CN1141139C - Anti-cancer medicine and its preparation method - Google Patents
Anti-cancer medicine and its preparation method Download PDFInfo
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- CN1141139C CN1141139C CNB021173052A CN02117305A CN1141139C CN 1141139 C CN1141139 C CN 1141139C CN B021173052 A CNB021173052 A CN B021173052A CN 02117305 A CN02117305 A CN 02117305A CN 1141139 C CN1141139 C CN 1141139C
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Abstract
The present invention discloses an anticancer medicine and a preparation method thereof. The anticancer medicine is mainly prepared from fresh pine needle, epimedium herb, pilos deer horn, stiff silkorm, prepared rhizoma arisaematis, pangolin scale, rhubarb, centipede, house lizard, manyprickle acanto-panax root, earthworm, eguus asinus, angelica, common selfheal fruit-spike, dahurian angelica, fresh dahurian rose fruit root and dry dahurian rose fruit root. The medicine has favorable effect for treating cancer.
Description
Technical field:
The present invention relates to a kind of pharmaceutical composition, particularly relate to a kind of pharmaceutical composition with antitumaous effect.
Background technology:
At present, the Therapeutic Method such as operation, radiotherapy, chemotherapy that adopt when treatment malignant tumor and cancer more, above-mentioned Therapeutic Method is the expense height not only, also has contraindication and toxic and side effects, is difficult to reach effective therapeutic purposes.The destruction of immune function of human body causes vital QI cannot conquer pathogen, makes cancerous cell remaining in the body extensively breed transfer, invades the many places internal organs and causes patient death; Also there is not medicine that cancer is had curative effect preferably at present.Bright Folium Pini (Folium Pini that the summer in winter is evergreen), the bitter temperature of nature and flavor is returned the Liver and kidney warp, the dry temperature of dispeling the wind, killing parasites for relieving itching cures mainly rheumatic arthralgia.Contain volatile oil, aminoacid, vitamin etc., the good sedative effect is arranged, and analgesia, antiinflammatory, antipyretic activity and Nutrition preferably.Herba Epimedii is hot sweet turbid, return the Liver and kidney warp, kidney invigorating and YANG supporting, expelling wind and removing dampness " Mingyi Bielu " " hard muscles and bones; the scrofula that disappears disease ... ", contain Flavonoid substances such as icariine, and contain volatile oil, sterin alkaloid etc., (pharmacology) has blood pressure lowering and increases coronary flow ... microcirculation improvement has promotion and two-way accent effect to body's immunity, and epimedium brevicornum polysaccharide (EPS) has the inducement interferon effect.The sweet salty temperature of Cornu Cervi Pantotrichum, return the Liver and kidney warp, the kidney-replenishing benefiting essence-blood, strengthening the tendons and bones, contain 25 seed amino acids, estrogen, androgen, prostaglandin and 26 kinds of trace element, wherein copper, ferrum, zinc, manganese, chromium, molybdenum, nickel, the necessary element of 8 kinds of human bodies of cobalt have strong effect, can improve the body ability to work, lessen fatigue, improve sleep, promote diet, improve malnutrition and protein metabolism, energy human body immunity improving effect strengthens erythrocyte, hematochrome and the erythrocytic new life of net matter, leukocyte increasing, can increase coronary flow, have cardiotonic, prevent and treat arrhythmia.Bombyx Batryticatus, acrid in the mouth, salty, property is put down, go into the heart, lung, spleen channel, dissipating phlegm and resolving masses, expelling wind to relieve convulsion, the anticancer cancer that presses down is used for the esophageal carcinoma, rhinocarcinoma, brain tumor, gastric cancer, pulmonary carcinoma, intestinal cancer ... apoplexy, headache, tuberculosis etc., main component is an ammonium oxalate protein, fat reaches, and bassianins and steroidal 11 α-materials such as hydroxylase system have good anticancer effectiveness, its alcohol extract reaches more than 35% mice ZAC solid type suppression ratio, and can suppress sarcoma (S180) growth in vivo and the breathing that suppresses the human hepatocyte effectively, clinical