CN112672788B - 抗金黄色葡萄球菌凝集因子a(clfa)的抗体 - Google Patents

抗金黄色葡萄球菌凝集因子a(clfa)的抗体 Download PDF

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Publication number
CN112672788B
CN112672788B CN201980058857.XA CN201980058857A CN112672788B CN 112672788 B CN112672788 B CN 112672788B CN 201980058857 A CN201980058857 A CN 201980058857A CN 112672788 B CN112672788 B CN 112672788B
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antibody
antigen
binding fragment
seq
amino acid
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Chinese (zh)
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CN112672788A (zh
Inventor
C·特卡奇克
B·塞尔曼
M·博罗奥克三世
D·科尔蒂
A·米诺拉
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Humabs Biomed SA
MedImmune LLC
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Humabs Biomed SA
MedImmune LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1271—Micrococcaceae (F); Staphylococcaceae (F), e.g. Staphylococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
CN201980058857.XA 2018-07-24 2019-07-24 抗金黄色葡萄球菌凝集因子a(clfa)的抗体 Active CN112672788B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202411220211.6A CN119176871A (zh) 2018-07-24 2019-07-24 抗金黄色葡萄球菌凝集因子a(clfa)的抗体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862702762P 2018-07-24 2018-07-24
US62/702,762 2018-07-24
PCT/US2019/043254 WO2020023644A2 (en) 2018-07-24 2019-07-24 Antibody directed against s. aureus clumping factor a (clfa)

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202411220211.6A Division CN119176871A (zh) 2018-07-24 2019-07-24 抗金黄色葡萄球菌凝集因子a(clfa)的抗体

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CN112672788A CN112672788A (zh) 2021-04-16
CN112672788B true CN112672788B (zh) 2024-09-17

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CN202411220211.6A Pending CN119176871A (zh) 2018-07-24 2019-07-24 抗金黄色葡萄球菌凝集因子a(clfa)的抗体

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Country Status (10)

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US (3) US11155606B2 (enExample)
EP (1) EP3840838A2 (enExample)
JP (2) JP7525471B2 (enExample)
KR (1) KR102955585B1 (enExample)
CN (2) CN112672788B (enExample)
AU (1) AU2019309366B2 (enExample)
BR (1) BR112021001214A2 (enExample)
MX (1) MX2021000889A (enExample)
TW (1) TWI902669B (enExample)
WO (1) WO2020023644A2 (enExample)

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DE102018115012A1 (de) 2018-06-21 2019-12-24 Carl Zeiss Microscopy Gmbh Teilchenstrahlsystem
MX2021000889A (es) 2018-07-24 2021-04-28 Medimmune Llc Anticuerpo dirigido contra el factor de agregación a (clfa) de s. aureus.
WO2020076790A1 (en) 2018-10-09 2020-04-16 Medimmune, Llc Antibodies directed against staphylococcus aureus leukotoxins
MX2021004173A (es) 2018-10-09 2021-09-08 Medimmune Llc Combinaciones de anticuerpos dirigidos contra staphylococcus aureus.
TWI743626B (zh) 2019-01-24 2021-10-21 德商卡爾蔡司多重掃描電子顯微鏡有限公司 包含多束粒子顯微鏡的系統、對3d樣本逐層成像之方法及電腦程式產品
DE102019008249B3 (de) 2019-11-27 2020-11-19 Carl Zeiss Multisem Gmbh Teilchenstrahl-System mit einer Multistrahl-Ablenkeinrichtung und einem Strahlfänger, Verfahren zum Betreiben des Teilchenstrahl-Systems und zugehöriges Computerprogrammprodukt
IL324469A (en) * 2023-05-09 2026-01-01 Astrazeneca Ab Anti-Pseudomonal bispecific antibodies with modified fc regions and methods of using them
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Publication number Publication date
US20240352098A1 (en) 2024-10-24
WO2020023644A3 (en) 2020-03-19
TWI902669B (zh) 2025-11-01
CN119176871A (zh) 2024-12-24
AU2019309366A1 (en) 2021-02-18
CN112672788A (zh) 2021-04-16
TW202019956A (zh) 2020-06-01
EP3840838A2 (en) 2021-06-30
AU2019309366B2 (en) 2025-06-05
US11970527B2 (en) 2024-04-30
MX2021000889A (es) 2021-04-28
US20220073595A1 (en) 2022-03-10
WO2020023644A2 (en) 2020-01-30
KR102955585B1 (ko) 2026-04-21
JP7525471B2 (ja) 2024-07-30
BR112021001214A2 (pt) 2021-04-27
JP7892714B2 (ja) 2026-07-21
JP2021530244A (ja) 2021-11-11
CA3107463A1 (en) 2020-01-30
US20200048330A1 (en) 2020-02-13
US11155606B2 (en) 2021-10-26
KR20210035846A (ko) 2021-04-01
JP2024105229A (ja) 2024-08-06

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