CN112566901A - 作为RORγt的调节剂的苯基取代的吡唑类 - Google Patents

作为RORγt的调节剂的苯基取代的吡唑类 Download PDF

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Publication number
CN112566901A
CN112566901A CN201980054161.XA CN201980054161A CN112566901A CN 112566901 A CN112566901 A CN 112566901A CN 201980054161 A CN201980054161 A CN 201980054161A CN 112566901 A CN112566901 A CN 112566901A
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CN
China
Prior art keywords
alkyl
ethyl
pyrazole
bromo
nhc
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CN201980054161.XA
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English (en)
Chinese (zh)
Inventor
S·戈德堡
C·L·马丁
E·G·芬妮玛
D·A·库默
R·T·尼西姆拉
C·R·沃斯
R·L·沃林
W·M·琼斯
A·M·傅立叶
X·薛
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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Publication of CN112566901A publication Critical patent/CN112566901A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201980054161.XA 2018-06-18 2019-06-17 作为RORγt的调节剂的苯基取代的吡唑类 Pending CN112566901A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862686308P 2018-06-18 2018-06-18
US62/686308 2018-06-18
PCT/IB2019/055043 WO2019243999A1 (en) 2018-06-18 2019-06-17 Phenyl substituted pyrazoles as modulators of roryt

Publications (1)

Publication Number Publication Date
CN112566901A true CN112566901A (zh) 2021-03-26

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CN201980054161.XA Pending CN112566901A (zh) 2018-06-18 2019-06-17 作为RORγt的调节剂的苯基取代的吡唑类

Country Status (6)

Country Link
US (1) US10975037B2 (https=)
EP (1) EP3790865A1 (https=)
JP (1) JP2021528405A (https=)
CN (1) CN112566901A (https=)
CA (1) CA3103929A1 (https=)
WO (1) WO2019243999A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115894374A (zh) * 2023-02-16 2023-04-04 广州佳途科技股份有限公司 一种氟甲腈的制备方法及其应用

Families Citing this family (5)

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ES2925473T3 (es) 2018-06-18 2022-10-18 Janssen Pharmaceutica Nv Pirazoles de piridinilo como moduladores de RORyt
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EP3806958B1 (en) 2018-06-18 2022-09-07 Janssen Pharmaceutica NV 6-aminopyridin-3-yl pyrazoles as modulators of roryt
JP2021528405A (ja) 2018-06-18 2021-10-21 ヤンセン ファーマシューティカ エヌ．ベー． ＲＯＲγｔのモジュレータとしてのアミド置換チアゾール

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Also Published As

Publication number Publication date
CA3103929A1 (en) 2019-12-26
EP3790865A1 (en) 2021-03-17
WO2019243999A1 (en) 2019-12-26
JP2021528405A (ja) 2021-10-21
US10975037B2 (en) 2021-04-13
US20190382349A1 (en) 2019-12-19

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