CN1117731A - 具有抑制精神病活性的芳香杂环化合物 - Google Patents

具有抑制精神病活性的芳香杂环化合物 Download PDF

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Publication number
CN1117731A
CN1117731A CN94191142A CN94191142A CN1117731A CN 1117731 A CN1117731 A CN 1117731A CN 94191142 A CN94191142 A CN 94191142A CN 94191142 A CN94191142 A CN 94191142A CN 1117731 A CN1117731 A CN 1117731A
Authority
CN
China
Prior art keywords
compound
benzisothiazole
butyl
piperazinyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN94191142A
Other languages
English (en)
Chinese (zh)
Inventor
M·H·诺曼
F·纳瓦斯三世
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of CN1117731A publication Critical patent/CN1117731A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN94191142A 1993-02-10 1994-02-10 具有抑制精神病活性的芳香杂环化合物 Pending CN1117731A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939302622A GB9302622D0 (en) 1993-02-10 1993-02-10 Heteroaromatic compounds
GB9302622.7 1993-02-10

Publications (1)

Publication Number Publication Date
CN1117731A true CN1117731A (zh) 1996-02-28

Family

ID=10730183

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94191142A Pending CN1117731A (zh) 1993-02-10 1994-02-10 具有抑制精神病活性的芳香杂环化合物

Country Status (15)

Country Link
EP (1) EP0683778A1 (cs)
JP (1) JPH08506337A (cs)
CN (1) CN1117731A (cs)
AU (1) AU6005194A (cs)
BG (1) BG99839A (cs)
CA (1) CA2155758A1 (cs)
CZ (1) CZ204495A3 (cs)
FI (1) FI953777A (cs)
GB (1) GB9302622D0 (cs)
HU (1) HUT73654A (cs)
IL (1) IL108601A0 (cs)
MX (1) MX9401080A (cs)
SK (1) SK99195A3 (cs)
WO (1) WO1994018196A1 (cs)
ZA (1) ZA94891B (cs)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776963A (en) 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
US5364866A (en) 1989-05-19 1994-11-15 Hoechst-Roussel Pharmaceuticals, Inc. Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
GB9420521D0 (en) * 1994-10-12 1994-11-30 Smithkline Beecham Plc Novel compounds
JP3274579B2 (ja) * 1995-01-12 2002-04-15 住友製薬株式会社 脳血管障害に伴う精神症候治療剤
ES2170177T3 (es) * 1995-03-17 2002-08-01 Aventis Pharma Inc Benzotienilpiperazinas sustituidas, su uso como medicamentos y procedimientos para su preparacion.
UA73981C2 (en) 2000-03-10 2005-10-17 Merck Patent Gmbh (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit
WO2002039988A2 (en) * 2000-11-14 2002-05-23 Merck Patent Gmbh Novel uses of combined selective dopamine d2 receptor antagonists and 5-ht1a receptor agonists
EP1361875A2 (en) * 2001-02-16 2003-11-19 Aventis Pharmaceuticals Inc. Novel heterocyclic amide derivatives and their use as dopamine d3 receptor ligands
HUP0402092A3 (en) 2001-07-26 2010-06-28 Merck Patent Gmbh Use of 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane and its physiologically acceptable salts for preparation of pharmaceutical compositions
GB0222909D0 (en) * 2002-10-03 2002-11-13 Astrazeneca Ab Novel process and intermediates
GB0222912D0 (en) 2002-10-03 2002-11-13 Astrazeneca Ab Novel process and intermediates
BRPI0511993A (pt) * 2004-07-20 2008-01-22 Siena Biotech Spa compostos moduladores de receptores de acetilcolina nicotìnicos alfa7, composições farmacêuticas e usos terapêuticos dos mesmos
TW200901974A (en) 2007-01-16 2009-01-16 Wyeth Corp Compounds, compositions, and methods of making and using them
US8981095B2 (en) 2011-07-28 2015-03-17 Mapi Pharma Ltd. Intermediate compounds and process for the preparation of lurasidone and salts thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0625181B2 (ja) * 1985-03-27 1994-04-06 住友製薬株式会社 新規なイミド誘導体
AU593194B2 (en) * 1986-09-26 1990-02-01 Sumitomo Pharmaceuticals Company, Limited Imide derivatives ,and their production and use
US5143923B1 (en) * 1991-04-29 1993-11-02 Hoechst-Roussel Pharmaceuticals Incorporated Benzoisothiazole-and benzisoxazole-3-carboxamides
MX9201991A (es) * 1991-05-02 1992-11-01 Jonh Wyeth & Brother Limited Derivados de piperazina y procedimiento para su preparacion.

Also Published As

Publication number Publication date
CA2155758A1 (en) 1994-08-18
JPH08506337A (ja) 1996-07-09
MX9401080A (es) 1994-08-31
SK99195A3 (en) 1995-12-06
IL108601A0 (en) 1994-05-30
CZ204495A3 (en) 1996-03-13
FI953777A0 (fi) 1995-08-09
AU6005194A (en) 1994-08-29
GB9302622D0 (en) 1993-03-24
HU9501881D0 (en) 1995-08-28
WO1994018196A1 (en) 1994-08-18
BG99839A (bg) 1996-02-28
ZA94891B (en) 1995-08-10
EP0683778A1 (en) 1995-11-29
FI953777A (fi) 1995-08-09
HUT73654A (en) 1996-09-30

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication