CN105106575A - Traditional Chinese medicine composition for treating constipation and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating constipation and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treating constipation. The traditional Chinese medicine composition comprises fructus forsythia, schizonepeta, cortex phellodendri, radix angelicae dahuricae, plantain, radix scutellariae, honey, radix scrophulariae, oriental wormwood, rhizoma alismatis, rhizoma anemarrhenae, fructus aurantii immaturus, peony tree bark, all-grass of desertliving cistanche and radix gentianae macrophyllae. Compared with pure western medicine treatment, the traditional Chinese medicine composition has the advantages that constipation index can be well lowered, the clinical signs of a patient can be improved, further deterioration of the constipation can be prevented, and meanwhile, the traditional Chinese medicine composition is free of toxic and side effects and high in safety and comfortableness.
Description
Technical field
The present invention relates to technical field of Chinese medicine, particularly relate to a kind of Chinese medicine composition being used for the treatment of constipation and preparation method thereof.
Background technology
Constipation is chronic digestible road symptom common clinically, and its main manifestations is that times of defecation reduces, and interval time extends, or normally, but excrement matter is dry, discharges difficulty; Or excrement matter is not done, discharge not smooth.Can accompany and see abdominal distention, stomachache, loss of appetite, heating installation regurgitation, the diseases such as stool band blood.Often can lay one's hand on and the visible peristalsis visible intestinal peristalsis of excrement block or spasm at left lower quadrant.
The sickness rate of constipation is high, and the cause of disease is complicated, often brings many miseries and worry to patient, has a strong impact on its healthy and quality of life.In addition, the operating pressure of modern society people is large, and spirit is in tension for a long time, easily causes the autonomic nerve controlling intestinal peristalsis promoting to get muddled, thus affects digesting and assimilating of food in intestinal, and these are all constipation major incentive occurred frequently.
Therefore, try to explore and find effectively to alleviate and treat the medicine of all kinds of tients with constipation's symptom, avoid the disease aggravation because tients with constipation causes and deterioration, be conducive to disease and the physical and psychological rehabilitation of patient, for extensive patients brings glad tidings.
Owing to causing the factor of constipation a lot, a class can not be summed up as, so different Therapeutic Method should be adopted to the constipation that different pathogeny causes.The traditional Chinese medical science is thought, constipation is primarily of caused by dryness-heat stagnating in the interior, depression and stagnation of QI, deficiency of body fluid and spleen-kidney vacuity cold: 1, the dryness-heat stagnating in the interior traditional Chinese medical science is thought that surfeit is pungent and thickly to be hidden, and crosses the product etc. taking temperature compensation and can cause the excess of YANG and burn cloudy; After calentura, waste heat is reluctant to leave the intestines and stomach, consumption impairment of body fluid liquid; Or damp invasion of lower energizer large intestine, make intestinal scorching, impairment of body fluid and constipation, this constipation is also called functional constipation.2, depression and stagnation of QI feelings will is not relaxed, sorrow ponders over, sitting less dynamic, prolonged illness bed etc. cause depression and stagnation of QI, cause large intestine to conduct in dereliction of duty, waste matter and stop, form constipated, be i.e. so-called " in gas stagnant and thing is not all right ".Feces is not tied dry, but discharges the feature that difficulty is this kind of, so be also called constipation due to disorder of QI.3, deficiency of body fluid prolonged illness, puerperal, old asthenia, QI and blood deficiency; Taste internal injury, amount of drinking water are few, change source not enough, too diaphoresis in disease, rush down lower impairment of YIN etc.The deficiency of vital energy then large intestine is passed on unable, and blood deficiency and depleted fluid then moist mistake of large intestine is supported, and intestinal is done withered, just goes involved and abstruse, so be called constipation due to insufficiency.4, spleen-kidney vacuity cold year high prolonged illness, kidney-yang deficiency, yang-energy does not transport then YIN pathogen condensation; Or have spleen YANG deficiency, send an expedition against by cold again, and cause spleen kidney yang and decline, Wen Zhao haves no right then QI stagnated by cold, and intestinal transmits unable, and difficulty in defecation, is called constipation due to accumulation of pathogenic cold.
China's treatment constipation medicine is a lot, as: the medicines such as SANHUANG PIAN, Radix Et Rhizoma Rhei clearing stomach ball, Oleum Ricini, magnesium sulfate, phenolphthalein, glycerin, compound Aloe capsule, TONGBIAN LING, the use had in clinical position is inconvenient, some dosage is wayward, few inoperative, there will be more and have loose bowels, more difficult grasp.Especially more not good to the anti-constipation effect of old people, but owing to being all based on symptomatic treatment, constipation patient only could relief of symptoms when prolonged administration of drugs, and after cutting out medicine, constipation can be recurred again, and the medicine that long-term taking has can produce toxic and side effects to human body.
