JP7371019B2 - 疾病の予後と管理のための方法 - Google Patents

疾病の予後と管理のための方法 Download PDF

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JP7371019B2
JP7371019B2 JP2020563696A JP2020563696A JP7371019B2 JP 7371019 B2 JP7371019 B2 JP 7371019B2 JP 2020563696 A JP2020563696 A JP 2020563696A JP 2020563696 A JP2020563696 A JP 2020563696A JP 7371019 B2 JP7371019 B2 JP 7371019B2
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biomarker
scd14
patients
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エイチ.アッペル スタンリー
アール.ビアーズ デイビッド
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ザ・メソジスト・ホスピタル
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2020563696A 2018-05-10 2019-05-10 疾病の予後と管理のための方法 Active JP7371019B2 (ja)

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JP2023179310A JP2023181255A (ja) 2018-05-10 2023-10-18 疾病の予後と管理のための方法

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US201862669915P 2018-05-10 2018-05-10
US62/669,915 2018-05-10
PCT/US2019/031858 WO2019217916A1 (en) 2018-05-10 2019-05-10 Methods for prognosis and management of disease

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JP2021523375A JP2021523375A (ja) 2021-09-02
JP2021523375A5 JP2021523375A5 (https=) 2022-05-18
JP7371019B2 true JP7371019B2 (ja) 2023-10-30

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US (1) US20210231686A1 (https=)
EP (1) EP3791188A1 (https=)
JP (2) JP7371019B2 (https=)
KR (1) KR20210014109A (https=)
CN (1) CN112424608A (https=)
AU (1) AU2019264996A1 (https=)
IL (1) IL278616B2 (https=)
WO (1) WO2019217916A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL309046B2 (en) 2017-04-21 2025-03-01 Implicit Bioscience Ltd CD14 antagonist antibodies for the treatment of neurodegenerative diseases
CN113842449B (zh) * 2021-09-08 2024-02-23 乐卫东 枸杞糖肽在制备预防和/或治疗肌萎缩侧索硬化的药物中的应用
WO2025049671A1 (en) * 2023-08-30 2025-03-06 The Methodist Hospital Markers of amyotrophic lateral sclerosis survival and uses thereof
WO2025058005A1 (ja) * 2023-09-15 2025-03-20 国立大学法人徳島大学 筋萎縮性側索硬化症(als)と関連するバイオマーカー

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110086894A1 (en) 2009-10-06 2011-04-14 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Biomarkers for the diagnosis of als
US20120058498A1 (en) 2009-03-11 2012-03-08 Anthony Marotta Compositions and Methods for Characterizing Arthritic Conditions
JP2013522589A (ja) 2010-03-10 2013-06-13 イエダ リサーチ アンド ディベロップメント カンパニー リミテッド Alsの早期診断およびals進行のための細胞性血液マーカー
WO2017103001A2 (en) 2015-12-16 2017-06-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Diagnostic markers of immunosenescence and methods for determining the susceptibility to nosocomial infections
JP2020517740A (ja) 2017-04-21 2020-06-18 インプリシット バイオサイエンス プロプライアタリー リミティド 神経変性疾患を治療するためのcd14アンタゴニスト抗体

