CN111514064A - Penicillin bottle freeze-dried mask and preparation method thereof - Google Patents
Penicillin bottle freeze-dried mask and preparation method thereof Download PDFInfo
- Publication number
- CN111514064A CN111514064A CN202010374782.0A CN202010374782A CN111514064A CN 111514064 A CN111514064 A CN 111514064A CN 202010374782 A CN202010374782 A CN 202010374782A CN 111514064 A CN111514064 A CN 111514064A
- Authority
- CN
- China
- Prior art keywords
- freeze
- parts
- dried
- mask
- penicillin bottle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229930182555 Penicillin Natural products 0.000 title claims abstract description 42
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 title claims abstract description 42
- 229940049954 penicillin Drugs 0.000 title claims abstract description 42
- 238000002360 preparation method Methods 0.000 title claims description 23
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 44
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 35
- 239000002904 solvent Substances 0.000 claims abstract description 34
- 239000008367 deionised water Substances 0.000 claims abstract description 32
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 32
- 239000002994 raw material Substances 0.000 claims abstract description 27
- SCVVSSZVLZQUDZ-UHFFFAOYSA-N 3-methyl-2,6-dihydro-1H-pyrimidine-2-carboxylic acid Chemical compound CN1C(NCC=C1)C(=O)O SCVVSSZVLZQUDZ-UHFFFAOYSA-N 0.000 claims abstract description 25
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims abstract description 24
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims abstract description 24
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims abstract description 24
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 22
- 229930195725 Mannitol Natural products 0.000 claims abstract description 22
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims abstract description 22
- 239000000594 mannitol Substances 0.000 claims abstract description 22
- 235000010355 mannitol Nutrition 0.000 claims abstract description 22
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims abstract description 22
- 235000019799 monosodium phosphate Nutrition 0.000 claims abstract description 22
- 239000011780 sodium chloride Substances 0.000 claims abstract description 22
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims abstract description 22
- 239000004744 fabric Substances 0.000 claims abstract description 21
- 239000012528 membrane Substances 0.000 claims abstract description 19
- 238000004108 freeze drying Methods 0.000 claims abstract description 18
- MVORZMQFXBLMHM-QWRGUYRKSA-N Gly-His-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)CN)CC1=CN=CN1 MVORZMQFXBLMHM-QWRGUYRKSA-N 0.000 claims abstract description 11
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims abstract description 8
- 239000000843 powder Substances 0.000 claims abstract description 6
- 238000003756 stirring Methods 0.000 claims description 28
- 238000011049 filling Methods 0.000 claims description 22
- 238000001816 cooling Methods 0.000 claims description 16
- 239000000243 solution Substances 0.000 claims description 16
- 230000001815 facial effect Effects 0.000 claims description 15
- 238000010438 heat treatment Methods 0.000 claims description 15
- 239000003906 humectant Substances 0.000 claims description 15
- 229920001503 Glucan Polymers 0.000 claims description 13
- 108010020346 Polyglutamic Acid Proteins 0.000 claims description 13
- 238000001914 filtration Methods 0.000 claims description 13
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 claims description 13
- 229920002643 polyglutamic acid Polymers 0.000 claims description 13
- 230000002829 reductive effect Effects 0.000 claims description 13
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 12
- 239000011259 mixed solution Substances 0.000 claims description 12
- 238000001035 drying Methods 0.000 claims description 11
- 238000005303 weighing Methods 0.000 claims description 11
- 241000530268 Lycaena heteronea Species 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 9
- 229920000433 Lyocell Polymers 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 7
- 238000007710 freezing Methods 0.000 claims description 6
- 229960003966 nicotinamide Drugs 0.000 claims description 6
- 235000005152 nicotinamide Nutrition 0.000 claims description 6
- 239000011570 nicotinamide Substances 0.000 claims description 6
- 238000003825 pressing Methods 0.000 claims description 6
- 238000005096 rolling process Methods 0.000 claims description 6
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 5
- 238000003795 desorption Methods 0.000 claims description 5
- 230000001804 emulsifying effect Effects 0.000 claims description 5
- 230000008014 freezing Effects 0.000 claims description 5
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 5
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical group [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 5
- 230000001954 sterilising effect Effects 0.000 claims description 5
- 238000002061 vacuum sublimation Methods 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 21
- 230000037394 skin elasticity Effects 0.000 abstract description 18
- 239000004480 active ingredient Substances 0.000 abstract description 4
- 230000002035 prolonged effect Effects 0.000 abstract description 2
- 230000003313 weakening effect Effects 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 24
- 238000012360 testing method Methods 0.000 description 22
- 230000037303 wrinkles Effects 0.000 description 9
- 239000002537 cosmetic Substances 0.000 description 7
- JGSARLDLIJGVTE-UHFFFAOYSA-N 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Chemical compound O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-UHFFFAOYSA-N 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 102000008186 Collagen Human genes 0.000 description 4
- 108010035532 Collagen Proteins 0.000 description 4
- 229920001436 collagen Polymers 0.000 description 4
- 238000003384 imaging method Methods 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 230000003020 moisturizing effect Effects 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 230000003712 anti-aging effect Effects 0.000 description 3