Object of the present invention is exactly that existing Western medicine toxic and side effects in order to overcome for constipation is large, therapeutic effect is difficult to continue, and the deficiency that Chinese traditional treatment effect is undesirable, according to traditional Chinese medical science prescription and preparation principle, Chinese medicine composition is developed meticulously, the advantages such as one is pointed by force, good effect, the cycle is short, price is low, have no side effect are provided, patient can be made again to take like a shot, the pure Chinese medicinal preparation of energy nursing for treating constipation preferably.Each component collaborative onset mutually in side, and medicine is prepared simple, rapid-action, short treating period, is had good therapeutical effect to constipation.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese medicine composition being used for the treatment of constipation, and its more simple western medicine can better constipation relieving, improves the clinical sign of patient, prevents constipation from worsening further.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition being used for the treatment of constipation, its raw material components comprises Fructus Forsythiae, Herba Schizonepetae, Cortex Phellodendri, the Radix Angelicae Dahuricae, Herba Plantaginis, Radix Scutellariae, Mel, Radix Scrophulariae, Herba Artemisiae Scopariae, Rhizoma Alismatis, the Rhizoma Anemarrhenae, Fructus Aurantii Immaturus, Cortex Moutan, Herba Cistanches and Radix Gentianae Macrophyllae.
Wherein, in described Chinese medicine composition, the weight portion of each raw material components is respectively Fructus Forsythiae 10-16 weight portion, Herba Schizonepetae 8-14 weight portion, Cortex Phellodendri 6-12 weight portion, Radix Angelicae Dahuricae 8-15 weight portion, Herba Plantaginis 5-10 weight portion, Radix Scutellariae 10-16 weight portion, Mel 9-18 weight portion, Radix Scrophulariae 6-14 weight portion, Herba Artemisiae Scopariae 5-10 weight portion, Rhizoma Alismatis 6-12 weight portion, Rhizoma Anemarrhenae 8-18 weight portion, Fructus Aurantii Immaturus 8-14 weight portion, Cortex Moutan 10-16 weight portion, Herba Cistanches 6-12 weight portion, Radix Gentianae Macrophyllae 5-10 weight portion.
Preferably, in described Chinese medicine composition, the weight portion of each raw material components is respectively Fructus Forsythiae 13-16 weight portion, Herba Schizonepetae 10-14 weight portion, Cortex Phellodendri 8-12 weight portion, Radix Angelicae Dahuricae 12-15 weight portion, Herba Plantaginis 8-10 weight portion, Radix Scutellariae 12-16 weight portion, Mel 14-18 weight portion, Radix Scrophulariae 10-14 weight portion, Herba Artemisiae Scopariae 8-10 weight portion, Rhizoma Alismatis 10-12 weight portion, Rhizoma Anemarrhenae 14-18 weight portion, Fructus Aurantii Immaturus 12-14 weight portion, Cortex Moutan 13-16 weight portion, Herba Cistanches 9-12 weight portion, Radix Gentianae Macrophyllae 8-10 weight portion.
Further preferably, in described Chinese medicine composition, the weight portion of each raw material components is respectively Fructus Forsythiae 13 weight portion, Herba Schizonepetae 10 weight portion, Cortex Phellodendri 8 weight portion, the Radix Angelicae Dahuricae 12 weight portion, Herba Plantaginis 8 weight portion, Radix Scutellariae 12 weight portion, Mel 14 weight portion, Radix Scrophulariae 10 weight portion, Herba Artemisiae Scopariae 8 weight portion, Rhizoma Alismatis 10 weight portion, the Rhizoma Anemarrhenae 14 weight portion, Fructus Aurantii Immaturus 12 weight portion, Cortex Moutan 13 weight portion, Herba Cistanches 9 weight portion, Radix Gentianae Macrophyllae 8 weight portion.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, its preparation process is:
(1) each component in described raw material components be mixed in proportion, pulverize, add 70% ethanol of medical material gross weight 3-8 times amount, reflux, extract, 3 times, each time is respectively 1.5,1,1 hours, filters, merging filtrate;
(2) 70 DEG C of concentrating under reduced pressure filtrates, concentration ratio is 1000ml medicinal liquid: 40g crude drug, then according to the amount of 60ml flocculating agent/1000ml medicinal liquid, adds 1% chitosan flocculant in 40-60 DEG C, makes its sedimentation 4 hours, high speed centrifugation;
(3) get supernatant, 80 DEG C-90 DEG C are concentrated into relative density 1.37-1.40, then add Cordyceps mycelia powder, and 75 DEG C of dry 4h, obtain compound preparation extract powder;
(4) extract powder is mixed granule processed with Icing Sugar, dextrin, cross 14 mesh sieves, make oral granular formulation.