application research confirms esophagus, stomach, pulmonary carcinoma and brain tumor truly have better effects, the tumor body is dwindled or disappear.Rhizoma Arisaematis (processed), the toil temperature, go into lung,, spleen, warp, expelling wind and relieving convulsion, dissipating phlegm and resolving masses, it is anticancer to subside a swelling, be used for pulmonary carcinoma, intracranial tumor, cervical cancer, nasopharyngeal carcinoma, esophagus, oral cavity, nervous system malignant tumor, contain several amino acids, Saponin and alkaloid, benzoic acid cupreol, phlegmatic temperament etc., more tangible anticancer effectiveness is arranged, tumor strains such as (S180) has the obvious suppression effect to murine sarcoma, cervical cancer (HeLa) cell is also had stronger inhibitory action, cervical cancer, brain tumor are had good result, total effective rate reaches more than 70%.Squama Manis, Cheng Han goes into liver, stomach, lung meridian, blood circulation promoting and dispersing pathogen accumulation, the expensive heavily fortified point of eliminating carbuncle, anticancer, with cancers such as Thyreoidine, mammary gland, skin, esophagus, liver, stomach and malignant lymphoma, leukemia etc., contain 16 kinds of free amino acids such as trace element such as stearic acid, cholesterol, water-soluble alkaloid and zinc, calcium, ferrum, sodium and aspartic acid; Squama Manis alkali has anticancer and leukemia resisting action.Radix Et Rhizoma Rhei, bitter cold, return stomach, intestinal, Liver Channel, the pathogenic fire purging heat clearing away, attack long-pending blood stasis removing, detoxicating and fighting cancer, contain Radix Et Rhizoma Rhei rope, chrysophanol, aloe-emodin, chrysophanic acid, physcione, good anticancer effectiveness is arranged, especially above-mentioned three kinds of compositions all have obvious inhibitory action to tumor, suppression ratio increases with drug level, Radix Et Rhizoma Rhei concentration just has obvious inhibitory action to the division of human body pulmonary carcinoma (A549) cell and the biosynthesis of DNA when 10 mcg/ml, emodin and chrysophanic acid have very strong inhibitory action to malignant melanoma.Breast carcinoma and ehrlich carcinoma also there are resistancing action, multiple cancer is had obvious inhibitory action.Scolopendra: Xin Xianwen, go into liver heart stomach warp, dispelling wind and removing obstruction in the collateral, relieving convulsion pain relieving, detoxicating and resolving stagnation of pathogens, the anticancer cancer that presses down are used for the treatment of the cerebral tumor, bone tumor, rhinocarcinoma, lymphatic cancer, hepatocarcinoma, gastric cancer, esophagus etc.Gekko Swinhonis: Cheng Han, go into conscience warp, dispelling wind and removing obstruction in the collateral, relieving convulsion pain relieving, detoxicating and resolving stagnation of pathogens, anticancer pressing down, be used for the treatment of various cancers, apoplexy, hemiplegia, tuberculosis are used always it, contain various trace elements such as the several amino acids of needed by human body such as glutamic acid, arginine and ferrum, calcium, magnesium, zinc, and protein, fatty wet goods composition, and contain the noxious substance of hornet poison sample, certain anticancer effectiveness is arranged, the Gekko Swinhonis aqueous solution can obviously suppress human hepatoma cell to be breathed, and cancers such as esophagus, lung, liver, cervix uteri, lymph are truly had better curative effect.Radix Et Caulis Acanthopanacis Senticosi: arduous temperature, return the Liver and kidney warp, wind-damp dispelling, bone and muscle strengthening, consumer edema contain multiple human body desired nutritional material and anticancer active constituent, as glycoside Radix Et Caulis Acanthopanacis Senticosi A, B, C, D, E, F, G etc. are arranged ... good anti-cancer and cancer-preventing effectiveness is arranged.Experiment shows Radix Et Caulis Acanthopanacis Senticosi and extract thereof to the zoografting tumor, and the spontaneous leukemia of the transfer of drug-induced cancer and mice all has inhibitory action in various degree.With Radix Et Caulis Acanthopanacis Senticosi polysaccharide 0.34g/4 gram, logotype 10 days has remarkable inhibitory action to murine sarcoma and ascitic type cancer.Radix