CN111419893B - Pharmaceutical composition for treating duck leg tenderness - Google Patents
Pharmaceutical composition for treating duck leg tenderness Download PDFInfo
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Abstract
The invention relates to a pharmaceutical composition for treating duck leg weakness, which comprises the following components in parts by weight: 35-45 parts of fructus psoraleae, 5-15 parts of lycopodium clavatum, 5-15 parts of caulis spatholobi, 25-35 parts of bighead atractylodes rhizome and 35-45 parts of radix achyranthis bidentatae. The invention takes the treatment principle of tonifying kidney and strengthening bones and warming and recuperating kidney yang, and has reasonable formula, simple preparation process and wide application range. The invention is dialectically prepared by adopting pure Chinese herbal medicines, has obvious effect of regulating body functions, can effectively treat the meat duck soft leg disease, and has strong pertinence, short recovery period and convenient use. Clinical tests prove that the cure rate reaches more than 90 percent and the Chinese medicinal preparation has unique curative effect.
Description
Technical Field
The invention relates to a pharmaceutical composition for treating duck soft leg disease, and belongs to the technical field of traditional Chinese veterinary medicines.
Background
In modern meat poultry breeding, the leg softening diseases of poultry mainly include damp field and no ventilation of poultry houses. The poultry bred in the housing is easy to cause the disease because of less sunlight, insufficient movement, overlarge density of poultry flock or insufficient nutrition of daily ration, lack of mineral substances, especially improper proportion of calcium and phosphorus, lack of vitamin D and the like.
Chinese patent document CN102512574A (application No. 201110427425.7) discloses a traditional Chinese medicine composition for treating animal osteomalacia, which comprises: the traditional Chinese medicine composition comprises, by weight, 10-20 parts of astragalus membranaceus, 10-20 parts of angelica sinensis, 10-20 parts of caulis spatholobi, 10-20 parts of donkey-hide gelatin, 10-20 parts of tortoise plastron, 5-10 parts of ephedra, 5-10 parts of cassia twig, 20-40 parts of semen cuscutae, 20-40 parts of fructus psoraleae, 20-40 parts of semen allii tuberosi, 10-20 parts of ochre and 10-20 parts of achyranthes bidentata. The raw material medicines are high in price, and when the raw material medicines are applied to meat ducks, the effect is general, and the treatment effect cannot meet the market requirement.
In the process of feeding meat ducks actually, the inventor finds out through research that the meat ducks are waterfowls, so that the main factors causing the soft-leg disease are not the currently generally considered reasons of damp field, no ventilation of poultry houses and the like. More, the large-scale meat duck breeding farm mostly adopts a complete barn feeding mode, the density of duck groups is too high, the movement is insufficient, and the meat ducks are generally fed in a duck-filling mode, so that the spleen and stomach of the meat ducks are not sufficiently transported and transformed, the liver and kidney functions are weakened, the bones and muscles of the meat ducks are weak, and the main reason for causing the duck leg weakness is solved.
Disclosure of Invention
The invention aims to solve the technical problem of providing a pharmaceutical composition for treating meat duck soft leg diseases, and the pharmaceutical composition can effectively treat the meat duck soft leg diseases through the synergistic attenuation of the compatibility of various pharmaceutical components.
The invention is realized by the following technical scheme:
a pharmaceutical composition for treating meat duck leg weakness comprises the following components in parts by weight:
35-45 parts of fructus psoraleae, 5-15 parts of lycopodium clavatum, 5-15 parts of caulis spatholobi, 25-35 parts of bighead atractylodes rhizome and 35-45 parts of radix achyranthis bidentatae.
The preferable proportion of the raw materials is as follows: 30 parts of fructus psoraleae, 10 parts of lycopodium clavatum, 10 parts of caulis spatholobi, 10 parts of bighead atractylodes rhizome and 40 parts of radix achyranthis bidentatae.
Preferably, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight:
30 parts of fructus psoraleae, 10 parts of lycopodium clavatum, 10 parts of caulis spatholobi, 10 parts of bighead atractylodes rhizome and 40 parts of radix achyranthis bidentatae.