The present invention also provides the application of above-mentioned raw materials component in the Chinese medicine composition for the preparation for the treatment of constipation.
Beneficial effect of the present invention:
The invention provides a kind of Chinese medicine composition being used for the treatment of constipation, its more simple Western medicine and existing treatment by Chinese herbs can better constipation relieving, improve the clinical sign of patient, prevent constipation from worsening further, have no side effect simultaneously, have safety and the comfort of height.
Detailed description of the invention
The weight portion that the present invention mentions is a proportionate relationship between each component.
The invention provides a kind of Chinese medicine composition being used for the treatment of constipation, its raw material components comprises Fructus Forsythiae, Herba Schizonepetae, Cortex Phellodendri, the Radix Angelicae Dahuricae, Herba Plantaginis, Radix Scutellariae, Mel, Radix Scrophulariae, Herba Artemisiae Scopariae, Rhizoma Alismatis, the Rhizoma Anemarrhenae, Fructus Aurantii Immaturus, Cortex Moutan, Herba Cistanches and Radix Gentianae Macrophyllae.
Further preferably, described Chinese medicine composition is only made up of above-mentioned raw materials component.
Chinese medicine composition compatibility of the present invention is reasonable, and action effect is remarkable, wherein:
Fructus Forsythiae: bitter, is slightly cold; Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens; For carbuncle, scrofula, mastalgia, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warm people battalion, high hot excessive thirst, coma sends out speckle, the puckery pain of pyretic stranguria.
Herba Schizonepetae: pungent, tepor; Induce sweat loose wind, rash, and disappear skin ulcer; For flu, headache, measles, rubella, skin infection from the beginning of.
Phellodendron amurense: bitter, cold;Heat dry wet, purging fire except steamed, detoxification cure sore;For damp heat, diarrhea, jaundice urine, grasps Yin Yang, hot shower acerbity pain, beriberi impotent Jiu, bone steaming consumptive fever, night sweats, spermatorrhea, ulcers swollen poison, eczema wet sores.
The Radix Angelicae Dahuricae: pungent, temperature; Induce sweat cold expelling, wind-expelling pain-stopping, a surname's clearing the nasal passage, dampness leukorrhagia stopping, detumescence and apocenosis.For headache due to common cold, eyebrow shuttle osteodynia, nasal obstruction watery nasal discharge, allergic rhinitis, nasal sinusitis, toothache, leukorrhagia, skin infection swells and ache.
Herba Plantaginis: sweet, cold; Clearing away heat and promoting diuresis is treating stranguria, expectorant, removing heat from blood, removing toxic substances; For the puckery pain of pyretic stranguria, edema oliguria, diarrhea due to summer heat and dampness, phlegm-heat cough, hematemesis and epistaxis, carbuncle sore tumefacting virus.
Radix Scutellariae: bitter, cold; Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive; For hygropyrexia, heat-damp in summer, vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Mel: sweet is flat; Invigorating middle warmer, moisturizes, pain relieving, removing toxic substances; External promoting tissue regeneration and ulcer healing; For the empty pain of gastral cavity abdomen, dryness of the lung dry cough, dryness of the intestine constipation, separates Aconitum poison of drug; External treatment skin infection is not held back, burn due to hot liquid or fire.
Radix Scrophulariae: sweet, bitter, salty, is slightly cold; Clearing away heat and cooling blood, nourishing YIN to lower pathogenic fire, detoxicating and resolving stagnation of pathogens; For thermal man's nutrient blood, maculae caused by violent heat pathogen, consumption of YIN caused by febrile disease, crimson tongue excessive thirst, constipation is hindered in Tianjin, hectic fever due to YIN-deficiency chronic cough; Conjunctival congestion, pharyngalgia, diphtheria, scrofula, carbuncle sore tumefacting virus.
Herba Artemisiae Scopariae: bitter, pungent, is slightly cold; Eliminating damp-heat, promoting the function of the gallbladder to alleviate jaundice; For jaundice oliguria, hygropyrexia heat-damp in summer, eczema pruritus.
