CN112481211B - 免疫调节性提高的细胞及其使用和生产方法 - Google Patents

免疫调节性提高的细胞及其使用和生产方法 Download PDF

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CN112481211B
CN112481211B CN202011413164.9A CN202011413164A CN112481211B CN 112481211 B CN112481211 B CN 112481211B CN 202011413164 A CN202011413164 A CN 202011413164A CN 112481211 B CN112481211 B CN 112481211B
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CN112481211A (zh
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保罗·菲奥里纳
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Children's Hospital Co
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CN202011413164.9A 2015-01-26 2016-01-26 免疫调节性提高的细胞及其使用和生产方法 Active CN112481211B (zh)

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US201562107517P 2015-01-26 2015-01-26
US62/107,517 2015-01-26
US201562112653P 2015-02-06 2015-02-06
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PCT/US2016/014942 WO2016123117A1 (en) 2015-01-26 2016-01-26 Cells with increased immuno-regulatory properties and methods for their use and manufacture
CN201680018098.0A CN107429232B (zh) 2015-01-26 2016-01-26 免疫调节性提高的细胞及其使用和生产方法
CN202011413164.9A CN112481211B (zh) 2015-01-26 2016-01-26 免疫调节性提高的细胞及其使用和生产方法

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Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6800859B2 (ja) 2015-01-26 2020-12-16 フェイト セラピューティクス，インコーポレイテッド 造血細胞分化を誘導するための方法および組成物
JP2018520688A (ja) 2015-07-21 2018-08-02 ザ チルドレンズ メディカル センター コーポレーション Ｐｄ−ｌ１発現造血幹細胞およびその使用
EP3371314B1 (en) 2015-11-04 2023-07-05 Fate Therapeutics, Inc. Genomic engineering of pluripotent cells
KR20250033315A (ko) 2015-11-04 2025-03-07 페이트 세러퓨틱스, 인코포레이티드 조혈 세포 분화를 유도하기 위한 방법 및 조성물
WO2017127755A1 (en) 2016-01-20 2017-07-27 Fate Therapeutics, Inc. Compositions and methods for immune cell modulation in adoptive immunotherapies
CN116376826A (zh) 2016-01-20 2023-07-04 菲特治疗公司 用来在过继性免疫疗法中进行免疫细胞调节的组合物和方法
US9918994B2 (en) 2016-03-04 2018-03-20 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for muscle regeneration using prostaglandin E2
WO2018106595A1 (en) 2016-12-05 2018-06-14 Fate Therapeutics, Inc. Compositions and methods for immune cell modulation in adoptive immunotherapies
KR102698911B1 (ko) 2017-06-09 2024-08-23 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 근육 질환을 예방하거나 치료하기 위한 조성물 및 방법
US11879137B2 (en) 2017-09-22 2024-01-23 The Children's Medical Center Corporation Treatment of type 1 diabetes and autoimmune diseases or disorders
CN107714717A (zh) * 2017-10-11 2018-02-23 刘志强 聚肌胞苷酸在制备治疗或预防结肠炎的药物中的应用
DK3752598T3 (da) * 2018-02-16 2022-11-21 Nextcell Pharma Ab Allogen sammensætning
US20210353679A1 (en) * 2018-10-10 2021-11-18 North Carolina State University Pd-l1 presenting platelets reverse new-onset type 1 diabetes
CN113474002A (zh) * 2018-10-12 2021-10-01 索尔克生物学研究所 逃避免疫检测和自身免疫的细胞、胰岛和类器官、其生产方法及其用途
CN109706180A (zh) * 2019-01-11 2019-05-03 杭州荣泽生物科技有限公司 一种脐带间充质干细胞过表达ido增强免疫抑制的方法及应用
CA3128871A1 (en) * 2019-02-09 2020-08-13 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Genetically modified hematopoietic stem and progenitor cells (hspcs) and mesenchymal cells as a platform to reduce or prevent metastasis, treat autoimmune and inflammatory disorders, and rebalance the immune milieu_and dysregulated niches
WO2021007180A1 (en) * 2019-07-05 2021-01-14 Case Western Reserve University Priming media and methods for stem cell culture and therapy
US20230119606A1 (en) * 2020-02-18 2023-04-20 Octagon Therapeutics, Inc. Immune cell modulators
EP4171589A4 (en) * 2020-06-26 2024-07-17 The Children's Medical Center Corporation Methods and compositions for treating multiple sclerosis
KR20230037044A (ko) * 2020-07-08 2023-03-15 더 잭슨 래보라토리 인간 hla-a201 제한 유전자를 발현하는 트랜스제닉 마우스 모델
JPWO2022202352A1 (cg-RX-API-DMAC7.html) 2021-03-24 2022-09-29
KR20220162394A (ko) * 2021-06-01 2022-12-08 에스씨엠생명과학 주식회사 기능강화 줄기세포 및 조절 t 세포를 포함하는 아토피 피부염 예방 또는 치료용 병용투여 조성물
WO2025043075A1 (en) * 2023-08-24 2025-02-27 The Johns Hopkins University Methods of treating myocardial infarction, ischemia, and ischemia reperfusion injury
WO2025199431A1 (en) * 2024-03-22 2025-09-25 Colorado State University Research Foundation Innate immune pathway activated mesenchymal stromal cells for treatment of musculoskeletal disorders or conditions

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102482329A (zh) * 2009-07-24 2012-05-30 免疫设计公司 用辛德毕斯病毒包膜糖蛋白假型化的慢病毒载体