Et Caulis Acanthopanacis Senticosi extract reaches more than 90% the suppression ratio of cervical cancer, and this product has obvious resisting fatigue, the anti-ageing effect of waiting for a long time.Pheretima: Cheng Han, go into liver, spleen, urinary bladder channel, the heat clearing away spasmolytic, the diuresis of relievining asthma, the collateral dredging eliminating impediment, the anticancer cancer that presses down is used for multiple malignant tumor such as nose, liver, breast, esophagus, thyroid, lymph, skin; Contain lumbrifebrine, lumbricin, terrestro-lumbrolysin, xanthine, adenine, and several amino acids, trace element.Good anticancer effectiveness is arranged, Pheretima extract has very strong active anticancer, human-like colon cancer, hepatoma carcinoma cell and mouse transplanted sarcoma etc. all there is obvious inhibitory action, human cervical carcinoma's suppression ratio is reached 50-70%, growth also has direct repression to stomach cancer cell, and radiosensitizing effect is arranged, and can obviously promote cancerous cell oxygen consumption to increase, Pheretima has the leukocyte increasing effect, and is better to nose, esophagus, liver, many malignant tumor of lymph curative effect.Colla Corii Asini: sweetly put down, return lung Liver and kidney warp, tonifying blood and arresting bleeding, nourishing YIN and moistening the lung, blood deficiency disease, tell hemorrhages such as nosebleed metrorrhagia, yin deficiency, asthenia is breathed with cough, deficiency of YIN cough caused by dryness ... form by Colla Corii Asini is former, hydrolysis can get several amino acids, and calcic, sulfur etc. have good blood tonification effect in addition, positive calcium balance effect is arranged, the healthy human lymphocyte transformation of promotion is arranged.Radix Angelicae Sinensis: Gan Xinwen, relieved liver spleen channel, enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation, the anticancer cancer that presses down, be used for liver, esophagus, stomach, colon, the cervix uteri ovary, bladder, cancers such as mammary gland, the treatment of leukemia malignant lymphoma contains volatile oil, Radix Angelicae Sinensis polysaccharide, alkaloid and aminoacid, trace element etc., its anticancer effective component are Radix Angelicae Sinensis polysaccharide, alkaloid, the effect of the tumor cell of inhibition is arranged, its suppression ratio is 50-70% (external), and Radix Angelicae Sinensis polysaccharide is to entity tumor (pulmonary carcinoma, hepatocarcinoma etc.) ehrlich carcinoma and leukemic therapeutical effect are stronger, and Radix Angelicae Sinensis also has pair cell to exempt from, the facilitation of humoral immunization can induce cytokine.Spica Prunellae: arduous cold, go into the liver and gall warp, relieving inflammation or internal heat makes eye bright, depressed liver-energy dispersing and QI regulating, powder detoxifcation is used for multiple cancer, can control hypertension, thyromegaly, acute mastitis, swollen skin ulcer ... containing triterpenoid saponin, flavonoid, ursolic acid, oleanolic acid, Coumarins, volatile oil and vitamin C etc. has better anticancer effectiveness, effective ingredient ursolic acid and derivant that leukaemia and human body lung carcinoma cell are all had remarkable cytotoxicity, 100% decocting liquid is to the Chinese mugwort ehrlich ascites carcinoma, and sarcoma, cervical cancer etc. all has inhibitory action.The Radix Angelicae Dahuricae: Xin Wen, return lung stomach spleen channel, expelling wind and removing dampness, understand things pain-stopping, detumescence and apocenosis, diseases caused by exogenous pathogenic factor ailment said due to cold or exposure, headache, sore swollen toxin etc., contain byak-angelicin, Byakangelicol, oxypeucedanin, ammidin, phellopterin, xanthotoxin etc., energy vitiligo and psoriasis, hemostasis have certain broad spectrum antibiotic activity.Thorn rose (rose hip, Arisaema balansae Engl.): mainly contain the catechu tanninoids, eliminating phlegm and stopping cough, dysentery relieving, hemostasis, to uterus carcinoma, lymphosarcoma, renal carcinoma, carcinoma of prostate etc. have better curative effect
Technology contents:
The object of the invention is to provide a kind of pharmaceutical composition with antitumaous effect and preparation method thereof.
