CN112513092B - 用于治疗癌症的dll3/cd3结合蛋白 - Google Patents

用于治疗癌症的dll3/cd3结合蛋白 Download PDF

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Publication number
CN112513092B
CN112513092B CN201980051335.7A CN201980051335A CN112513092B CN 112513092 B CN112513092 B CN 112513092B CN 201980051335 A CN201980051335 A CN 201980051335A CN 112513092 B CN112513092 B CN 112513092B
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seq
dll3
amino acid
acid sequence
heavy chain
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CN112513092A (zh
Inventor
S·希普
P·亚当
M·吉列夫斯基
R·加内桑
P·N·戈尔曼
P·古普塔
J·舍尔
V·H·沃伊诺夫
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Boehringer Ingelheim International GmbH
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Boehringer Ingelheim International GmbH
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Priority to CN202411358798.7A priority Critical patent/CN119490599A/zh
Priority to CN202411429697.4A priority patent/CN119499365A/zh
Priority to CN202411404799.0A priority patent/CN119241717A/zh
Priority to CN202411433636.5A priority patent/CN120131936A/zh
Priority to CN202411404784.4A priority patent/CN119285788A/zh
Priority to CN202411369181.5A priority patent/CN119529097A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide

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  • Proteomics, Peptides & Aminoacids (AREA)
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CN201980051335.7A 2018-06-09 2019-06-07 用于治疗癌症的dll3/cd3结合蛋白 Active CN112513092B (zh)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN202411358798.7A CN119490599A (zh) 2018-06-09 2019-06-07 用于治疗癌症的dll3/cd3结合蛋白
CN202411429697.4A CN119499365A (zh) 2018-06-09 2019-06-07 用于治疗癌症的dll3/cd3结合蛋白
CN202411404799.0A CN119241717A (zh) 2018-06-09 2019-06-07 用于治疗癌症的dll3/cd3结合蛋白
CN202411433636.5A CN120131936A (zh) 2018-06-09 2019-06-07 用于治疗癌症的dll3/cd3结合蛋白
CN202411404784.4A CN119285788A (zh) 2018-06-09 2019-06-07 用于治疗癌症的dll3/cd3结合蛋白
CN202411369181.5A CN119529097A (zh) 2018-06-09 2019-06-07 用于治疗癌症的dll3/cd3结合蛋白

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP18176889.6 2018-06-09
EP18176888 2018-06-09
EP18176889 2018-06-09
EP18176888.8 2018-06-09
EP19159321 2019-02-26
EP19159321.9 2019-02-26
PCT/EP2019/064942 WO2019234220A1 (en) 2018-06-09 2019-06-07 Dll3-cd3 bispecific antibodies

Related Child Applications (6)

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CN202411429697.4A Division CN119499365A (zh) 2018-06-09 2019-06-07 用于治疗癌症的dll3/cd3结合蛋白
CN202411369181.5A Division CN119529097A (zh) 2018-06-09 2019-06-07 用于治疗癌症的dll3/cd3结合蛋白
CN202411404784.4A Division CN119285788A (zh) 2018-06-09 2019-06-07 用于治疗癌症的dll3/cd3结合蛋白
CN202411358798.7A Division CN119490599A (zh) 2018-06-09 2019-06-07 用于治疗癌症的dll3/cd3结合蛋白
CN202411404799.0A Division CN119241717A (zh) 2018-06-09 2019-06-07 用于治疗癌症的dll3/cd3结合蛋白
CN202411433636.5A Division CN120131936A (zh) 2018-06-09 2019-06-07 用于治疗癌症的dll3/cd3结合蛋白

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CN112513092A CN112513092A (zh) 2021-03-16
CN112513092B true CN112513092B (zh) 2024-11-08

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CN201980051335.7A Active CN112513092B (zh) 2018-06-09 2019-06-07 用于治疗癌症的dll3/cd3结合蛋白
CN202411429697.4A Pending CN119499365A (zh) 2018-06-09 2019-06-07 用于治疗癌症的dll3/cd3结合蛋白
CN202411358798.7A Pending CN119490599A (zh) 2018-06-09 2019-06-07 用于治疗癌症的dll3/cd3结合蛋白
CN202411433636.5A Pending CN120131936A (zh) 2018-06-09 2019-06-07 用于治疗癌症的dll3/cd3结合蛋白
CN202411369181.5A Pending CN119529097A (zh) 2018-06-09 2019-06-07 用于治疗癌症的dll3/cd3结合蛋白
CN202411404784.4A Pending CN119285788A (zh) 2018-06-09 2019-06-07 用于治疗癌症的dll3/cd3结合蛋白
CN202411404799.0A Pending CN119241717A (zh) 2018-06-09 2019-06-07 用于治疗癌症的dll3/cd3结合蛋白

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CN202411429697.4A Pending CN119499365A (zh) 2018-06-09 2019-06-07 用于治疗癌症的dll3/cd3结合蛋白
CN202411358798.7A Pending CN119490599A (zh) 2018-06-09 2019-06-07 用于治疗癌症的dll3/cd3结合蛋白
CN202411433636.5A Pending CN120131936A (zh) 2018-06-09 2019-06-07 用于治疗癌症的dll3/cd3结合蛋白
CN202411369181.5A Pending CN119529097A (zh) 2018-06-09 2019-06-07 用于治疗癌症的dll3/cd3结合蛋白
CN202411404784.4A Pending CN119285788A (zh) 2018-06-09 2019-06-07 用于治疗癌症的dll3/cd3结合蛋白
CN202411404799.0A Pending CN119241717A (zh) 2018-06-09 2019-06-07 用于治疗癌症的dll3/cd3结合蛋白

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