CN112188886A - 口罩涂布用制剂 - Google Patents
口罩涂布用制剂 Download PDFInfo
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- CN112188886A CN112188886A CN201980034824.1A CN201980034824A CN112188886A CN 112188886 A CN112188886 A CN 112188886A CN 201980034824 A CN201980034824 A CN 201980034824A CN 112188886 A CN112188886 A CN 112188886A
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Abstract
本发明的课题在于提供一种能够通过涂布至口罩而使有效成分长期吸入到鼻腔内或咽喉内的制剂,解决了该课题的本发明的口罩涂布用制剂的特征在于,其含有(A)挥发性有效成分、(B)蜡剂、(C)挥发调整剂和(D)固定性提高剂。
Description
技术领域
本发明涉及口罩涂布用制剂,更详细地说,涉及通过将下述挥发性有效成分涂布至口罩而能够有效且长期地扩散出该有效成分的口罩涂布用制剂,所述挥发性有效成分能够降低花粉症等过敏症状,改善鼻涕、鼻子堵塞等鼻症状、咳嗽、咽喉炎、喉痛等咽喉症状、眼部不适感、眼发痒等眼症状。
背景技术
为了抑制、防止例如花粉、屋尘、各种粉尘、病毒等浮游在空气中的颗粒侵入到口、鼻中,佩戴口罩是有效的。作为用于这样的目的的口罩,例如通常广泛普及了由无纺布等构成的布制口罩。
特别是近年来,为了抑制花粉症、过敏症状而佩戴口罩的人群正在增加,并且作为防止吸入病毒飞沫、PM2.5之类的极小颗粒的对策而选择口罩的人群也在增加。
随着佩戴口罩的人群的增加,对于口罩也进行了用于提高其效果和易用性的研究,例如为了抑制极小颗粒在口罩中透过,提出了使口罩处理剂附着于口罩的方案。
作为这样的口罩处理剂,专利文献1中公开了含有非离子型表面活性剂、甘油等多元醇、低级醇和精制水的口罩处理剂,专利文献2中公开了含有水、醇、以及阳离子型表面活性剂的口罩处理剂。
另外,作为用于药剂给予的口罩,提出了使纱布包含药物、或者将包含药物的东西放入置于纱布之间的袋中的药用口罩(专利文献3);利用纱布覆盖浸渗了具有花粉症改善效果的蜂胶提取液的布来进行使用的花粉症用卫生口罩(专利文献4)。
上述各技术中,是在纱布等口罩覆盖部包含水分、试剂等,均通过呼吸使上述水分、试剂挥发并随着吸气而吸入,由此进行鼻症状、花粉症等过敏的预防和治疗。但是,在口罩的覆盖部直接浸渗水和试剂等、或者插入浸渗有试剂等的布等时,覆盖部变重,口罩容易从脸上滑落,使用感显著受损。另外,不仅如此,而且还具有下述问题:浸渗的试剂从覆盖部渗出,润湿佩戴者的嘴角、鼻周,带来不适感,或者由于药剂的作用而使皮肤粗糙。
另一方面,还提出了利用气味消除鼻孔的不适感的方法:将薄荷精、薄荷醇、扁柏酚等香料溶液在即将戴用前喷雾到口罩覆盖部的内侧使其包覆鼻孔(专利文献5)。
在该方法中,尽管不存在上述的问题,但在以戴用口罩的状态进行喷雾时,会附着于眼、脸的皮肤,因此存在必须暂时摘下口罩后进行喷雾处理再重新佩戴的烦恼。另外,这样的喷雾还具有不便于随身携带的问题。