Rhizoma Alismatis: sweet, light, cold; Promoting diuresis to eliminate damp pathogen, expels the heat-evil, and changes turbid blood fat reducing; For dysuria, edema distension, oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria, hyperlipemia.
The Rhizoma Anemarrhenae: bitter, sweet, cold; Clearing away heat-fire is nourshing Yin and drynsessmoistening prescription; For fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, dryness of the intestine constipation.
Fructus Aurantii Immaturus: bitter, pungent, sour, is slightly cold; Dispelling the stagnated QI removing food stagnancy, loose painful abdominal mass of reducing phlegm; Stop in stagnant, feeling of fullness distending pain, heavy after dysentery, constipation, the stagnant vapour lock of expectorant, the thoracic obstruction, blocked-up chest, visceroptosis.
Cortex Moutan: bitter, pungent, is slightly cold; Clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling; For thermal man's nutrient blood, maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, falls and flutters the pain of injury, carbuncle sore tumefacting virus.
Herba Cistanches: sweet, salty, temperature; Kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation; For insufficiency of kidney-YANG, blood and essence asthenia, sexual impotence is infertile, soreness of the waist and knees, and muscles and bones is unable, dryness of the intestine constipation.
Radix Gentianae Macrophyllae: pungent, bitter is flat; Wind-damp dispelling, clearing away damp-heat, stopping numbness pain, reducing the asthenic fever; For rheumatic arthralgia, apoplexy and hemiplegia, the contracture of muscle arteries and veins, joint is ached, jaundice due to damp-heat; Osteopyrexia and fever, infantile malnutrition generates heat.
In described Chinese medicine composition, the weight portion of each raw material components is respectively Fructus Forsythiae 10-16 weight portion, Herba Schizonepetae 8-14 weight portion, Cortex Phellodendri 6-12 weight portion, Radix Angelicae Dahuricae 8-15 weight portion, Herba Plantaginis 5-10 weight portion, Radix Scutellariae 10-16 weight portion, Mel 9-18 weight portion, Radix Scrophulariae 6-14 weight portion, Herba Artemisiae Scopariae 5-10 weight portion, Rhizoma Alismatis 6-12 weight portion, Rhizoma Anemarrhenae 8-18 weight portion, Fructus Aurantii Immaturus 8-14 weight portion, Cortex Moutan 10-16 weight portion, Herba Cistanches 6-12 weight portion, Radix Gentianae Macrophyllae 5-10 weight portion.
Preferably, in described Chinese medicine composition, the weight portion of each raw material components is respectively Fructus Forsythiae 13-16 weight portion, Herba Schizonepetae 10-14 weight portion, Cortex Phellodendri 8-12 weight portion, Radix Angelicae Dahuricae 12-15 weight portion, Herba Plantaginis 8-10 weight portion, Radix Scutellariae 12-16 weight portion, Mel 14-18 weight portion, Radix Scrophulariae 10-14 weight portion, Herba Artemisiae Scopariae 8-10 weight portion, Rhizoma Alismatis 10-12 weight portion, Rhizoma Anemarrhenae 14-18 weight portion, Fructus Aurantii Immaturus 12-14 weight portion, Cortex Moutan 13-16 weight portion, Herba Cistanches 9-12 weight portion, Radix Gentianae Macrophyllae 8-10 weight portion.
Further preferably, in described Chinese medicine composition, the weight portion of each raw material components is respectively Fructus Forsythiae 13 weight portion, Herba Schizonepetae 10 weight portion, Cortex Phellodendri 8 weight portion, the Radix Angelicae Dahuricae 12 weight portion, Herba Plantaginis 8 weight portion, Radix Scutellariae 12 weight portion, Mel 14 weight portion, Radix Scrophulariae 10 weight portion, Herba Artemisiae Scopariae 8 weight portion, Rhizoma Alismatis 10 weight portion, the Rhizoma Anemarrhenae 14 weight portion, Fructus Aurantii Immaturus 12 weight portion, Cortex Moutan 13 weight portion, Herba Cistanches 9 weight portion, Radix Gentianae Macrophyllae 8 weight portion.
