CN112424608A - 用于疾病的预后和管理的方法 - Google Patents
用于疾病的预后和管理的方法 Download PDFInfo
- Publication number
- CN112424608A CN112424608A CN201980045566.7A CN201980045566A CN112424608A CN 112424608 A CN112424608 A CN 112424608A CN 201980045566 A CN201980045566 A CN 201980045566A CN 112424608 A CN112424608 A CN 112424608A
- Authority
- CN
- China
- Prior art keywords
- als
- subject
- biomarker
- scd14
- patients
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862669915P | 2018-05-10 | 2018-05-10 | |
| US62/669,915 | 2018-05-10 | ||
| PCT/US2019/031858 WO2019217916A1 (en) | 2018-05-10 | 2019-05-10 | Methods for prognosis and management of disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112424608A true CN112424608A (zh) | 2021-02-26 |
Family
ID=66655475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980045566.7A Pending CN112424608A (zh) | 2018-05-10 | 2019-05-10 | 用于疾病的预后和管理的方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20210231686A1 (https=) |
| EP (1) | EP3791188A1 (https=) |
| JP (2) | JP7371019B2 (https=) |
| KR (1) | KR20210014109A (https=) |
| CN (1) | CN112424608A (https=) |
| AU (1) | AU2019264996A1 (https=) |
| IL (1) | IL278616B2 (https=) |
| WO (1) | WO2019217916A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113842449A (zh) * | 2021-09-08 | 2021-12-28 | 乐卫东 | 枸杞糖肽在制备预防和/或治疗肌萎缩侧索硬化的药物中的应用 |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3612566A4 (en) * | 2017-04-21 | 2021-03-03 | Implicit Bioscience Limited | CD14 ANTAGONIST ANTIBODIES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES |
| WO2025049671A1 (en) * | 2023-08-30 | 2025-03-06 | The Methodist Hospital | Markers of amyotrophic lateral sclerosis survival and uses thereof |
| JPWO2025058005A1 (https=) * | 2023-09-15 | 2025-03-20 |
Citations (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0559795A1 (en) * | 1990-11-30 | 1993-09-15 | Monoclonetics Int | Methods for the diagnosis of chronic lower back and cervical pain. |
| CA2467333A1 (en) * | 2001-11-16 | 2003-06-12 | Tennore M. Ramesh | Methods for monitoring amyotrophic lateral sclerosis |
| US20070105105A1 (en) * | 2003-05-23 | 2007-05-10 | Mount Sinai School Of Medicine Of New York University | Surrogate cell gene expression signatures for evaluating the physical state of a subject |
| CN1968962A (zh) * | 2004-05-11 | 2007-05-23 | 持田制药株式会社 | 新型可溶性cd14抗原 |
| CN102573500A (zh) * | 2009-08-06 | 2012-07-11 | 纽拉尔图斯制药公司 | 巨噬细胞相关疾病的治疗 |
| US20120276114A1 (en) * | 2009-11-18 | 2012-11-01 | Universite D'aix-Marseille | Ifn-gamma inhibitors in the treatment of motoneuron diseases |
| US20130230499A1 (en) * | 2010-03-10 | 2013-09-05 | Michal Eisenbach-Schwartz | Cellular blood markers for early diagnosis of als and for als progression |
| CN103733068A (zh) * | 2011-08-12 | 2014-04-16 | 三菱化学美迪恩斯株式会社 | 术后感染症的诊断方法 |
| CN104011210A (zh) * | 2011-10-11 | 2014-08-27 | 布里格姆及妇女医院股份有限公司 | 神经退行性病症中的microRNA |
| CN105102984A (zh) * | 2012-12-28 | 2015-11-25 | 美迪恩斯生命科技株式会社 | sCD14或它的片段或衍生物用于风险分级、诊断和预后的用途 |
| CN106413721A (zh) * | 2014-05-16 | 2017-02-15 | 纽拉尔图斯制药公司 | 用于治疗巨噬细胞相关病症的方法和组合物 |
| WO2017103001A2 (en) * | 2015-12-16 | 2017-06-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Diagnostic markers of immunosenescence and methods for determining the susceptibility to nosocomial infections |
| CN107003320A (zh) * | 2014-11-25 | 2017-08-01 | 豪夫迈·罗氏有限公司 | 慢性肾脏疾病的快速进展的生物标志物 |
