CN111615556A - 产生t细胞组合物的方法 - Google Patents
产生t细胞组合物的方法 Download PDFInfo
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- CN111615556A CN111615556A CN201880084187.4A CN201880084187A CN111615556A CN 111615556 A CN111615556 A CN 111615556A CN 201880084187 A CN201880084187 A CN 201880084187A CN 111615556 A CN111615556 A CN 111615556A
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K40/00—Cellular immunotherapy
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- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/421—Immunoglobulin superfamily
- A61K40/4211—CD19 or B4
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
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- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- C12N2501/20—Cytokines; Chemokines
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762580435P | 2017-11-01 | 2017-11-01 | |
| US62/580,435 | 2017-11-01 | ||
| US201762584687P | 2017-11-10 | 2017-11-10 | |
| US62/584,687 | 2017-11-10 | ||
| US201862699709P | 2018-07-17 | 2018-07-17 | |
| US62/699,709 | 2018-07-17 | ||
| US201862711494P | 2018-07-28 | 2018-07-28 | |
| US62/711,494 | 2018-07-28 | ||
| PCT/US2018/058812 WO2019090004A1 (en) | 2017-11-01 | 2018-11-01 | Process for producing a t cell composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111615556A true CN111615556A (zh) | 2020-09-01 |
Family
ID=64332414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880084187.4A Pending CN111615556A (zh) | 2017-11-01 | 2018-11-01 | 产生t细胞组合物的方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20210254000A1 (https=) |
| EP (1) | EP3704229B1 (https=) |
| JP (1) | JP7258899B2 (https=) |
| KR (1) | KR20200097253A (https=) |
| CN (1) | CN111615556A (https=) |
| AU (1) | AU2018360801A1 (https=) |
| BR (1) | BR112020008565A2 (https=) |
| CA (1) | CA3080509A1 (https=) |
| ES (1) | ES2971659T3 (https=) |
| IL (1) | IL274330A (https=) |
| MA (1) | MA50859A (https=) |
| MX (1) | MX2020004239A (https=) |
| SG (1) | SG11202003657VA (https=) |
| WO (1) | WO2019090004A1 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025002479A1 (zh) * | 2023-06-30 | 2025-01-02 | 中国科学院分子细胞科学卓越创新中心 | 一种基于胞内区截短体的嵌合抗原受体 |
| WO2025130722A1 (zh) * | 2023-12-21 | 2025-06-26 | 深圳普瑞金生物药业股份有限公司 | 靶向cd19和bcma的双特异性嵌合抗原受体 |
| WO2025237062A1 (zh) * | 2024-05-13 | 2025-11-20 | 深圳普瑞金生物药业股份有限公司 | 一种靶向cd19和cd22的嵌合抗原受体及其car-t细胞和应用 |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113474450A (zh) | 2018-08-09 | 2021-10-01 | 朱诺治疗学股份有限公司 | 产生工程化细胞的方法以及所述工程化细胞的组合物 |
| EP3874024A1 (en) | 2018-10-31 | 2021-09-08 | Juno Therapeutics GmbH | Methods for selection and stimulation of cells and apparatus for same |
| AU2019375997A1 (en) * | 2018-11-08 | 2021-06-03 | Neximmune, Inc. | T cell compositions with improved phenotypic properties |
| AU2019379815A1 (en) * | 2018-11-16 | 2021-06-03 | Rapa Therapeutics, Llc | Methods for treating cancer with manufactured T cells |
| AU2020232691B2 (en) | 2019-03-05 | 2023-06-29 | Nkarta, Inc. | CD19-directed chimeric antigen receptors and uses thereof in immunotherapy |
| CN113203718B (zh) * | 2021-05-13 | 2022-05-31 | 桂林电子科技大学 | 一种基于荧光共振能量转移的gpc3检测方法 |
| KR102733064B1 (ko) * | 2022-10-17 | 2024-11-21 | 주식회사 이뮤니스바이오 | Treg 세포 분화 및 활성화를 이용한 IBD치료용 약제학적 조성물 |
| WO2025051339A1 (en) | 2023-09-05 | 2025-03-13 | Tiber Biotech Srl | SINGLE-CHAIN VARIABLE FRAGMENT AND MOLECULES DERIVING THEREFROM THAT BIND FRAGMENT TRVB5-1 OF THE β CHAIN OF HUMAN T-CELL RECEPTOR |
| WO2025096493A1 (en) * | 2023-11-01 | 2025-05-08 | Memorial Sloan-Kettering Cancer Center | Biomarkers and uses thereof for treatment of cancer with cd19-targeted adoptive cell therapies |
| CN119055654B (zh) * | 2024-07-23 | 2025-09-09 | 湖北工业大学 | Voxtalisib在制备抗ADV7病毒药物中的应用 |
| WO2026074188A1 (en) * | 2024-10-03 | 2026-04-09 | Mpc Therapeutics Sa | Use of an mpc inhibitor during in-vitro cell culture |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130102613A1 (en) * | 2011-10-19 | 2013-04-25 | Signal Pharmaceuticals, Llc | Treatment of cancer with tor kinase inhibitors |
| US20130225518A1 (en) * | 2012-02-24 | 2013-08-29 | Signal Pharmaceuticals, Llc | Methods for treating cancer using tor kinase inhibitor combination therapy |
| WO2015188119A1 (en) * | 2014-06-06 | 2015-12-10 | Bluebird Bio, Inc. | Improved t cell compositions |
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- 2018-11-01 CN CN201880084187.4A patent/CN111615556A/zh active Pending
- 2018-11-01 MA MA050859A patent/MA50859A/fr unknown
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- 2018-11-01 JP JP2020543739A patent/JP7258899B2/ja active Active
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- 2018-11-01 US US16/760,873 patent/US20210254000A1/en not_active Abandoned
- 2018-11-01 WO PCT/US2018/058812 patent/WO2019090004A1/en not_active Ceased
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| WO2025237062A1 (zh) * | 2024-05-13 | 2025-11-20 | 深圳普瑞金生物药业股份有限公司 | 一种靶向cd19和cd22的嵌合抗原受体及其car-t细胞和应用 |
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| SG11202003657VA (en) | 2020-05-28 |
| AU2018360801A1 (en) | 2020-05-14 |
| JP2021501607A (ja) | 2021-01-21 |
| WO2019090004A1 (en) | 2019-05-09 |
| ES2971659T3 (es) | 2024-06-06 |
| CA3080509A1 (en) | 2019-05-09 |
| EP3704229B1 (en) | 2023-12-20 |
| US20210254000A1 (en) | 2021-08-19 |
| MX2020004239A (es) | 2020-09-09 |
| MA50859A (fr) | 2020-09-09 |
| JP7258899B2 (ja) | 2023-04-17 |
| KR20200097253A (ko) | 2020-08-18 |
| BR112020008565A2 (pt) | 2020-10-20 |
| IL274330A (en) | 2020-06-30 |
| EP3704229A1 (en) | 2020-09-09 |
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