The Chinese medicine composition for the treatment of constipation provided by the invention can be prepared into various peroral dosage form according to regular dosage form preparation method.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, comprising:
(1) each component in described raw material components be mixed in proportion, pulverize, add 70% ethanol of medical material gross weight 3-8 times amount, reflux, extract, 3 times, each time is respectively 1.5,1,1 hours, filters, merging filtrate;
(2) 70 DEG C of concentrating under reduced pressure filtrates, concentration ratio is 1000ml medicinal liquid: 40g crude drug, then according to the amount of 60ml flocculating agent/1000ml medicinal liquid, adds 1% chitosan flocculant in 40-60 DEG C, makes its sedimentation 4 hours, high speed centrifugation;
(3) get supernatant, 80 DEG C-90 DEG C are concentrated into relative density 1.37-1.40, then add Cordyceps mycelia powder, and 75 DEG C of dry 4h, obtain compound preparation extract powder;
(4) extract powder is mixed granule processed with Icing Sugar, dextrin, cross 14 mesh sieves, make oral granular formulation.
The present invention also provides the application of above-mentioned raw materials component in the Chinese medicine composition for the preparation for the treatment of constipation.
Embodiment
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1
Get Fructus Forsythiae 10 weight portion, Herba Schizonepetae 8 weight portion, Cortex Phellodendri 6 weight portion, the Radix Angelicae Dahuricae 8 weight portion, Herba Plantaginis 5 weight portion, Radix Scutellariae 10 weight portion, Mel 9 weight portion, Radix Scrophulariae 6 weight portion, Herba Artemisiae Scopariae 5 weight portion, Rhizoma Alismatis 6 weight portion, the Rhizoma Anemarrhenae 8 weight portion, Fructus Aurantii Immaturus 8 weight portion, Cortex Moutan 10 weight portion, Herba Cistanches 6 weight portion, Radix Gentianae Macrophyllae 5 weight portion, be mixed in proportion, pulverize; Add 70% ethanol of medical material gross weight 3 times amount, reflux, extract, 3 times, each time is respectively 1.5,1,1 hours, filters, merging filtrate; 70 DEG C of concentrating under reduced pressure filtrates, concentration ratio is 1000ml medicinal liquid: 40g crude drug, then according to the amount of 60ml flocculating agent/1000ml medicinal liquid, adds 1% chitosan flocculant in 40 DEG C, makes its sedimentation 4 hours, high speed centrifugation; Get supernatant, 80 DEG C are concentrated into relative density 1.37, then add Cordyceps mycelia powder, and 75 DEG C of dry 4h, obtain compound preparation extract powder; Extract powder is mixed granule processed with Icing Sugar, dextrin, crosses 14 mesh sieves, make oral granular formulation.
Usage and consumption: every day three times, one after each meal.
Taboo: (1) avoids eating anything raw or cold food; (2) diet raw meat thing; (3) internal and external haemorrhage disease, ulcerate disease tool avoid clothes first; (4) female menstrual period, the pregnancy period is not used.
Embodiment 2
Get Fructus Forsythiae 16 weight portion, Herba Schizonepetae 14 weight portion, Cortex Phellodendri 12 weight portion, the Radix Angelicae Dahuricae 15 weight portion, Herba Plantaginis 10 weight portion, Radix Scutellariae 16 weight portion, Mel 18 weight portion, Radix Scrophulariae 14 weight portion, Herba Artemisiae Scopariae 10 weight portion, Rhizoma Alismatis 12 weight portion, the Rhizoma Anemarrhenae 18 weight portion, Fructus Aurantii Immaturus 14 weight portion, Cortex Moutan 16 weight portion, Herba Cistanches 12 weight portion, Radix Gentianae Macrophyllae 10 weight portion, be mixed in proportion, pulverize; Add 70% ethanol of medical material gross weight 8 times amount, reflux, extract, 3 times, each time is respectively 1.5,1,1 hours, filters, merging filtrate; 70 DEG C of concentrating under reduced pressure filtrates, concentration ratio is 1000ml medicinal liquid: 40g crude drug, then according to the amount of 60ml flocculating agent/1000ml medicinal liquid, adds 1% chitosan flocculant in 60 DEG C, makes its sedimentation 4 hours, high speed centrifugation; Get supernatant, 90 DEG C are concentrated into relative density 1.40, then add Cordyceps mycelia powder, and 75 DEG C of dry 4h, obtain compound preparation extract powder; Extract powder is mixed granule processed with Icing Sugar, dextrin, crosses 14 mesh sieves, make oral granular formulation.
Usage and consumption, avoid same embodiment 1.