| CN107683142A (zh) * | 2015-04-02 | 2018-02-09 | 卫理公会医院 | 基于多孔硅微粒的癌症疫苗和增强抗肿瘤免疫性的方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4018653A (en) | 1971-10-29 | 1977-04-19 | U.S. Packaging Corporation | Instrument for the detection of Neisseria gonorrhoeae without culture |
| US4016043A (en) | 1975-09-04 | 1977-04-05 | Akzona Incorporated | Enzymatic immunological method for the determination of antigens and antibodies |
| US4424279A (en) | 1982-08-12 | 1984-01-03 | Quidel | Rapid plunger immunoassay method and apparatus |
| ATE335072T1 (de) | 1993-05-28 | 2006-08-15 | Scripps Research Inst | Methoden für inhibition der cd14-abhängigen zellaktivierung |
| CA2319828A1 (en) | 1998-01-29 | 1999-08-05 | Miller, Samuel | High density arrays for proteome analysis and methods and compositions therefor |
| US6406921B1 (en) | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
| US20010041349A1 (en) | 2000-04-17 | 2001-11-15 | Andrew Patron | Protein expression system arrays and use in biological screening |
| GB0022978D0 (en) | 2000-09-19 | 2000-11-01 | Oxford Glycosciences Uk Ltd | Detection of peptides |
| AU2002220236A1 (en) | 2000-11-09 | 2002-05-21 | Bionova Pharmaceutials, Inc. | A method for identifying the proteome of cells using an antibody library microarray |
| US7264967B2 (en) | 2000-11-22 | 2007-09-04 | Mochida Pharmaceutical Co., Ltd. | Anti-CD14 monoclonal antibody having effect of inhibiting CD14/TLR binding |
| EP1360490B1 (en) | 2001-01-23 | 2011-12-21 | President and Fellows of Harvard College | Nucleic-acid programmable protein arrays |
| WO2003062444A2 (en) | 2001-11-13 | 2003-07-31 | Emory University | Array systems and methods |
| EP1502102B1 (en) | 2002-03-11 | 2009-01-14 | caprotec bioanalytics GmbH | Compounds and methods for analyzing the proteome |
| CA2754741C (en) * | 2009-03-11 | 2019-02-12 | Augurex Life Sciences Corporation | Compositions and methods for characterizing arthritic conditions |
| US8465727B2 (en) | 2009-10-06 | 2013-06-18 | University of Pittsburgh—of the Commonwealth System of Higher Education | Biomarkers for the diagnosis of ALS |
| WO2012004276A2 (en) * | 2010-07-06 | 2012-01-12 | Fondazione Telethon | Multiprotein biomarkers of amyotrophic lateral sclerosis in peripheral blood mononuclear cells, diagnostic methods and kits |
| US11131676B2 (en) * | 2016-02-25 | 2021-09-28 | The Trustees Of Columbia University In The City Of New York | Systemic immune activation and biomarkers of nonceliac wheat/gluten sensitivity |
| EP3612566A4 (en) | 2017-04-21 | 2021-03-03 | Implicit Bioscience Limited | CD14 ANTAGONIST ANTIBODIES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES |
| AU2024238511A1 (en) * | 2023-03-21 | 2025-10-02 | Coya Therapeutics, Inc. | Biomarkers of amyotrophic lateral sclerosis and uses thereof |
-
2019
- 2019-05-10 AU AU2019264996A patent/AU2019264996A1/en not_active Abandoned
- 2019-05-10 WO PCT/US2019/031858 patent/WO2019217916A1/en not_active Ceased
- 2019-05-10 CN CN201980045566.7A patent/CN112424608A/zh active Pending
- 2019-05-10 JP JP2020563696A patent/JP7371019B2/ja active Active
- 2019-05-10 KR KR1020207034330A patent/KR20210014109A/ko not_active Ceased
- 2019-05-10 US US17/054,131 patent/US20210231686A1/en not_active Abandoned
- 2019-05-10 IL IL278616A patent/IL278616B2/en unknown
- 2019-05-10 EP EP19726841.0A patent/EP3791188A1/en not_active Withdrawn
-
2023