Preferably, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight:
35 parts of fructus psoraleae, 15 parts of lycopodium clavatum, 5 parts of caulis spatholobi, 15 parts of bighead atractylodes rhizome and 45 parts of radix achyranthis bidentatae.
The granularity of the fructus psoraleae, the lycopodium clavatum, the caulis spatholobi, the bighead atractylodes rhizome and the radix achyranthis bidentatae is 20-200 meshes.
The feeding mode of the traditional Chinese medicine composition is to mix the traditional Chinese medicine composition into feed or to decoct the traditional Chinese medicine composition with water, 0.5g of water per kilogram of body weight is decocted and then mixed into the feed to administer the medicine to sick meat ducks for 1 time every day for 5 days continuously.
A feed for treating meat duck leg weakness is prepared by adding the medicinal composition for treating meat duck leg weakness into traditional meat duck feed.
The feed is applied to the large-scale duck farm for breeding meat ducks;
preferably, the meat duck is cherry valley meat duck or semi-Muscovy meat duck.
The properties of the drug are as follows:
psoralea fruit: pungent and bitter in flavor, warm in nature, entering kidney and spleen meridians. Has the functions of warming kidney and strengthening yang, absorbing qi and stopping diarrhea, and is used for treating waist and hip cold pain, kidney deficiency cold diarrhea, kidney deficiency asthma, impotence, spermatorrhea, frequent micturition and the like.
B, common clubmoss herb: slightly bitter and pungent taste, warm. It enters liver, spleen and kidney meridians. Dispel wind and dampness, relax tendons and activate collaterals. Can be used for treating joint pain and difficulty in flexion and extension.
Caulis spatholobi: bitter, sweet and warm in taste. It enters liver and kidney meridians. Promoting blood circulation, tonifying blood, regulating menstruation, relieving pain, relaxing muscles and tendons, and expelling collateral obstruction. Can be used for treating numbness and paralysis of limbs, rheumatalgia, and deficiency of qi and blood.
White atractylodes rhizome: bitter, sweet and warm in taste. It enters spleen and stomach meridians. Invigorate spleen, replenish qi, dry dampness, induce diuresis, stop sweating, prevent abortion. Can be used for treating deficiency of spleen-deficiency type food, abdominal distention, diarrhea, phlegm retention, dizziness, palpitation, edema, spontaneous perspiration, and threatened abortion.
Achyranthes bidentata: bitter, sweet and sour in taste and neutral in nature. It enters liver and kidney meridians. Tonify liver and kidney, strengthen tendons and bones, dispel blood stasis and dredge channels, draw blood and draw herbs downwards. Can be used for treating lumbago, hip pain, traumatic injury, puerperal blood stasis, and retained afterbirth.
The Chinese veterinarian considers that the kidney governs bones and tonifies the kidney first. Due to kidney qi deficiency, kidney essence deficiency, insufficient bone marrow source and incapability of nourishing bones, the bones are empty and the bone mineral content is reduced, so that standing and walking are difficult. Whether the skeleton is strong or weak is also related to the strength of spleen function. Spleen qi deficiency, food essence and food essence are poorly transported and transformed, and bone nourishment cannot be guaranteed, and essence and blood in kidney cannot be nourished, thereby resulting in bone loss and bone loosening. In view of this, the therapeutic principle of the leg tenderness of meat ducks is to nourish liver and kidney, strengthen tendons and bones and strengthen spleen and stomach.
The traditional Chinese medicine composition is prepared from 5 traditional Chinese medicines of fructus psoraleae, lycopodium clavatum, caulis spatholobi, bighead atractylodes rhizome and radix achyranthis bidentatae according to the monarch, minister, assistant and guide compatibility principle. In the formula, the fructus psoraleae is a monarch drug, and has the effects of tonifying liver and kidney, strengthening muscles and bones, warming kidney, tonifying yang and dispelling cold pain; the pungent, warm, flee and descending nature of the lycopodium clavatum is better for treating pain and cold in feet and knees, dispelling wind and eliminating dampness, relaxing tendons and activating collaterals; the caulis spatholobi can activate blood and nourish blood, has the functions of relaxing tendons and activating collaterals, and is used as a ministerial drug. The bighead atractylodes rhizome, rhizoma atractylodis macrocephalae, as an adjuvant drug, has the effects of strengthening spleen and replenishing qi, and eliminating dampness and inducing diuresis; achyranthes root, radix Achyranthis bidentatae, as a guiding drug, can tonify kidney and strengthen bone, and guide the drug to the kidney. The traditional Chinese medicine composition has the effects of tonifying kidney and spleen, nourishing bone and marrow, promoting bone nutrition and calcium absorption, regulating qi and blood circulation in vivo, relaxing tendons and activating collaterals, and quickly relieving pain and other symptoms.