Embodiment 3
Get Fructus Forsythiae 13 weight portion, Herba Schizonepetae 10 weight portion, Cortex Phellodendri 8 weight portion, the Radix Angelicae Dahuricae 12 weight portion, Herba Plantaginis 8 weight portion, Radix Scutellariae 12 weight portion, Mel 14 weight portion, Radix Scrophulariae 10 weight portion, Herba Artemisiae Scopariae 8 weight portion, Rhizoma Alismatis 10 weight portion, the Rhizoma Anemarrhenae 14 weight portion, Fructus Aurantii Immaturus 12 weight portion, Cortex Moutan 13 weight portion, Herba Cistanches 9 weight portion, Radix Gentianae Macrophyllae 8 weight portion, be mixed in proportion, pulverize; Add 70% ethanol of medical material gross weight 6 times amount, reflux, extract, 3 times, each time is respectively 1.5,1,1 hours, filters, merging filtrate; 70 DEG C of concentrating under reduced pressure filtrates, concentration ratio is 1000ml medicinal liquid: 40g crude drug, then according to the amount of 60ml flocculating agent/1000ml medicinal liquid, adds 1% chitosan flocculant in 50 DEG C, makes its sedimentation 4 hours, high speed centrifugation; Get supernatant, 85 DEG C are concentrated into relative density 1.39, then add Cordyceps mycelia powder, and 75 DEG C of dry 4h, obtain compound preparation extract powder; Extract powder is mixed granule processed with Icing Sugar, dextrin, crosses 14 mesh sieves, make oral granular formulation.
Usage and consumption, avoid same embodiment 1.
The acute toxicity testing of embodiment 4, Chinese medicine composition of the present invention
Below test, without special instruction, all use the Chinese medicine composition that the embodiment of the present invention 3 is obtained.
Acute toxicity (maximum tolerated dose): Continuous Observation 7 days after mice lavage administration, without obvious adverse reaction and death; Its mouse stomach maximum tolerated dose is 197.1g (crude drug)/kg, and toxicity is lower, is equivalent to 121.22 times of quantity.Result shows, the toxicity of Chinese medicine preparation of the present invention is less, and pharmaceutical safety is higher.
Embodiment 5, Chinese medicine composition of the present invention are on the impact of mice with constipation Small intestine advance activity
1, animal:
Healthy ICR mice, male and female half and half, heavy 18-22g, is provided by Nanjing Medical University's animal center, production licence number SCXK (Soviet Union) 2002-0031.
2, medicine and reagent:
The granule of the present invention prepared by above-described embodiment 3 is distributed into 10g granule/bag, containing crude drug 16.1g in every bag of granule, clinical people's consumption per day is each 1 bag, and every day 3 times, namely clinical people's consumption per day is 48.3g crude drug, therefore determine that every mice consumption is 48.3x0.0026=0.13g crude drug, with a kilogram calculating, dosage is 6g crude drug/kg, and this is low dosage, dosage 12g crude drug/kg is middle dosage, and dosage 24g crude drug/kg is high dose.
Phenolphthalein tablets (phenolphthalein sugar-tablet), Junan, Shandong Province pharmaceutical factory, specification: 100mg*100 sheet/box, lot number 20100106, people's consumption per day 0.8g/ days, being equivalent to every mice consumption is 0.8gx0.0026=0.002g, with a kilogram calculating, dosage is 0.1g/kg, and with 3 times amount for dosage, namely positive group gives phenolphthalein tablets 0.3g/kg.All the other reagent are domestic analytical pure.
R-1132, Wujin pharmaceutical factory, 20100324.
3, process of the test:
Get ICR mice 60, with the modeling of R-1132 50m/kg gavage, continuous 10 days, period normal diet, form Constipation Model, random packet, often organize each 10, male and female half and half, be divided into model group, Normal group, positive drug control group, Chinese medicine composition of the present invention is large, in, little three dosage groups, administration is the same, successive administration 14d, before experiment, water 12h is can't help in fasting, 2h after last administration, gavage with the charcoal end arabic gum suspension lml/g that volume fraction is 5% respectively, each group of mice is put to death after 20min, cut open the belly and measure every Mus small intestinal charcoal end displacement and total small intestinal length, be converted into the percentage rate that charcoal end displacement accounts for total small intestinal length, t test and judge group difference, the results are shown in Table 1.
Table 1: granule of the present invention is on the impact of mice with constipation Small intestine advance activity
Compare with model group,
*p<0.01,
*p<0.05, compares with positive drug control group,
##p<0.01,
#p<0.05.
Result: Chinese medicine composition group of the present invention compares with model group, has and obviously promotes mice with constipation Small intestine advance activity, promotes gastrointestinal motility in mice, has significant difference.Compare with positive drug, the big or middle dosage group of medicine of the present invention has significant difference in promotion mice with constipation Small intestine advance activity, and effect is better than positive drug.