- 230000002421 anti-septic effect Effects 0.000 description 3
- 238000005562 fading Methods 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 230000004224 protection Effects 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
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- 239000000686 essence Substances 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
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- 238000001556 precipitation Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
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- 230000004936 stimulating effect Effects 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 230000036572 transepidermal water loss Effects 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 206010051246 Photodermatosis Diseases 0.000 description 1
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- 208000027418 Wounds and injury Diseases 0.000 description 1
- 229940124532 absorption promoter Drugs 0.000 description 1
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- 230000001153 anti-wrinkle effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
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- 230000032798 delamination Effects 0.000 description 1
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- 229920000768 polyamine Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical group 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
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- 238000004321 preservation Methods 0.000 description 1
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- 238000009777 vacuum freeze-drying Methods 0.000 description 1
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- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
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- A—HUMAN NECESSITIES
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/88—Two- or multipart kits
- A61K2800/882—Mixing prior to application
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention discloses a penicillin bottle freeze-dried mask which consists of a freeze-dried part and a solvent part; the freeze-dried powder part is prepared from the following raw materials in parts by weight: 85-100 parts of deionized water, 2-6 parts of mannitol, 0.5-2 parts of nicotinamide, 0.6-1.8 parts of NB835, 0.6-1.2 parts of trehalose, 0.2-0.6 part of copper peptide, 0.15-0.25 part of disodium hydrogen phosphate, 0.08-0.18 part of sodium chloride, 0.05-0.15 part of tetrahydro-methylpyrimidine carboxylic acid and 0.05-0.15 part of sodium dihydrogen phosphate. The penicillin bottle freeze-dried mask is stored and packaged by the penicillin bottles, so that active ingredients can be effectively protected, the stability of the freeze-dried mask can be improved, and the shelf life can be prolonged; the gel has excellent effects of weakening fine lines, increasing skin elasticity and tightening skin, and when in use, the solvent part is poured into the freeze-drying part to be fully and uniformly absorbed by the membrane cloth, so that the gel can be used.
Description
Technical Field
The invention relates to the technical field of cosmetic masks, and particularly relates to a penicillin bottle freeze-dried mask and a preparation method thereof.
Background
Nowadays, active substances from organisms, especially functional skin care products, are widely used in cosmetics, and the active substances have strong activity, are not high temperature resistant, are easy to oxidize or hydrolyze and deteriorate, and lose activity, such as proteins, vitamins, polyphenols and the like. Traditional dosage forms such as creams, emulsions, essences and the like have large water content and are not suitable for storing active ingredients, so that the phenomena of discoloration, delamination, precipitation and the like are common, the components are unavailable or have greatly reduced functions or even lose valuable properties, and the freeze-drying technology is very necessary for storing the components.
The traditional freeze drying technology in the field of medicine is developed, upgraded and applied to the field of cosmetics. The freeze drying technology is based on a patent formula and a vacuum freeze drying process, the effective components are stored in a solid matrix by means of overspeed deep-freezing sublimation drying, and the penicillin bottles are used for vacuum packaging, so that the activity and the stability of the effective components are perfectly combined. The dormant dry cosmetics can be preserved for a long time under the condition of no corrosion resistance, and are also a good innovation in the field of no-additive cosmetics.
Traditional facial mask all is in the aluminium-plastic bag that contains facial mask cloth with facial mask essence filling, then sealed with it, tears the sealed bag again during the use and takes out, all is in the liquid state from production to use, for long-term the preservation, can add the antiseptic in the solution, some actives are unstable to heat simultaneously, easy oxidation, easy degradation, lead to depositing for a long time can make the efficiency reduce, and antiseptic has the irritability to people's skin simultaneously.
Disclosure of Invention
The freeze-dried facial mask adopts penicillin bottles for storage and packaging, active ingredients can be effectively protected, and the freeze-dried facial mask has excellent effects of fading fine wrinkles, increasing skin elasticity and tightening skin.
The invention adopts the following technical scheme for solving the technical problems:
a penicillin bottle freeze-dried mask which consists of a freeze-dried part and a solvent part; the freeze-dried powder part is prepared from the following raw materials in parts by weight: 85-100 parts of deionized water, 2-6 parts of mannitol, 0.5-2 parts of nicotinamide, 0.6-1.8 parts of NB835, 0.6-1.2 parts of trehalose, 0.2-0.6 part of copper peptide, 0.15-0.25 part of disodium hydrogen phosphate, 0.08-0.18 part of sodium chloride, 0.05-0.15 part of tetrahydro-methylpyrimidine carboxylic acid and 0.05-0.15 part of sodium dihydrogen phosphate.