Of the present invention basic composition is:
Bright Folium Pini 2000-4000 weight portion Herba Epimedii 100-300 weight portion
Cornu Cervi Pantotrichum 20-80 weight portion Bombyx Batryticatus 50-150 weight portion
Rhizoma Arisaematis (processed) 50-150 weight portion Squama Manis 50-150 weight portion
Radix Et Rhizoma Rhei 20-80 weight portion Scolopendra 50-150 bar
Gekko Swinhonis 50-150 weight portion Radix Et Caulis Acanthopanacis Senticosi 100-300 weight portion
Pheretima 100-300 weight portion Colla Corii Asini 100-300 weight portion
Radix Angelicae Sinensis 200-400 weight portion Spica Prunellae 100-200 weight portion
The bright thorn of Radix Angelicae Dahuricae 50-150 weight portion rose root 1000-3000 weight portion
Do thorn rose root 500-1500 weight portion
The pharmaceutical composition that above component is formed is that the core of medicine of the present invention is formed.The medicated powder that said composition is made has the good result of treatment cancer.
Folium Pini and Herba Epimedii are fried in shallow oil juice, concentrated; Radix Angelicae Sinensis, Spica Prunellae, the Radix Angelicae Dahuricae three flavors are fried in shallow oil juice, are concentrated; Thorn rose root is fried in shallow oil juice, is concentrated.Above-mentioned raw materials can not close and fry in shallow oil; All the other raw materials are ground into fine powder, and Colla Corii Asini grinds standby in addition; After each concentrated solution after the cold and medicated powder (except the Colla Corii Asini) close even oven dry or dries, add the Colla Corii Asini powder at last and get final product.
Optimum ratio of the present invention is:
Bright Folium Pini 3000 weight portion Herba Epimedii 200 weight portion Cornu Cervi Pantotrichums 50 weight portions
Bombyx Batryticatus 100 weight portion Rhizoma Arisaematis (processed) 100 weight portion Squama Maniss 100 weight portions
100 Gekko Swinhonis 100 weight portions of Radix Et Rhizoma Rhei 50 weight portion Scolopendras
Radix Et Caulis Acanthopanacis Senticosi 200 weight portion Pheretimas 200 weight portion Colla Corii Asini 200 weight portions
The Radix Angelicae Sinensis 300 weight portion Spica Prunellaes 150 weight portion Radixs Angelicae Dahuricae 100 weight portions
Bright thorn rose root 2000 weight portions are done thorn rose root 1000 weight portions
According to the situation of treatment various cancers, can on the basis of above-mentioned composition, change sanction, below provide several prescriptions to change based on above-mentioned core component.
Wherein a kind of for having increased Scorpio 10-20 weight portion, Mylabris 4-10 weight portion composition compositions on the basis of the above; Scorpio, Mylabris are burnt till carbon to add in the basic prescription treatment hepatocarcinoma, pulmonary carcinoma, breast carcinoma is had good result.
Another kind is to increase Sargassum 100-300 weight portion, Thallus Laminariae (Thallus Eckloniae) 100-300 weight portion composition compositions in basic prescription; Sargassum, Thallus Laminariae (Thallus Eckloniae) are fried in shallow oil juice, concentrated and admix in the basic prescription, treatment thyroid carcinoma, lymphosarcoma, laryngeal carcinoma are had good result.
Another kind is to increase Concha Arcae 500-1000 weight portion, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 20-80 weight portion composition compositions in basic prescription; Concha Arcae, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) are burnt till carbon add in the basic prescription, treatment gastric cancer is had good result.
Another kind is to increase Indigo Naturalis 20-80 weight portion, Nidus Vespae 20-80 weight portion, Periostracum Serpentis 10-50 weight portion composition compositions in basic prescription;
Indigo Naturalis, Nidus Vespae, Periostracum Serpentis are added in the basic prescription, the treatment leukemia is had good result.
Another kind is to increase Rhizoma Gastrodiae 50-100 weight portion, Fructus Xanthii 20-800 weight portion composition compositions in basic prescription; Rhizoma Gastrodiae, Fructus Xanthii are added in the basic prescription, treatment is had good result.
Another kind is to increase Polyporus 100-200 weight portion, Rhizoma Osmundae 100-200 weight portion in basic prescription, forms compositions; Polyporus, Rhizoma Osmundae are added in the basic prescription, treatment renal carcinoma, bladder cancer, carcinoma of testis are had good result.
Clinical data:
This is organized among the 336 routine patients, male's 234 examples, women's 102 examples, maximum 78 years old age, minimal ages 13 years old.13-40 year person's 39 examples wherein, 41-50 year person's 73 examples, 51-60 year person's 106 examples, person's 118 examples more than 61 years old all through cytology or pathological examination, confirm scale cancer person 236 examples before the patient treatment, adenocarcinoma person's 75 examples, adeno-squamous carcinoma amalgamator 6 examples, typing cancer person 19 examples are not all decided III type (late period) malignant tumor by " clinical disease diagnosis is according to curing the improvement standard " and " up-to-date domestic and international medical diagnosis on disease standard ".100% process chemicotherapy and anticancer drug therapy effect do not show or the recurrence after operation person.