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4018653A (en) 1971-10-29 1977-04-19 U.S. Packaging Corporation Instrument for the detection of Neisseria gonorrhoeae without culture
US4016043A (en) 1975-09-04 1977-04-05 Akzona Incorporated Enzymatic immunological method for the determination of antigens and antibodies
US4424279A (en) 1982-08-12 1984-01-03 Quidel Rapid plunger immunoassay method and apparatus
ES2083152T3 (es) * 1990-11-30 1996-04-01 Monoclonetics Int Metodos para el diagnostico de dolores cronicos lumbares y cervicales.
US5820858A (en) 1993-05-28 1998-10-13 The Scripps Research Institute Methods and compositions for inhibiting CD14 mediated cell activation
CA2319828A1 (en) 1998-01-29 1999-08-05 Miller, Samuel High density arrays for proteome analysis and methods and compositions therefor
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
AU2001255436A1 (en) 2000-04-17 2001-10-30 Transtech Pharma Protein expression system arrays and use in biological screening
GB0022978D0 (en) 2000-09-19 2000-11-01 Oxford Glycosciences Uk Ltd Detection of peptides
US20050130320A1 (en) 2000-11-09 2005-06-16 George Shaji. T. Method for identifying the proteome of cells using an antibody library microarray
AU2001290315A1 (en) 2000-11-22 2002-06-03 Mochida Pharmaceutical Co., Ltd. Anti-cd14 monoclonal antibody having effect of inhibiting cd14/tlr binding
US6800453B2 (en) 2001-01-23 2004-10-05 President And Fellows Of Harvard College Nucleic-acid programmable protein arrays
WO2003062444A2 (en) 2001-11-13 2003-07-31 Emory University Array systems and methods
JP2005510524A (ja) * 2001-11-16 2005-04-21 アルス・セラピー・デベロツプメント・フアンデーシヨン・インコーポレーテツド ポリアミン経路の調節による神経変性障害の治療
AU2003224674A1 (en) 2002-03-11 2003-09-29 Hk Pharmaceuticals, Inc. Compounds and methods for analyzing the proteome
WO2005020784A2 (en) * 2003-05-23 2005-03-10 Mount Sinai School Of Medicine Of New York University Surrogate cell gene expression signatures for evaluating the physical state of a subject
ES2406266T3 (es) * 2004-05-11 2013-06-06 Mochida Pharmaceutical Co., Ltd. Antígeno CD14 soluble novedoso
BR112012002333A2 (pt) * 2009-08-06 2017-07-18 Neuraltus Pharmaceuticals Inc método de reduzir os efeitos colaterais e método de potencializar o efeito de um imunomodulador administrado a um sujeito que dele necessita; métodos para tratar doença associada com excesso de ativação de monócitos para macrófagos ativados, diabetes tipo ii ou complicações relacionadas, doença associada com a migração de monócitos ou macrófagos ativados, doença associada a excesso de produção de scd14 e/ou scd163 por macrófagos ativados; composto de cloreto de sódio; composição farmacêutica; método para diagnosticar uma doença relacionada com macrófagos em um sujeito; e método para determinar a eficácia do tratamento com um agente oxidante para uma doença relacionada a macrófagos em um sujeito.
EP2501720A2 (en) * 2009-11-18 2012-09-26 Lascco SA Ifn inhibitors in the treatment of motoneuron diseases
WO2012004276A2 (en) * 2010-07-06 2012-01-12 Fondazione Telethon Multiprotein biomarkers of amyotrophic lateral sclerosis in peripheral blood mononuclear cells, diagnostic methods and kits
US9506923B2 (en) * 2011-08-12 2016-11-29 Lsi Medience Corporation Method of diagnosing surgical site infections
US10184151B2 (en) * 2011-10-11 2019-01-22 The Brigham And Women's Hospital, Inc. Micrornas in neurodegenerative disorders
WO2014102333A1 (en) * 2012-12-28 2014-07-03 Mitsubishi Chemical Medience Corporation Use of scd14 or its fragments or derivatives for risk stratisfaction, diagnosis and prognosis
EP3142674A4 (en) * 2014-05-16 2018-01-17 Neuraltus Pharmaceuticals, Inc. Methods and compositions for treatment of macrophage-related disorders
WO2016083374A1 (en) * 2014-11-25 2016-06-02 F. Hoffmann-La Roche Ag Biomarkers of fast progression of chronic kidney disease
HK1250012A1 (zh) * 2015-04-02 2018-11-23 The Methodist Hospital System 基於多孔硅微粒的癌症疫苗及增强抗肿瘤免疫的方法
WO2017147378A1 (en) * 2016-02-25 2017-08-31 The Trustees Of Columbia University In The City Of New York Systemic immune activation and biomarkers of nonceliac wheat/gluten sensitivity
AU2024238511A1 (en) * 2023-03-21 2025-10-02 Coya Therapeutics, Inc. Biomarkers of amyotrophic lateral sclerosis and uses thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120058498A1 (en) 2009-03-11 2012-03-08 Anthony Marotta Compositions and Methods for Characterizing Arthritic Conditions
US20110086894A1 (en) 2009-10-06 2011-04-14 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Biomarkers for the diagnosis of als
JP2013522589A (ja) 2010-03-10 2013-06-13 イエダ リサーチ アンド ディベロップメント カンパニー リミテッド Alsの早期診断およびals進行のための細胞性血液マーカー
WO2017103001A2 (en) 2015-12-16 2017-06-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Diagnostic markers of immunosenescence and methods for determining the susceptibility to nosocomial infections
JP2020517740A (ja) 2017-04-21 2020-06-18 インプリシット バイオサイエンス プロプライアタリー リミティド 神経変性疾患を治療するためのcd14アンタゴニスト抗体