As a most preferred scheme, the freeze-drying part is prepared from the following raw materials in parts by weight: 92.2 parts of deionized water, 4 parts of mannitol, 1 part of nicotinamide, 1 part of NB835, 0.9 part of trehalose, 0.4 part of blueish peptide, 0.18 part of disodium hydrogen phosphate, 0.12 part of sodium chloride, 0.1 part of tetrahydro-methylpyrimidine carboxylic acid and 0.1 part of sodium dihydrogen phosphate.
As a preferable scheme, the solvent part is prepared from the following raw materials in parts by weight: 90-100 parts of deionized water, 0.04-0.06 part of humectant, 0.03-0.05 part of polyglutamic acid, 0.8-1.2 parts of oat glucan and 0.4-0.8 part of hexanediol.
As a most preferred scheme, the solvent part is prepared from the following raw materials in parts by weight: 98.3 parts of deionized water, 0.05 part of humectant, 0.05 part of polyglutamic acid, 1 part of oat glucan and 0.6 part of hexanediol.
Preferably, the humectant is sodium hyaluronate.
The invention also provides a preparation method of the penicillin bottle freeze-dried mask, which comprises the preparation of a freeze-dried part and the preparation of a solvent part;
the preparation method of the freeze-dried part comprises the following steps:
s1: weighing the raw materials according to the proportion, putting mannitol, trehalose, sodium chloride, disodium hydrogen phosphate, sodium dihydrogen phosphate, tetrahydro-methylpyrimidine carboxylic acid and deionized water into stirring equipment, and stirring for 8-12 min at the rotating speed of 550-650 r/min to uniformly mix the mannitol, the trehalose, the sodium chloride, the disodium hydrogen phosphate, the sodium dihydrogen phosphate, the tetrahydro-methylpyrimidine carboxylic acid and the deionized water;
s2: sterilizing the mixed solution at 115-125 ℃ for 25-35 min;
s3: cooling, adding the blue copper peptide, the nicotinamide and the NB835, and stirring at the rotating speed of 550-650 r/min for 8-12 min to uniformly mix;
s4: filtering the mixed solution by using a 0.18-0.24 um microporous filter membrane, and storing in an aseptic sealed container to obtain a freeze-dried mask solution;
s5: rolling the membrane cloth into a strip shape, placing the strip shape into a sterile-processed penicillin bottle, and filling 6-10 g of freeze-dried membrane solution;
s6: putting the filled penicillin bottle into a vacuum freeze dryer, cooling to minus 45 to minus 40 ℃, preserving heat for 4 to 8 hours, and performing pre-freezing operation; heating to-10-0 ℃, preserving heat for 10-15 h, and carrying out vacuum sublimation drying; finally, heating to 40-45 ℃, preserving heat for 4-8 hours, and performing desorption drying to complete freeze drying;
s7: and (5) pressing the plug in a vacuum state, and taking out of the box to finish the production steps of the freeze-drying part.
As a most preferred solution, the membrane cloth is dupont 417 tencel membrane cloth.
Preferably, the temperature in the step S3 is reduced to 35-45 ℃.
As a preferred scheme, the preparation method of the solvent part comprises the following steps:
(1) weighing the raw materials according to the proportion, putting deionized water, a humectant, polyglutamic acid and oat glucan into an emulsifying pot, heating to 80-90 ℃, uniformly stirring at the rotating speed of 650-750 r/min, and keeping the temperature for 18-22 min;
(2) cooling to 40-45 ℃, adding hexanediol, uniformly stirring at the rotating speed of 650-750 r/min, and filtering;
(3) and filling the qualified solvent liquid into an aseptically processed blank penicillin bottle, wherein the filling amount is 18-22 g.
As a preferable scheme, the filter cloth for filtering is 450-550 meshes.
Mannitol: mannitol is a white acicular crystalline powder. Odorless, refreshing and sweet, and has effects in inhibiting light injury and photoaging to skin, and keeping moisture.
Trehalose: trehalose is a natural sugar, is present in a plurality of plants, forms a layer of glassy matrix when the plants are dried, protects the internal structure of the plants, and can surprisingly start to die and regenerate until rainwater comes; a large number of researches and practices show that the trehalose can effectively protect the epidermal cell membrane structure, activate cells, condition the skin and enable the skin to be healthy, natural and elastic. The epidermal cells are easy to lose moisture under the environments of high temperature, high cold, dryness, strong ultraviolet radiation and the like to damage the skin, and the trehalose can form a special protective film on the surface layer of the cells under the condition, so that the original nutrition and moisture of the skin are kept, the skin sunburn and melanin precipitation are avoided, and the skin aging phenomenon is effectively resisted; the mucus precipitated from the membrane can mildly moisten skin, and make skin bright, glossy and tender.
Sodium chloride: the sodium chloride has astringent and skin firming effects, and can stabilize formula system.
Disodium hydrogen phosphate: it is used with sodium dihydrogen phosphate, acting as a PH buffer.
Sodium dihydrogen phosphate: it is used with disodium hydrogen phosphate to act as a PH buffer.