Compared with the prior art, the invention has the beneficial effects that:
the invention takes the treatment principle of tonifying kidney and strengthening bones and warming and recuperating kidney yang, and has reasonable formula, simple preparation process and wide application range. The invention is dialectically prepared by adopting pure Chinese herbal medicines, has obvious effect of regulating body functions, can effectively treat the meat duck soft leg disease, and has strong pertinence, short recovery period and convenient use. Clinical tests prove that the cure rate reaches more than 90 percent and the Chinese medicinal preparation has unique curative effect.
Detailed Description
The following detailed description of the embodiments provided in accordance with the present invention is provided in conjunction with the preferred embodiments:
example 1
Pulverizing various raw materials in the formula, sieving with a 200-mesh sieve, weighing 30 parts of fructus psoraleae, 10 parts of lycopodium clavatum, 10 parts of caulis spatholobi, 10 parts of rhizoma atractylodis macrocephalae and 40 parts of radix achyranthis bidentatae, and uniformly mixing.
Example 2
Pulverizing the raw materials in the formula, sieving with a 100-mesh sieve, weighing 35 parts of fructus psoraleae, 15 parts of lycopodium clavatum, 5 parts of caulis spatholobi, 15 parts of rhizoma atractylodis macrocephalae and 45 parts of radix achyranthis bidentatae, and uniformly mixing.
Example 3
Pulverizing the raw materials in the formula, sieving with a 20-mesh sieve, weighing 45 parts of fructus psoraleae, 5 parts of lycopodium clavatum, 15 parts of caulis spatholobi, 5 parts of rhizoma atractylodis macrocephalae and 35 parts of radix achyranthis bidentatae, and uniformly mixing.
Example 4
Pulverizing the raw materials in the formula, sieving with a 200-mesh sieve, weighing 38 parts of fructus psoraleae, 12 parts of lycopodium clavatum, 8 parts of caulis spatholobi, 12 parts of rhizoma atractylodis macrocephalae and 42 parts of radix achyranthis bidentatae, and uniformly mixing.
Example 5
Pulverizing the raw materials in the formula, sieving with a 200-mesh sieve, weighing 42 parts of fructus psoraleae, 8 parts of lycopodium clavatum, 12 parts of caulis spatholobi, 8 parts of rhizoma atractylodis macrocephalae and 38 parts of radix achyranthis bidentatae, and uniformly mixing.
Comparative example 1
Pulverizing the raw materials in the formula, sieving with a 200-mesh sieve, weighing 30 parts of parasitic loranthus, 10 parts of lycopodium clavatum, 10 parts of caulis spatholobi, 10 parts of bighead atractylodes rhizome and 40 parts of radix achyranthis bidentatae, and uniformly mixing.
Comparative example 2
Pulverizing the raw materials in the formula, sieving with a 200-mesh sieve, weighing 30 parts of fructus psoraleae, 10 parts of lycopodium clavatum, 10 parts of rhizoma cibotii, 10 parts of rhizoma atractylodis macrocephalae and 40 parts of radix achyranthis bidentatae, and uniformly mixing.
Comparative example 3
Pulverizing the raw materials in the formula, sieving with a 200-mesh sieve, weighing 30 parts of fructus psoraleae, 10 parts of lycopodium clavatum, 10 parts of caulis spatholobi, 10 parts of codonopsis pilosula and 40 parts of radix achyranthis bidentatae, and uniformly mixing.
Application example 1:
lotus and Wu certain cherry valley meat duck farm
2000 meat ducks suffered from the disease in the field successively showed that the diseased ducks were listened, inconvenient to move, often could not turn over, had soft and weak feet, ran and could not stand.