Non-Patent Citations (14)

* Cited by examiner, † Cited by third party
Title
Anita C. E. Vreugdenhil,Lipopolysaccharide Binding Protein and Serum Amyloid A Secretion by Human Intestinal Epithelial Cells During the Acute Phase Response,J Immunol,1999年09月01日,Vol.163 No.5,Page.2792-2798
Benjamin J. Murdock,Correlation of Peripheral Immunity With Rapid Amyotrophic Lateral Sclerosis Progression,JAMA Neurol,2017年09月25日,Vol.74 No.12,Page.1446-1454
Carey L. Shive,Soluble CD14 is a nonspecific marker of monocyte activation,AIDS,2015年,Vol.29,Page.1263-1265
Christian Lunetta,Serum C-Reactive Protein as a Prognostic Biomarker in Amyotrophic Lateral Sclerosis,JAMA Neurol,2017年06月01日,Vol.74 No.6,Page.660-667
David R. Beers,Elevated acute phase proteins reflect peripheral inflammation and disease severity in patients with amyotrophic lateral sclerosis,Scientific Reports,2020年11月17日,Vol.10 No.1,Page.15295
David R. Beers,Tregs Attenuate Peripheral Oxidative Stress and Acute Phase Proteins in ALS,ANN NEUROL,2022年,Vol.92,Page.195-200
H. Blasco,Further development of biomarkers in amyotrophic lateral sclerosis,EXPERT REVIEW OF MOLECULAR DIAGNOSTICS,2016年06月20日,Vol.60 No.8,Page.853-868
Jason Thonhoff,Plasmapheresis Improves the Suppressive Function of Regulatory T Cells in Patients with Fast-Progressing Amyotrophic Lateral Sclerosis (P3.183),Neurology,2016年04月04日,Vol.86 No.16 Supplement,Paeg.P3.183
Keizman D,Low-grade systemic inflammation in patients with amyotrophic lateral sclerosis,Acta Neurol Scand,2009年,Vol.119,Page.383-389
Michael P. Gustafson,Comprehensive immune profiling reveals substantial immune system alterations in a subset of patients with amyotrophic lateral sclerosis,PLOS ONE,2017年07月25日,Vol.12 No.7,Page.e0182002
S.D. Sussmuth,CSF glial markers correlate with survival in amyotrophic lateral sclerosis,Neurology,Vol.74 No.12,2010年03月23日,Page.982-987
Sylvette Bas,CD14 Is an Acute-Phase Protein,The Journal of Immunology,2004年04月01日,Vol.172 No.7,Page.4470-4479
Weihua Zhao,Potential Immune Biomarkers for Disease Progression in ALS (P5.040),Neurology,2016年04月05日,Vol.86 No.16 Supplement,Page.P5.040
Yang Hu,Increased peripheral blood inflammatory cytokine levels in amyotrophic lateral sclerosis: a meta-analysis study,Scientific Reports,2017年08月22日,Vol.7,Page.9094

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Publication number Publication date
IL278616B2 (en) 2025-02-01
IL278616A (https=) 2021-01-31
JP2021523375A (ja) 2021-09-02
US20210231686A1 (en) 2021-07-29
IL278616B1 (en) 2024-10-01
CN112424608A (zh) 2021-02-26
EP3791188A1 (en) 2021-03-17
WO2019217916A1 (en) 2019-11-14
JP2023181255A (ja) 2023-12-21
AU2019264996A1 (en) 2020-11-26
KR20210014109A (ko) 2021-02-08

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