Blue copper peptide: the function is as follows: 1) restoring the skin repairing ability, increasing the production of intercellular adhesions of the skin, and reducing the skin damage; 2) stimulating the formation of glucose polyamine, increasing the thickness of the skin, reducing the looseness of the skin and compacting the skin; 3) stimulating the formation of collagen and elastin, firming skin and reducing fine lines; 4) the auxiliary antioxidant enzyme SOD has strong and powerful free radical resisting function; 5) promoting blood vessel proliferation, and increasing oxygen supply to skin.
Tetrahydro-methyl-pyrimidine-carboxylic acid: the tetrahydro-methyl pyrimidine carboxylic acid has the functions of protection, prevention, repair, regeneration and the like. Its excellent stability and protection brings about a visible and long-term anti-ageing effect on our skin. Clinical studies have shown that continued exserotonergic decreases TEWL (transepidermal water loss), increases hydration, and retains skin water for 7 days without repeated use.
Sodium hyaluronate: sodium hyaluronate is an acidic mucopolysaccharide, has a special water retention effect, has more than 500 times of water carried by hyaluronic molecules, is a substance which is found to have the best moisture retention in nature at present, is an ideal natural moisture retention factor, is a good transdermal absorption promoter, and can play a role in promoting nutrient absorption when being matched with other nutrient components.
Polyglutamic acid: it is a water-soluble, biodegradable, non-toxic biopolymer produced by microbial fermentation. The molecular weight is more than 70 ten thousands, the special molecular structure ensures that the cosmetic has extremely strong moisturizing capability, can effectively increase the moisturizing capability of the skin and promote the health of the skin, and the super-strong moisturizing capability of the cosmetic is better than hyaluronic acid and collagen and is a new-generation biological technology moisturizing component; has long-lasting anti-wrinkle performance as a whitening agent and has more advantages than other polymer commodities.
Oat glucan: the collagen-containing anti-aging cream has an excellent anti-aging effect, can smooth fine wrinkles, improve skin elasticity and skin texture, has a unique linear chain molecular structure, is endowed with good transdermal absorption performance, promotes fibroblasts to synthesize collagen, promotes wound healing, repairs damaged skin, and gives the skin a silky moist and smooth touch feeling.
Hexanediol: it is a polyol with enhanced preservative effect.
The invention has the beneficial effects that: (1) the penicillin bottle freeze-dried mask disclosed by the invention is stored and packaged by the penicillin bottles, so that active ingredients can be effectively protected, the stability of the freeze-dried mask can be improved, and the shelf life can be prolonged; (2) the freeze-dried mask disclosed by the invention has excellent effects of fading fine lines, increasing skin elasticity and tightening skin, wherein the effects of fading fine lines, increasing skin elasticity and tightening skin can be remarkably improved by the aid of the bluecopper peptide and the tetrahydro-methyl pyrimidine carboxylic acid in the formula, and the freeze-dried mask has a synergistic effect; (3) when the freeze-dried facial mask is used, the solvent part is poured into the freeze-dried part, so that the solvent part is fully and uniformly absorbed by the mask cloth, and the freeze-dried facial mask can be used; (4) the freeze-dried mask disclosed by the invention adopts an advanced freeze-drying technology, so that the activity of the raw materials is greatly preserved, and meanwhile, the freeze-dried mask adopts non-antiseptic addition, so that the irritation is reduced, and the freeze-dried mask belongs to a green and healthy product.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are a part of the embodiments of the present invention, but not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The lyophilized part of the penicillin bottle mask is prepared from the following raw materials in parts by weight: 92.2 parts of deionized water, 4 parts of mannitol, 1 part of nicotinamide, 1 part of NB835, 0.9 part of trehalose, 0.4 part of blueish peptide, 0.18 part of disodium hydrogen phosphate, 0.12 part of sodium chloride, 0.1 part of tetrahydro-methylpyrimidine carboxylic acid and 0.1 part of sodium dihydrogen phosphate.
The NB835 is available from cantonese biotechnology, guangzhou.
The solvent part is prepared from the following raw materials in parts by weight: 98.3 parts of deionized water, 0.05 part of humectant, 0.05 part of polyglutamic acid, 1 part of oat glucan and 0.6 part of hexanediol.
The humectant is sodium hyaluronate.