此外,作为双方共同的缺点,还具有水分或试剂在早期挥发,效果不持久的问题。
现有技术文献
专利文献
专利文献1:日本专利第5072198号公报
专利文献2:日本专利第5553563号公报
专利文献3:日本实开平1-133941号公报
专利文献4:日本特开平5-76597号公报
专利文献5:日本特开平7-39574号公报
发明内容
发明所要解决的课题
本发明用于解决在试图提高口罩功能时的问题,提供一种不会给使用者带来不适感、能够发挥出用于降低过敏原活性、改善鼻症状等的生理活性物质的效果的口罩用制剂。
用于解决课题的手段
本发明人为了提高口罩佩戴时的功能而进行了深入研究,结果发现,通过将含有挥发性有效成分的制剂涂布至口罩,能够使有效成分长期被吸入到鼻腔内或咽喉内,并且发现了适于此的制剂配方,从而完成了本发明。
即,本发明涉及一种口罩涂布用制剂,其含有成分(A)至(D)。
(A)挥发性有效成分
(B)蜡剂
(C)挥发调整剂
(D)固定性提高剂
另外,本发明涉及一种挥发性有效成分的吸入方法,其中,将上述口罩涂布用制剂涂布至口罩,将其应用至口鼻部。
发明效果
根据本发明,能够在不给使用者带来不适感的情况下使挥发性的有效成分长期吸入到鼻腔内或咽喉内。即,能够长期吸入具有过敏原活性降低剂、鼻症状改善剂、咽喉症状改善剂等效果的有效成分。
另外,由于为固态或半固态型的制剂,因此能够在佩戴口罩的状态下涂布药剂,而且能够自由地控制涂布在口罩上的量。
此外,不具有在利用液态制剂时不能避免的浸渗在载体上的试剂从覆盖部渗出而润湿穿戴者的嘴角和鼻周从而带来不适感或者使皮肤粗糙的问题。
此外,通过涂布至口罩,花粉等过敏原或灰尘等空气中的浮游颗粒被捕捉在口罩的纤维上,能够抑制透过。
具体实施方式
以下详细说明本发明的实施方式。需要说明的是,以下的优选实施方式的说明实质上不过是例示,并非旨在限制本发明、其适用物或其用途。
本说明书的口罩涂布用制剂是含有挥发性有效成分的固态或半固态的制剂,其是指涂布至通常的应用于人的口鼻部的口罩来进行使用的制剂。
如上所述,本发明的口罩涂布用制剂(下文中称为“本发明制剂”)含有下述4种成分。
(A)挥发性有效成分
(B)蜡剂
(C)挥发调整剂
(D)固定性提高剂
其中,成分(A)的挥发性有效成分通过挥发而在人的鼻腔内或咽喉内起作用。从作用方面来看,该成分(A)是以过敏活性降低剂、鼻症状或咽喉症状改善剂等为目的的成分。
具体地说,例如可以举出l-薄荷醇、dl-樟脑、d-龙脑、母菊兰烯、萜品烯-4-醇、香叶醇、香茅醛、香叶醛、柠檬醛、扁柏酚、薄荷油、桉树油、罗汉柏油、肉桂油、佛手柑油、松节油、玫瑰油、来自茴香、鼠尾草的精油、日本柳杉、日本扁柏、桉树、库页冷杉、金松等植物的精油。这些之中,优选使用选自由柏科扁柏属、柏科柳杉属和松科冷杉属组成的组中的树木中的1种或2种以上的木质部和/或叶的精油。
上述植物的精油中,来自松科冷杉属、金松科金松属、柏科罗汉柏属等树木的木质部或叶的精油发挥出过敏原降低作用、鼻症状改善作用,这一点已经由本发明人所报告(日本特开2015-30704号公报、日本特开2015-117197号公报),可以将这些用作本发明的成分(A)。