The medicines of examples 1 to 5 and comparative examples 1 to 3 of the present invention were decocted in water at a dose of 0.5g per kg body weight, and then mixed into feed to be administered to the affected duck 1 time per day for 5 days, taking the normal walking and normal ingestion of the duck as the cure criteria, and meanwhile, the technical scheme of example 2 described in chinese patent document CN102512574A (application No. 201110427425.7) was adopted, and the treatment was performed at the same administration amount as comparative example 4, and any medicine was not used as a control group, and the results are shown in the following table:
TABLE 1
| The groupTotal number of items | The number of cured patients | Number of incurable cases | Number of deaths | Cure rate | |
| Example 1 | 200 | 187 | 13 | 5 | 93.5% |
| Example 2 | 200 | 181 | 19 | 7 | 90.5% |
| Example 3 | 200 | 189 | 11 | 2 | 94.5% |
| Example 4 | 200 | 186 | 16 | 5 | 93% |
| Example 5 | 200 | 180 | 20 | 9 | 90% |
| Comparative example 1 | 200 | 173 | 27 | 10 | 86.5% |
| Comparative example 2 | 200 | 168 | 32 | 9 | 84% |
| Comparative example 3 | 200 | 175 | 25 | 11 | 87.5% |
| Comparative example 4 | 200 | 114 | 56 | 30 | 57% |
| Control group | 200 | 0 | 200 | 29 | 0 |
Application example 2:
anhui Funan certain half Muscovy meat duck farm
2600 patients had the disease in this time, the sick ducks had poor mental performance, the feed intake was reduced obviously, the feet were soft and weak at the beginning, the walking was unstable, the ducks turned over, and the ducks died seriously and gradually.
The medicines of examples 1 to 5 and comparative examples 1 to 3 of the present invention were decocted in water at a dose of 0.5g per kg body weight, and then mixed into feed to be administered to the affected duck 1 time per day for 5 days, taking the normal walking and normal ingestion of the duck as the cure criteria, and meanwhile, the technical scheme of example 2 described in chinese patent document CN102512574A (application No. 201110427425.7) was adopted, and the treatment was performed at the same administration amount as comparative example 4, and any medicine was not used as a control group, and the results are shown in the following table:
TABLE 2
| Total number of the group | The number of cured patients | Number of incurable cases | Number of deaths | Cure rate | |
| Example 1 | 260 | 237 | 23 | 10 | 91.2% |
| Example 2 | 260 | 242 | 18 | 9 | 93.1% |
| Example 3 | 260 | 241 | 19 | 8 | 92.3% |
| Example 4 | 260 | 235 | 25 | 12 | 90.4% |
| Example 5 | 260 | 245 | 15 | 5 | 94.2% |
| Comparative example 1 | 260 | 226 | 34 | 14 | 86.9% |
| Comparative example 2 | 260 | 223 | 37 | 17 | 85.7% |
| Comparative example 3 | 260 | 221 | 39 | 17 | 85% |
| Comparative example 4 | 260 | 143 | 80 | 37 | 55% |
| Control group | 260 | 0 | 260 | 36 | 0 |
Analysis of results
The medicine has no toxic and side effect and is convenient to use. When in use, the medicine is mixed into feed according to 0.5g of body weight per kilogram and is administrated to ducks for 1 time per day for 5 days continuously, the ducks walk normally and feed intake normally is taken as a cure standard, and clinical tests prove that the medicine has unique curative effect, and the cure rate is over 90 percent.