The preparation method of the penicillin bottle freeze-dried mask comprises the steps of preparing a freeze-dried part and preparing a solvent part;
the preparation method of the freeze-dried part comprises the following steps:
s1: weighing the raw materials according to the proportion, putting mannitol, trehalose, sodium chloride, disodium hydrogen phosphate, sodium dihydrogen phosphate, tetrahydro-methylpyrimidine carboxylic acid and deionized water into stirring equipment, and stirring for 10min at the rotating speed of 600r/min to uniformly mix the mannitol, the trehalose, the sodium chloride, the disodium hydrogen phosphate, the sodium dihydrogen phosphate, the tetrahydro-methylpyrimidine carboxylic acid and the deionized water;
s2: sterilizing the mixed solution at 121 deg.C under high pressure for 30 min;
s3: cooling to 40 deg.C, adding blue copper peptide, nicotinamide and NB835, stirring at 600r/min for 10min, and mixing;
s4: filtering the mixed solution with a 0.22um microporous filter membrane, and storing in a sterile sealed container to obtain a freeze-dried mask solution;
s5: rolling DuPont 417 tencel mask cloth into strips, placing into sterile-processed penicillin bottles, and filling into lyophilized mask solution with a filling amount of 8 g;
s6: putting the filled penicillin bottle into a vacuum freeze dryer, cooling to-42 ℃, preserving heat for 6 hours, and performing pre-freezing operation; heating to-10-0 ℃, preserving heat for 12 hours, and carrying out vacuum sublimation drying; finally, heating to 40-45 ℃, preserving heat for 6 hours, and performing desorption drying to complete freeze drying;
s7: and (5) pressing the plug in a vacuum state, and taking out of the box to finish the production steps of the freeze-drying part.
The preparation method of the solvent part comprises the following steps:
(1) weighing the raw materials according to the proportion, putting deionized water, humectant, polyglutamic acid and oat glucan into an emulsifying pot, heating to 85 ℃, uniformly stirring at the rotating speed of 700r/min, and keeping the temperature for 20 min;
(2) cooling to 45 deg.C, adding hexanediol, stirring at 700r/min, and filtering with 500 mesh filter cloth;
(3) and filling the qualified solvent liquid into an aseptically processed blank penicillin bottle, wherein the filling amount is 20 g.
Example 2
The difference between the example 2 and the example 1 is that the freeze-dried part and the solvent part of the penicillin bottle freeze-dried mask are different in proportion, and the rest parts are the same.
A penicillin bottle freeze-dried mask which consists of a freeze-dried part and a solvent part; the freeze-dried powder part is prepared from the following raw materials in parts by weight: 85 parts of deionized water, 2 parts of mannitol, 0.5 part of nicotinamide, 0.6 part of NB835, 0.6 part of trehalose, 0.2 part of bluecopper peptide, 0.15 part of disodium hydrogen phosphate, 0.08 part of sodium chloride, 0.05 part of tetrahydro-methylpyrimidine carboxylic acid and 0.05 part of sodium dihydrogen phosphate.
The solvent part is prepared from the following raw materials in parts by weight: 90 parts of deionized water, 0.04 part of humectant, 0.03 part of polyglutamic acid, 0.8 part of oat glucan and 0.4 part of hexanediol.
Example 3
Example 3 is different from example 1 in that the ratio of the freeze-dried part and the solvent part of the penicillin bottle freeze-dried mask is different, and the rest is the same.
A penicillin bottle freeze-dried mask which consists of a freeze-dried part and a solvent part; the freeze-dried powder part is prepared from the following raw materials in parts by weight: 100 parts of deionized water, 6 parts of mannitol, 2 parts of nicotinamide, 1.8 parts of NB835, 1.2 parts of trehalose, 0.6 part of blueish peptide, 0.25 part of disodium hydrogen phosphate, 0.18 part of sodium chloride, 0.15 part of tetrahydro-methylpyrimidine carboxylic acid and 0.15 part of sodium dihydrogen phosphate.
The solvent part is prepared from the following raw materials in parts by weight: 100 parts of deionized water, 0.06 part of humectant, 0.05 part of polyglutamic acid, 1.2 parts of oat glucan and 0.8 part of hexanediol.
Example 4
Example 4 differs from example 1 in the preparation method of the lyophilized fraction and the vehicle fraction, and is otherwise the same.
The preparation method of the freeze-dried part comprises the following steps:
s1: weighing the raw materials according to the proportion, putting mannitol, trehalose, sodium chloride, disodium hydrogen phosphate, sodium dihydrogen phosphate, tetrahydro-methylpyrimidine carboxylic acid and deionized water into a stirring device, and stirring for 8min at the rotating speed of 550r/min to uniformly mix the mannitol, the trehalose, the sodium chloride, the disodium hydrogen phosphate, the sodium dihydrogen phosphate, the tetrahydro-methylpyrimidine carboxylic acid and the deionized water;
s2: autoclaving the mixed solution at 115 deg.C for 25 min;
s3: cooling to 35 deg.C, adding blue copper peptide, nicotinamide and NB835, stirring at 550r/min for 8min, and mixing;
s4: filtering the mixed solution by using a 0.18um microporous filter membrane, and storing in a sterile sealed container to obtain a freeze-dried mask solution;
s5: rolling DuPont 417 Tencel mask cloth into strips, placing into sterile-processed penicillin bottles, and filling lyophilized mask solution with a filling amount of 6 g;
s6: putting the filled penicillin bottle into a vacuum freeze dryer, cooling to-45 ℃, preserving heat for 4 hours, and performing pre-freezing operation; heating to-10 deg.C, maintaining the temperature for 10h, and vacuum sublimation drying; finally, heating to 40 ℃, preserving heat for 4 hours, and performing desorption drying to finish freeze drying;
s7: and (5) pressing the plug in a vacuum state, and taking out of the box to finish the production steps of the freeze-drying part.