By " up-to-date domestic and international disease treatment standard " and the unified national traditional Chinese medical herbal treatment malignant tumor efficacy assessment standard Comprehensive Assessment of formulating of Ministry of Public Health.
Cure: the positive sign of treatment back symptom and objective determination disappears, and recovers certain work capacity, and seeing to look into more than 3 years does not continuously have the recidivist.
Clinical cure: the positive sign of treatment back symptom and objective determination disappears substantially, tumor dwindle half or over half, recover certain work capacity, observe July-2 years no recidivists continuously.
Produce effects: treatment back cardinal symptom disappears, and the disease kitchen range dwindles or steady and continuous is observed 2-6 month no longer compound recipe exhibition person.
Invalid: treatment back symptom and objective determination do not have change or only short-term improve then back deterioration person rapidly.
Late malignant tumour 336 examples are observed in this group treatment; Treat and all can improve symptom rapidly after 7-10 days; Stimulating appetite; The elder of tumor extinction time 150 days, the shortest person's medication 40 days. cases example number cure the invalid cancer of the esophagus 76 examples of clinical cure produce effects 20 examples 15 examples 16 examples 12 routine cancer of the stomach 62 examples 19 examples 15 examples 26 examples 2 routine liver cancer 39 examples 4 examples 5 examples 23 examples 7 routine lung cancer 53 examples 15 examples 10 examples 18 examples 7 routine rhinocarcinoma 9 examples 2 examples 1 example 5 examples 1 routine intestinal cancer 28 examples 9 examples 10 examples 8 examples 1 routine breast cancer 15 examples 7 examples 7 examples 1 example 0 routine cervical cancer 27 examples 13 examples 9 examples 4 examples 1 routine cancer of pancreas 6 examples 2 examples 1 example 3 examples 0 routine osteosarcoma 11 examples 7 examples 2 examples 1 example 1 other tumour 10 examples 3 examples 0 example 6 examples 1 examples of example
Embodiment:
Get bright Folium Pini 3000g Herba Epimedii 200g Cornu Cervi Pantotrichum 50g
Bombyx Batryticatus 100g Rhizoma Arisaematis (processed) 100g Squama Manis 100g
100 Gekko Swinhonis 100g of Radix Et Rhizoma Rhei 50g Scolopendra
Radix Et Caulis Acanthopanacis Senticosi 200g Pheretima 200g Colla Corii Asini 200g
Radix Angelicae Sinensis 300g Spica Prunellae 150g Radix Angelicae Dahuricae 100g
Bright Shu Meigen 2000g does Shu Meigen 1000g
Folium Pini and Herba Epimedii are fried in shallow oil juice, concentrated; Radix Angelicae Sinensis, Spica Prunellae, the Radix Angelicae Dahuricae three flavors are fried in shallow oil juice, are concentrated; Thorn rose root is fried in shallow oil juice, is concentrated.Above-mentioned raw materials can not close and fry in shallow oil; All the other raw materials are ground into fine powder, and Colla Corii Asini grinds standby in addition; After each concentrated solution after the cold and medicated powder (except the Colla Corii Asini) close even oven dry or dries, add the Colla Corii Asini powder at last, make 10000 capsules.
Claims (9)
1, a kind of pharmaceutical composition with antitumaous effect is characterized in that this pharmaceutical composition is to be made by following materials of weight proportions:
Bright Folium Pini 2000-4000 weight portion Herba Epimedii 100-300 weight portion
Cornu Cervi Pantotrichum 20-80 weight portion Bombyx Batryticatus 50-150 weight portion
Rhizoma Arisaematis (processed) 50-150 weight portion Squama Manis 50-150 weight portion
Radix Et Rhizoma Rhei 20-80 weight portion Scolopendra 50-150 bar
Gekko Swinhonis 50-150 weight portion Radix Et Caulis Acanthopanacis Senticosi 100-300 weight portion
Pheretima 100-300 weight portion Colla Corii Asini 100-300 weight portion
Radix Angelicae Sinensis 200-400 weight portion Spica Prunellae 100-200 weight portion
The bright thorn of Radix Angelicae Dahuricae 50-150 weight portion rose root 1000-3000 weight portion
Do thorn rose root 500-1500 weight portion.