As can be seen from the results, the drug combination of example 1 of the present application is significantly higher in cure rate than the group of comparative example 1. The fructus psoraleae serving as the monarch drug in the embodiment 1 enters spleen and kidney meridians, can warm water and nourish fire to generate soil, so that the vital yang in the kidney can nourish and rise, and can decay cooked rice and steam dregs to refine essence. Spleen qi disperses essence and enters lung to nourish five zang organs, so it is mainly used for internal organs. Therefore, the specific monarch drug fructus psoraleae in the pharmaceutical composition has the effects of tonifying kidney and strengthening yang, tonifying spleen and invigorating stomach, strengthening spleen qi, promoting qi and blood generation, and combining muscles to dominate four limbs, and is used together with lycopodium clavatum, caulis spatholobi, rhizoma atractylodis macrocephalae and radix achyranthis bidentatae serving as a channel-inducing drug to achieve the effects of promoting qi and blood circulation, relaxing tendons and activating collaterals, and strengthening tendons and bones. Therefore, the traditional Chinese medicine composition can effectively treat symptoms of swollen joints of two legs, difficult transportation, swinging during walking, incapability of standing and the like caused by the soft leg disease of ducks. Although the monarch drug loranthus parasiticus in the group of the comparative example 1 also has the functions of nourishing liver and kidney and strengthening tendons and bones, the traditional Chinese medicine loranthus parasiticus can be used for treating liver and kidney deficiency, soreness and pain of waist and knees and weakness of muscles and bones. However, the overall compatibility and the synergistic effect are slightly inferior to those of the drug compatibility combination in example 1, and the cure rate is lower than that of the group in example 1.
The cure rate of example 1 of the present invention is significantly higher than that of comparative example 2. The Chinese medicinal composition is bitter but not dry, warm but not strong, and has the effects of enriching and nourishing blood, promoting blood circulation to remove blood stasis, relaxing muscles and tendons and activating collaterals. It is combined with Bu Gu Zhi to tonify essence and qi, tonify kidney and strengthen bone. Although the cibotium barometz in the comparative example 2 enters liver and kidney meridians, it also has the effects of nourishing liver and kidney, strengthening waist and knees, and dispelling wind-damp. However, in the comparative example, the treatment effect is obviously reduced after the caulis spatholobi is replaced by the rhizoma cibotii, and the effect of the rhizoma cibotii on promoting blood circulation and relaxing muscles and tendons in the formula is probably related to weaker compatibility and synergism of the whole formula. Therefore, the pharmaceutical composition has the effects of promoting qi and blood circulation, relaxing tendons and activating collaterals and strengthening tendons and bones through scientific compatibility, and can effectively treat symptoms such as swollen joints of two legs, difficult transportation, swinging during walking, incapability of standing and the like caused by the soft leg disease of ducks.
Application example 3
Shandong Qingdao certain laying hen farm
In the field, 3000 laying hens suffer diseases in sequence, the laying rate is reduced, the treatment of eggshells is poor, and the egg breakage rate is increased. Feather is fluffy, standing is difficult, legs are soft, joints are not flexible, paralysis is caused in the later period of the disease, and sporadic death occurs.
The medicine applied to the embodiment of the invention is mixed into feed according to 0.5g per kilogram of body weight and is added into the feed to sick chicken for administration 1 time per day for 5 days continuously, so that the sick chicken can walk normally, eat normally and do not relapse after 1 month as a cure standard, meanwhile, the technical scheme of the embodiment 2 recorded in Chinese patent document CN102512574A (application No. 201110427425.7) is adopted, the sick chicken is treated as a comparative example 4 according to the same application amount, no medicine is used as a control group, and the results are shown in the following table:
TABLE 3
| Total number of the group | The number of cured patients | Number of incurable cases | Number of deaths | Cure rate | |
| Example 1 | 300 | 180 | 120 | 13 | 60% |
| Example 2 | 300 | 186 | 114 | 11 | 62% |
| Example 3 | 300 | 178 | 122 | 15 | 59.3% |
| Example 4 | 300 | 166 | 134 | 23 | 55% |
| Example 5 | 300 | 183 | 117 | 16 | 61% |
| Comparative example 1 | 300 | 179 | 121 | 12 | 59.7% |
| Comparative example 2 | 300 | 173 | 127 | 17 | 57.7% |
| Comparative example 3 | 300 | 168 | 132 | 21 | 56% |
| Comparative example 4 | 300 | 252 | 40 | 8 | 84% |
| Control group | 300 | 0 | 300 | 56 | 0 |
Analysis of results
The chickens are birds, which are obviously different from duck waterfowls belonging to water animals, and the soft leg diseases of the chickens and the ducks are different from the soft leg diseases of the ducks due to the fact that the ducks mainly inhabit the humid environment; the principle of treating the leg tenderness of the meat ducks is to nourish liver and kidney, strengthen tendons and bones and strengthen spleen and stomach. Tonifying kidney, strengthening bone and expelling wind-damp are the therapeutic principles for chicken leg weakness. And the difference causes the difference in the process of medicine compatibility, and the data in the table 3 also show that the prescription has a remarkably poorer effect than that of ducks when used for treating the chicken leg weakness.