作为上述松科冷杉属的树木,可以举出库页冷杉、日本冷杉、日光冷杉、白叶冷杉(Abies veitchii(Shirabiso))、大白叶冷杉、白叶冷杉(Abies veitchii(Shirabe))、胶冷杉、伞序冷杉(Abies x umbellata(Mitsuminemomi))、白冷杉、太平洋冷杉、北海道冷杉、加州红冷杉、大冷杉、壮丽冷杉等,作为金松科金松属的树木,可以举出金松等,作为柏科罗汉柏属的树木,可以举出白带罗汉柏(Thujopsis dolabrate(Hiba))、明日罗汉柏(Thujopsisdolabrata(Asunaro))、扁柏罗汉柏(Thujopsis dolabrata var.hondai(Hinokiasunaro))、细叶罗汉柏(Thujopsis dolabrata var.hondae f.uchimappeana(Hosobaasunaro))等,这些之中,优选使用库页冷杉、日本冷杉、金松、白带罗汉柏等。这些之中,作为树木的种类,松科冷杉属的树木对鼻症状的改善效果优异,因而优选,特别优选库页冷杉、日本冷杉。
从这些树木的木质部和/或叶取得精油的方法也已经在日本特开2015-117197号公报等中报告,可以利用提取、蒸馏等现有公知方法来进行,简单说明如下。
即,例如以将上述植物的带有叶的木枝切碎并粉碎而成的物质或碎片化的树木的木质部作为原料,将其利用水、乙醇、甲醇、丁醇、乙二醇、丙二醇、甘油等醇系溶剂;氯仿等含卤素系溶剂;二氧六环等醚系溶剂;丙酮、乙酸乙酯等羰基系溶剂或它们的混合液等,通过进行溶剂提取或常压蒸馏、减压蒸馏、水蒸汽蒸馏等蒸馏而得到精油。其中,蒸馏优选在减压下利用微波进行加热。
另外,作为本发明中的优选的成分(A),可以举出来自植物的精油,例如可以举出将来自选自松科冷杉属、金松科金松属和柏科罗汉柏属中的树木的木质部和/或叶的精油(成分(A-1))与l-薄荷醇、dl-樟脑、d-龙脑、茴香、鼠尾草等精油、薄荷油、桉树油、罗汉柏油、扁柏酚、肉桂油、佛手柑油、松节油、玫瑰油、来自茴香的精油和来自鼠尾草的精油(成分(A-2))进行混合而得到的成分。本发明中,通过混配成分(A-1)和成分(A-2),可得到鼻症状的改善效果高的效果。
对于将成分(A-1)与成分(A-2)组合使用的情况下的混配比例没有特别限定,以质量比计优选为100:0.01~1:1、特别优选为10:0.1~5:1。
作为本发明的成分(B)的蜡剂为本发明制剂的基剂,使其剂型为固态或半固态,具有保持上述(A)成分使其缓慢释放的作用。
该成分(B)是熔点为常温以上、例如为30℃以上的油脂。具体地说,可以举出小烛树蜡、蜂蜡、巴西棕榈蜡、白蜂蜡、漆树蜡、小冠巴西棕榈蜡、鲸蜡、米糠蜡、甘蔗蜡、虫胶蜡、霍霍巴蜡、木蜡、油料种子蜡、乳木果油、芒果脂、芦荟脂、酪梨脂、可可脂、狭翅娑罗双脂、石蜡、凡士林、纯白地蜡、地蜡、微晶蜡、褐煤蜡、乙烯均聚物、聚乙烯、乙烯-丙烯共聚物等合成烃蜡、油酸胆甾醇酯、油酸二氢胆甾醇酯、油酸植物甾醇酯、硬脂酸胆甾醇酯、异硬脂酸胆甾醇酯、异硬脂酸植物甾醇酯、羟基硬脂酸胆甾醇酯、六(羟基硬脂酸-硬脂酸-松香酸)二季戊四醇酯、六(羟基硬脂酸-异硬脂酸)二季戊四醇酯、六(羟基硬脂酸)二季戊四醇酯、三(辛酸-硬脂酸-己二酸)甘油酯、三(辛酸-癸酸-十四酸-硬脂酸)甘油酯、四(羟基硬脂酸/异硬脂酸)二季戊四醇酯等。其中,作为优选成分,可以举出小烛树蜡、石蜡、巴西棕榈蜡、凡士林、蜂蜡、纯白地蜡、微晶蜡、四(羟基硬脂酸/异硬脂酸)二季戊四醇酯、聚乙烯蜡和乙烯-丙烯共聚物等合成烃蜡。