2, the pharmaceutical composition with antitumaous effect as claimed in claim 1 is characterized in that this pharmaceutical composition is to be made by following materials of weight proportions:
Bright Folium Pini 3000 weight portion Herba Epimedii 200 weight portion Cornu Cervi Pantotrichums 50 weight portions
Bombyx Batryticatus 100 weight portion Rhizoma Arisaematis (processed) 100 weight portion Squama Maniss 100 weight portions
100 Gekko Swinhonis 100 weight portions of Radix Et Rhizoma Rhei 50 weight portion Scolopendras
Radix Et Caulis Acanthopanacis Senticosi 200 weight portion Pheretimas 200 weight portion Colla Corii Asini 200 weight portions
The Radix Angelicae Sinensis 300 weight portion Spica Prunellaes 150 weight portion Radixs Angelicae Dahuricae 100 weight portions
Bright thorn rose root 2000 weight portions are done thorn rose root 1000 weight portions.
3, the pharmaceutical composition with antitumaous effect as claimed in claim 1 is characterized in that this pharmaceutical composition crude drug has also added Scorpio 10-20 weight portion, Mylabris 4-10 weight portion.
4, the pharmaceutical composition with antitumaous effect as claimed in claim 1 is characterized in that this pharmaceutical composition crude drug has also added Sargassum 100-300 weight portion, Thallus Laminariae (Thallus Eckloniae) 100-300 weight portion.
5, the pharmaceutical composition with antitumaous effect as claimed in claim 1 is characterized in that this pharmaceutical composition crude drug has also added Concha Arcae 500-1000 weight portion, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 20-80 weight portion.
6, the pharmaceutical composition with antitumaous effect as claimed in claim 1 is characterized in that this pharmaceutical composition crude drug has also added Indigo Naturalis 20-80 weight portion, Nidus Vespae 20-80 weight portion, Periostracum Serpentis 10-50 weight portion composition compositions.
7, the pharmaceutical composition with antitumaous effect as claimed in claim 1 is characterized in that this pharmaceutical composition crude drug has also added Rhizoma Gastrodiae 50-100 weight portion, Fructus Xanthii 20-800 weight portion.
8, the pharmaceutical composition with antitumaous effect as claimed in claim 1 is characterized in that this pharmaceutical composition crude drug has also added Polyporus 100-200 weight portion, Rhizoma Osmundae 100-200 weight portion.
9, as claim 1,2,3,4,5,6,7 or 8 described preparation of drug combination methods, it is characterized in that this method is with antitumaous effect: weighting raw materials in proportion, Folium Pini and Herba Epimedii are fried in shallow oil juice, concentrated; Radix Angelicae Sinensis, Spica Prunellae, the Radix Angelicae Dahuricae three flavors are fried in shallow oil juice, are concentrated; Thorn rose root is fried in shallow oil juice, is concentrated; Above-mentioned raw materials can not close and fry in shallow oil; All the other raw materials are ground into fine powder, and Colla Corii Asini grinds standby in addition; After each concentrated solution after the cold and other medicated powder except the Colla Corii Asini close even oven dry or dries, add the Colla Corii Asini powder at last, make acceptable forms clinically.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021173052A CN1141139C (en) | 2002-04-17 | 2002-04-17 | Anti-cancer medicine and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021173052A CN1141139C (en) | 2002-04-17 | 2002-04-17 | Anti-cancer medicine and its preparation method |
Publications (2)
| Publication Number | Publication Date |
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| CN1380089A CN1380089A (en) | 2002-11-20 |
| CN1141139C true CN1141139C (en) | 2004-03-10 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB021173052A Expired - Fee Related CN1141139C (en) | 2002-04-17 | 2002-04-17 | Anti-cancer medicine and its preparation method |
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| CN105106262A (en) * | 2015-09-23 | 2015-12-02 | 泸州市谢国清中草药配方研究有限公司 | Traditional Chinese medicine composition for treating esophagus cancer |
| CN105106261A (en) * | 2015-09-23 | 2015-12-02 | 泸州市谢国清中草药配方研究有限公司 | Traditional Chinese medicine composition for treating lymphoma |
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