The preparation method of the solvent part comprises the following steps:
(1) weighing the raw materials according to the proportion, putting deionized water, humectant, polyglutamic acid and oat glucan into an emulsifying pot, heating to 80 ℃, uniformly stirring at the rotating speed of 650r/min, and keeping the temperature for 18 min;
(2) cooling to 40 deg.C, adding hexanediol, stirring at 650r/min, and filtering with 450 mesh filter cloth;
(3) and filling the qualified solvent liquid into an aseptically processed blank penicillin bottle, wherein the filling amount is 18 g.
Example 5
Example 5 differs from example 1 in the preparation method of the lyophilized fraction and the vehicle fraction, and is otherwise the same.
The preparation method of the freeze-dried part comprises the following steps:
s1: weighing raw materials according to a ratio, placing mannitol, trehalose, sodium chloride, disodium hydrogen phosphate, sodium dihydrogen phosphate, tetrahydro-methylpyrimidine carboxylic acid and deionized water in a stirring device, and stirring at a rotation speed of 650r/min for 12min to uniformly mix the mannitol, the trehalose, the sodium chloride, the disodium hydrogen phosphate, the sodium dihydrogen phosphate, the tetrahydro-methylpyrimidine carboxylic acid and the deionized water;
s2: sterilizing the mixed solution at 125 deg.C for 35 min;
s3: cooling to 45 deg.C, adding blue copper peptide, nicotinamide and NB835, stirring at 650r/min for 12min, and mixing;
s4: filtering the mixed solution by using a 0.24um microporous filter membrane, and storing in an aseptic sealed container to obtain a freeze-dried mask solution;
s5: rolling DuPont 417 Tencel mask cloth into strips, placing into sterile-processed penicillin bottles, and filling into lyophilized mask solution with a filling amount of 10 g;
s6: putting the filled penicillin bottle into a vacuum freeze dryer, cooling to-40 ℃, preserving heat for 8 hours, and performing pre-freezing operation; heating to 0 ℃, preserving heat for 15h, and carrying out vacuum sublimation drying; finally, heating to 45 ℃, preserving heat for 8 hours, and performing desorption drying to finish freeze drying;
s7: and (5) pressing the plug in a vacuum state, and taking out of the box to finish the production steps of the freeze-drying part.
The membrane cloth is DuPont 417 tencel membrane cloth.
The preparation method of the solvent part comprises the following steps:
(1) weighing the raw materials according to the proportion, putting deionized water, humectant, polyglutamic acid and oat glucan into an emulsifying pot, heating to 90 ℃, uniformly stirring at the rotating speed of 750r/min, and keeping the temperature for 22 min;
(2) cooling to 45 deg.C, adding hexanediol, stirring at 750r/min, and filtering with 550 mesh filter cloth;
(3) and filling the qualified solvent liquid into an aseptically processed blank penicillin bottle, wherein the filling amount is 18-22 g.
Comparative example 1
The difference between the comparative example 1 and the example 1 is that the lyophilized part and the solvent part are directly compounded together to form the mask liquid in the comparative example 1, and the mask liquid is filled into an aluminum plastic bag containing DuPont 417 Tencel film cloth, and the rest is the same.
Comparative example 2
Comparative example 2 differs from example 1 in that comparative example 2 was stored without vial filling and with a correspondingly sized brown jar, all other things being equal.
Comparative example 3
Comparative example 3 differs from example 1 in that comparative example 3 does not contain a blue copper peptide, and is otherwise the same.
Comparative example 4
Comparative example 4 differs from example 1 in that comparative example 4 does not contain tetrahydro-methyl-pyrimidine-carboxylic acid, all other things being equal.
Comparative example 5
Comparative example 5 differs from example 1 in that comparative example 5 does not contain the bluepatin peptide, the tetrahydro-methyl pyrimidine carboxylic acid, and is otherwise identical.
Comparative example 6
Comparative example 6 is different from example 1 in that the lyophilized portion was prepared in a different manner, i.e., without the step of S6 described in example, but otherwise the same.
S1: weighing the raw materials according to the proportion, putting mannitol, trehalose, sodium chloride, disodium hydrogen phosphate, sodium dihydrogen phosphate, tetrahydro-methylpyrimidine carboxylic acid and deionized water into stirring equipment, and stirring for 10min at the rotating speed of 600r/min to uniformly mix the mannitol, the trehalose, the sodium chloride, the disodium hydrogen phosphate, the sodium dihydrogen phosphate, the tetrahydro-methylpyrimidine carboxylic acid and the deionized water;
s2: sterilizing the mixed solution at 121 deg.C under high pressure for 30 min;
s3: cooling to 40 deg.C, adding blue copper peptide, nicotinamide and NB835, stirring at 600r/min for 10min, and mixing;
s4: filtering the mixed solution with a 0.22um microporous filter membrane, and storing in a sterile sealed container to obtain a freeze-dried mask solution;
s5: rolling DuPont 417 tencel mask cloth into strips, placing into sterile-processed penicillin bottles, and filling into lyophilized mask solution with a filling amount of 8 g;
s6: and (5) pressing the plug in a vacuum state, and taking out of the box to finish the production steps of the freeze-drying part.