该成分(B)可以根据本发明制剂所要求的硬度、涂布性将上述1种或者2种以上混合使用,可以根据需要混配其他液态油成分。
另外,作为本发明制剂的成分(C)的挥发调节剂为具有下述功能的成分:与上述成分(B)一起保留涂布在口罩上的成分(A),适宜调整其挥发,使其长期发挥出效果。
例如,上述的来自选自松科冷杉属、金松科金松属和柏科罗汉柏属中的树木的木质部和/或叶的精油、l-薄荷醇、dl-樟脑等的挥发性非常高,因此若不进行任何处理,则不仅在口罩上涂布后数分钟到数十分钟效果即会消失,而且在高浓度的成分迅速被吸入到口、鼻中时,尽管可获得其效果,但有时会严重损害嗜好性。因此,为了避免这样的问题,向本发明制剂中加入成分(C)以起到按照能够抑制挥发性高的成分(A)的释放并缓慢地吸入的方式进行调整的作用。另外,作为其他效果,还兼具适宜地调整上述的成分(B)的硬度、使涂布至口罩时的均匀性良好、提高涂布性的效果。
作为该成分(C),例如可以举出植物油、脂肪酸酯、脂肪酸二醇、脂肪酸甘油酯、高级脂肪酸醇、烃油、其他成分等。
其中,作为植物油,可以举出橄榄油、霍霍巴油、澳洲坚果油、葡萄籽油、玫瑰果油、豆油、芝麻油、葵花籽油、椰子油、固化油(植物油的氢化油)、棕榈油、鳄梨油、杏仁油、米糠油、红花油、玉米油、菜子油、杏核仁油、棕榈核油、蓖麻油、罂粟油、可可油、月见草油、棉籽油、花生油、山茶油、山茶花油、夏威夷核果油、小麦胚芽油、白芒花油、西番莲油(Chabotoke-sou oil)等,优选为橄榄油、霍霍巴油、澳洲坚果油。
另外,作为脂肪酸酯,可以举出十四酸丁酯、十四酸异丙酯、十四酸癸酯、十四酸十六烷基酯、十四酸异十六烷基酯、十四酸肉豆蔻酯、十四酸异硬脂酯、十四酸辛基十二烷基酯、十四酸异十三烷基酯、棕榈酸异丙酯、棕榈酸2-乙基己酯、棕榈酸辛酯、棕榈酸十六烷基酯、棕榈酸异十六烷基酯、棕榈酸异硬脂酯、棕榈酸2-乙基己酯、硬脂酸乙酯、硬脂酸丁酯、硬脂酸2-乙基己酯、硬脂酸辛酯、硬脂酸异十六烷基酯、硬脂酸硬脂酯、油酸十六烷基酯、油酸癸酯、油酸异癸酯、油酸油酯、油酸辛基十二烷基酯、亚油酸乙酯、亚油酸异丙酯、月桂酸己酯、月桂酸异硬脂酯、月桂酸己基癸酯、异壬酸异壬酯、异壬酸异十三烷基酯、异壬酸鲸蜡硬脂酯、异硬脂酸乙酯、异硬脂酸异丙酯、异硬脂酸己酯、异硬脂酸异十六烷基酯、异硬脂酸异硬脂酯、异硬脂酸辛基十二烷基酯、异棕榈酸2-乙基己酯、羟基硬脂酸-2-乙基己酯、12-硬脂酰羟基硬脂酸异十六烷基酯、12-硬脂酰羟基硬脂酸硬脂酯、12-硬脂酰羟基硬脂酸异硬脂酯、蓖麻油酸十六烷基酯、蓖麻油酸辛基十二烷基酯、蓖麻油酸十六烷基酯、新戊酸辛基十二烷基酯、2-乙基己酸异丙酯、2-乙基己酸十六烷基酯、2-乙基己酸鲸蜡硬脂酯、2-乙基己酸硬脂酯、辛酸异十六烷基酯、辛酸异硬脂酯、二甲基辛酸己基癸酯、二甲基辛酸辛基十二烷基酯、乳酸月桂酯、乳酸肉豆蔻酯、乳酸十六烷基酯、乳酸辛基十二烷基酯、乳酸异硬脂酯、柠檬酸三乙酯、柠檬酸乙酰基三乙酯、柠檬酸乙酰基三丁酯、柠檬酸三辛酯、柠檬酸三异十六烷基酯、柠檬酸三辛基十二烷基酯、苹果酸二异硬脂酯、琥珀酸二2-乙基己酯、己二酸二异丙酯、己二酸二异丁酯、己二酸二辛酯、己二酸二丁酯、癸二酸二乙酯、癸二酸二异丙酯、癸二酸二辛酯、异壬酸2-乙基己酯、芥酸油酯、辛酸十六烷基酯、碳酸二辛酯、脂肪酸(C10-30)胆固醇/羊毛甾醇酯等,优选异壬酸异十三烷基酯、异硬脂酸辛基十二烷基酯、苹果酸二异硬脂酯、棕榈酸2-乙基己酯、棕榈酸十六烷基酯、脂肪酸(C10-30)胆固醇/羊毛甾醇酯。
