CN111440795A - 促血管生成素样3表达的调节 - Google Patents

促血管生成素样3表达的调节 Download PDF

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Publication number
CN111440795A
CN111440795A CN202010264228.7A CN202010264228A CN111440795A CN 111440795 A CN111440795 A CN 111440795A CN 202010264228 A CN202010264228 A CN 202010264228A CN 111440795 A CN111440795 A CN 111440795A
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certain embodiments
antisense
angpt
modified
oligonucleotide
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CN202010264228.7A
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Chinese (zh)
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S·M·弗赖尔
M·J·格雷厄姆
R·M·克鲁克
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Ionis Pharmaceuticals Inc
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Ionis Pharmaceuticals Inc
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
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    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
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CN202010264228.7A 2013-12-24 2014-12-24 促血管生成素样3表达的调节 Pending CN111440795A (zh)

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US201361920652P 2013-12-24 2013-12-24
US61/920,652 2013-12-24
CN201480068063.9A CN105814204B (zh) 2013-12-24 2014-12-24 促血管生成素样3表达的调节

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CN202010264228.7A Pending CN111440795A (zh) 2013-12-24 2014-12-24 促血管生成素样3表达的调节
CN202010264234.2A Pending CN111394355A (zh) 2013-12-24 2014-12-24 促血管生成素样3表达的调节
CN201480068063.9A Expired - Fee Related CN105814204B (zh) 2013-12-24 2014-12-24 促血管生成素样3表达的调节

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CN201480068063.9A Expired - Fee Related CN105814204B (zh) 2013-12-24 2014-12-24 促血管生成素样3表达的调节

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US (3) US20170037409A1 (enExample)
EP (2) EP3770259A1 (enExample)
JP (2) JP6643996B2 (enExample)
KR (2) KR102198082B1 (enExample)
CN (3) CN111440795A (enExample)
AU (2) AU2014369900B2 (enExample)
BR (1) BR112016013473A2 (enExample)
CA (1) CA2931510A1 (enExample)
DK (1) DK3087183T3 (enExample)
ES (1) ES2830257T3 (enExample)
HU (1) HUE052243T2 (enExample)
IL (2) IL245707B (enExample)
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NZ (1) NZ720286A (enExample)
PL (1) PL3087183T3 (enExample)
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RU (1) RU2706964C2 (enExample)
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JP7365052B2 (ja) 2017-12-01 2023-10-19 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用
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WO2019105418A1 (zh) 2017-12-01 2019-06-06 苏州瑞博生物技术有限公司 双链寡核苷酸、含双链寡核苷酸的组合物与缀合物及制备方法和用途
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JP2021533800A (ja) 2018-08-21 2021-12-09 スーチョウ リボ ライフ サイエンス カンパニー、リミテッドSuzhou Ribo Life Science Co., Ltd. 核酸、当該核酸を含む薬物組成物及び複合体ならびにその使用
CN111655297A (zh) 2018-09-30 2020-09-11 苏州瑞博生物技术有限公司 一种siRNA缀合物及其制备方法和用途
WO2020099525A2 (en) * 2018-11-13 2020-05-22 Lipigon Pharmaceuticals Ab Oligonucleotides influencing the regulation of the fatty acid metabolism
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CN111973617A (zh) * 2019-05-23 2020-11-24 苏州瑞博生物技术股份有限公司 核酸、药物组合物与缀合物及制备方法和用途
MX2022011550A (es) * 2020-03-18 2023-01-04 Dicerna Pharmaceuticals Inc Composiciones y métodos para inhibir la expresión de angptl3.
BR112022020407A2 (pt) 2020-04-09 2023-05-02 Verve Therapeutics Inc Edição base do pcsk9 e métodos de uso do mesmo para tratamento de doenças
JP2023546103A (ja) * 2020-10-16 2023-11-01 サノフイ Ａｎｇｐｔｌ３を阻害するための新規のｒｎａ組成物および方法
WO2023122656A1 (en) 2021-12-22 2023-06-29 Regeneron Pharmaceuticals, Inc. Treatment of kidney diseases with angiopoietin like 3 (angptl3) inhibitors
WO2023134705A1 (zh) * 2022-01-11 2023-07-20 上海金中锘美生物医药科技有限公司 抑制angptl3表达的rna干扰剂及其用途
AU2023227443A1 (en) 2022-03-01 2024-10-10 Crispr Therapeutics Ag Methods and compositions for treating angiopoietin-like 3 (angptl3) related conditions
KR20250054795A (ko) * 2022-08-22 2025-04-23 애로우헤드 파마슈티컬스 인코포레이티드 Angptl3-관련 질환 및 장애의 치료 방법
IL320389A (en) 2022-11-10 2025-06-01 Regeneron Pharma Treatment of kidney disease using a combination of angiopoietin-like 3 (ANGPTL3) inhibitors and solute carrier family 5 member 2 (SLC5A2) inhibitors

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