To further demonstrate the effect of the present invention, the following test methods were provided:
experimental methods
Testing an instrument: CCD test sensor, skin elasticity tester MPA580, sine stripe projector, and skin rapid three-dimensional imaging system.
Skin rapid three-dimensional imaging system: the digital optical three-dimensional image analysis instrument is developed on the basis of a digital microscopic stripe projector. The stripe light with sinusoidal density is projected to the skin or surface of the object under test. Due to the uneven height of the skin or the surface of the object to be measured, the stripe light is bent and deformed, and a CCD camera placed at a specific angle records the change at the same time. By measuring the position change of the stripe light and the grey values of all image points, a digital three-dimensional image of the entire test skin surface or test object can be obtained.
Skin elasticity tester MPA 580: the test principle is based on the principle of suction and stretching, where a negative pressure is generated on the skin surface to be tested to suck the skin into a specific test probe, and the depth of the skin sucked into the test probe is measured by a non-contact optical test system. The test probe includes a transmitter and receiver of light, the ratio of which (the ratio of the transmitted light to the received light) is proportional to the depth of the skin into which it is sucked, and then analyzed by MPA software to determine the elastic properties of the skin.
The test method comprises the following steps: 110 tested volunteers (age 35-55 years) are selected and divided into 11 groups, 10 persons in each group are basically half of men and women, the test part is a whole face, the penicillin bottle freeze-dried mask disclosed by the invention is respectively used in examples 1-5 and comparative examples 1-6, and the test time is 21 days. Volunteers were asked twice a day and data were analyzed before and after the test, respectively.
Uniformly smearing a small amount of test samples on a test part of a tested volunteer, irradiating the test part by using a sine stripe projector after a certain time, collecting three-dimensional image data of the test part by using a CCD (charge coupled device) test sensor, and processing the data by using a skin rapid three-dimensional imaging system PRIMOS lite to obtain an experimental result.
Skin fast three-dimensional imaging system PRIMOS lite data processing: the CCD test sensor is used for collecting original three-dimensional image data.
And screening the region with concentrated filter expression lines, and measuring the surface area, volume and depth of the wrinkles.
And comparing the image data matched with the same sample, and calculating the wrinkle shrinkage rate by using an Overlay ghost image overlapping test method.
Skin elasticity test data processing results: the skin elasticity parameters and curves are automatically obtained, data and personnel detailed data are recorded and integrated, the skin elasticity parameters are calculated, the test result is shown in table 1, and the closer the skin stretching amount is to 1, the better the skin elasticity is.
TABLE 1 Fine grain shrinkage test results
As can be seen from table 1, the cillin bottle freeze-dried facial mask provided by the invention has excellent effects of reducing fine wrinkles, increasing skin elasticity and tightening skin, wherein example 1 is the best implementation mode, comparative examples 1 to 3 show that when the proportion of the freeze-dried part and the solvent part of the cillin bottle freeze-dried facial mask is different, the effects of reducing fine wrinkles, increasing skin elasticity and tightening skin of the cillin bottle freeze-dried facial mask are reduced, and comparative examples 1, 4 and 5 show that when the preparation parameters of the freeze-dried part and the solvent part of the cillin bottle freeze-dried facial mask are different, the effects of reducing fine wrinkles, increasing skin elasticity and tightening skin of the cillin bottle freeze-dried facial mask are reduced, and when the facial mask provided by the invention is contained in containers such as an aluminum plastic bag and a brown wide-mouth bottle, the effects of reducing fine wrinkles, increasing skin elasticity and tightening skin are reduced, and the comparative examples 1 and 2 show that when the, The skin tightening effect is remarkably reduced, when the solvent part and the freeze-dried part are compounded to form facial mask liquid, fine lines are reduced, the skin elasticity is increased, and the skin tightening effect is also remarkably reduced, and as can be seen from comparative examples and comparative examples 3-5, in the formula disclosed by the invention, one of the two is absent, and the effects of fine lines are reduced, the skin elasticity is increased, and the skin tightening effect is remarkably reduced, and the two have a synergistic effect; comparing example 1 with comparative example 6, it can be seen that when the step S6 is omitted in the method for preparing the lyophilized portion according to the present invention, the effects of weakening fine wrinkles, increasing skin elasticity, and tightening skin are significantly reduced.
In light of the foregoing description of preferred embodiments according to the invention, it is clear that many changes and modifications can be made by the person skilled in the art without departing from the scope of the invention. The technical scope of the present invention is not limited to the contents of the specification, and must be determined according to the scope of the claims.