Embodiment 6, clinical experiment
One, experimenter selects
(1) experimenter's standard, is included in:
1, defecation frequency reduces and stool hardness enhancer;
2, defecate and within one week, be less than 3 persons;
3, without organic constipation person;
4, habitual constipation person.
(2), Subject Exclusion Criteria:
1, can not oral feeding person maybe can not by the regulation person that takes given the test agent;
2, the unclear person of main suit;
3, have a delicate constitution and cannot carry out experimenter;
4, carrying out surgical operation in 30 days causes constipation symptom to send out survivor;
5, because serious structural disease becomes recent difficult defecation person (colon cancer, serious enteritis, the intestinal obstruction, and inflammatory bowel etc. caused;
6, constipation difficulty and with pain person;
7, there is acute gastroenteropathy person in 30 days;
8, pregnancy period and menstrual woman;
9, the severe total disease patients such as cardiovascular, liver, kidney and hemopoietic system are associated with;
10, other accompanying diseases is had just in therapist;
11, take the article relevant with tested function in a short time, affect the judgement person to result.
Patient 50 example is selected with exclusion standard according to above-mentioned including in.Wherein male 31 example, women 19 example; Age reckling 22 years old, the maximum 71 years old; The shortest person of defecation time 2 days, most elder 8 days; The shortest person of the course of disease 11 days, most elder 35 days.
Two, EXPERIMENTAL DESIGN, grouping and date processing:
Adopt own control EXPERIMENTAL DESIGN before and after test, the situation before and after capsule is taken in comparative study.Data with
represent, own control test adopts paired t-test.
1, observation index:
1 blood, urine, stool routine and Liver and kidney function inspection is respectively done before and after treatment.Observe the change of defecation frequency before and after administration, persistent period, defecation condition and feces character.
Defecation condition according to difficult defecation degree (stomachache or anus burn feeling, bearing down, sense of discomfort, whether just frequently but difficult defecation and measure the symptoms such as few) be divided into I-IV level, statistics integrated value.
I level (0 point): defecation is normal;
II level (1 point): only have bearing down, sense of discomfort;
III level (2 points): bearing down, sense of discomfort are obvious, or have just frequently but difficult defecation and measure few, less appearances is suffered from abdominal pain or anus burn feeling;
IV level (3 points): often occur stomachache or anus burn feeling, affect defecation.
Feces character is divided into I-III level according to Bristol (Bristol) feces character classification method by feces character.
I level (0 point): as sausage or Serpentis, level and smooth and soft; Picture sausage, but have slight crack on its surface; Soft agglomerate, has obvious edge (easily discharging);
II level (1 point): sausage shape, but have agglomerate; Loose bulk, edge roughness, as slimy feces;
III level (2 points): the hard group of separation, as pit (not easily discharging).
Three, Therapeutic Method:
All patients all takes Chinese medicine composition of the present invention, each 1 bag, and every day 3 times, warm boiled water send down, can improve situation take the circumstances into consideration increase and decrease according to patient's body constitution situation and constipation.
Four, curative effect determinate standard:
Clinical cure: stool deliquescing, every day defecation 1 time, other symptoms all disappear;
Effective: constipation is clearly better, just matter is normal, and time interval 1-2 days, other symptoms 2/3 disappear;
Effective: just matter is dry and hard makes moderate progress, the stool intermittent time shortened 1-2 days more originally, and other symptoms have certain improvement;
Invalid: constipation and other symptoms are all without improvement.
Six, result:
Patient's abdominal distention poor appetite, stomachache, dizziness headache, bitter taste sleep difference etc. subjective symptom be improved significantly.Compared with before treatment, take patient's defecation frequency showed increased after Chinese medicine composition of the present invention, defecation decreased duration, difficult defecation degree and feces character are clearly better (table 2).50 routine patients fully recover 27 example, effective 11 example, effective 9 example, invalid 3 example, total effective rate 94%.
Table 2: take before Chinese medicine composition of the present invention and take patient's defecation condition and feces character after 14 days change (
n=50)
| Group | Defecation frequency (secondary/2d) | The defecation persistent period (min) | Difficult defecation degree integration | Feces character integration |
| Before taking | 0.49±0.13 | 25.7±6.74 | 2.07±0.63 | 1.71±0.68 |
| After taking | 1.31±0.75 * | 17.4±4.13 * | 0.77±0.35 ** | 0.62±0.36 ** |
Compared with before taking,
*p < 0.001.