此外,作为脂肪酸二醇,可以举出二辛酸乙二醇酯、二油酸乙二醇酯、二油酸丙二醇酯、二癸酸丙二醇酯、二(癸酰基-癸酸)丙二醇酯、新戊二醇二辛酸酯、新戊二醇二癸酸酯等。
进而,作为脂肪酸甘油酯,可以举出硬脂酸甘油酯、二异硬脂酸甘油酯、1-异硬脂酰-3-肉豆蔻酰基甘油酯、三辛酸甘油酯、三(癸酰基-癸酸)甘油酯、三(辛酸-癸酸-椰子油脂肪酸)甘油酯、三(十一酸)甘油酯、三异棕榈酸甘油酯、三异硬脂酸甘油酯、三2-乙基己酸甘油酯、聚氧乙烯椰子油脂肪酸甘油酯、聚氧乙烯(癸酰基-癸酸)甘油酯、硬脂酸聚甘油酯等,优选为三2-乙基己酸甘油酯、三异硬脂酸甘油酯、硬脂酸甘油酯、硬脂酸聚甘油酯、三异硬脂酸甘油酯。
此外,作为高级脂肪酸醇,可以举出油醇、异硬脂醇、棕榈醇、肉豆蔻醇(鲸蜡醇)、辛基十二醇、己基癸醇、二辛基环己烷和(癸酰基-癸酸)椰子油烷基酯等,优选为辛基十二醇。
作为烃油,可以举出角鲨烷等。上述成分(C)中,可以将上述各成分1种或者2种以上混合使用。
作为本发明制剂的成分(D)的固定性提高剂是用于将本发明制剂涂布至口罩后使其附着、固定于口罩而不会发生剥落的成分。
作为该成分(D),具体地说,可以举出液体石蜡、液体异链烷烃、聚丁烯、聚异丁烯、脂肪酸聚甘油酯、二亚油酸酯、松香、松香衍生物、异硬脂酸氢化蓖麻油、(PPG-7-琥珀酸)共聚物、(己基癸酸-癸二酸)二甘油基低聚酯、烯烃低聚物、十甲基环五硅氧烷、聚二甲基硅氧烷等硅油等,可以使用其1种或2种以上。
本发明制剂包含上述的成分(A)~(C)的各成分,基本上为疏水性的,但也可以根据需要混配抗氧化剂、紫外线吸收剂、色素、香料、以及水分。这种情况下,制剂中,优选油包水型之类的连续层为油性成分的制剂。
关于本发明的制剂,将相对于全部组成优选为1~30质量%(下文中表示为“%”)、更优选为10~20%的成分(B)、优选为10~50%、更优选为15~30%的成分(C)、优选为1~30%、更优选为5~20%的成分(D)和必要时的任选成分在60℃~120℃的程度加热熔解后,向其中添加优选为1~20%、更优选为5~10%的成分(A),进行搅拌混合,使所得到的混合物流入到模具中,进行冷却,由此制造该制剂。另外,在制造软膏剂、乳膏剂的情况下,可以向上述各成分中进一步加入表面活性剂和水,进行搅拌混合,填充到管、杯等适当的容器,由此进行制造。
这样制作的本发明的口罩处理剂为固态或半固态(软膏状),因此也能够装入容器中并用手指涂布到口罩上,优选将其收纳在唇膏状的容器中而能够从容器中直接进行涂布。
即,唇膏状的容器是指呈细长的圆筒形(极少数情况下为棱柱)且上部能够使内容物进出的带有盖的容器,在旋转容器的底时,内底上升,收纳在内部的固体状的内容物露出,通过利用该容器,能够在不与本发明制剂直接接触的情况下涂布至口罩。
这样得到的本发明制剂例如涂布至布制造的口罩上进行使用。对于涂布本发明制剂的面没有特别限制,为了避免直接与皮肤、口唇等接触,优选涂布至吸入外部气体的一侧。在其使用时,按照拿着容器直接在口罩的外侧(不与皮肤接触的外表面)擦涂1次或数次的方式来进行涂布即可。
另外,对于涂布、应用本发明制剂的口罩的种类等没有特别限定,可应用于将无纺布、机织物、纱布等制成单层的单层结构或者多层重叠的多层结构的口罩。此外,作为口罩中所使用的无纺布的制造方法,例如可以举出纺粘法、针刺法等,也可以为经成型的无纺布。