Claims (10)
1. The penicillin bottle freeze-dried mask is characterized by comprising a freeze-dried part and a solvent part; the freeze-dried powder part is prepared from the following raw materials in parts by weight: 85-100 parts of deionized water, 2-6 parts of mannitol, 0.5-2 parts of nicotinamide, 0.6-1.8 parts of NB835, 0.6-1.2 parts of trehalose, 0.2-0.6 part of copper peptide, 0.15-0.25 part of disodium hydrogen phosphate, 0.08-0.18 part of sodium chloride, 0.05-0.15 part of tetrahydro-methylpyrimidine carboxylic acid and 0.05-0.15 part of sodium dihydrogen phosphate.
2. The penicillin bottle freeze-dried mask as claimed in claim 1, wherein the freeze-dried part is prepared from the following raw materials in parts by weight: 92.2 parts of deionized water, 4 parts of mannitol, 1 part of nicotinamide, 1 part of NB835, 0.9 part of trehalose, 0.4 part of blueish peptide, 0.18 part of disodium hydrogen phosphate, 0.12 part of sodium chloride, 0.1 part of tetrahydro-methylpyrimidine carboxylic acid and 0.1 part of sodium dihydrogen phosphate.
3. The penicillin bottle freeze-dried mask as claimed in claim 1, wherein the solvent part is prepared from the following raw materials in parts by weight: 90-100 parts of deionized water, 0.04-0.06 part of humectant, 0.03-0.05 part of polyglutamic acid, 0.8-1.2 parts of oat glucan and 0.4-0.8 part of hexanediol.
4. The penicillin bottle freeze-dried mask as claimed in claim 3, wherein the solvent part is prepared from the following raw materials in parts by weight: 98.3 parts of deionized water, 0.05 part of humectant, 0.05 part of polyglutamic acid, 1 part of oat glucan and 0.6 part of hexanediol.
5. A vial freeze-dried mask according to claim 3, wherein the humectant is sodium hyaluronate.
6. The preparation method of the penicillin bottle freeze-dried mask as claimed in any one of claims 1 to 5, which comprises the steps of preparing a freeze-drying part and a solvent part;
the preparation method of the freeze-dried part comprises the following steps:
s1: weighing the raw materials according to the proportion, putting mannitol, trehalose, sodium chloride, disodium hydrogen phosphate, sodium dihydrogen phosphate, tetrahydro-methylpyrimidine carboxylic acid and deionized water into stirring equipment, and stirring for 8-12 min at the rotating speed of 550-650 r/min to uniformly mix the mannitol, the trehalose, the sodium chloride, the disodium hydrogen phosphate, the sodium dihydrogen phosphate, the tetrahydro-methylpyrimidine carboxylic acid and the deionized water;
s2: sterilizing the mixed solution at 115-125 ℃ for 25-35 min;
s3: cooling, adding the blue copper peptide, the nicotinamide and the NB835, and stirring at the rotating speed of 550-650 r/min for 8-12 min to uniformly mix;
s4: filtering the mixed solution by using a 0.18-0.24 um microporous filter membrane, and storing in an aseptic sealed container to obtain a freeze-dried mask solution;
s5: rolling the membrane cloth into a strip shape, placing the strip shape into a sterile-processed penicillin bottle, and filling 6-10 g of freeze-dried membrane solution;
s6: putting the filled penicillin bottle into a vacuum freeze dryer, cooling to minus 45 to minus 40 ℃, preserving heat for 4 to 8 hours, and performing pre-freezing operation; heating to-10-0 ℃, preserving heat for 10-15 h, and carrying out vacuum sublimation drying; finally, heating to 40-45 ℃, preserving heat for 4-8 hours, and performing desorption drying to complete freeze drying;
s7: and (5) pressing the plug in a vacuum state, and taking out of the box to finish the production steps of the freeze-drying part.
7. The method for preparing a vial freeze-dried facial mask according to claim 6, wherein the membrane cloth is DuPont 417 Tencel membrane cloth.
8. The preparation method of a penicillin bottle freeze-dried mask as claimed in claim 6, wherein the temperature is reduced to 35-45 ℃ in the step S3.
9. The preparation method of the vial freeze-dried mask as claimed in claim 5, wherein the solvent part is prepared by:
(1) weighing the raw materials according to the proportion, putting deionized water, a humectant, polyglutamic acid and oat glucan into an emulsifying pot, heating to 80-90 ℃, uniformly stirring at the rotating speed of 650-750 r/min, and keeping the temperature for 18-22 min;
(2) cooling to 40-45 ℃, adding hexanediol, uniformly stirring at the rotating speed of 650-750 r/min, and filtering;
(3) and filling the qualified solvent liquid into an aseptically processed blank penicillin bottle, wherein the filling amount is 18-22 g.
10. The preparation method of the penicillin bottle freeze-dried mask as claimed in claim 9, wherein the filtration is performed by using 450-550 mesh filter cloth.
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