi has effects of dispersing lung qi, relieving sore throat, eliminating phlegm, and expelling pus, and can be used for treating lung cancer and brain tumor. Aloe can clear heat and relieve constipation, and can be used for treating leukemia and lung cancer.

In addition, the invention also provides a preparation method of the anticancer analgesic composition, the preparation method adopts different processing methods for different medicinal materials, for example, medicinal materials such as donkey hide and the like are processed in a repeated decoction mode, and medicinal materials such as marsdenia tenacissima and the like are processed in a concentration and paste collection mode, so that the beneficial components of the medicinal materials in the processing and processing process can be kept most, and partial procedures are repeatedly carried out for a plurality of times, for example, water is added for decoction in donkey-hide gelatin preparation, so that impurities in the medicinal materials can be fully removed, the purity of the beneficial components in the anticancer analgesic composition is ensured, and the curative effect of the anticancer analgesic composition is improved. In addition, the invention also provides a preparation method of the anticancer analgesic composition, the preparation method adopts different processing methods for different medicinal materials, for example, medicinal materials such as donkey hide and the like are processed in a repeated decoction mode, and medicinal materials such as marsdenia tenacissima and the like are processed in a concentrated paste-collecting mode, so that the beneficial components of the medicinal materials in the processing process can be kept most, and partial procedures are repeatedly carried out for a plurality of times, for example, water is added for decoction in donkey-hide gelatin preparation, so that impurities in the medicinal materials can be fully removed, the purity of the beneficial components in the anticancer analgesic composition is ensured, and the curative effect of the anticancer analgesic composition is improved.

The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims (10)

1. The anticancer and analgesic composition is characterized by comprising the following raw materials in parts by weight: 150 portions of marsdenia tenacissima, 550 portions of propolis, 450 portions of gecko, 30-70 portions of cutis Bufonis, 550 portions of squama Manis, 350 portions of scorpio, 250 portions of centipede, 250 portions of gecko, 150 portions of Orostachys japonica, 250 portions of earthworm, 350 portions of leech, 150 portions of leech, 350 portions of hiberna, 550 portions of cicada slough, 350 portions of pilose antler, 150 portions of antler, 250 portions of turtle shell, 150 portions of tortoise plastron, 250 portions of frankincense, 150 portions of myrrh, 250 portions of corydalis, 550 portions of greater celandine, 150 portions of chella, 350 portions of borneol, 250 portions of dragon's blood, 350 portions of catechu, 150 portions of sculellaria, 350 portions of notoginseng, 350 portions of oldenlandia, 350 portions of white selfheal, 350 portions of white flower sauce, 350 portions of patrinia, 250 portions of dahurian patrinia, 250 portions of acacia, 250 portions of scorpio, 250 portions of notoginseng, 250 portions of mangnolia, 350 parts of Chinese lobelia, 350 parts of common burreed rhizome, 250 parts of common burreed rhizome, 350 parts of zedoary, 200 parts of Chinese stellera root, 350 parts of platycodon grandiflorum, 250 parts of blister beetle, 150 parts of rhizoma arisaematis, 350 parts of radix scutellariae, 250 parts of aloe and 350 parts of rhubarb.

2. The anticancer analgesic composition of claim 1, comprising the following raw materials in parts by weight: 200 parts of marsdenia tenacissima, 500 parts of propolis, 50 parts of dried toad skin, 500 parts of pangolin scales, 300 parts of scorpion, 300 parts of centipede, 200 parts of gecko, 200 parts of herba orostachyos, 300 parts of earthworm, 200 parts of leech, 300 parts of hibernating insect, 500 parts of cicada slough, 300 parts of pilose antler, 200 parts of turtle shell, 200 parts of tortoise plastron, 200 parts of frankincense, 200 parts of myrrh, 500 parts of corydalis tuber, 200 parts of celandine, 300 parts of borneol, 200 parts of dragon's blood, 300 parts of catechu, 200 parts of sculellaria barbata, 300 parts of pseudo-ginseng, 300 parts of oldenlandia diffusa, 300 parts of common selfheal fruit-spike, 300 parts of patrinia villosa, 300 parts of Chinese lobelia, 300 parts of rhizoma sparganii, 300 parts of curcuma zedoary, 150 parts of radix euphorbiae lantu, 300 parts.