实施例
下面举出实施例、制造例、制剂例对本发明进行说明,但本发明不受这些实施例等的任何限定。
制造例1
使用库页冷杉的叶作为原料,按下述操作得到其精油。即,将库页冷杉叶用压碎式粉碎机(KYB制作所制)粉碎,将其约50kg投入到微波水蒸汽蒸馏装置的蒸馏槽中。在搅拌下将蒸馏槽内的压力保持在约20KPa的减压条件下(蒸气温度约为67℃),进行1小时微波照射,蒸馏出精油。所得到的精油的量为180mL,精油相对于投入试样的比例为0.34%。
实施例1
按照下述配方、制造方法制作棒状的口罩涂布用制剂(实施品1)。
(配方)
[表1]
(制造方法)
将上述表1中的成分(A)以外的成分加热熔解,向其中加入成分(A),之后流入模具中进行冷却,成型为棒状。将其安装在图2所示的唇膏容器中,作为口罩涂布用制剂。
实施例2
将实施例1中制备的口罩涂布用制剂(φ16mm;长度70mm)和无纺布制口罩交给具有花粉症的症状的受试者,在进行了涂布至口罩的外侧面的鼻腔周边来进行使用的说明后,使受试者自由使用。之后填写针对使用感的效果的调查表。将该结果示于表2至表8。需要说明的是,这些表中,涂布次数是指,将沿口罩的横向进行4~5cm的涂布作为1次涂布,在使用之前将该操作反复进行了多少次,使用感受是询问“强烈感受”、“稍有感受”、“不能确定”“不太能感受到”“完全不能感受到”这五个阶段中的评价的结果。
[表2]
[表3]
[表4]
[表5]
[表6]
[表7]
[表8]
如以上结果所示,能够由进行使用的人自由控制涂布在口罩上的涂布量(涂布次数),得到与之相应的使用感。另外,能够在佩戴口罩的状态下涂布药剂,其结果没有皮肤粗糙的申诉。另外还具有便于随身携带、即使在外出地等也能够进行涂布的优点。
比较例1
按照下述配方、制造方法制作比较品1的鼻症状改善剂(液体)。
(配方)
[表9]
(制造方法)
将全部成分混合,搅拌至均匀。
将所得到的制剂收纳在市售的泵喷雾容器中,向口罩进行2次喷雾,使用后鼻症状立刻改善,但效果仅持续10分钟左右。另外,口罩被润湿,口周产生不适感,使用感差。
实施例3
按照下述的配方、制造方法制作棒状的口罩涂布用制剂。
(配方)
[表10]
(制造方法)
将上述表10的成分(A)以外的成分加热熔解,向其中加入成分(A),之后流入模具中进行冷却,成型为棒状。将其安装在图2所示的唇膏容器中,作为口罩涂布用制剂。
实施例4
将实施例3中制备的实施品2或3的口罩涂布用制剂(φ16mm;长度70mm)和无纺布制口罩交给具有花粉症的症状的受试者60名,在进行了涂布至口罩的外侧面的鼻腔周边来进行使用的说明后,使受试者自由使用。之后填写针对花粉症和花症状的主要症状的效果感受的调查表。将结果示于表11~表14。需要说明的是,表中上段的数值为该选项的回答人数,下段为该选项的回答人数在回答人数整体中所占的比例(%)。
将针对鼻涕的症状的效果的评价结果示于表11。
[表11]
将针对鼻塞的症状的效果的评价结果示于表12。
[表12]
将针对打喷嚏的症状的效果的评价结果示于表13。
[表13]
将对于花粉症的减轻效果整体的满意度的评价结果示于表14。
[表14]
如以上结果所示,本发明品对于鼻涕、鼻塞、打喷嚏之类的花粉症和鼻症状的主要症状具有改善效果。
制剂例1
棒剂:
按下述组成制备棒剂。
<配方>
制剂例2
棒剂:
按下述组成制备棒剂。
<配方>