Result shows, Chinese medicine composition of the present invention has extremely significant effect to treatment constipation patient.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (6)
1. be used for the treatment of a Chinese medicine composition for constipation, it is characterized in that: raw material components comprises Fructus Forsythiae, Herba Schizonepetae, Cortex Phellodendri, the Radix Angelicae Dahuricae, Herba Plantaginis, Radix Scutellariae, Mel, Radix Scrophulariae, Herba Artemisiae Scopariae, Rhizoma Alismatis, the Rhizoma Anemarrhenae, Fructus Aurantii Immaturus, Cortex Moutan, Herba Cistanches and Radix Gentianae Macrophyllae.
2. Chinese medicine composition as claimed in claim 1, it is characterized in that: the weight portion of each raw material components is respectively Fructus Forsythiae 10-16 weight portion, Herba Schizonepetae 8-14 weight portion, Cortex Phellodendri 6-12 weight portion, Radix Angelicae Dahuricae 8-15 weight portion, Herba Plantaginis 5-10 weight portion, Radix Scutellariae 10-16 weight portion, Mel 9-18 weight portion, Radix Scrophulariae 6-14 weight portion, Herba Artemisiae Scopariae 5-10 weight portion, Rhizoma Alismatis 6-12 weight portion, Rhizoma Anemarrhenae 8-18 weight portion, Fructus Aurantii Immaturus 8-14 weight portion, Cortex Moutan 10-16 weight portion, Herba Cistanches 6-12 weight portion, Radix Gentianae Macrophyllae 5-10 weight portion.
3. Chinese medicine composition as claimed in claim 1 or 2, it is characterized in that: the weight portion of each raw material components is respectively Fructus Forsythiae 13-16 weight portion, Herba Schizonepetae 10-14 weight portion, Cortex Phellodendri 8-12 weight portion, Radix Angelicae Dahuricae 12-15 weight portion, Herba Plantaginis 8-10 weight portion, Radix Scutellariae 12-16 weight portion, Mel 14-18 weight portion, Radix Scrophulariae 10-14 weight portion, Herba Artemisiae Scopariae 8-10 weight portion, Rhizoma Alismatis 10-12 weight portion, Rhizoma Anemarrhenae 14-18 weight portion, Fructus Aurantii Immaturus 12-14 weight portion, Cortex Moutan 13-16 weight portion, Herba Cistanches 9-12 weight portion, Radix Gentianae Macrophyllae 8-10 weight portion.
4. the Chinese medicine composition as described in claims 1 to 3, is characterized in that: the weight portion of each raw material components is respectively Fructus Forsythiae 13 weight portion, Herba Schizonepetae 10 weight portion, Cortex Phellodendri 8 weight portion, the Radix Angelicae Dahuricae 12 weight portion, Herba Plantaginis 8 weight portion, Radix Scutellariae 12 weight portion, Mel 14 weight portion, Radix Scrophulariae 10 weight portion, Herba Artemisiae Scopariae 8 weight portion, Rhizoma Alismatis 10 weight portion, the Rhizoma Anemarrhenae 14 weight portion, Fructus Aurantii Immaturus 12 weight portion, Cortex Moutan 13 weight portion, Herba Cistanches 9 weight portion, Radix Gentianae Macrophyllae 8 weight portion.
5. the preparation method of Chinese medicine composition described in Claims 1-4, is characterized in that, preparation process is:
(1) each component in described raw material components be mixed in proportion, pulverize, add 70% ethanol of medical material gross weight 3-8 times amount, reflux, extract, 3 times, each time is respectively 1.5,1,1 hours, filters, merging filtrate;
(2) 70 DEG C of concentrating under reduced pressure filtrates, concentration ratio is 1000ml medicinal liquid: 40g crude drug, then according to the amount of 60ml flocculating agent/1000ml medicinal liquid, adds 1% chitosan flocculant in 40-60 DEG C, makes its sedimentation 4 hours, high speed centrifugation;
(3) get supernatant, 80 DEG C-90 DEG C are concentrated into relative density 1.37-1.40, then add Cordyceps mycelia powder, and 75 DEG C of dry 4h, obtain compound preparation extract powder;
(4) extract powder is mixed granule processed with Icing Sugar, dextrin, cross 14 mesh sieves, make oral granular formulation.
6. the application of the raw material components any one of claim 1-4 in the Chinese medicine composition for the preparation for the treatment of constipation.
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Application publication date: 20151202 |