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5061620A (en) 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US5635387A (en) 1990-04-23 1997-06-03 Cellpro, Inc. Methods and device for culturing human hematopoietic cells and their precursors
US5460964A (en) 1992-04-03 1995-10-24 Regents Of The University Of Minnesota Method for culturing hematopoietic cells
US5409813A (en) 1993-09-30 1995-04-25 Systemix, Inc. Method for mammalian cell separation from a mixture of cell populations
US5677136A (en) 1994-11-14 1997-10-14 Systemix, Inc. Methods of obtaining compositions enriched for hematopoietic stem cells, compositions derived therefrom and methods of use thereof
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
WO2000038663A2 (en) 1998-12-24 2000-07-06 Alcon Laboratories, Inc. Ep4 receptor agonists for treatment of dry eye
DK1132086T3 (da) 2000-01-31 2006-08-28 Pfizer Prod Inc Anvendelse af prostaglandin (PGE2) selektive receptor 4 (EP4) agonister til behandling af akut og kronisk nyresvigt
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
EP1501918A4 (en) * 2002-04-12 2006-03-29 Med College Georgia Res Inst ANTIGEN PRESENTING CELL POPULATIONS AND THEIR USE AS REAGENTS TO INCREASE OR REDUCE IMMUNO TOLERANCE
US7763251B2 (en) * 2002-04-12 2010-07-27 Medical College Of Georgia Research Institute, Inc. Kits to assess the risk of tumor progression
US6747037B1 (en) 2003-06-06 2004-06-08 Allergan, Inc. Piperidinyl prostaglandin E analogs
WO2005040391A1 (en) * 2003-10-27 2005-05-06 Murdoch Childrens Research Institute Compositions and methods for differentiating stem cells
US7592177B2 (en) 2003-11-10 2009-09-22 The Scripps Research Institute Compositions and methods for inducing cell dedifferentiation
US7682828B2 (en) 2003-11-26 2010-03-23 Whitehead Institute For Biomedical Research Methods for reprogramming somatic cells
DE102005062741A1 (de) 2005-12-22 2007-06-28 Bayer Schering Pharma Ag Fluorene und Carbazole als Liganden des EP2 Rezeptors
WO2008054825A2 (en) * 2006-11-03 2008-05-08 Aastrom Biosciences, Inc. Mixed cell populations for tissue repair and separation technique for cell processing
MX352541B (es) 2007-04-07 2017-11-29 Whitehead Inst Biomedical Res Reprogramación de células somáticas.
EP2581441A1 (en) * 2007-08-09 2013-04-17 Genzyme Corporation Method of treating autoimmune disease with mesenchymal stem cells
WO2009032194A1 (en) 2007-08-31 2009-03-12 Whitehead Institute For Biomedical Research Wnt pathway stimulation in reprogramming somatic cells
CA2718904C (en) 2008-03-17 2017-01-03 The Scripps Research Institute Combined chemical and genetic approaches for generation of induced pluripotent stem cells
RU2573912C2 (ru) * 2008-10-08 2016-01-27 Интрексон Корпорейшн Сконструированные клетки, экспрессирующие множественные иммуномодуляторы, и их применения
ES2845641T3 (es) 2008-11-06 2021-07-27 Univ Indiana Res & Tech Corp Materiales y métodos para mejorar procedimientos de injerto funcionante de células madre hematopoyéticas
ES2645869T3 (es) 2008-12-17 2017-12-11 The Scripps Research Institute Generación y mantenimiento de células madre
WO2010108028A2 (en) 2009-03-19 2010-09-23 Fate Therapeutics, Inc. Compositions comprising cyclic amp enhancers and/or ep ligands, and methods of preparing and using the same
JP5808331B2 (ja) 2009-10-16 2015-11-10 ザ スクリプス リサーチ インスティテュート 多能性細胞の誘導法
CA2780572A1 (en) * 2009-11-13 2011-05-19 The United States Of America, As Represented By The Secretary, Departmen T Of Health And Human Services Modulated programmed death ligand-1
CA2782757C (en) * 2009-12-08 2017-07-18 Yong Zhao Stem cell immune modulation methods of use and apparatus
RU2612788C2 (ru) * 2010-03-23 2017-03-13 Интрексон Корпорейшн Векторы, условно экспрессирующие терапевтические белки, клетки-хозяева, содержащие указанные векторы, и их применение
MX342017B (es) * 2010-03-26 2016-09-09 Dartmouth College Proteina mediadora de celula t regulatoria vista, agentes de enlace de vista y uso de los mismos.
BR112013003366A2 (pt) * 2010-08-12 2020-08-04 Fate Therapeutics, Inc. terapia aperfeiçoada de células tronco hematopoiéticas e progenitoras
WO2013040552A2 (en) * 2011-09-16 2013-03-21 Georgia Health Sciences University Methods of promoting immune tolerance
EP3785767A1 (en) * 2011-12-02 2021-03-03 Fate Therapeutics, Inc. Enhanced stem cell composition
US20150139994A1 (en) * 2013-11-12 2015-05-21 The Regents Of The University Of California Compositions and methods for preventing allogeneic immune rejection
JP2018520688A (ja) * 2015-07-21 2018-08-02 ザ チルドレンズ メディカル センター コーポレーション Ｐｄ−ｌ１発現造血幹細胞およびその使用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102482329A (zh) * 2009-07-24 2012-05-30 免疫设计公司 用辛德毕斯病毒包膜糖蛋白假型化的慢病毒载体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Ex Vivo Expanded Hematopoietic Stem Cells Overcome the MHC Barrier in Allogeneic Transplantation;Junke Zheng et al.;《Cell Stem Cell》;第9卷;摘要，第124页图4F，第126页第4段 *

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