制剂例3
棒剂:
按下述组成制备棒剂。
<配方>
制剂例4
软膏剂:
按下述的组成制备软膏剂。
<配方>
制剂例5
乳膏剂:
按照下述组成制备乳膏剂。
<配方>
工业实用性
本发明制剂为固态型或半固态型的形状,因此能够在佩戴口罩的状态下涂布药剂,并且能够由使用者自由地控制涂布至口罩的涂布量。
另外,与以往提供的制剂相比,具有效果持续的特征,进而不具有所浸渗的试剂从覆盖部渗出,润湿穿戴者的嘴角和鼻周而带来不适感、使皮肤粗糙的问题。
因此,本发明的制剂为涂布至口罩进行使用的新型制剂,不会给使用者带来不适感,能够长期发挥出用于降低过敏原活性、改善鼻、咽喉症状的挥发性有效成分的效果,非常便利。
Claims (12)
1.一种口罩涂布用制剂,其特征在于,其含有下述成分(A)至(D):
(A)挥发性有效成分
(B)蜡剂
(C)挥发调整剂
(D)固定性提高剂。
2.如权利要求1所述的口罩涂布用制剂,其中,成分(A)是以减轻过敏原、改善鼻症状或改善咽症状为目的的挥发性有效成分中的任一种。
3.如权利要求1或2所述的口罩涂布用制剂,其为棒状。
4.如权利要求3所述的口罩涂布用制剂,其是将棒状的制剂填充在上部能够使内容物进出的带有盖的容器中而成的。
5.如权利要求1~4中任一项所述的口罩涂布用制剂,其中,成分(A)的混配量为1质量%~20质量%,成分(B)的混配量为1质量%~30质量%,成分(C)的混配量为10质量%~50质量%,成分(D)的混配量为0.1质量%~30质量%。
6.如权利要求1~5中任一项所述的口罩涂布用制剂,其中,成分(A)的挥发性有效成分为l-薄荷醇、dl-樟脑、d-龙脑、母菊兰烯、萜品烯-4-醇、香叶醇、香茅醛、香叶醛、柠檬醛、扁柏酚、薄荷油、桉树油、罗汉柏油、肉桂油、佛手柑油、松节油、玫瑰油、来自茴香的精油、来自鼠尾草的精油、来自选自由柏科扁柏属、柏科柳杉属和松科冷杉属组成的组中的树木的精油。
7.如权利要求1~6中任一项所述的口罩涂布用制剂,其中,成分(A)的挥发性有效成分为下述成分(A-1)和(A-2)的组合:
(A-1)来自植物的精油,例如来自选自松科冷杉属、金松科金松属和柏科罗汉柏属中的树木的木质部和/或叶的精油;
(A-2)l-薄荷醇、dl-樟脑、d-龙脑、茴香、鼠尾草等的精油、薄荷油、桉树油、罗汉柏油、扁柏酚、肉桂油、佛手柑油、松节油、玫瑰油、来自茴香的精油或来自药用鼠尾草的精油。
8.如权利要求1~7中任一项所述的口罩涂布用制剂,其中,成分(C)为选自由植物油、脂肪酸酯、脂肪酸二醇、脂肪酸甘油酯、高级脂肪酸醇和烃油组成的组中的1种或2种以上。
9.如权利要求1~8中任一项所述的口罩涂布用制剂,其中,成分(D)为选自由液体石蜡、液体异链烷烃、聚丁烯、聚异丁烯、脂肪酸聚甘油酯、二亚油酸酯、松香、松香衍生物、异硬脂酸氢化蓖麻油、(PPG-7-琥珀酸)共聚物、(己基癸酸-癸二酸)二甘油基低聚酯、烯烃低聚物和硅油组成的组中的1种或2种以上。
10.一种挥发性有效成分的吸入方法,其特征在于,将权利要求1~9中任一项所述的口罩涂布用制剂涂布至口罩,将其应用至口鼻部。
11.如权利要求10所述的挥发性有效成分的吸入方法,其为了降低过敏原活性而进行。
12.如权利要求10所述的挥发性有效成分的吸入方法,其为了改善鼻症状而进行。
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