CN111819217A - 一种两亲性嵌段共聚物及其制备方法和纳米胶束载药系统 - Google Patents

一种两亲性嵌段共聚物及其制备方法和纳米胶束载药系统 Download PDF

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CN111819217A
CN111819217A CN201980013304.2A CN201980013304A CN111819217A CN 111819217 A CN111819217 A CN 111819217A CN 201980013304 A CN201980013304 A CN 201980013304A CN 111819217 A CN111819217 A CN 111819217A
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block copolymer
formula
amphiphilic block
linker
chain segment
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CN111819217B (zh
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张富尧
邵玉湘
李火明
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Shanghai biling Biotechnology Co.,Ltd.
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Selection Bioscience LLC
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Abstract

本发明涉及一种如式I所示的两亲性嵌段共聚物及其制备方法，以及该共聚物与难溶性药物形成的纳米胶束载药系统。该两亲性嵌段共聚物包括亲水性链段、疏水性链段以及用于连接亲水性链段和疏水性链段的连接子。连接子含有不饱和结构，可以增强难溶性药物与共聚物的相互作用，提高胶束的载药能力和稳定性。本发明还涉及了一种纳米载药胶束系统及其制备方法，以及该纳米载药胶束系统用于制备治疗肿瘤、炎症、糖尿病、中枢神经疾病、心血管疾病、精神疾病药物方面的用途。

Description

PCT国内申请，说明书已公开。

Claims (26)

  1. PCT国内申请，权利要求书已公开。
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