3. The anticancer analgesic composition as set forth in claim 1 or 2, further comprising the following raw materials in parts by weight: 10000 portions of ox bone 20000 portions, 10000 portions of sheep bone 20000 portions, 10000 portions of deer bone 20000 portions, 45000 portions of donkey skin 55000 portions, 1500 portions of yellow wine 2250 portions, 1750 portions of crystal sugar 2250 portions, 1000 portions of sesame oil 1500 portions, 200 portions of alum and 300 portions of flavoring agent 200 portions.

4. The anticancer analgesic composition of claim 3, comprising the following raw materials in parts by weight: 15000 parts of ox bone, 15000 parts of sheep bone, 15000 parts of deer bone, 50000 parts of donkey skin, 1750 parts of yellow wine, 2000 parts of rock candy, 1250 parts of sesame oil, 250 parts of alum and 250 parts of flavoring agent.

5. Use of an anticancer and analgesic composition according to any one of claims 1 to 4 for the preparation of a broad spectrum anticancer drug, a chemo-radiotherapy sensitizer, a combination anticancer drug and/or an analgesic drug.

6. A method for preparing the anticancer analgesic composition as set forth in claim 3 or 4, which comprises the steps of:

preparing a mixed rubber block: mixing cornu Cervi, Os bovis Seu Bubali, Os Caprae Seu Ovis, carapax Trionycis and carapax et Plastrum Testudinis with alkali solution, decocting, soaking, decocting in water, concentrating, and collecting paste to obtain mixed gelatin block;

preparation of donkey gelatin: adding water into donkey hide, decocting into colloidal solution, adding alum into the colloidal solution, stirring uniformly, standing to obtain supernatant, heating and concentrating the supernatant, adding flavoring agent, adding yellow wine and crystal sugar after concentration to obtain a first mixture, decocting the first mixture, adding sesame oil, stopping heating, taking out of a pot to obtain a second mixture, and drying the second mixture to obtain donkey hide glue;

mixing to obtain a medicine: decocting TONGGUANGSAN, herba Scutellariae Barbatae, herba Hedyotidis Diffusae, herba Ajugae, herba Patriniae, herba Lobeliae chinensis, rhizoma Sparganii, rhizoma Curcumae, radix Euphorbiae Fischerianae, radix Platycodonis, rhizoma arisaematis, radix Scutellariae, Aloe, radix Et rhizoma Rhei, and herba Chelidonii, concentrating, collecting paste, grinding propolis, cutis Bufonis, squama Manis, Scorpio, Scolopendra, Gekko Swinhonis, herba Orostachyos, Pheretima, Hirudo, Eupolyphaga Seu Steleophaga, periostracum Cicadae, cornu Cervi Pantotrichum, Olibanum, Myrrha, rhizoma corydalis, Borneolum Syntheticum, sanguis Draxonis, Catechu, radix Notoginseng, and Mylabris into powder, adding into the paste, and decocting with the mixed gelatin block and colla Corii Asini to obtain the anticancer and analgesic composition.

7. The method for preparing an anticancer analgesic composition as set forth in claim 6, wherein the mixed gel block is prepared by removing bone marrow from deer bone, cow bone and sheep bone and mixing the removed bone marrow with alkali solution for decoction.

8. The method of claim 7, wherein the soaking step comprises rinsing the decocted material with the alkali solution with clear water for 6-8 days, air drying for 12-18 days, oven drying, pulverizing into blocks, and rinsing with clear water for 7-9 days.

9. The method for preparing anticancer analgesic composition as claimed in claim 8, wherein the decocting of donkey-hide gelatin comprises the steps of decocting for 10-20min, soaking in clear water for 2-3 days, filtering, repeating for 5-6 times until donkey hide is melted to form colloid solution, wherein the weight ratio of single clear water to donkey hide is (4-6): 1.

10. The method for preparing a composition for anticancer and analgesic purposes as set forth in claim 9, wherein the air-drying step comprises the steps of spreading and drying the mixture II on a net rack, turning over the mixture once every 2 to 3 days, placing the mixture II in a wooden box after 7 to 8 days, sealing and flattening the mixture, and taking out the mixture when the appearance of the mixture is soft; the drying is repeated for 2-3 times.