- 2023-10-18 JP JP2023179310A patent/JP2023181255A/ja active Pending
Patent Citations (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0559795A1 (en) * | 1990-11-30 | 1993-09-15 | Monoclonetics Int | Methods for the diagnosis of chronic lower back and cervical pain. |
| CA2467333A1 (en) * | 2001-11-16 | 2003-06-12 | Tennore M. Ramesh | Methods for monitoring amyotrophic lateral sclerosis |
| CN1606694A (zh) * | 2001-11-16 | 2005-04-13 | Slil生物医学股份有限公司 | 监测和治疗肌萎缩性侧索硬化症的方法 |
| US20070105105A1 (en) * | 2003-05-23 | 2007-05-10 | Mount Sinai School Of Medicine Of New York University | Surrogate cell gene expression signatures for evaluating the physical state of a subject |
| CN1968962A (zh) * | 2004-05-11 | 2007-05-23 | 持田制药株式会社 | 新型可溶性cd14抗原 |
| CN102573500A (zh) * | 2009-08-06 | 2012-07-11 | 纽拉尔图斯制药公司 | 巨噬细胞相关疾病的治疗 |
| US20120276114A1 (en) * | 2009-11-18 | 2012-11-01 | Universite D'aix-Marseille | Ifn-gamma inhibitors in the treatment of motoneuron diseases |
| US20130230499A1 (en) * | 2010-03-10 | 2013-09-05 | Michal Eisenbach-Schwartz | Cellular blood markers for early diagnosis of als and for als progression |
| CN103733068A (zh) * | 2011-08-12 | 2014-04-16 | 三菱化学美迪恩斯株式会社 | 术后感染症的诊断方法 |
| CN104011210A (zh) * | 2011-10-11 | 2014-08-27 | 布里格姆及妇女医院股份有限公司 | 神经退行性病症中的microRNA |
| CN105102984A (zh) * | 2012-12-28 | 2015-11-25 | 美迪恩斯生命科技株式会社 | sCD14或它的片段或衍生物用于风险分级、诊断和预后的用途 |
| CN106413721A (zh) * | 2014-05-16 | 2017-02-15 | 纽拉尔图斯制药公司 | 用于治疗巨噬细胞相关病症的方法和组合物 |
| CN107003320A (zh) * | 2014-11-25 | 2017-08-01 | 豪夫迈·罗氏有限公司 | 慢性肾脏疾病的快速进展的生物标志物 |
| CN107683142A (zh) * | 2015-04-02 | 2018-02-09 | 卫理公会医院 | 基于多孔硅微粒的癌症疫苗和增强抗肿瘤免疫性的方法 |
| WO2017103001A2 (en) * | 2015-12-16 | 2017-06-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Diagnostic markers of immunosenescence and methods for determining the susceptibility to nosocomial infections |
Non-Patent Citations (6)
| Title |
|---|
| CHRISTIAN LUNETTA, MD等: ""Serum C-Reactive Protein as a Prognostic Biomarker in Amyotrophic Lateral Sclerosis"", 《JAMA NEUROLOGY》, vol. 74, no. 6, pages 1 * |
| S.D. SUSSMUTH, MD等: ""CSF glial markers correlate with survival in amyotrophic lateral sclerosis"", 《NEUROLOGY》, vol. 74, no. 12, pages 982 - 988 * |
| VALENTE, T 等: "C/EBPβ expression in activated microglia in amyotrophic lateral sclerosis", NEUROBIOLOGY OF AGING, vol. 33, no. 9, pages 2186 - 2199 * |
| 叶学义 等: "基于张量的2D-PCA人脸识别算法", 计算机工程与应用, vol. 53, no. 06, pages 1 - 6 * |
| 拱忠影;臧大维;: "肌萎缩侧索硬化生物标记物研究的新进展", 中华老年心脑血管病杂志, no. 03, pages 330 - 333 * |
| 方鑫;吴艳;王芳;孙圣刚;: "CD14 mRNA、TLR4 mRNA在急性和亚急性MPTP帕金森病小鼠模型中的表达", 华中科技大学学报(医学版), no. 06, pages 775 - 779 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113842449A (zh) * | 2021-09-08 | 2021-12-28 | 乐卫东 | 枸杞糖肽在制备预防和/或治疗肌萎缩侧索硬化的药物中的应用 |
| CN113842449B (zh) * | 2021-09-08 | 2024-02-23 | 乐卫东 | 枸杞糖肽在制备预防和/或治疗肌萎缩侧索硬化的药物中的应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| IL278616B2 (en) | 2025-02-01 |
| JP2021523375A (ja) | 2021-09-02 |
| AU2019264996A1 (en) | 2020-11-26 |
| JP7371019B2 (ja) | 2023-10-30 |
| IL278616B1 (en) | 2024-10-01 |
| IL278616A (https=) | 2021-01-31 |
| WO2019217916A1 (en) | 2019-11-14 |
| KR20210014109A (ko) | 2021-02-08 |
| JP2023181255A (ja) | 2023-12-21 |
| US20210231686A1 (en) | 2021-07-29 |
| EP3791188A1 (en) | 2021-03-17 |
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Application publication date: 20210226 |
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