The above detailed description of the Chinese medicinal composition for treating duck leg weakness with reference to the embodiments is illustrative and not restrictive, and several embodiments can be enumerated according to the limited scope, so that changes and modifications without departing from the general concept of the present invention shall fall within the protection scope of the present invention.
Claims (7)
1. The pharmaceutical composition for treating the meat duck soft leg disease is characterized by comprising the following components in parts by weight:
fructus psoraleae 45 parts, lycopodium clavatum 5 parts, caulis spatholobi 15 parts, bighead atractylodes rhizome 5 parts and radix achyranthis bidentatae 35 parts.
2. The pharmaceutical composition for treating the meat duck soft leg disease is characterized by comprising the following raw material medicines in parts by weight:
30 parts of fructus psoraleae, 10 parts of lycopodium clavatum, 10 parts of caulis spatholobi, 10 parts of bighead atractylodes rhizome and 40 parts of radix achyranthis bidentatae.
3. The pharmaceutical composition for treating the meat duck soft leg disease is characterized by comprising the following raw material medicines in parts by weight:
35 parts of fructus psoraleae, 15 parts of lycopodium clavatum, 5 parts of caulis spatholobi, 15 parts of bighead atractylodes rhizome and 45 parts of radix achyranthis bidentatae.
4. The pharmaceutical composition for treating the meat duck soft leg disease is characterized by comprising the following raw material medicines in parts by weight:
38 parts of fructus psoraleae, 12 parts of lycopodium clavatum, 8 parts of caulis spatholobi, 12 parts of bighead atractylodes rhizome and 42 parts of radix achyranthis bidentatae.
5. The pharmaceutical composition for treating the meat duck soft leg disease is characterized by comprising the following raw material medicines in parts by weight:
42 parts of fructus psoraleae, 8 parts of lycopodium clavatum, 12 parts of caulis spatholobi, 8 parts of bighead atractylodes rhizome and 38 parts of radix achyranthis bidentatae.
6. The pharmaceutical composition of any one of claims 1-5, wherein the particle size of fructus Psoraleae, Lycopodium clavatum, caulis Spatholobi, Atractylodis rhizoma, and Achyranthis radix is 20-200 mesh.
7. A feed for treating meat duck soft leg diseases is characterized in that the pharmaceutical composition for treating the meat duck soft leg diseases as claimed in any one of claims 1 to 5 is added into a traditional meat duck feed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010321864.9A CN111419893B (en) | 2020-04-22 | 2020-04-22 | Pharmaceutical composition for treating duck leg tenderness |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010321864.9A CN111419893B (en) | 2020-04-22 | 2020-04-22 | Pharmaceutical composition for treating duck leg tenderness |
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| CN102512574A (en) * | 2011-12-20 | 2012-06-27 | 青岛农业大学 | Traditional Chinese medicine composition for treating animal rickets, its preparation method and its application |
| CN102935163A (en) * | 2012-11-26 | 2013-02-20 | 任玉金 | Traditional Chinese preparation for treating hyperosteogeny |
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| CN102512574A (en) * | 2011-12-20 | 2012-06-27 | 青岛农业大学 | Traditional Chinese medicine composition for treating animal rickets, its preparation method and its application |
| CN102935163A (en) * | 2012-11-26 | 2013-02-20 | 任玉金 | Traditional Chinese preparation for treating hyperosteogeny |
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Denomination of invention: Drug composition for treating duck soft leg disease Effective date of registration: 20230530 Granted publication date: 20210803 Pledgee: Gaoqing County sub branch of China Postal Savings Bank Co.,Ltd. Pledgor: ZIBO WELLCELL BIOTECHNOLOGY Co.,Ltd. Registration number: Y2023980042036 |
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