CN112368051A - 用于治疗骨病的基因治疗剂 - Google Patents

用于治疗骨病的基因治疗剂 Download PDF

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CN112368051A
CN112368051A CN201980031173.0A CN201980031173A CN112368051A CN 112368051 A CN112368051 A CN 112368051A CN 201980031173 A CN201980031173 A CN 201980031173A CN 112368051 A CN112368051 A CN 112368051A
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bone
gly
nucleic acid
pro
raav
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沈载赫
高光平
谢军
金瀞慜
王丹
梁软淑
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University of Massachusetts Amherst
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CN201980031173.0A 2018-03-23 2019-03-22 用于治疗骨病的基因治疗剂 Pending CN112368051A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862647595P 2018-03-23 2018-03-23
US62/647,595 2018-03-23
US201962799843P 2019-02-01 2019-02-01
US62/799,843 2019-02-01
PCT/US2019/023759 WO2019183605A1 (en) 2018-03-23 2019-03-22 Gene therapeutics for treating bone disorders

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CN112368051A true CN112368051A (zh) 2021-02-12

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CN201980031173.0A Pending CN112368051A (zh) 2018-03-23 2019-03-22 用于治疗骨病的基因治疗剂

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US (2) US12194108B2 (https=)
EP (2) EP4169576A1 (https=)
JP (1) JP2021519065A (https=)
KR (1) KR20200135433A (https=)
CN (1) CN112368051A (https=)
AU (1) AU2019237514A1 (https=)
CA (1) CA3094217A1 (https=)
WO (1) WO2019183605A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113913463A (zh) * 2021-09-19 2022-01-11 郭保生 抑制sost基因表达的重组质粒及其骨靶向重组腺相关病毒与应用
CN118453845A (zh) * 2024-05-30 2024-08-09 山东第一医科大学附属省立医院(山东省立医院) 提高dj-1基因表达量的试剂在制备抗血管钙化药物中的应用
CN121249673A (zh) * 2025-12-05 2026-01-02 北京大学第三医院（北京大学第三临床医学院） 一种靶向ybx1的骨关节炎治疗与诊断产品及应用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4169576A1 (en) 2018-03-23 2023-04-26 University of Massachusetts Gene therapeutics for treating bone disorders
US20240002844A1 (en) * 2020-08-19 2024-01-04 University Of Massachusetts Development of novel gene therapeutics for inflammation-induced bone loss
US20250388925A1 (en) * 2021-11-04 2025-12-25 University Of Massachusetts Wnt-modulating gene silencers as bone anabolic therapy for osteoporosis and critical-sized bone defect
WO2024220463A2 (en) * 2023-04-17 2024-10-24 University Of Massachusetts Aav5 capsid with non-canonical amino acid incorporation and uses thereof
CN120535659B (zh) * 2025-07-29 2025-10-17 苏州大学 一种骨靶向的三聚体蛋白及其制备方法与应用

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